LOCUS NC_019977:3 18791 bp DNA linear BCT 16-MAR-2013 DEFINITION Methanomethylovorans hollandica DSM 15978, complete genome. ACCESSION NC_019977 SOURCE Methanomethylovorans hollandica DSM 15978, complete genome. COMMENT locus start: 302454; locus end: 321244 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.705791; n0_4mer:D = 26.899927; n0_4mer:PS = 43.995267 FEATURES Location/Qualifiers source 1..18791 /organism="Methanomethylovorans hollandica DSM 15978, complete genome." gene 1..3075 /gene="" /locus_tag="" /db_xref="302454..305528" CDS 1..3075 /gene="" /product="PAS domain S-box" /translation="VKKIALLQSFVDEIPNLFCRLEIHGYYVHTSFLLEENIIDEIKR NQYDAFLLDLSGTPIEELRKNHYLSEISGHIPVILIAPYVDYPLLESLGNVHISGCLI PPFSDEQLCSTIELACHNHNILKTNAYDMKNTLFEKERSYAMLLSNLPGMAYRCDNDQ EWTMRFVSEGCYKLTGYDSEALLHNRDISYNRLITPENQAHIWKKYQEMLARKETFQD EYTITTAIGEVKWVWEQGKGVYADNGELIAIEGFIADITEKKKVQETLRESESRYRSL FENNHSAMLVIDPEIGSIIDANPAAVSLYGWTREELRSKTIKEINALSPFEVKEEMDR AVKGQRIRFFFKHSLADGSVRDVEVFSSPILMDRKMLLYSIINDITELNRMEQELLLN RFCIDHSVVGIFRIEEPDGRIVSVNDHACQSLGYSREELCSMTVLDIDPTFTPETWIE HRKNVRKLKSGTIETILCKKDGTEFPVEITINDMEHEGKVFYLSFAKDITKRKVAEQA LKESEEFFRITLYSIADGVITTDINGNLRQMNHVAEKLTGWNEAEARGKKVEEIFNIF NEDTRQQVEIPVRRVLREGRVMGQANHKLLISKDNREIPIADSGSPIVNEKGEIIGVV LVFRDQSEERKAQRSLRESEARFRQLVENAPEAIFVQANGCFAYVNPAALRLFGVDSA SQLIGKPVMERFHPDFRDIVRERIHLINDMHEEVPNIEKIYLRLDGTPFNVEISRVPI IYDGLNGSLVFFRDVTERKRVERALIRAKMVSDEANRSKTEFLANTSHELKTPLNSII GFSELMLAGELGKISKQQKKYIGTILESGCMLLNIVNKILDISSIDYGRMDLSYTKFN LCDAIQDTCAMMQAAANRKSIKHVVDIDPQINGINADAIKFKEIVYNLVDNSIKFTPY GGIVIITATQNESHVKISVTDNGIGIAKENIERIFDPFYQVDSSTTRRYGGTGLGLAL IKQFIKMHGGNIWVESEPGKGSTFTFTIPLDYGEQPIRMLQVSEDQDLDFCS" gene complement(3119..4609) /gene="" /locus_tag="" /db_xref="305572..307062" CDS complement(3119..4609) /gene="" /product="type I restriction-modification system methyltransferase subunit" /translation="MSENTSSIVSKVWSFCNVLRDGGVSYGDYLEQLTFLIFLKMAEE YRKPPYSRDIGIPEKYTWDVLKQKRGAELDTHYKELLEELGKKPGMLGQIFLKAQNKI SDPAMLYKVIDMIDKESWVMMGVDTKGEIYEGLLQKNAEDTKSGAGQYFTPRPLIKAM VQCLRPEPMKTIGDPCCGTGGFFLAAYDFLTNNYEPDRDHSRFLKAKTFGGNEIVAGT RRLALMNLFLHNIGEIDGEPMISNSDALIADPNIRYDYVLTNPPFGKKSSMTFTNDEG EQEKEDLTYNRQDFWVTTSNKQLNFVQHIHTILKTGGQAAVVLPDNVLFEGGAGETVR KKLLETTDLHTILRLPTGIFYAHGVKANVLFFEAKPASKEPWTREIWIYDYRTNVHHT LKKNPLRFTDLEDFIRCYNPENRFQRKETWSREDPEGRFRRFTYEEIASRDKTNLDIF WLKDKSLADLDNLPDPDILANEIIENIEAGLESFKEIVETLNGNRK" gene complement(4825..5616) /gene="" /locus_tag="" /db_xref="307278..308069" CDS complement(4825..5616) /gene="" /product="NADPH-dependent FMN reductase" /translation="MKILVIMGSPRKGNTYRAAKKIEEVMHSMGDVEFEYLMLKDANL