Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:1973867 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
197476819757901023transposase for insertion sequence IS100QuickGO ontologyBLASTP
19757871976569783transposaseIS proteinQuickGO ontologyBLASTP
1976985197706076tRNA-AsnQuickGO ontologyBLASTP
19772381978050813hypothetical proteinBLASTP
19784401978724285hypothetical proteinBLASTP
19789611979812852hypothetical proteinBLASTP
197991519816331719putative ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
19822891982453165hypothetical proteinBLASTP
19825351982921387AraC-family transcriptional regulatory proteinQuickGO ontologyBLASTP
19834771983716240hypothetical proteinBLASTP
19838071984025219hypothetical proteinBLASTP
19846231984898276hypothetical proteinBLASTP
19851611985460300hypothetical proteinBLASTP
19855031985814312hypothetical proteinBLASTP
198605119874241374aromatic amino acid transport proteinQuickGO ontologyBLASTP
19877291988328600hypothetical proteinBLASTP
19893301989446117hypothetical proteinBLASTP
19894891989698210cold shock proteinQuickGO ontologyBLASTP
19897891990544756hypothetical proteinBLASTP
19909391991778840rRNA guanine-N1--methyltransferaseQuickGO ontologyBLASTP
19920001992278279hypothetical proteinBLASTP
199264619936681023transposase for insertion sequence IS100QuickGO ontologyBLASTP
19936651994447783transposaseIS proteinQuickGO ontologyBLASTP
199689919991752277ferrichrome receptor proteinQuickGO ontologyBLASTP