LOCUS NC_021182:16 18013 bp DNA linear BCT 09-MAY-2013 DEFINITION Clostridium pasteurianum BC1, complete genome. ACCESSION NC_021182 SOURCE Clostridium pasteurianum BC1, complete genome. COMMENT locus start: 1245692; locus end: 1263704 COMMENT n1_4mer:GRV/n1_4mer:RV = 2.408841; n0_4mer:D = 18.108585; n0_4mer:PS = 35.601169 FEATURES Location/Qualifiers source 1..18013 /organism="Clostridium pasteurianum BC1, complete genome." gene 1..429 /gene="" /locus_tag="" /db_xref="1245692..1246120" CDS 1..429 /gene="" /product="hypothetical protein" /translation="MMNLKKIFAATTITALLLTGCSSNAGAPKTQNTEQNESAAKGEK TLSIAEGSKNMKDVLKDMKSKLENKDEEGAVNASAGLEDNWKVFEDNVKDKNKELYEK VEQPLHTINAAVKIKPLDTKTLIDAIDVLDKQLDEVGKLK" gene 993..1838 /gene="" /locus_tag="" /db_xref="1246684..1247529" CDS 993..1838 /gene="" /product="cobalamin biosynthesis protein CbiK, Co2+ chelatase" /translation="LHKKKDKVILVVSFGTTYGETRKLTIDSIEQCIQDRFKDYDMKR AFTSHMIIKVLRERDRYIVDTPEEALEKIAEEGYKEVIVQSLHIMPGEEYEYVERVVE SYRQKDVFNKIELGRPILYFKGDGEQLQDDYLMAMEAIKLQLPETGSVVFMGHGTTHP ANACYSCLQMVLRDHQINNVYIGTVEGYPSLDNIINTLKRDKVEEITLMPLMVVAGDH CNNDMASDEEDSWKKILEKEDFKVNLYMHGMGENPLFRKIFVNHVEDTIIGKYKNMGR TKKGI" gene 1841..3478 /gene="" /locus_tag="" /db_xref="1247532..1249169" CDS 1841..3478 /gene="" /product="cobyric acid synthase CobQ" /translation="MAKLMIQGTASSVGKSILVTALCRIFKQDGYKVVPYKSQNMSLN SYITLDGKEMGRAQVLQAYACGMEPEAYMNPILLKPTSDKKSQVIVNGKVYGNYTAME YHNMKPVFRDMLKQQFEELEKEFDIIVMEGAGSPAEINLRDRDIVNMGMAELVDAPVI LAGDIDKGGVFASLAGTMLLLRDDEKKRVKGTIINKFRGDIDILKPGLNMLQDIVKIP CIGVVPYFNLQLEDEDGAVEFENKPHGAIDIAVIKLPHISNFTDLDALKAEEDVSIRF ITNIEEFGNPDMIIIPGSKNTIEDLLKLRKSGLESKIREYSKAGIVIGICGGYQMLGN SVKDPYEVETNMLNTEGMKLLDIDTTFEKEKVTTRVRAVVASDDLSKDIDTCMVNYNN VGEKEDRKLYSLQYKVDKRVYKEINQEDNMKIKENNYKNKEVYGYEIHMGICKYGDNS KPLFNITDKNGLKVNYSDGAINEKGNIMGTYIHGIFDSIYFREYIVNLLRSKKGIILK KSKEYEKLREKELDKLAAIVRNALDMESIYKFMGLKK" gene 3478..4434 /gene="" /locus_tag="" /db_xref="1249169..1250125" CDS 3478..4434 /gene="" /product="cobalamin biosynthesis protein CobD" /translation="MYTALDIVLAVILDFILGDPRWLPHPIIYIGKIISFLEKKARKF SRNNNQLRLFGALIVIVVGSISFIIPFCVLEIVKSFIILHHILNVLIIWTTLAAKSLN IAAMKVHTSLQNKDIKDARIKLSYIVGRDTKELSEEKIIRADVETVAENTSDGVIAPI IFAMIGGAPLAMLYKGINTMDSMLGYKNKKYYYIGFFPAKTDDLFNLIPARITGILIA LVSPLVKGNILESLKIMIRDRKNHKSPNCAYPEAAAAGAMKIQLGGTNSYFGELVYKP TLGDKKQNLDKKHIKEVIKLMYGSEILLLIIYVIVVYLKVII" gene 4727..4843 /gene="" /locus_tag="" /db_xref="1250418..1250534" CDS 4727..4843 /gene="" /product="" /translation="SKRSFYEKESINSNWSVRELKRQIDTSLYCARLFYHVR" gene 4849..5886 /gene="" /locus_tag="" /db_xref="1250540..1251577" CDS 4849..5886 /gene="" /product="putative MccF-like protein (microcin C7 resistance)" /translation="MLKLVKAQGLNRGDKVATVSLSWGGAGDTDLLWRYNLGKKRLQE WFGLEVVEMPNTLKGSDYLYHHPEKRAEDLMAAFSDTSIKAIFSCIGGNESVRMLSYI DFNIIKSNPKIFIGYSDATITHFMCLKANLSSFYGASILAELAENIKVFDYTSSWLEK VLFDTSPIGLIPVTTEWTGERIEWSESNANVAKTMVKNQGYEFLQGKGVTQGHLIGGC IEVMEMIKGTSLWPSNDIFEDAILFFETSEDMPGSIYIEYWLRNYGSQGILQKAKAII FGKPYQEKYYNEYKNSILKILLELGLYHLPIVYNMSFGHNEPMICLPYGAMAEIDCDR RTFSILESGVV" gene 5984..7033 /gene="" /locus_tag="" /db_xref="1251675..1252724" CDS 5984..7033 /gene="" /product="PLP-dependent enzyme, histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase" /translation="MIHGGDIYTDGIFKGQELLDFSSNINPLGVPEGFKNNIAEALDS VTRYPDIKYREVIKNLSDYTGTAEENFVLGNGAAEIIDLVISNFKSILIVVPSFVEYE INAKKWGCHIEYSKLLDNMDFDYEDIENKLNDVEAVIVGNPNNPNGNIIDKVKVETII EICEAKNKTIIMDEAFIEFTGRIKNSFLDKIEDNKCIFIIRAITKFFAMPGVRFGYGI SSNKVLLNNIRKKQNPWNINCFAELAVKYSLKDKEYIKKSLQWIEEEREFFVKQLNEI PFIEQIFKSFSNFVLCKLRNVNEEKLYEYCLENGIIIRKTSNFRGLDKSYVRFAIKDR ESNEKLIKILKDSSF" gene 7223..7762 /gene="" /locus_tag="" /db_xref="1252914..1253453" CDS 7223..7762 /gene="" /product="ATP:corrinoid adenosyltransferase" /translation="MGKLSKGYVQIYTGNGKGKTTAAVGLGVRAAGDGYSVFMVQFLK SGSTGELESIKKLEPNFKVFRFEKKRGFFWTLNDSEKAELKLEVQEAYRFCLDTLKNN