Pre_GI Gene

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Host: NC_002950 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002950:1981155 Porphyromonas gingivalis W83, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain (also known as HG66) is virulent in a mouse model and has been extensively studied. It was originally isolated by H. Werner in the 1950s in Bonn, Germany, from an unknown human infection. Associated with severe and chronic periodontal disease. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin.Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
198115519832422088polyphosphate kinaseQuickGO ontologyBLASTP
198340619846261221GTP-binding protein HflXQuickGO ontologyBLASTP
198470519857391035rhodanese-like domain proteinQuickGO ontologyBLASTP
19857361986350615hypothetical proteinBLASTP
19864911987150660hypothetical proteinBLASTP
19877051987932228lipoprotein putativeQuickGO ontologyBLASTP
19879961988505510hypothetical proteinBLASTP
19895651989951387hypothetical proteinBLASTP
19911001991873774hypothetical proteinBLASTP
19924171992995579hypothetical protein
19936021994300699hypothetical proteinBLASTP
199472619960151290S-adenosylmethionine synthetaseQuickGO ontologyBLASTP
19961431996820678thiamin pyrophosphokinase catalytic domain proteinQuickGO ontologyBLASTP
19968171997425609transporter putativeQuickGO ontologyBLASTP
199743019998142385TonB-dependent receptor putativeQuickGO ontologyBLASTP
19998892000836948ribosome-associated GTPaseQuickGO ontologyBLASTP
20009212001442522ribosome releasing factorQuickGO ontologyBLASTP
20015182002237720uridylate kinaseQuickGO ontologyBLASTP
200232020043111992hypothetical proteinBLASTP