Pre_GI Gene

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Host: NC_000921 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000921:1343701 Helicobacter pylori J99, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13437011344315615hypothetical proteinBLASTP
1345094134544435150S ribosomal protein L17QuickGO ontologyBLASTP
134544413464781035DNA-directed RNA polymerase alpha subunitQuickGO ontologyBLASTP
1346490134711662730S ribosomal protein S4QuickGO ontologyBLASTP
1347126134752139630S ribosomal protein S11QuickGO ontologyBLASTP
1347544134790636330S ribosomal protein S13QuickGO ontologyBLASTP
1347910134802311450S RIBOSOMAL PROTEIN L36QuickGO ontology
13481021348320219translation initiation factor IF-1QuickGO ontologyBLASTP
13483201349081762methionine aminopeptidaseQuickGO ontologyBLASTP
134908113503431263preprotein translocase SecYQuickGO ontologyBLASTP
1350378135077940250S ribosomal protein L15QuickGO ontologyBLASTP
1350797135125846230S ribosomal protein S5QuickGO ontologyBLASTP
1351255135161135750S ribosomal protein L18QuickGO ontologyBLASTP
1351625135216153750S ribosomal protein L6QuickGO ontologyBLASTP
1352173135256839630S ribosomal protein S8QuickGO ontologyBLASTP
1352578135276318630S RIBOSOMAL PROTEIN S14QuickGO ontologyBLASTP
1352773135331854650S ribosomal protein L5QuickGO ontologyBLASTP
1353332135355322250S ribosomal protein L24QuickGO ontologyBLASTP
1353553135392136950S ribosomal protein L14QuickGO ontologyBLASTP
1353924135418426130S ribosomal protein S17QuickGO ontologyBLASTP
1354198135439820150S ribosomal protein L29QuickGO ontologyBLASTP
1354385135481042650S ribosomal protein L16QuickGO ontologyBLASTP
1354813135551770530S ribosomal protein S3QuickGO ontologyBLASTP
1355521135588936950S ribosomal protein L22QuickGO ontologyBLASTP
1355899135618028230S ribosomal protein S19QuickGO ontologyBLASTP
1356192135702283150S ribosomal protein L2QuickGO ontologyBLASTP
1357038135731928250S ribosomal protein L23QuickGO ontologyBLASTP
1357323135797064850S ribosomal protein L4QuickGO ontologyBLASTP
1358005135858057650S ribosomal protein L3QuickGO ontologyBLASTP
1358617135893131530S ribosomal protein S10QuickGO ontologyBLASTP
135909713602271131hypothetical proteinBLASTP
13604921361070579hypothetical proteinBLASTP
13610441361673630RIBONUCLEASE HIIQuickGO ontologyBLASTP
13616891361883195hypothetical proteinBLASTP
136196413633551392FUMARASEQuickGO ontologyBLASTP
13635301363907378hypothetical proteinBLASTP
136391213651501239hypothetical proteinBLASTP
136514713661721026CATION EFFLUX SYSTEM PROTEINQuickGO ontologyBLASTP