Pre_GI Gene

Some Help

Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:2741478 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27405972741481885chelated iron transport system membrane proteinQuickGO ontologyBLASTP
27414782742371894chelated iron transport system membrane proteinQuickGO ontologyBLASTP
27424392742651213hypothetical proteinBLASTP
27426762743551876hypothetical proteinBLASTP
27436802744234555putative yfeABCD locus regulatorQuickGO ontologyBLASTP
27446452745310666hypothetical proteinBLASTP
274556127467691209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
274713027482451116putative sarcosine oxidaseQuickGO ontologyBLASTP
27485122749126615putative LuxR-family regulatory proteinQuickGO ontologyBLASTP
274969827507561059hypothetical proteinBLASTP
275090527519721068hypothetical proteinBLASTP
27520162752144129hypothetical proteinBLASTP
27523312752693363hypothetical proteinBLASTP
27528252752986162hypothetical proteinBLASTP
27530232753721699hypothetical proteinBLASTP
27541192754775657N-acylhomoserine lactone synthase YpeIQuickGO ontologyBLASTP
27547682755505738quorum-sensing transcriptional activator YpeRQuickGO ontologyBLASTP
27559922756972981putative LysR-family transcriptional regulatorQuickGO ontologyBLASTP
275736627587241359putative transporter proteinQuickGO ontologyBLASTP
27587712759274504hypothetical proteinBLASTP
275928527603041020putative oxidoreductaseQuickGO ontologyBLASTP
27603822760936555hypothetical proteinBLASTP
276094727619511005hypothetical proteinBLASTP
27619692762919951hypothetical proteinBLASTP
276291627642621347hypothetical proteinBLASTP