Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:1630000 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
163008316322212139hypothetical proteinBLASTP
16322511632697447hypothetical proteinBLASTP
163289116348761986putative helicase IVQuickGO ontologyBLASTP
16349371635401465methylglyoxal synthaseQuickGO ontologyBLASTP
16355801636260681hypothetical proteinBLASTP
16365761636992417hypothetical proteinBLASTP
16371011637442342hypothetical proteinBLASTP
163747916386691191hypothetical proteinBLASTP
16387631639041279putative acylphosphataseQuickGO ontologyBLASTP
16390931639419327putative sulfite reductase subunit proteinQuickGO ontologyBLASTP
164306816454852418putative oxidoreductaseQuickGO ontologyBLASTP
16456391646385747putative short chain dehydrogenaseQuickGO ontologyBLASTP
16470141647334321hypothetical proteinBLASTP
16476641648122459putative 3R-hydroxymyristoyl-acyl-carrier-protein dehydraseQuickGO ontologyBLASTP
164811216493951284putative beta-ketoacyl-acyl-carrier-protein synthaseQuickGO ontologyBLASTP
16493881650134747putative beta-ketoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
165015016513881239putative hydroxymethylglutaryl-coenzyme A synthaseQuickGO ontologyBLASTP
16513811652100720putative enoyl-CoA hydrataseQuickGO ontologyBLASTP
16520931652854762enoyl-CoA hydrataseQuickGO ontologyBLASTP
16528571653645789putative short chain dehydrogenaseQuickGO ontologyBLASTP
16536841654172489hypothetical proteinBLASTP
16542101654458249putative acyl carrier proteinQuickGO ontologyBLASTP
16545571655405849putative acyl transferaseQuickGO ontologyBLASTP
16555621655729168hypothetical proteinBLASTP
16563941656894501hypothetical proteinBLASTP
165693716584871551hypothetical proteinBLASTP
165849916598511353hypothetical proteinBLASTP
16598481660534687hypothetical proteinBLASTP
166053416622701737hypothetical proteinBLASTP
16622741662765492hypothetical proteinBLASTP
166315316657952643putative ATPase subunit of ATP-dependent proteaseQuickGO ontologyBLASTP
166579816681462349hypothetical proteinBLASTP
166816216704622301hypothetical proteinBLASTP
16704591671232774hypothetical proteinBLASTP
16713861671646261hypothetical proteinBLASTP
167166216738452184hypothetical proteinBLASTP
16740181674488471hypothetical proteinBLASTP