Pre_GI Gene

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Host: NC_002950 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002950:2098454 Porphyromonas gingivalis W83, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain (also known as HG66) is virulent in a mouse model and has been extensively studied. It was originally isolated by H. Werner in the 1950s in Bonn, Germany, from an unknown human infection. Associated with severe and chronic periodontal disease. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin.Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
20984542099191738DNA repair protein RecO putativeQuickGO ontologyBLASTP
209936021010121653phosphomannomutase putativeQuickGO ontologyBLASTP
21043162104579264CRISPR-associated protein Cas2QuickGO ontologyBLASTP
210457921055951017CRISPR-associated protein Cas1QuickGO ontologyBLASTP
21055922106104513CRISPR-associated protein Cas4QuickGO ontologyBLASTP
210612421084602337CRISPR-associated helicase Cas3QuickGO ontologyBLASTP
210843521094511017hypothetical proteinBLASTP
210946221109611500hypothetical proteinBLASTP
21109582111752795hypothetical proteinBLASTP
21116982112363666CRISPR-associated TM1814 family proteinQuickGO ontologyBLASTP
211301121149421932hypothetical proteinBLASTP
211494621174892544hypothetical proteinBLASTP