Pre_GI Gene

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Host: NC_002950 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002950:1270132 Porphyromonas gingivalis W83, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain (also known as HG66) is virulent in a mouse model and has been extensively studied. It was originally isolated by H. Werner in the 1950s in Bonn, Germany, from an unknown human infection. Associated with severe and chronic periodontal disease. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin.Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
127013212720121881hypothetical proteinBLASTP
12722521273205954glycerate dehydrogenaseQuickGO ontologyBLASTP
1274119127526711498-amino-7-oxononanoate synthaseQuickGO ontologyBLASTP
12752671275419153hypothetical proteinBLASTP
127556512766501086ISPg1 transposaseQuickGO ontologyBLASTP
12767901277029240hypothetical proteinBLASTP
12770331277458426hypothetical proteinBLASTP
12775701278082513hypothetical proteinBLASTP
127968212831043423hypothetical protein
12833271283536210transcriptional regulator putativeQuickGO ontologyBLASTP
12840931284563471DNA-binding protein histone-like familyQuickGO ontologyBLASTP
12846491284870222hypothetical proteinBLASTP
12848631285021159hypothetical proteinBLASTP
128508312870051923molecular chaperone DnaKQuickGO ontologyBLASTP
128758512891351551hypothetical proteinBLASTP
128918412909711788peptidase M24 familyQuickGO ontologyBLASTP
12909411291519579hexapeptide transferase family proteinQuickGO ontologyBLASTP
129153212925451014TPR domain proteinQuickGO ontologyBLASTP
12925731293223651ribonuclease HQuickGO ontologyBLASTP
129317212944101239hypothetical proteinBLASTP
12947611295573813lipoprotein protein putativeQuickGO ontologyBLASTP
12955701295725156hypothetical proteinBLASTP
12957151296047333hypothetical proteinBLASTP