Pre_GI Gene

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Host: NC_002942 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002942:2943206 Legionella pneumophila subsp. pneumophila str. Philadelphia 1,

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain is the isolate from the initial event of Legionellosis in Philadelphia, USA. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29432062944120915UDP-3-O-acyl-N-acetylglucosamine deacetylaseQuickGO ontologyBLASTP
294436829455641197cell division protein FtsZQuickGO ontologyBLASTP
294575929470211263cell division protein FtsAQuickGO ontologyBLASTP
29469972947716720cell division protein FtsQQuickGO ontologyBLASTP
294773229488381107D-alanine-D-alanine ligase AQuickGO ontologyBLASTP
29488102949748939UDP-N-acetylenolpyruvoylglucosamine reductaseQuickGO ontologyBLASTP
294974529511541410UDP-N-acetylmuramateL-alanine ligase MurCQuickGO ontologyBLASTP
295116429523481185cell division protein FtsWQuickGO ontologyBLASTP
295234529536881344UDP-N-muramoylalanine-D-glutamate ligaseQuickGO ontologyBLASTP
295370229548201119phospho-N-acetylmuramoyl-pentapeptide transferaseQuickGO ontologyBLASTP
295490229562871386UDP-N-acetylmuramoylalanyl-D-glutamyl-2 6-diaminopimelate-D-alanyl-D-alanyl ligaseQuickGO ontologyBLASTP
29564802957259780cell division protein ZipAQuickGO ontologyBLASTP
295726429607583495chromosome segregation SMC proteinQuickGO ontologyBLASTP
29609332961613681acid phosphatase class BQuickGO ontologyBLASTP
296171529627761062hypothetical proteinBLASTP
29630862963898813transmembrane proteinQuickGO ontologyBLASTP
29639732964455483transcription elongation factor GreAQuickGO ontologyBLASTP