Pre_GI Gene

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Host: NC_002950 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002950:1571383 Porphyromonas gingivalis W83, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain (also known as HG66) is virulent in a mouse model and has been extensively studied. It was originally isolated by H. Werner in the 1950s in Bonn, Germany, from an unknown human infection. Associated with severe and chronic periodontal disease. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin.Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
157138315734762094DNA topoisomerase IIIQuickGO ontologyBLASTP
15734821573757276hypothetical proteinBLASTP
15742251574695471DNA-binding protein histone-like familyQuickGO ontologyBLASTP
15747961575710915hypothetical protein
15756641576161498hypothetical protein
157623915785302292hypothetical proteinBLASTP
15785901579189600transcriptional regulator tetR familyQuickGO ontologyBLASTP
15803651581315951LytB-related proteinQuickGO ontologyBLASTP
15813331582319987NAD dependent proteinQuickGO ontologyBLASTP
15823831583261879radical SAM domain proteinQuickGO ontologyBLASTP
158376015861892430hypothetical proteinBLASTP
15862001586748549hypothetical proteinBLASTP
15868311587499669HAD-superfamily hydrolase subfamily IA variant 1 family proteinQuickGO ontologyBLASTP
15875191587626108hypothetical proteinBLASTP
15877491587910162hypothetical proteinBLASTP
15879031588520618hypothetical proteinBLASTP
158860915899251317phosphoribosyltransferase putativephosphoglycerate mutase family proteinQuickGO ontologyBLASTP
15899401590929990glycerol dehydrogenase-related proteinQuickGO ontologyBLASTP
159091715919301014ribulose bisphosphate carboxylase-related proteinQuickGO ontologyBLASTP
159188115932571377hypothetical protein
159584515974851641hypothetical proteinBLASTP
159814415991931050O-succinylbenzoic acid--CoA ligaseQuickGO ontologyBLASTP
159919016002601071mandelate racemasemuconate lactonizing enzyme family proteinQuickGO ontologyBLASTP
16002601601078819naphthoate synthaseQuickGO ontologyBLASTP
1601103160283617342-succinyl-6-hydroxy-2 4-cyclohexadiene-1-carboxylic acid synthase2-oxoglutarate decarboxylaseQuickGO ontologyBLASTP
160284916039551107isochorismate synthase putativeQuickGO ontologyBLASTP
160402216054611440hypothetical proteinBLASTP
16056571605884228hypothetical proteinBLASTP
160592316072481326hypothetical proteinBLASTP
160737516095132139hypothetical proteinBLASTP
16095101610400891hypothetical proteinBLASTP