Pre_GI Gene

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Host: NC_002971 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002971:1545924 Coxiella burnetii RSA 493, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Causes Q-fever. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15460651546610546hypothetical proteinBLASTP
15469411547426486hypothetical proteinBLASTP
15474231548328906ribosomal protein S6 modification proteinQuickGO ontologyBLASTP
154833115493591029hypothetical proteinBLASTP
15493521549462111hypothetical protein
154951415516102097hypothetical proteinBLASTP
15520101552408399hypothetical proteinBLASTP
15527471553055309hypothetical proteinBLASTP
155306715545181452ankyrin repeat family proteinQuickGO ontologyBLASTP
15545151555057543hypothetical proteinBLASTP
15550971555420324hypothetical proteinBLASTP
1555602155569796hypothetical protein
15558011555956156hypothetical proteinBLASTP
15559891556408420hypothetical proteinBLASTP
15565261557287762hypothetical proteinBLASTP
15573001557743444hypothetical proteinBLASTP
15577721557876105hypothetical protein
15580361558389354hypothetical proteinBLASTP
15584461558745300hypothetical proteinBLASTP
15587421558972231hypothetical proteinBLASTP
15591901559327138hypothetical proteinBLASTP
155934215623533012IcmB proteinQuickGO ontologyBLASTP
15624261563064639IcmJ proteinQuickGO ontologyBLASTP
15630771563493417IcmD protein putativeQuickGO ontologyBLASTP
15635871564096510IcmC protein putativeQuickGO ontologyBLASTP
15641671564901735IcmG protein putativeQuickGO ontologyBLASTP
156491915680233105IcmE proteinQuickGO ontologyBLASTP