SQCRGCLVCFGEGEDHCPFKDDAPLIEQKMHDADGVIFATPVYGMNVSAQMKTFIDRF SYIFHRPRFFDKKALLLCSTGLMGHRDVLDYLELVAGIWGFEISHKVGIITRVPLPMK TELENERKLKQAAVIFHDALMKKARRSPGLRDVFIFRGQKATFGELAHISPADHTYWK EKGWLDPKTKYYVNVPVNPLYNAIGWTFEHIQKRKMKKEMREAQK" gene complement(5672..7183) /gene="" /locus_tag="" /db_xref="308125..309636" gene complement(7189..8694) /gene="" /locus_tag="" /db_xref="309642..311147" CDS complement(7189..8694) /gene="" /product="restriction endonuclease S subunit" /translation="MLKMNNSISFNNAGIENLPRLSEGWQWVRLGEAHILKSDKHNGS GESLFYIGLEHIEKDRGTLTQDVKIDTITTIKNSFKKGDLLYGKLRPYLNKVYLANED GVCSTDILVFKSASISNLNYSKYFFLSRKFVSDMTHNSSGVNLPRVSTKYLQEYPFPL PPLPEQRAIVSKIEQLFSELDNGIANLRLAQEQLKVYRQAVLKKAFEGELTRKWREQQ TDLPDARDLLEHIRKEREEAAKYSGKKMKPVKPLTEDEIVEFPGLPEGWGWVKIEELG EVTGGLTKNSKRNAISTTLPYLRVANVYSNELRLDDLKYIGIEEQEVSRVLLKEGDLL IVEGNGSVNQIGRVAIWNGKISPCIHQNHIIKVRFEIVKIRKFILYWLLSFDGRNQIT KVASSTSGLYTLNLSKIASLCIPVAPLPEQQAIVQEIETRLSVCDKIAQDIDEALEKA EALRQSILKKAFEGKLLSERELAEVRMAEDWEPADVLLERIKVKKEGKEKR" gene complement(8813..10159) /gene="" /locus_tag="" /db_xref="311266..312612" CDS complement(8813..10159) /gene="" /product="putative transcriptional regulator with HTH domain" /translation="MEFSIKDIIEAGEGYHIEFKEFLDKSFVEEVCAFANSGGGRVIL GVADNGTIKGTHTDNSFRSRVQDSLRQLQLYLDIEIRVQDNLIIVEVPEGSDKPYACS RGFFIRNGANSQKLTRNEIIDFFQKEGRIRFEELRNEKAVFDNDFDERAFENFLNMAG VSRSIDRMSLLRNLDCINDEGKLTNAGVLFFAKDIDFLMNHAIVVCVLYKGTEKVHIL DKKDFKENIVENIDNAILFVKRHTNVQYKIEGVQREEIPDIPDVALREAIINAVCHRD YFDRSSNVLIEVFDDRVQISNPGGLPSGLRPSEFGRKSVTRNPLIASLLHRINYIEKV GTGISRIIQAVDENKKSSVEFEYNSGFSVIFRKLDRTSEADLGESSEKTKGKNAEIIL EAIRDNPTVTREELCQITGLSIQGVEWNLRKLKAEGKIKRIGPAKGGHWEVIDYSC" gene complement(10162..12918) /gene="" /locus_tag="" /db_xref="312615..315371" CDS complement(10162..12918) /gene="" /product="helicase, type I site-specific restriction-modification system restriction subunit" /translation="MSHNQSPEQEARNRIDGKLEASGWIVQERNRIDWSAADGIAVKE YFTDVGPADYVLFVDKSPVGIIEAKKEEEGHRLTVVEEQSGEYATSKLKYLNNDPLPF VYESTGTLTRFTDHRDPKPRSRPVFSFHRPETFREWLKEERSLRNRLLDIPGLRTEGL HDCQIRAINNLERSFKENHPRALIQMATGSGKTYTAVTFIYRLLKYADAKRVLFLVDT RNLGKQAEQEFMAYTPNDDNRKFTELYNVQRLRSSYMASDSQVCISTIQRLYSILKGE ELDEETEETNPAESGWQPKEPLPVVYNEKVPIEQFDFIVIDECHRSIYNLWKQVLDYF DAFLIGLTATPDKRTFGFFNENVVSEYSYEDAVADGVNVGYDVYTIETEITKKGAEIK AREFVDKREKLSRRKRWEQLDEAFTYTGRQLDRDVVNPSQIRNVIRAFRDKLPEIFPG RQEIPKTLIFAKTDSHADDIIQIVREEFGEGNAFCKKVTYKAEEDADSVLSALRNDYN PRIAVTVDMIATGTDVKPLECLLFMRDVKSRNYFEQMKGRGTRVMGYDDLRKVTPSVV SAKTHFVIVDAVGVTKSMKTDSRPLERKKGAPLKDLLAAVTFGAQDEDLYVSLANRLA RLDKMITPDEKIVYAEKASGKTINQTIRDLLNAYNPDVIEGRAFEIREIQPDMPQEKA