KCDILIMDEIMGALSNELVSKEQLLQLIEAKPHNMELILTGRNVPEEIIDRADLVTEM KEIKHYFGKGVPAREGIEY" gene 7767..9086 /gene="" /locus_tag="" /db_xref="1253458..1254777" CDS 7767..9086 /gene="" /product="cobyrinic acid a,c-diamide synthase" /translation="MKSIVISSNGSSGGKTTITMGLLKVLKDRGFEVQSYKVGPDYID PDFHEYITKVPARNLDLYLMGEEGVKASFSRGKGDYAVVEGVMGLYDGKGISTQYSTA HVSKVLNLPVILVLSPKAKASTLCAEIQGLMNFESINIAGIIFNNIKESYYKLLKAAV EKYCKVKVFGYVPKDERLSLKSRHLGLVQSAEIEDLNKKIEICAELIENNVDVDLLLK YFVPAEKYSDNFHVKNMKIKSAVAYDKASSFYYKENIELLQEAGQVQFFSPLEDKELP KEVDFIYLGGGYPEVFIERLSENKTMLNSIRNALNSGTRCYAECGGLMYLTGAINGKE TVGFFKGESNMTNRLQNFGYAKVKVVNENSVLPVGLRFNCHEFHKSQVILEESNIYEI TKDSYDNSKKQWNCGYVKGNTLGSYAHVHFFGNLAMFKYLIGNGLMG" gene 9113..9559 /gene="" /locus_tag="" /db_xref="1254804..1255250" CDS 9113..9559 /gene="" /product="acetyltransferase" /translation="MSEIARFIKYDELNELLDLYKQLQPEDPDVSNNENLHEIWNSIY NNANLYYIVVEVDGKLVSSCNISIIENLTRNLRPYGLIENVITDSAYRKKGYATKVLN KAVEIAKEKKCYKVMLLTGSKKEETLRFYEKAGFARGIKTGFIIKL" gene 9657..10283 /gene="" /locus_tag="" /db_xref="1255348..1255974" CDS 9657..10283 /gene="" /product="precorrin isomerase" /translation="MDYIKMPMDIEKKSFEIIGEEMGEHDFSEREISIVKRVIHTTAD FEYKDLLYIREGSIDRALEVLKNGTTIYTDTNMALTGINKKALKELNCKVECFVSRED IAKEAKERKITRSMAAVEKAVEEGVQFFVFGNAPTALYRLKELIIEGKADAKFIVGAP IGFVGAAESKKEIEKLDLPLITVRGRKGGSTVAAAIVNALMYMIIERE" gene 10288..11379 /gene="" /locus_tag="" /db_xref="1255979..1257070" CDS 10288..11379 /gene="" /product="cobalamin biosynthesis protein CbiD" /translation="MLDLYINCDGKKLRCGYTTGSCAAAAAKAAAIMLYHGNEVKEIR IDTPKGIELSLEVTKIVKGENYVECCIIKDGGDDPDVTHGLEIWARAEKKDSGYTLKG GKGVGVVNGEGLYVKKGEPAINPVPRNMTEKEVREVLPKDKGIEITIFVPKGEEIAKK TFNPRLNIEGGISILGTTGIVVPMSEEALKESIKLEINQKAVLGYKELVLVFGNMGED KAKELGVDPKRIVSMSNYVGFALNSCVEKKIKKITVIGHIGKLCKVAAGCFNTHSRVC DVRLEVIALELALMGENTEIVQKVYNEKTTEGAVNLLGDNYEQIYHRIGNKIKQKIQQ FSYNQVEVDVVMFSMERGVLFDSRDNINT" gene 11612..12022 /gene="" /locus_tag="" /db_xref="1257303..1257713" CDS 11612..12022 /gene="" /product="hypothetical protein" /translation="MKKIIILFSIAVFLIGFIVIYKYYYNKVVKINVYEISKYNQSQK TYLTSLTNPKSIDIVVESIKHGKKINGTLDVLPANYIVELYYTTNRRETIYLWLTKEY NTSSMYMYVNKTSTGYTIPKQYTSKLQQVLFYTK" gene 12142..12879 /gene="" /locus_tag="" /db_xref="1257833..1258570" CDS 12142..12879 /gene="" /product="precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit" /translation="MLYIVGLGPGSRKYMLVKAIEILDRSDIIIGFKRAIESIAFIKD KNRILVKTLKEILDIINNNADKSISIVASGDPCFYGISDYINRNYKGELITIPGISSF QYLMAKLNKSWQEAYLGSLHGREENFIEKIKDYKVSIWLTDKVNSPEEICKRLFKEKL SVKVYIGENLSYDDERILIGKPEEFIHREFYPMTSRCNIPPSKGGDNSDTSLDNSSKL VGSTNSQQVRFIDDLAVVVIENEIHKG" gene 12860..13426 /gene="" /locus_tag="" /db_xref="1258551..1259117" CDS 12860..13426 /gene="" /product="precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit" /translation="MRYIRDEEFIRGKTPMTKEEIRILSISKLNLEKDFKVMDVGAGT GSVSVQMSKICYEGQITAVERDKEAIDLIEKNKEKFSAHNISIIEGEALKAVNSIQGE FDAIFIGGSGGNIEDIITSYGGKLKQGKNMVLNFITIDNVYRAMHTLRNLEYDIDLIQ VAVSKGKGKSGMLVAINPIFIVTAVKKH" gene 13481..14146 /gene="" /locus_tag="" /db_xref="1259172..1259837" CDS 13481..14146 /gene="" /product="precorrin-2 C20-methyltransferase" /translation="MAKLYGIGVGPGDKELLTLKAVKTIKNSEVVVVPSGMAGGRSIA LEIAEDYISKDTEIIVKHFPMGGKEQEQKIYEAFEVIEEMLKAGKNVSFLTIGDPFVY STYIYLLKYIEEKGYETETVPGITSFCACASLAKEPLVIGNEPLLIVPGEKVNTIKDE KYVVIMKVYKMEEEILNILEEKGFTYVYIKKAGREGQEVLRDRDDILKNREYMSLIIA NRK" gene 14163..14939 /gene="" /locus_tag="" /db_xref="1259854..1260630" CDS 14163..14939 /gene="" /product="precorrin-4 C11-methyltransferase" /translation="MVYFIGAGPGDVDLITVKGRDILAKADIVIYAGSLVSKEHMSFC KKDVEIYNSASMNLEEVIEVIKKGSTENKIIVRLHTGDPAIYGAIKEQMDILDSLNIS YEVIPGVSSFTAAAAAIKREFTLPKVSQTVILTRIEGRTPVPKGEDLERLAAIGASMA IFLSVSMIDKVVGKLKKGYGRNVPVAIVERATWKDERTIIGTLDDISEKVKEANITKC AQILVGDFIDCEYEKSKLYDKSFTHMFREGINENSSNKSE" gene 14911..15996 /gene="" /locus_tag="" /db_xref="1260602..1261687" CDS 14911..15996 /gene="" /product="cobalamin biosynthesis protein CbiG" /translation="MKIAVISLNNKGDIIAERIGKSIDIDLYSKTKIKEFNINNITKE LMKEYEAVIFLSSTGIAVRSIAPYIKSKDIDPAIIVIDVLGKYVISLLSGHLGGANAL SIKLAEIVGALPVITTATDILKVKAPDIIALENNLIIDSLKDAKEISALLVDGKKVAF VDDKNEIDLPEGYINLEDKLESYRLMNSDDHSNCRLHTKEVSLKKEKEQINGIVYVTD KAKIQGFNKAEYNNQKKLKLIRRDVVLGIGCKKNYPAEKMIEQVCEKLEELNIDKRAV KYVATVEIKKDEKAILELNKALKGELKIFTREAIRKVQHKYKGSDFVEKSIGIRAVCE PCVELCGGILLTEKLSISGMTLCVGKA" gene 16174..16890 /gene="" /locus_tag="" /db_xref="1261865..1262581" CDS 16174..16890 /gene="" /product="precorrin-3B C17-methyltransferase" /translation="VGKLYVVGIGPGGLEHMTVKARQVIEESEIIVGYTKYIELIKSL IKGKEIFSTGMMKEEERCRAALRLSKDKVVSIISTGDAGIYGMAGLVLEMRKDEQVEV VPGVTASSAAASVLGAPIMHDSCNISLSDLMTPYELIKKRVEMAAQGDFVITLYNPKS KGRPYYLKESIEIIKRYRKGHTPVAIVKNALREGQKQQLFTLDSFDDSDADMLSVVII GNSQSFVRNGIFITPRGYKL" gene 16887..17660 /gene="" /locus_tag="" /db_xref="1262578..1263351" CDS 16887..17660 /gene="" /product="precorrin-6x reductase" /translation="MIGLILGTSEGKNILSKLNRYTDNIFITTATEYGGQLLENFKFK KLNTKPLVLEELIEQLRENRIEILVDASHPYALVITQNAMVACKRLGIIYVRYERKSI LDKFKGNNNIIQVKDYDELKEELLHINGTILNTTGSNNIEKFINMKLNNRIIHRVLPS VKVMDKCFGLGVKTENIIAIKGLIGYELNCSFIKEYDSKAVILKDSGVQGGTEEKLRA ALDMGIKALVIERHTINTENSFSSEDEVVDFVVNKLSLM" gene 17678..18013 /gene="" /locus_tag="" /db_xref="1263369..1263704" CDS 17678..18013 /gene="" /product="hypothetical protein" /translation="MGILKSIFYFVLAGVFEIGGGYLIWLWLRDGKSIWYGLAGAISL IIYGVVPTLQPPSSSFGRVYAAYGGIFIVLSILWGWKIDKVIPDRFDLIGGFIALIGV LIIMYYPRG" ORIGIN 1 atgatgaatt taaaaaaaat atttgcagca acaacaataa cagcactttt actaactgga 61 tgcagttcta atgcaggagc acctaaaact caaaatacag aacaaaatga atctgctgct 121 aaaggtgaaa aaacattaag tatagctgaa ggttctaaaa atatgaaaga tgttttaaag 181 gatatgaaat caaaacttga gaataaagat gaggaaggcg ctgtaaatgc atctgcagga 241 cttgaggata actggaaggt atttgaagat aacgttaaag ataaaaataa ggaattgtat 301 gaaaaagtag aacagccgct acatacaata aatgcagcag taaaaataaa accacttgat 361 actaagactt tgattgatgc cattgatgtt ttagataaac agcttgatga agtgggaaaa 421 ttgaaataga gtattctata caattaatta ctggagtatt ttttactaca tgtattgcta 481 taatattcat tatgatataa actaaagtag aaaatttaat agaagcttag gtgccttgca 541 aaaaggtgaa aagggaatgc ggttgaagtc cgcagcagcc cccgctactg taaatgagga 601 cgaaccttaa tatgccactc aatgatttcg tatggagtat atactaaaat tatatgggga 661 aggctaaggt taggatgata cataagtcag gagacctgcc taagttgtaa tttgtccgag 721 gactacccgc tctaatactc ccatcgcact ctgtggaagt gggagtaaag agcggctacg 781 tccctggata acgatttcta agcatcagat gggataaaaa ctccacctga tgccaagaac 841 tctgtttata aagctttcgg aggggaagat cttttggtga taaaaatttc tgataatttg 901 tgaatttttt attttagaag gtagtgctac tgaaagcact acctttttta ttttttacaa 961 acttgcagct attttgattg gaggaaaagt gtttgcataa gaaaaaggat aaggtgatac 1021 ttgtagtaag ttttggaact acttatgggg aaactagaaa attaactata gacagcattg 1081 aacagtgcat acaggatagg tttaaggact atgatatgaa gagggcattc acttctcata 1141 tgataattaa agtacttagg gaaagagata gatatattgt agatacgcca gaagaagctt 1201 tagaaaagat agctgaggaa ggctacaaag aagttattgt tcagtccctt catataatgc 1261 ctggagagga atatgagtat gtagaaaggg tagtggaaag ctacagacaa aaggatgtat 1321 ttaataaaat tgagttagga agacctatac tttattttaa gggagatggt gaacagcttc 1381 aggatgatta tttaatggct atggaagcta taaagcttca gctgcctgaa acaggttcag 1441 tagtgtttat ggggcatgga acaactcatc ctgcaaatgc ctgctattcc tgtcttcaga 1501 tggtccttag agatcaccag ataaataatg tatatattgg aacggtggaa ggttatcctt 1561 cgctggacaa tattataaac acactaaaaa gagataaggt agaagaaatt acgttaatgc 1621 ctcttatggt ggtagctgga gatcactgta ataatgacat ggcttcagat gaagaggatt 1681 catggaaaaa gattcttgaa aaagaggact ttaaggttaa tttatatatg catggtatgg 1741 gagaaaatcc tttatttaga aagatatttg taaaccatgt agaagacact attataggta 1801 aatataaaaa tatgggaaga actaaaaagg ggatttaaat atggcaaagt taatgataca 1861 gggtacagcc tcttctgtag gtaagagtat tcttgttaca gcattatgca ggatttttaa 1921 gcaggatggc tacaaggttg taccgtacaa atcacaaaat atgtctttaa attcttatat 