Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:1233128 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12323491233131783transposaseIS proteinQuickGO ontologyBLASTP
123312812341501023transposase for insertion sequence IS100QuickGO ontologyBLASTP
12342391234340102phage integrase partialQuickGO ontologyBLASTP
12347521235063312putative prophage proteinQuickGO ontologyBLASTP
12350711235391321putative DNA-binding prophage proteinQuickGO ontologyBLASTP
123574012368281089putative regulatory prophage proteinQuickGO ontologyBLASTP
12368251237784960putative prophage DNA primaseQuickGO ontologyBLASTP
12377771238319543putative prophage proteinQuickGO ontologyBLASTP
12385121239408897putative DNA-binding prophage proteinQuickGO ontologyBLASTP
12394211239711291hypothetical proteinBLASTP
12398031239976174hypothetical proteinBLASTP
12402071240434228hypothetical proteinBLASTP
124059612422661671hypothetical proteinBLASTP
124231712434051089hypothetical proteinBLASTP
124348412446831200putative prophage integraseQuickGO ontologyBLASTP
12449071245365459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
12460001246482483SsrA-binding proteinQuickGO ontologyBLASTP
12466431247077435hypothetical proteinBLASTP
12470701247354285hypothetical proteinBLASTP
12475041247854351hypothetical proteinBLASTP
124795912496381680DNA repair protein RecNQuickGO ontologyBLASTP
12497071250588882inorganic polyphosphateATP-NAD kinaseQuickGO ontologyBLASTP
12507121251290579heat shock protein GrpEQuickGO ontologyBLASTP
125139812526781281citrate synthaseQuickGO ontologyBLASTP
12533881253777390succinate dehydrogenase cytochrome b556 large membrane subunitQuickGO ontologyBLASTP
12537711254118348succinate dehydrogenase cytochrome b556 small membrane subunitQuickGO ontologyBLASTP
125411912558851767succinate dehydrogenase catalytic subunitQuickGO ontologyBLASTP
12559351256651717succinate dehydrogenase catalytic subunitQuickGO ontologyBLASTP
1257007125981428082-oxoglutarate dehydrogenase E1 componentQuickGO ontologyBLASTP