Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:1691000 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
169144616930411596ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
16932691693922654hypothetical proteinBLASTP
169396616951741209transposaseQuickGO ontologyBLASTP
16953101696077768molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
169608216973561275molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
169789116992011311putative heme-binding proteinQuickGO ontologyBLASTP
16992111699879669ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
169988117011431263hypothetical proteinBLASTP
170114517035052361hypothetical proteinBLASTP
17035891703801213hypothetical proteinBLASTP
17040581704900843putative esteraseQuickGO ontologyBLASTP
170492117060541134alcohol dehydrogenaseQuickGO ontologyBLASTP
17063341707203870putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
170733917084901152hypothetical proteinBLASTP
17086741709336663GTP cyclohydrolase IQuickGO ontologyBLASTP
170939117105571167hypothetical proteinBLASTP