1981 aactttagac ggaaaagaaa tgggaagagc ccaggtactt caagcttatg cctgtggtat 2041 ggagccagag gcttatatga atcccatact gcttaagcct acttctgata agaaatctca 2101 agttatagtt aatggtaaag tctatggaaa ttacaccgcc atggaatatc acaatatgaa 2161 accggtgttt agggatatgc taaagcagca atttgaggaa ctggaaaaag aatttgatat 2221 aatagttatg gaaggagcag gaagccctgc tgagataaac ctaagagaca gggatatagt 2281 taatatgggc atggcagaac tggtggatgc acctgtaata ctagcaggag atattgataa 2341 aggtggagtt tttgcttctc ttgcaggtac tatgctcttg ctaagggatg atgaaaagaa 2401 aagagttaag ggtactatta taaacaaatt cagaggggac atagatatac taaaaccagg 2461 cctcaatatg cttcaggata tagtaaaaat accctgcatt ggagtagtac cttattttaa 2521 tctacagctg gaagacgagg acggagcagt agaatttgaa aataagccgc atggagcaat 2581 agatatagca gttattaagc ttcctcatat atctaatttt acagatctag atgcacttaa 2641 agctgaagag gatgtatcca taagatttat aactaacata gaagagtttg gaaatcctga 2701 tatgataatt ataccaggaa gtaagaatac catagaggat ttattaaagc ttcgcaaaag 2761 tggtttggaa tcaaagataa gagaatacag taaagctgga attgttatag gtatatgtgg 2821 tggatatcag atgctgggga actccgttaa agatccctat gaagttgaaa caaatatgtt 2881 aaatacagag ggaatgaagc tgttagatat tgatacaact tttgaaaaag aaaaggttac 2941 aacaagagta agggcggttg tggcgtcaga tgatttatcc aaggatattg atacatgtat 3001 ggtaaattac aataatgtag gtgaaaaaga agataggaaa ttgtatagtt tacagtataa 3061 agtagataaa agagtctaca aagaaataaa tcaagaagat aatatgaaaa ttaaagaaaa 3121 caattataaa aataaagaag tttatggcta tgaaattcac atgggaatat gtaaatatgg 3181 agataactca aagccacttt ttaatataac agataaaaat ggactgaaag taaattacag 3241 tgatggtgct attaatgaaa aaggaaacat tatgggtacc tatattcatg gaatatttga 3301 cagcatttat tttagagagt acatagtgaa tttgttaaga agtaaaaaag gtataattct 3361 taaaaaatct aaggaatatg aaaagcttag agaaaaagaa ctggataaat tagcagctat 3421 agttaggaac gctttggaca tggagagtat atataaattt atggggttga aaaaatgatg 3481 tatacagctt tggatatagt tttagcagta attttagatt tcatattagg agacccaaga 3541 tggcttccac accctataat atatattgga aaaatcataa gctttttgga aaagaaagct 3601 agaaaattct ctagaaataa taatcagtta agattattcg gtgctttaat tgtaatagtt 3661 gttggatcta ttagctttat cattccattt tgtgtattag aaattgttaa atcatttata 3721 atattacatc acatattgaa tgtactgata atttggacta cactagcagc aaagagctta 3781 aatatagcag caatgaaggt acacacttct cttcaaaata aggacataaa ggatgccaga 3841 ataaagcttt cctatattgt aggaagagat acaaaagaac tttcagaaga gaaaataata 3901 agggcggatg ttgaaactgt agcagaaaac acttctgatg gagttatagc acctatcatt 3961 tttgccatga ttggtggagc acctttagct atgctgtata aaggcataaa taccatggat 4021 tccatgctgg ggtataagaa taaaaaatat tattacatag gtttttttcc ggcaaagaca 4081 gatgatctgt ttaatttaat acctgccaga attacaggta tacttatagc attagtttct 4141 cctttggtga agggaaatat tttagagagt ctcaaaataa tgattaggga tagaaaaaat 4201 cacaaaagtc caaactgtgc ctaccctgag gcagcagctg ctggtgcaat gaaaatacag 4261 ctgggtggta ctaacagcta ttttggagag cttgtttaca agcctacatt aggggataaa 4321 aagcagaatt tagataaaaa gcatattaaa gaagttatta agttgatgta tggttcggag 4381 attttgttgc taattattta tgttattgta gtttatttga aagtaataat ttgagaaatg 4441 ctatttcaac gattcaacca gatggaacaa aaagaagaca tcatgaaatc tatttatctg 4501 atccgcgaaa aacaagtccc gaaaaattaa aaactgtttt aagacatcct gttgagtaca 4561 agtaataaat ttcaattagg gctattttat ggtttttatt ggaatactaa ctatgataat 4621 ataacatcag aaggttaagc ctaagaggtg gtaaaatggc acaaaataat attgaaaata 4681 taattacaga tattaaaaaa atagtatcta cagcaagaaa aaatgtagca aaagaagctt 4741 ctacgaaaaa gaaagtatta attctaattg gtcagtgaga gagttaaaaa ggcagataga 4801 cacatcttta tattgtgcaa gattatttta tcatgtgagg tgaaataaat gctgaaatta 4861 gtaaaagctc aaggattaaa ccgaggcgat aaggtagcca ccgtaagcct gtcgtggggc 4921 ggtgctggtg atacagattt actctggaga tataacttag gaaaaaagag attgcaagag 4981 tggtttggtt tagaagttgt agaaatgcca aacactttaa aaggatctga ctatctatac 5041 catcatccag aaaaacgtgc agaagattta atggcagcct tttctgacac atctataaaa 5101 gcgattttct cttgtatagg tggtaatgaa agtgtacgaa tgttgtcata tattgatttt 5161 aatatcataa aaagtaatcc taaaatattt ataggttact ctgatgcaac