Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:2849377 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
284937728506601284putative lipoproteinQuickGO ontologyBLASTP
28514192852183765gluconate 5-dehydrogenaseQuickGO ontologyBLASTP
28522322852768537putative thermosensitive gluconokinaseQuickGO ontologyBLASTP
28528462853313468hypothetical proteinBLASTP
285365128548411191hypothetical proteinBLASTP
285507728565401464NADH dehydrogenase subunit NQuickGO ontologyBLASTP
285654728580791533NADH dehydrogenase subunit MQuickGO ontologyBLASTP
285811928599631845NADH dehydrogenase subunit LQuickGO ontologyBLASTP
28599602860262303NADH dehydrogenase kappa subunitQuickGO ontologyBLASTP
28602592860804546NADH dehydrogenase subunit JQuickGO ontologyBLASTP
28608172861359543NADH dehydrogenase subunit IQuickGO ontologyBLASTP
28613742862351978NADH dehydrogenase subunit HQuickGO ontologyBLASTP
286234828650922745NADH dehydrogenase gamma subunitQuickGO ontologyBLASTP
286517928665641386NADH dehydrogenase I chain FQuickGO ontologyBLASTP
28665612867079519ATP synthase subunit EQuickGO ontologyBLASTP
286712728689231797NADH dehydrogenase I chain CDQuickGO ontologyBLASTP
28690642869741678NADH dehydrogenase beta subunitQuickGO ontologyBLASTP
28698432870337495NADH dehydrogenase alpha subunitQuickGO ontologyBLASTP
28710212871953933LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP