Pre_GI Gene

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Host: NC_002971 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002971:211331 Coxiella burnetii RSA 493, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Causes Q-fever. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2113312154584128DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP
2157272199714245DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP
22031322068737530S ribosomal protein S12QuickGO ontologyBLASTP
22070022127557630S ribosomal protein S7QuickGO ontologyBLASTP
2212852233842100translation elongation factor GQuickGO ontologyBLASTP
2234002245931194translation elongation factor TuQuickGO ontologyBLASTP
224783225115333ribosomal protein S10QuickGO ontologyBLASTP
225137225790654ribosomal protein L3QuickGO ontologyBLASTP
22579022640761850S ribosomal protein L4QuickGO ontologyBLASTP
226404226691288ribosomal protein L23QuickGO ontologyBLASTP
22671122753882850S ribosomal protein L2QuickGO ontologyBLASTP
227551227838288ribosomal protein S19QuickGO ontologyBLASTP
227838228185348ribosomal protein L22QuickGO ontologyBLASTP
228185228868684ribosomal protein S3QuickGO ontologyBLASTP
22888022929341450S ribosomal protein L16QuickGO ontologyBLASTP
229294229491198ribosomal protein L29QuickGO ontologyBLASTP
229484229753270ribosomal protein S17QuickGO ontologyBLASTP
229764230132369ribosomal protein L14QuickGO ontologyBLASTP
230144230467324ribosomal protein L24QuickGO ontologyBLASTP
230584231132549ribosomal protein L5QuickGO ontologyBLASTP
231137231436300ribosomal protein S14QuickGO ontologyBLASTP
231439231831393ribosomal protein S8QuickGO ontologyBLASTP
23186923240553750S ribosomal protein L6QuickGO ontologyBLASTP
232405232758354ribosomal protein L18QuickGO ontologyBLASTP
232770233276507ribosomal protein S5QuickGO ontologyBLASTP
233280233471192ribosomal protein L30pL7eQuickGO ontologyBLASTP
233474233905432ribosomal protein L15QuickGO ontologyBLASTP
2339232352511329preprotein translocase SecYQuickGO ontologyBLASTP
235264235386123ribosomal protein L36QuickGO ontologyBLASTP
23552623562196hypothetical protein
23562623598536030S ribosomal protein S13QuickGO ontologyBLASTP
23601323638437230S ribosomal protein S11QuickGO ontologyBLASTP
23639723701762130S ribosomal protein S4QuickGO ontologyBLASTP
237030238013984DNA-directed RNA polymerase alpha subunitQuickGO ontologyBLASTP
238025238405381ribosomal protein L17QuickGO ontologyBLASTP
2384082396341227glucosegalactose transporter family proteinQuickGO ontologyBLASTP
239721239837117hypothetical protein
239903240127225hypothetical protein
240157240819663hypothetical protein
240792241010219hypothetical protein
2411592423791221hypothetical proteinBLASTP
242391242867477single-strand binding proteinQuickGO ontologyBLASTP