Pre_GI Gene

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Host: NC_002971 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002971:1523065 Coxiella burnetii RSA 493, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Causes Q-fever. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
152306515255842520hypothetical protein
15255501526494945LysM domain proteinQuickGO ontologyBLASTP
15264971527333837ribonuclease BN putativeQuickGO ontologyBLASTP
15274441528037594flavoprotein WrbA proteinQuickGO ontologyBLASTP
152803415291311098hypothetical proteinBLASTP
15295421529664123hypothetical protein
15297051530085381monovalent cationproton antiporter MnhGPhaG subunitQuickGO ontologyBLASTP
15300781530380303monovalent cationproton antiporter subunit putativeQuickGO ontologyBLASTP
15303771530724348monovalent cationproton antiporter subunit putativeQuickGO ontologyBLASTP
153072115322201500monovalent cationproton antiporter subunit putativeQuickGO ontologyBLASTP
15322171532588372monovalent cationproton antiporter subunit putativeQuickGO ontologyBLASTP
15325851532992408monovalent cationproton antiporter subunit putativeQuickGO ontologyBLASTP
153298915352952307monovalent cationproton antiporter subunit putativeQuickGO ontologyBLASTP
15354161535724309hypothetical protein
153581315370661254monovalent cationproton antiporter subunit putativeQuickGO ontologyBLASTP
153746315384821020IS1111A transposaseQuickGO ontologyBLASTP
15384991538624126hypothetical protein
15386931538917225ribosomal protein S21QuickGO ontologyBLASTP
15389451539394450GatBYqey domain proteinQuickGO ontologyBLASTP
153949215411531662DNA primaseQuickGO ontologyBLASTP
154127315433692097RNA polymerase sigma factor RpoDQuickGO ontologyBLASTP