Pre_GI Gene

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Host: NC_000921 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000921:1147394 Helicobacter pylori J99, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11473941148056663putative Outer membrane proteinQuickGO ontologyBLASTP
11483391148899561indolepyruvate ferredoxin oxidoreductaseQuickGO ontologyBLASTP
11489151149307393Pyruvate ferrodoxin oxidoreductaseQuickGO ontologyBLASTP
1149317115054012242-oxoglutarate ferredoxin oxidoreductaseQuickGO ontologyBLASTP
11505531151497945ferrodoxin oxidoreductase beta subunitQuickGO ontologyBLASTP
115160511529271323adenylosuccinate lyaseQuickGO ontologyBLASTP
11532261154059834putative Outer membrane proteinQuickGO ontologyBLASTP
115408411560601977excinuclease ABC subunit BQuickGO ontologyBLASTP
11561091156912804hypothetical proteinBLASTP
11569091157292384hypothetical proteinBLASTP
115743611609003465hypothetical proteinBLASTP
11613191162089771hypothetical proteinBLASTP
116422411660441821flagellar hook-associated proteinQuickGO ontologyBLASTP
11660461166480435hypothetical protein
11665591167311753hypothetical protein
11684121168615204hypothetical protein
11694691170464996hypothetical proteinBLASTP