tataacacac 5221 tttatgtgtc ttaaagctaa tttgtcaagt ttctatggtg catctattct tgcggaattg 5281 gcagaaaata ttaaagtgtt tgactatact tctagctggt tagaaaaagt tctatttgat 5341 acttctccaa ttgggttaat accagtaact acagaatgga ctggagaaag aatagaatgg 5401 agtgaaagta acgccaatgt tgcaaaaact atggtgaaaa atcaagggta tgagtttttg 5461 caaggcaagg gtgtgactca aggccattta attggtggat gtattgaagt aatggagatg 5521 ataaaaggta cttcgttatg gccatcaaat gatatatttg aagatgctat tctattcttt 5581 gaaacatcag aggatatgcc aggatcaatt tatatagaat attggcttag aaattatggt 5641 agtcaaggta tattgcaaaa agcaaaagca ataatttttg gaaaaccata tcaagaaaaa 5701 tattataatg aatacaagaa ttcaatcttg aagatcctgt tagaattagg actttatcat 5761 cttcctattg tctataatat gtcttttggg cataatgagc caatgatatg tttgccatat 5821 ggtgcaatgg cagaaattga ttgtgatagg aggacttttt ccatacttga atccggggta 5881 gtataacttc ttgttataat caatagtgat tagtgacaaa ttataatgaa caaaaggata 5941 aatatacgta aataaactta tgtgaaaatg gggtggctta tatatgattc acggcggaga 6001 catatatacc gatggtattt ttaaaggaca agagcttcta gatttcagct ccaacataaa 6061 tccacttgga gtaccggaag gctttaaaaa caatatagca gaggctttag attctgtaac 6121 cagatatcca gatattaagt atagggaagt tattaaaaac ctttcagatt atactggtac 6181 tgcagaagaa aattttgtgc tgggaaatgg tgcagcagaa attatagatt tagttataag 6241 caattttaaa agtatattaa tagtagtgcc ttcttttgta gaatatgaaa taaacgcaaa 6301 aaagtggggc tgccacatag aatattcgaa attactagat aacatggatt ttgactatga 6361 ggatattgag aataaactaa atgatgttga agcagttata gtaggaaatc ccaataatcc 6421 taatgggaat attatagaca aagttaaagt ggagactatt atagagattt gtgaagctaa 6481 gaataaaaca ataattatgg atgaagcctt tatagagttt acaggcagaa taaaaaacag 6541 tttcctagat aaaatagaag ataataaatg tatttttatt ataagagcta taactaagtt 6601 ttttgctatg ccaggagtaa ggtttggata cggtataagc agtaataaag ttttgttaaa 6661 taatataaga aaaaagcaaa atccatggaa tataaactgt tttgccgaat tagcagttaa 6721 atactccttg aaagataaag aatatatcaa aaaatctctt cagtggatag aagaagagag 6781 agaatttttt gttaagcagc ttaatgagat tccatttata gagcaaatct ttaaaagctt 6841 ttcaaatttt gtactttgta agctgaggaa tgtaaatgaa gagaaactat atgaatattg 6901 ccttgagaat gggataatta tcagaaaaac cagtaatttt agaggacttg ataagagtta 6961 tgtaagattt gccataaagg atagagaatc caatgaaaaa ttaattaaga ttttaaaaga 7021 tagtagcttt taaatatttt attattttct aaaataccaa actagttgta aatatcaata 7081 gactttaatt gatagcaatt agcagttagt taatttatta tgcatatctt aggtatgaat 7141 taaaaattat tcattgtaaa aaggatttat tagaaaacta taattaatat tgagctggta 7201 aacataagaa aagaggagtt ttatgggaaa gctatctaaa ggttatgtac agatttatac 7261 aggaaacgga aaaggtaaaa ctactgctgc tgtgggactg ggagttaggg cagcaggaga 7321 tggttatagt gtattcatgg ttcaattttt aaaatctggt tccactggag agcttgaaag 7381 tataaaaaag ttagaaccta attttaaggt ttttagattt gaaaaaaaga gaggtttctt 7441 ttggacttta aatgacagtg aaaaagcgga attaaagctt gaagtacagg aagcttatag 7501 attttgcttg gacaccttaa aaaacaataa atgtgatatt ttgattatgg atgaaattat 7561 gggagcactg tcaaatgaac ttgtgtcaaa ggagcagctt ttacagctta tagaagctaa 7621 gcctcataat atggagctta tactaacggg aagaaatgta ccagaggaaa taatagatag 7681 ggcagatttg gttacagaaa tgaaagaaat aaagcattat tttggtaaag gagttcccgc 7741 tagagaaggg atagagtatt aagcatatga aaagtattgt tatatcctct aatggaagtt 7801 caggggggaa aaccacaata actatgggac tattaaaggt tcttaaagac agaggatttg 7861 aggtacaaag ctataaggtg ggtcctgatt atatagatcc agattttcat gaatacatta 7921 caaaagttcc agctagaaat ctagatttgt atcttatggg agaagagggg gttaaagcta 7981 gcttttctag aggtaaaggt gattatgctg tagtggaagg ggttatgggc ctttatgatg 8041 gaaagggaat aagtactcag tattctacag cccatgtatc aaaggtactt aatttacctg 8101 taattttagt cttatcacca aaagctaaag cttctacttt atgtgcagaa atacagggat 8161 tgatgaattt tgaaagtatc aatatagcag gaataatatt taataatata aaggaaagtt 8221 actataaact tttaaaggca gcagttgaga aatactgtaa agttaaagtc tttggatatg 8281 taccaaagga tgagagactt tcacttaaga gcaggcattt aggacttgta caaagtgctg 8341 aaattgagga cctaaataaa aagattgaga tctgtgcaga gcttatagaa aataatgtgg 8401 atgttgattt gctgttaaag tactttgttc ctgctgaaaa