Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:1880000 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
188005018832323183beta-galactosidaseQuickGO ontologyBLASTP
18837731883985213cold shock proteinQuickGO ontologyBLASTP
18842001884391192hypothetical proteinBLASTP
18869121887082171hypothetical proteinBLASTP
18874221888132711Mg2 transport ATPase protein CQuickGO ontologyBLASTP
188853318912322700Mg2 transport ATPase protein BQuickGO ontologyBLASTP
18927721893356585flagellum biosynthesis transcription activatorQuickGO ontologyBLASTP
18935611894448888flagellar motor proteinQuickGO ontologyBLASTP
189444518957281284flagellar motor proteinQuickGO ontologyBLASTP
189573918979102172chemotaxis protein CheAQuickGO ontologyBLASTP
18980731898570498chemotaxis protein CheWQuickGO ontologyBLASTP
189886219000971236hypothetical proteinBLASTP
19001101900487378YjgF-family lipoproteinQuickGO ontologyBLASTP
19004841901470987hypothetical proteinBLASTP
19016481902325678putative DNA-binding proteinQuickGO ontologyBLASTP