Pre_GI Gene

Some Help

Host: NC_003134 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003134:64672 Yersinia pestis CO92 plasmid pMT1, complete sequence

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6467265349678putative DNA methylaseQuickGO ontologyBLASTP
6496965496528hypothetical proteinBLASTP
6574266050309hypothetical proteinBLASTP
66212676091398putative DNA-binding proteinQuickGO ontologyBLASTP
6798868959972partitioning protein BQuickGO ontologyBLASTP
68956701611206partitioning protein AQuickGO ontologyBLASTP
7046370690228hypothetical proteinBLASTP
7069071016327hypothetical proteinBLASTP
7121671836621putative resolvaseQuickGO ontologyBLASTP
7185772843987hypothetical proteinBLASTP
7286673141276hypothetical proteinBLASTP
7388174369489putative phospholipase DQuickGO ontologyBLASTP
74447762101764murine toxinQuickGO ontologyBLASTP
7645576925471reverse transcriptaseQuickGO ontologyBLASTP
7699677304309hypothetical proteinBLASTP
7721977590372hypothetical proteinBLASTP
78286793081023transposaseQuickGO ontologyBLASTP
79777809851209putative transposaseQuickGO ontologyBLASTP
8133482257924putative F1 operon positive regulatory proteinQuickGO ontologyBLASTP
8256783343777putative F1 chaperone proteinQuickGO ontologyBLASTP
83368858692502putative F1 capsule anchoring proteinQuickGO ontologyBLASTP
8595086462513F1 capsule antigenQuickGO ontologyBLASTP
8832088706387hypothetical proteinBLASTP
8896989181213hypothetical proteinBLASTP