Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:2778494 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
277849427797801287putative solute-binding proteinQuickGO ontologyBLASTP
278005227810921041LacI-family transcriptional regulatory proteinQuickGO ontologyBLASTP
278110927824971389phosphomannomutaseQuickGO ontologyBLASTP
278259727836761080putative mannitol transport ATP-binding proteinQuickGO ontologyBLASTP
27839412784486546hypothetical proteinBLASTP
27847442785196453hypothetical proteinBLASTP
27852962785700405hypothetical proteinBLASTP
27858422786009168hypothetical proteinBLASTP
27862122786409198hypothetical proteinBLASTP
278641927884522034hypothetical proteinBLASTP
27886652789003339hypothetical protein
27891162789367252hypothetical proteinBLASTP
27896122790115504hypothetical proteinBLASTP
279012327977307608putative hemolysinQuickGO ontologyBLASTP
279787427995621689putative hemolysin activator proteinQuickGO ontologyBLASTP