Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:1033500 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10335231034344822pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
10346321035186555hypothetical proteinBLASTP
10351831035473291hypothetical proteinBLASTP
10355731036166594putative deoxyribonucleotide triphosphate pyrophosphataseQuickGO ontologyBLASTP
103615910372891131coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
103747910468119333putative virulence determinantQuickGO ontologyBLASTP
10481551049081927glutaminaseQuickGO ontologyBLASTP
10491921049518327hypothetical proteinBLASTP
10495181050237720tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
105057510516901116AG-specific adenine glycosylaseQuickGO ontologyBLASTP
10518681052140273hypothetical proteinBLASTP
105231110533991089membrane-bound lytic murein transglycosylase CQuickGO ontologyBLASTP
10538281054799972hypothetical proteinBLASTP
105483710569362100putative hydroxamate-type ferrisiderophore receptorQuickGO ontologyBLASTP
105701910580381020putative sugar transport system permease proteinQuickGO ontologyBLASTP
105803510595341500putative sugar transport ATP-binding proteinQuickGO ontologyBLASTP