Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:1059580 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10595801060539960putative sugar ABC transporter periplasmic binding proteinQuickGO ontologyBLASTP
106109510632572163ornithine decarboxylaseQuickGO ontologyBLASTP
1063926106400176tRNA-PheQuickGO ontologyBLASTP
10642541064562309integrase partialQuickGO ontologyBLASTP
10645861065221636hypothetical proteinBLASTP
10658291066185357insertion sequence proteinQuickGO ontologyBLASTP
10662511066526276insertion sequence proteinQuickGO ontologyBLASTP
10666221067371750hypothetical proteinBLASTP
106737610696732298putative kinaseQuickGO ontologyBLASTP
10696891070324636hypothetical proteinBLASTP
10708591071191333insertion sequence protein partialQuickGO ontologyBLASTP
10712451071520276insertion sequence proteinQuickGO ontologyBLASTP
10719071072287381hypothetical proteinBLASTP
107239810746202223hypothetical proteinBLASTP
107463510769832349hypothetical proteinBLASTP
107698010796282649Clp ATPaseQuickGO ontologyBLASTP
10800461080537492hypothetical proteinBLASTP
108054110822771737putative OmpA-family membrane proteinQuickGO ontologyBLASTP
10822771082963687hypothetical proteinBLASTP
108296010843121353hypothetical proteinBLASTP
108432410858681545hypothetical proteinBLASTP
10859111086411501hypothetical proteinBLASTP
10878111088155345putative phage protein partialQuickGO ontologyBLASTP
1088261108832060insertion element protein partialQuickGO ontology
10883561088619264insertion element proteinQuickGO ontologyBLASTP
10886871089082396putative lipoproteinQuickGO ontologyBLASTP
10895331090183651hypothetical proteinBLASTP
10913631092013651N-acylhomoserine lactone synthase YspIQuickGO ontologyBLASTP
10919941092737744quorum-sensing transcriptional regulatorQuickGO ontologyBLASTP
109329910946751377hypothetical proteinBLASTP