Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:2433190 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24331902433741552putative nitroreductaseQuickGO ontologyBLASTP
243396624350121047selenophosphate synthetaseQuickGO ontologyBLASTP
243507124369991929DNA topoisomerase IIIQuickGO ontologyBLASTP
24369962437286291hypothetical proteinBLASTP
24372992437685387putative pyrophosphohydrolaseQuickGO ontologyBLASTP
24377832438589807exodeoxyribonuclease IIIQuickGO ontologyBLASTP
24393992440259861putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
2440767244085185tRNA-TyrQuickGO ontologyBLASTP
244113124423391209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
24432552443719465hypothetical proteinBLASTP
244505324460691017probable response regulatorQuickGO ontologyBLASTP
244637624477221347putative nucleotide sugar dehydrogenaseQuickGO ontologyBLASTP
24481572448555399DNA-binding protein HnsQuickGO ontologyBLASTP
24493052449895591thymidine kinaseQuickGO ontologyBLASTP
24502642451046783transposaseIS proteinQuickGO ontologyBLASTP
245104324520651023transposase for insertion sequence IS100QuickGO ontologyBLASTP
245260524552802676aldehyde-alcohol dehydrogenaseQuickGO ontologyBLASTP
24560872456731645hypothetical proteinBLASTP
245756924592061638periplasmic oligopeptide-binding protein precursorQuickGO ontologyBLASTP