Pre_GI Gene

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Host: NC_002942 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002942:675829 Legionella pneumophila subsp. pneumophila str. Philadelphia 1,

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain is the isolate from the initial event of Legionellosis in Philadelphia, USA. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6758296771121284major facilitator family transporterQuickGO ontologyBLASTP
6771096783321224phosphopentomutaseQuickGO ontologyBLASTP
678519679067549heat shock protein HslVU proteasome-related peptidase subunitQuickGO ontologyBLASTP
6790516803941344ATP dependent Hsl protease ATP binding subunitQuickGO ontologyBLASTP
6805946821681575hypothetical proteinBLASTP
6822156834531239ribonuclease BNQuickGO ontologyBLASTP
6838686883314464hypothetical proteinBLASTP
6908836929282046hypothetical proteinBLASTP
693107693706600trp repressor binding proteinQuickGO ontologyBLASTP
6938216952271407hypothetical proteinBLASTP
696023696805783exodeoxyribonuclease IIIQuickGO ontologyBLASTP
696777697568792exodeoxyribonuclease IIIQuickGO ontologyBLASTP
69770569793222850S ribosomal protein L31QuickGO ontologyBLASTP
6980596992941236malate oxidoreductaseQuickGO ontologyBLASTP