Pre_GI Gene

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Host: NC_000915 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000915:547783 Helicobacter pylori 26695, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was originally isolated from a patient in the United Kingdom who had gastritis before 1987, this strain has undergone repeated subculturing prior to being sequenced. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5481345495791446cag pathogenicity island protein cag3QuickGO ontologyBLASTP
549589550098510cag pathogenicity island protein cag4QuickGO ontologyBLASTP
5502175524632247cag pathogenicity island protein cag5QuickGO ontologyBLASTP
552472553464993virB11 homologQuickGO ontologyBLASTP
553469554068600cag pathogenicity island protein cag6QuickGO ontologyBLASTP
5542065599895784cag pathogenicity island protein cag7QuickGO ontologyBLASTP
5600045615721569cag pathogenicity island protein cag8QuickGO ontologyBLASTP
5616255632321608cag pathogenicity island protein cag9QuickGO ontologyBLASTP
563237563995759cag pathogenicity island protein cag10QuickGO ontologyBLASTP
564381565037657cag pathogenicity island protein cag11QuickGO ontologyBLASTP
565073565915843cag pathogenicity island protein cag12QuickGO ontologyBLASTP
56603556612490hypothetical proteinBLASTP
566126566716591cag pathogenicity island protein cag13QuickGO ontologyBLASTP
567142567522381cag pathogenicity island protein cag14QuickGO ontologyBLASTP
567955568299345cag pathogenicity island protein cag15QuickGO ontologyBLASTP