Pre_GI Gene

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Host: NC_002971 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002971:1379567 Coxiella burnetii RSA 493, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Causes Q-fever. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13795671380112546hypothetical protein
13809211381850930tRNA pseudouridine synthase BQuickGO ontologyBLASTP
13818281382187360ribosome-binding factor AQuickGO ontologyBLASTP
138227513846862412translation initiation factor IF-2QuickGO ontologyBLASTP
138469213862031512transcription elongation factor NusAQuickGO ontologyBLASTP
13862071386668462hypothetical proteinBLASTP
138704613884941449NADH dehydrogenase subunit NQuickGO ontologyBLASTP
138850413900241521NADH dehydrogenase I M subunitQuickGO ontologyBLASTP
139002913919901962NADH dehydrogenase I L subunitQuickGO ontologyBLASTP
13920471392352306NADH dehydrogenase I K subunitQuickGO ontologyBLASTP
13923491392954606NADH dehydrogenase I J subunitQuickGO ontologyBLASTP
13929681393459492NADH dehydrogenase subunit IQuickGO ontologyBLASTP
139345613944781023NADH dehydrogenase I H subunitQuickGO ontologyBLASTP
139447813968412364NADH dehydrogenase gamma subunitQuickGO ontologyBLASTP
139695213982201269NADH dehydrogenase I F subunitQuickGO ontologyBLASTP
13982101398734525NADH dehydrogenase I E subunitQuickGO ontologyBLASTP
139873413999871254NADH dehydrogenase delta subunitQuickGO ontologyBLASTP
13999801400663684NADH dehydrogenase I C subunitQuickGO ontologyBLASTP
14006731401158486NADH dehydrogenase beta subunitQuickGO ontologyBLASTP
14011631401519357NADH dehydrogenase I A subunitQuickGO ontologyBLASTP
14018161402112297preprotein translocase SecG subunitQuickGO ontologyBLASTP
14020941402861768triosephosphate isomeraseQuickGO ontologyBLASTP