Pre_GI Gene

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Host: NC_002971 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002971:780502 Coxiella burnetii RSA 493, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Causes Q-fever. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
779513780505993NAD dependent epimerasedehydratase family proteinQuickGO ontologyBLASTP
7805027816561155polysaccharide biosynthesis proteinQuickGO ontologyBLASTP
7816597835571899asparagine synthetase B glutamine-hydrolyzingQuickGO ontologyBLASTP
783558784109552acetyltransferase putativeQuickGO ontologyBLASTP
7841207859251806ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
785938786924987hypothetical proteinBLASTP
786933787202270hypothetical proteinBLASTP
787314788282969radical SAM domain proteinQuickGO ontologyBLASTP
7882977897811485hypothetical proteinBLASTP
7901397911671029glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
7913037925951293glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
7925957945081914asparagine synthetase B glutamine-hydrolyzingQuickGO ontologyBLASTP
7945157956481134glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
7958797969761098UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
7970057981441140glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
7981497991531005capsular polysaccharide biosynthesis protein IQuickGO ontologyBLASTP
7991568004451290UDP-glucoseGDP-mannose dehydrogenase familyQuickGO ontologyBLASTP
8005038018521350UDP-glucose 6-dehydrogenaseQuickGO ontologyBLASTP
8018668026307653-oxoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP