Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:2101902 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
210190221030321131hypothetical proteinBLASTP
210304321043471305hypothetical proteinBLASTP
21044332105032600TrpR binding protein WrbAQuickGO ontologyBLASTP
210542621066041179hypothetical proteinBLASTP
210673021081541425D-serineD-alanineglycine transporterQuickGO ontologyBLASTP
2108507210858276tRNA-LysQuickGO ontologyBLASTP
21092692109820552attachment invasion locus proteinQuickGO ontologyBLASTP
21098592110041183hypothetical proteinBLASTP
21101602110414255hypothetical proteinBLASTP
21104422110783342hypothetical proteinBLASTP
21109112111135225hypothetical proteinBLASTP
21117982112454657response regulatorQuickGO ontologyBLASTP
211244721142791833excinuclease ABC subunit CQuickGO ontologyBLASTP
21143382114886549CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
2115031211510676tRNA-GlyQuickGO ontology
2115159211523274tRNA-CysQuickGO ontologyBLASTP
2115243211532886tRNA-LeuQuickGO ontologyBLASTP
21156262116141516hypothetical proteinBLASTP
21162522116479228replicative DNA helicase partialQuickGO ontologyBLASTP
21168482116994147hypothetical proteinBLASTP
21178162117974159hypothetical proteinBLASTP
21180032118347345hypothetical proteinBLASTP
21185672119526960putative transposaseQuickGO ontologyBLASTP
21195982120044447hypothetical proteinBLASTP