Pre_GI Gene

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Host: NC_002971 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002971:951102 Coxiella burnetii RSA 493, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Causes Q-fever. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
950404951108705bioH proteinQuickGO ontologyBLASTP
95110295225611558-amino-7-oxononanoate synthaseQuickGO ontologyBLASTP
952243953208966biotin synthaseQuickGO ontologyBLASTP
9535779549051329adenosylmethionine-8-amino-7-oxononanoate aminotransferaseQuickGO ontologyBLASTP
955276955590315hypothetical proteinBLASTP
9556419568251185dioxygenase putativeQuickGO ontologyBLASTP
9572499589521704hypothetical proteinBLASTP
958949959440492hypothetical proteinBLASTP
95965095972071tRNA-CysQuickGO ontology
960466960660195hypothetical proteinBLASTP
961125961670546hypothetical proteinBLASTP
961969962121153hypothetical proteinBLASTP
9622369633781143hypothetical proteinBLASTP
963556963912357hypothetical proteinBLASTP
963953964198246hypothetical proteinBLASTP
964423964674252hypothetical proteinBLASTP
964833965276444nucleotidyltransferase substrate-binding protein putativeQuickGO ontologyBLASTP
965269965568300nucleotidyltransferase domain proteinQuickGO ontologyBLASTP
966362967309948alcohol dehydrogenase zinc-containingQuickGO ontologyBLASTP
9676669700082343ankyrin repeat domain proteinQuickGO ontologyBLASTP
97001797011296hypothetical protein
970478970645168hypothetical protein
9706179720081392hypothetical proteinBLASTP
972024972926903hypothetical proteinBLASTP