atacagtgat aattttcatg 8461 taaagaatat gaaaataaaa tcagcagtgg cctatgacaa ggcttctagc ttttattata 8521 aggaaaatat agagcttttg caggaagcag ggcaggtaca gttttttagt ccactagaag 8581 acaaagaact acctaaggaa gtggacttca tctacctagg aggaggatat ccagaggtat 8641 ttatagaaag acttagcgaa aataaaacta tgctaaatag tataagaaat gcattaaatt 8701 ctggaacaag atgttatgct gagtgcggag gtttgatgta tctcacggga gcaataaatg 8761 gaaaagaaac tgtaggtttt tttaaaggtg agtctaatat gactaatagg cttcagaact 8821 ttgggtatgc aaaagtaaag gtagtcaatg agaattcagt attacctgta ggtttacgtt 8881 ttaattgtca tgagtttcat aagtcgcagg ttatattaga agaaagcaat atatatgaga 8941 ttacaaaaga tagttatgat aattccaaaa agcagtggaa ctgtggctat gttaaaggta 9001 atacattagg aagctatgct catgtgcatt tttttggaaa cttggcaatg tttaagtatt 9061 taattgggaa tggcttgatg ggatagcata taaaaagatg gagggtaatt aaatgtctga 9121 aattgcaagg ttcataaaat atgatgaact aaatgaatta cttgatttat acaaacagtt 9181 acagcctgaa gaccctgatg tgtcaaataa cgaaaattta catgaaatat ggaattcaat 9241 atataataat gccaatttat attatattgt tgttgaagtg gatggtaaat tagtatcttc 9301 ctgcaatata tcaattatag aaaatcttac tagaaactta cgaccttatg gacttataga 9361 gaatgttatt acagattcag cttataggaa aaaagggtat gcaaccaaag tattgaataa 9421 agcagtagaa attgcaaaag aaaagaagtg ttataaagtt atgttgttaa caggttcaaa 9481 aaaagaagaa actttgaggt tttatgaaaa agctggattt gctaggggta taaagacagg 9541 ctttataata aagctttaat taaaagtatt gtaagataaa ttagatgagg gatagaaagg 9601 aagtgacact tagtgagttc tattatttac atatttttac tcactaaaaa taaattatgg 9661 attatataaa aatgcctatg gatatagaga agaaaagctt tgaaataata ggggaagaaa 9721 tgggggagca tgatttttct gagagagaga ttagcatagt aaagagagta atacatacca 9781 cagcagattt tgagtacaag gatttgcttt atatacgaga gggttctatt gacagggctc 9841 tggaagtatt aaagaatggt actactattt acacggatac aaatatggct ttaacaggga 9901 taaacaagaa ggcacttaag gagctaaatt gcaaagtgga gtgctttgtg tcaagagagg 9961 atatagctaa agaggctaag gagagaaaga taacccgttc tatggcagct gtggagaagg 10021 cagtagagga aggtgtgcaa ttttttgtgt ttggaaatgc accaacggct ttgtatagac 10081 ttaaggaact tataattgaa ggaaaagctg atgcaaaatt tattgtaggt gcaccaatag 10141 gttttgtagg ggcagctgag tccaagaagg aaatagaaaa attggattta ccactaataa 10201 ctgtaagagg tagaaaaggt ggaagtacag tggcagcggc tattgtaaat gcacttatgt 10261 atatgattat agagagagag tagaaatatg cttgatttat atataaattg tgatgggaaa 10321 aagcttagat gtggatatac tacaggttcc tgcgcagcag cagcagctaa agcagcggct 10381 atcatgcttt accatggcaa tgaagtgaag gaaattagaa tagacacacc taaaggaata 10441 gagctttcat tggaagttac gaaaatagtt aaaggtgaaa attatgtgga gtgttgtatt 10501 ataaaagatg gtggagatga tccagatgta acccatggac tggaaatatg ggctagagcg 10561 gagaagaagg acagtggata tactttaaaa ggtggaaaag gtgtaggtgt agttaatggt 10621 gaaggtttat atgttaaaaa aggtgaacca gccataaatc cagtaccaag aaatatgaca 10681 gaaaaagagg taagagaggt cttacctaag gataaaggta tagaaataac tatatttgtg 10741 ccaaaaggag aagaaatagc taaaaagaca tttaatccaa gacttaatat agaaggcggt 10801 atttccatac tgggtacaac gggaatagta gtgcctatgt ctgaagaagc actaaaggaa 10861 tccataaagc tggagataaa tcaaaaagct gtattgggtt ataaagaatt agttttggtt 10921 tttggaaata tgggagaaga taaagctaaa gaacttggag ttgatcctaa aagaatagta 10981 tccatgtcca actatgtagg ctttgcacta aatagttgtg tggaaaagaa gataaaaaag 11041 attacggtta taggtcacat aggaaagttg tgtaaagtag cagcaggctg cttcaatact 11101 catagtagag tatgtgatgt aaggcttgag gtaatagctc ttgaactggc acttatggga 11161 gaaaatacag aaattgtaca aaaggtgtat aatgaaaaaa ctactgaagg ggcagttaat 11221 cttttagggg ataattatga acagatttat catagaatag gaaataagat aaagcagaaa 11281 attcagcagt tttcctataa tcaagtagag gtagatgtag ttatgttctc catggaaaga 11341 ggagtacttt ttgatagtag agataatatt aatacataat tgtgagaaag ggcgaaataa 11401 acaccaaatt gattaaacta ataaatggga atattagctc gttaacaagt gaaagctttt 11461 tacctagctg acgcggcgaa aaagtgaaag attgccgaca cgcggcaagg taaaagattt 11521 aaccggggct tcgctggtta aataggtagt taaaatactc acaaatgggt tatcgcacta 11581 aaaaaacttt ttagaattgg aggttaatta tatgaagaaa ataattattt tattttcaat 11641 