Pre_GI Gene

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Host: NC_000915 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000915:1583967 Helicobacter pylori 26695, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was originally isolated from a patient in the United Kingdom who had gastritis before 1987, this strain has undergone repeated subculturing prior to being sequenced. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15836301583983354hypothetical proteinBLASTP
15839671584293327hypothetical proteinBLASTP
158444715870802634iron-regulated outer membrane protein frpBQuickGO ontologyBLASTP
158730715884671161selenocysteine synthaseQuickGO ontologyBLASTP
158856915897561188transcription elongation factor NusAQuickGO ontologyBLASTP
1589956159004893hypothetical protein
15901091590648540hypothetical proteinBLASTP
159064915944883840type IIS restriction enzyme R and M protein ECO57IRQuickGO ontologyBLASTP
15944901594777288hypothetical proteinBLASTP
15949081595660753hypothetical proteinBLASTP
159577015970621293hypothetical proteinBLASTP
159719616000992904type III restriction enzyme R protein resQuickGO ontologyBLASTP
160208816039591872DNA recombinase recGQuickGO ontologyBLASTP
16040411604388348hypothetical proteinBLASTP
16043921605027636hypothetical proteinBLASTP
16050241605776753exodeoxyribonuclease lexAQuickGO ontologyBLASTP