Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:2992295 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
299229529940131719urease alpha subunitQuickGO ontologyBLASTP
29943092995004696urease accessory proteinQuickGO ontologyBLASTP
29950262995712687urease accessory proteinQuickGO ontologyBLASTP
29958392996501663urease accessory proteinQuickGO ontologyBLASTP
29976562998648993putative urea transporterQuickGO ontologyBLASTP
299879729998551059putative nickel transport proteinQuickGO ontologyBLASTP
30000243000353330hypothetical proteinBLASTP
300097130021461176putative potassium channel proteinQuickGO ontologyBLASTP
30022443002648405camphor resistance protein CrcBQuickGO ontologyBLASTP
30026643003044381camphor resistance protein CrcBQuickGO ontologyBLASTP
30040853004402318PTS system cellobiose-specific IIB componentQuickGO ontologyBLASTP
300441330057741362PTS system cellobiose-specific IIC componentQuickGO ontologyBLASTP
30059413006288348PTS system cellobiose-specific IIA componentQuickGO ontologyBLASTP
30063253007167843cel operon repressorQuickGO ontologyBLASTP
30072193007980762hypothetical proteinBLASTP
30079873008163177hypothetical proteinBLASTP
30082753008643369hypothetical proteinBLASTP
30091383009665528putative negative regulator of replication initiationQuickGO ontologyBLASTP
300973830113811644phosphoglucomutaseQuickGO ontologyBLASTP