Pre_GI Gene

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Host: NC_000915 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000915:53715 Helicobacter pylori 26695, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was originally isolated from a patient in the United Kingdom who had gastritis before 1987, this strain has undergone repeated subculturing prior to being sequenced. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
52459537181260hypothetical proteinBLASTP
53715561862472adeninecytosine DNA methyltransferaseQuickGO ontologyBLASTP
56224577141491proline permease putPQuickGO ontologyBLASTP
57741612983558delta-1-pyrroline-5-carboxylate dehydrogenaseQuickGO ontologyBLASTP
6161961828210hypothetical proteinBLASTP
61943631431201
6314563999855hypothetical proteinBLASTP
64016664572442hypothetical proteinBLASTP
6645467023570hypothetical proteinBLASTP
6703967299261hypothetical proteinBLASTP
67310688001491hypothetical proteinBLASTP
6877069189420hypothetical proteinBLASTP
6919169544354hypothetical proteinBLASTP
69468719632496conserved hypothetical ATP-binding proteinQuickGO ontologyBLASTP
7202172818798urease accessory protein ureHQuickGO ontologyBLASTP
7281873417600urease accessory protein ureGQuickGO ontologyBLASTP
7344674210765urease accessory protein ureFQuickGO ontologyBLASTP
7423374745513urease accessory protein ureEQuickGO ontologyBLASTP
7474775334588urease accessory protein ureIQuickGO ontologyBLASTP
75527772361710urease beta subunit urea amidohydrolase ureBQuickGO ontologyBLASTP
7724077956717urease alpha subunit ureA urea amidohydrolaseQuickGO ontologyBLASTP