agcagtgttt ttaattggat ttattgtaat ttataaatac tattataata aagttgtcaa 11701 aataaatgta tatgaaatat ccaaatataa tcaatctcaa aaaacttatt taacttcttt 11761 aactaatcct aaaagtatag atatagtggt ggaatccata aaacatggta aaaagataaa 11821 cggtacgctt gatgtacttc cagctaatta cattgttgaa ttatattaca ctacaaatag 11881 aagagaaact atttatttat ggttgactaa agaatataat acttcttcta tgtatatgta 11941 tgtaaataaa acttcaacag gttatactat tccaaaacaa tacacaagta aattgcagca 12001 agttcttttt tatacaaaat gatattatat aattaatgaa aggacaattg atatgaagaa 12061 aaaatattag tgcgaaatat tattaaggtt attctataat taaaatatat gaaaactctt 12121 tataattgtg aggataaaat tatgctttat atagtaggtc ttggtccagg cagcagaaaa 12181 tacatgttgg ttaaagctat agaaatttta gataggtcag atattattat aggttttaaa 12241 agagcaatag agagtatagc ttttattaaa gataaaaata gaatattagt gaagacttta 12301 aaggaaatac tggatataat aaataataat gcggataaga gtatttccat tgtagcttct 12361 ggagaccctt gtttctatgg aatttcagat tacataaata ggaattacaa aggtgaatta 12421 attacaatac caggtataag ttcttttcaa tatcttatgg caaaactcaa taaatcctgg 12481 caggaagcct atcttggaag tcttcatgga agagaagaaa attttataga gaaaattaaa 12541 gactataaag tatctatatg gcttacagat aaggtaaatt ctccagaaga aatttgtaaa 12601 agattattta aggaaaagct ttcagttaaa gtatatatag gagaaaactt gtcctatgat 12661 gatgaaagaa ttttaattgg aaagccagag gaatttatac atagagaatt ttatccgatg 12721 actagtcgct gtaatattcc accttctaaa ggtggagata acagcgacac gtccctggat 12781 aattcatcta aacttgttgg gagtacaaat tcccaacaag taagattcat tgatgattta 12841 gcggtggtgg tgatagaaaa tgagatacat aagggatgaa gaatttataa ggggtaaaac 12901 tcctatgaca aaggaagaaa tacgaatact cagtatttct aagcttaatt tagaaaaaga 12961 ttttaaggtg atggatgtag gtgctggaac tggttctgta tctgtacaga tgagcaaaat 13021 atgttatgag ggtcagatta cagctgttga aagagacaaa gaagcaatag atttaataga 13081 gaaaaataaa gagaaattta gtgctcataa tattagtatt atagaaggag aagctcttaa 13141 ggcagtaaat agtatacaag gagaatttga tgctatattt atcggcggca gtggtggaaa 13201 tatagaggat ataataacta gctatggagg aaagttaaag cagggaaaga atatggtgtt 13261 aaattttatt accattgata atgtatatag agcaatgcac acacttagga atctggaata 13321 tgatatagat ttaattcagg tagcagtgag caaaggcaag ggaaagagcg gtatgctggt 13381 ggcaatcaat cctattttta tagtaacagc ggtaaagaaa cattagaaag aatatgtgtt 13441 taaggtgaat catataagat tcaaatacag gagggaaaaa atggctaaat tatatggcat 13501 aggggttgga cctggagata aggaactgct tacacttaaa gcagttaaaa caataaaaaa 13561 ttctgaagta gtggtagttc ccagtggtat ggctggtggg agaagcatag cactagaaat 13621 agcagaagat tacataagta aggatacaga gataatagtg aaacatttcc ctatgggagg 13681 aaaggagcag gaacagaaaa tatatgaagc ctttgaggtc atagaggaaa tgcttaaagc 13741 aggcaaaaat gtgtcctttt taacgatagg agatcctttt gtatacagta cttatatata 13801 tcttttaaaa tacatagaag aaaagggata tgaaacagaa acggtgcctg gaataacctc 13861 cttctgcgcc tgtgccagtc ttgcgaagga acctttagta attggcaatg aaccacttct 13921 tatagttcca ggagagaaag taaatactat taaagatgaa aaatatgtgg ttataatgaa 13981 agtatataaa atggaggaag aaatacttaa tatcttggaa gaaaaaggtt ttacctatgt 14041 atacataaaa aaagctggca gagaaggaca ggaagtttta agagatagag atgatatatt 14101 aaaaaacaga gaatatatgt cacttattat agcaaatagg aaatagaaaa gggagtgagt 14161 gcatggttta ttttatagga gcaggaccgg gagatgtgga tcttataacg gtaaagggaa 14221 gagatatttt agctaaggct gacatagtga tttatgcagg ttcactagta agcaaagaac 14281 atatgagttt ctgtaaaaaa gatgtggaaa tttacaattc tgcctctatg aatcttgaag 14341 aggtaattga agttattaaa aaaggcagta ctgaaaacaa aattatagtg agattacata 14401 ctggagatcc agctatatac ggtgctataa aggagcagat ggacatattg gatagcctga 14461 acataagcta tgaagttatc cctggagtaa gctcttttac agctgcagcg gcggcaataa 14521 agagagaatt tacccttcca aaggtgagtc aaactgtaat tctcacaaga atagaaggca 14581 gaacgccagt accaaaggga gaagatcttg aaagattagc agctatagga gcctctatgg 14641 caatttttct atcagttagt atgattgata aagtagtggg aaaattgaaa aagggttatg 14701 gtagaaatgt accagtggca atagtagaaa gagctacctg gaaagatgag aggactatta 14761 ttggtacttt agatgatatt tctgaaaagg taaaagaagc aaatataact aaatgtgcac 14821 agatattggt