Pre_GI Gene

Some Help

Host: NC_002971 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002971:619355 Coxiella burnetii RSA 493, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Causes Q-fever. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6183466193801035NAD dependent epimerasedehydratase family proteinQuickGO ontologyBLASTP
6193556209351581ADP-heptose synthase putativeQuickGO ontologyBLASTP
620938621882945oxidoreductase GfoIdhMocA familyQuickGO ontologyBLASTP
6218676231771311UDP-glucoseGDP-mannose dehydrogenase family proteinQuickGO ontologyBLASTP
623170624075906hypothetical proteinBLASTP
624078624731654hypothetical proteinBLASTP
6247286259901263methyltransferase FkbM familyQuickGO ontologyBLASTP
6263296277471419hypothetical proteinBLASTP
6281926315303339hypothetical proteinBLASTP
631761632468708acetoin dehydrogenase putativeQuickGO ontologyBLASTP
6324856341281644hypothetical proteinBLASTP
634508635506999GDP-fucose synthetaseQuickGO ontologyBLASTP
6354996365451047GDP-mannose 46-dehydrataseQuickGO ontologyBLASTP
636572637411840glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
6374646386421179NDP-hexose 3-C-methyltransferase TylCIIIQuickGO ontologyBLASTP
6386636397241062dehydrogenase E1 component beta subunitQuickGO ontologyBLASTP
6397216407461026dehydrogenase E1 component alpha subunitQuickGO ontologyBLASTP
6408976420091113glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
6420716434471377hypothetical proteinBLASTP
6434406445881149pleiotropic regulatory proteinQuickGO ontologyBLASTP
6446256457851161pleiotropic regulatory proteinQuickGO ontologyBLASTP
6458086469771170hypothetical proteinBLASTP