Pre_GI Gene

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Host: NC_002950 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002950:209569 Porphyromonas gingivalis W83, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain (also known as HG66) is virulent in a mouse model and has been extensively studied. It was originally isolated by H. Werner in the 1950s in Bonn, Germany, from an unknown human infection. Associated with severe and chronic periodontal disease. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin.Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2095692161836615lipoprotein putativeQuickGO ontologyBLASTP
2165422176271086ISPg1 transposaseQuickGO ontologyBLASTP
2184692215223054ragA proteinQuickGO ontologyBLASTP
2215522230571506lipoprotein RagBQuickGO ontologyBLASTP
2240742254441371lipoprotein putativeQuickGO ontology
225431226138708hypothetical protein
226216226980765undecaprenyl diphosphate synthaseQuickGO ontologyBLASTP
2269982296732676outer membrane protein putativeQuickGO ontologyBLASTP
229730230254525cationic outer membrane protein OmpHQuickGO ontologyBLASTP
230289230780492cationic outer membrane protein OmpHQuickGO ontologyBLASTP
231068231970903ISPg3 transposaseQuickGO ontologyBLASTP