cggagatttc atagattgtg aatatgaaaa gagtaagctt tatgataaga 14881 gctttacaca tatgtttaga gagggtataa atgaaaatag cagtaataag tctgaataat 14941 aaaggtgata ttatagctga aagaattggc aaaagtattg atatagactt atattctaaa 15001 actaaaataa aagagtttaa tataaataat ataactaaag aacttatgaa agaatatgaa 15061 gcagtgatat ttctatcctc tacgggtatt gcagtgaggt ctatagctcc ctacataaaa 15121 tctaaagaca tagatccagc aataatagtt atagatgtgc ttggaaaata tgtaataagt 15181 cttttaagtg ggcatttagg tggagctaat gctctctcta taaagcttgc agagatagta 15241 ggagcattac cagttataac tacagctacg gatattttaa aagtaaaggc accagatatt 15301 attgcattgg aaaataattt gataatagat agcctaaagg atgcaaagga aatatcagct 15361 ctattggtag atgggaaaaa ggtggcattt gtagatgata aaaatgaaat tgatttgccg 15421 gaggggtata ttaatctaga agataaactt gaaagttata gattaatgaa ttcagatgat 15481 catagtaatt gtagattaca tacaaaggaa gttagtctga aaaaagaaaa agaacagatt 15541 aatggaattg tatatgtaac tgataaggct aagatacaag gctttaacaa agccgagtac 15601 aataatcaaa aaaaattaaa acttataaga agagatgttg tgcttggaat aggttgtaaa 15661 aagaattacc cagcagaaaa gatgatagag caggtttgtg aaaaattaga agaacttaat 15721 atagataaaa gagcagtaaa atatgtagct actgtagaga taaaaaagga tgaaaaggct 15781 attctggaat taaataaggc tttaaaggga gaattgaaaa tttttactag agaggccata 15841 aggaaagttc agcacaaata taaaggcagt gattttgtgg agaagagtat aggtataaga 15901 gcagtttgtg agccatgcgt agaactatgt ggtggcatac ttttaacaga aaagttaagt 15961 atttctggaa tgactttatg tgttggaaaa gcttaaaatt aagatattaa tttatatagg 16021 ctgcaattaa aataattaac agatgagaat taaatagaat agttacttta taatgaatat 16081 aatttattgc aatatgtatt aacataattg atatgaatga atttaagaag tcattagtat 16141 actaagattt aataatggaa aggagaaatc ctcgtgggaa aattgtacgt ggtaggtata 16201 ggtccaggtg gtcttgaaca tatgacagta aaggctagac aggtgataga ggaaagtgaa 16261 attatagtag gttacactaa atatattgaa ttgataaaat cattaattaa aggtaaagaa 16321 atattttcta caggaatgat gaaggaagag gaaaggtgta gagcggctct gagactctca 16381 aaggataagg tagtatccat aattagtact ggagatgcag gaatctatgg aatggcgggg 16441 cttgttttag aaatgagaaa agatgaacag gtagaagtag taccaggagt tacagcctct 16501 agtgcagcag cttccgtttt aggagcacct attatgcatg atagctgtaa tataagtctt 16561 agtgacctta tgacacccta tgaacttata aagaaaagag tcgaaatggc agcacaaggt 16621 gattttgtaa ttacactgta caatcctaaa agcaaaggaa gaccatatta ccttaaggaa 16681 agtatagaaa taataaagag atacaggaag ggacatacgc ctgtggcaat agttaaaaat 16741 gctctaaggg aagggcaaaa acagcaatta tttactttgg attcttttga tgatagtgat 16801 gcagatatgc tttctgttgt tattattgga aacagccaaa gctttgtaag aaatggaata 16861 ttcataactc ctagaggata taagctatga taggccttat acttggaact tcagagggta 16921 aaaatatact ttcaaagctt aaccggtata ctgataatat atttattacc acagctactg 16981 agtatggtgg acaactactg gaaaatttta aatttaaaaa gttgaatacg aagcctcttg 17041 ttttagaaga acttatagag caattaaggg aaaacaggat agaaattttg gtagatgcat 17101 cccatcccta tgccttagtt attacacaaa atgctatggt ggcatgtaaa agacttggga 17161 taatttatgt caggtatgaa agaaaatcta tcttagataa atttaaggga aataacaata 17221 taattcaagt taaagattat gatgagctta aagaagaact tttacatatt aatggaacaa 17281 ttttaaatac tactggcagc aataatattg aaaagtttat caatatgaaa ctaaacaaca 17341 gaataataca tagggttctt ccctctgtta aggttatgga taagtgtttt ggcttaggtg 17401 taaagaccga aaatataata gctattaaag gtctcatagg ttatgaactt aactgcagtt 17461 ttataaagga gtacgattca aaagcagtga tccttaagga cagcggtgtt cagggtggaa 17521 ctgaggaaaa gctgagagcc gctttagata tgggaataaa ggcactggta attgaaagac 17581 acacaattaa tactgaaaat agttttagca gtgaagatga ggtagttgat tttgtagtga 17641 ataaattatc actaatgtga gaaagtaggt gctactgatg ggaatactta aatcaatatt 17701 ttattttgtg ttagctggag tatttgaaat aggtggagga tatcttatat ggttatggct 17761 aagagatggt aaaagcatat ggtacggttt agcaggagct ataagtttaa tcatttatgg 17821 agtagtacca acattacaac cgccaagttc tagttttgga cgggtatatg cagcctatgg 17881 aggaatattt attgttcttt caattttatg gggatggaag atagacaagg ttatcccaga 17941 tagatttgac ttaattggag gctttattgc acttataggt gttttaataa taatgtatta 18001 tccaagaggg taa //