Pre_GI Gene

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Host: NC_002942 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_002942:1109618 Legionella pneumophila subsp. pneumophila str. Philadelphia 1,

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain is the isolate from the initial event of Legionellosis in Philadelphia, USA. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
110961811121462529cation efflux transporterQuickGO ontologyBLASTP
111213311133921260chemiosmotic efflux system B protein CQuickGO ontologyBLASTP
111338911145221134chemiosmotic efflux system B protein BQuickGO ontologyBLASTP
111460111177443144chemiosmotic efflux system B protein AQuickGO ontologyBLASTP
111774111191021362metallo-beta lactamase familyQuickGO ontologyBLASTP
111906011206131554thymidine phosphorylase TdRPaseQuickGO ontologyBLASTP
11206101121521912ribose-phosphate pyrophosphokinaseQuickGO ontologyBLASTP
112177911239892211copper efflux ATPaseQuickGO ontologyBLASTP
11241291125010882sensory boxGGDEFEAL familyQuickGO ontologyBLASTP
11251471125521375putative outer membrane lipoproteinQuickGO ontologyBLASTP
112552211268591338chemiosmotic efflux system C protein CQuickGO ontologyBLASTP
11268561127824969chemiosmotic efflux system C protein BQuickGO ontologyBLASTP
112782511310403216chemiosmotic efflux system protein A-like proteinQuickGO ontologyBLASTP
11310371131489453hypothetical proteinBLASTP
11316281131972345hypothetical proteinBLASTP