Pre_GI Gene

Some Help

Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:2258636 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
225863622607982163hypothetical proteinBLASTP
226137622634872112hypothetical proteinBLASTP
22637342264372639hypothetical proteinBLASTP
22645072265166660hypothetical proteinBLASTP
22652712265951681putative dehydrogenaseQuickGO ontologyBLASTP
22662922267242951hypothetical proteinBLASTP
22672292268161933hypothetical proteinBLASTP
22681672269072906hypothetical proteinBLASTP
226986322709361074hypothetical proteinBLASTP
22711492271619471hypothetical proteinBLASTP
22716742272096423putative decarboxylaseQuickGO ontologyBLASTP
227237322737641392putative two-component system sensor proteinQuickGO ontologyBLASTP
22737702274462693transcriptional activatorQuickGO ontologyBLASTP
227472722758181092hypothetical proteinBLASTP
22759672276674708flavodoxinQuickGO ontologyBLASTP
22766892277384696hypothetical proteinBLASTP
22775932278435843hypothetical proteinBLASTP