SRQAQQELIDVARFTFTGELNEYIENVRRVHEQIIDTVNIDVVTRTEWDKDAVVRADE LVRDFREYLEAHKDEITALRIFYNQPYQRRDVTFAMIKEVLERLKLEKPLFAPLRVWQ AYEQLEKVNGNSPKKELTALVSLIRRVTEIDPVLTAYDLTVNRNFRDWVFKKQAGTVK FNEEQMQWLRMIKDYIIDNVHMELDDLDYRPFDREGSRSRMYQLFGDEMNSIISELNE ALAA" gene 13196..14278 /gene="" /locus_tag="" /db_xref="315649..316731" CDS 13196..14278 /gene="" /product="DNA modification methylase" /translation="MLHDSFNYSICILDWSCKNPSALRRLKVLIYCCNIVPPRMRDTY YNQDCITGARDHIPDRSVDLIITDPPFAINGNNLHKHYHRKEEHVFEGYVEVDQEEYR DFSIKWMHEAHRVLKDTGSMYVVSGWSNLLDILLALEKNDFELINHIIWKYNFGVSTR HKFVTSHYHILYCKKSAAKKVKFNTFCRFGTSEKHDDNSSMLYNDLEDVWVINRDFKK GRLRNKNTLPAELLKKMILYSSDENDLVCDFFLGSFSTAKISKSLNRYSTGFEVNSDV YDYQLEQMHNIERGYILKELCSNGGNPHHNQRKRWTEEEANKVIARYDAIKSAGLTDK KAYQLLSMEFGRGYFSMMNITKKNRK" gene complement(14286..15266) /gene="" /locus_tag="" /db_xref="316739..317719" CDS complement(14286..15266) /gene="" /product="hypothetical protein" /translation="MTDPNVERKLIEIMRIISKSDKPLGARLIADELQNRGYAIGERA VRYHLRILDERGFTKKHGYIGRTITEHGQKELSDALISDRLDLVITRIEELVYKTTYD LREKKGNVIVNVSIIDKSDYEKAMDVLKYAINAGISISPRIRIVDEDSEEDDIFVPDG KFAIANVCSITYDGILLKNGIPSTPLYGGLMQMEAHQPVSFVDIIGYSGTSIDPIKIF INRHSTSVLDYIESGNGKLLANLRHIPGSAREKAHEVMELAKDSDINGYLQIGETSED VFNVPMERGKAGIPVIVGSNAISAIAEAGIPVKAYPVSTIMDYNIMKKLE" gene 15568..15843 /gene="" /locus_tag="" /db_xref="318021..318296" CDS 15568..15843 /gene="" /product="Protein of unknown function (DUF3303)" /translation="MLFMDISTWAPEHREDILKHFKEIRPPAGIHVVNQWLDLTGGRF FILYEAESSEAYAAFNLPWSDVCTIDSVPVMEAIDFIKHMAEHGLKF" gene complement(15910..16518) /gene="" /locus_tag="" /db_xref="318363..318971" CDS complement(15910..16518) /gene="" /product="hypothetical protein" /translation="VSNTKKKKSSFLNLLKTINRPKYRDLDISTNNMNVNWEHIPELP LVGDTLTITGSTDPEAKVKVKVSFEKKVPVIDGKYEYNMDKVEIPDGPNKFTIKGRKA KDLSFSVKMFITYTRTFEANSDEAVYSEENVPSGKYDISIHGQAKEGEKEVTIYLEAA EIIDADNEGKFTYDYNTAALPAGDFNLLVGDSDRKITLSAAM" gene complement(16564..16944) /gene="" /locus_tag="" /db_xref="319017..319397" CDS complement(16564..16944) /gene="" /product="hypothetical protein" /translation="MKDTLKKVGLFGIGLWALTEDKINEISKELIDSGEMNKKEGKKF VKEVLEEQKKQTEEMEKKINAKVQETFKRAEVVKKDDLKILKEQMQQLQNKLDEMIGE KKEETEEVEKEAESEEEMKKEQEE" gene complement(17073..18791) /gene="" /locus_tag="" /db_xref="319526..321244" CDS complement(17073..18791) /gene="" /product="ATPase component of various ABC-type transport systems with duplicated ATPase domain" /translation="MLRVKNLAKDYNVLDERKRVLEGISFTVNDGEILGITGKSGSGK STLLRILRGVESFDEGVIELEGKQFFPDSDKDDMMDLIQNTAIHLQRNFGLWNGPAIE NIIRKINSRNEGHEGLPESDSPYYDEMYEESMEYLKLVGLEHKALHATSALSGGEKQR LILARQIVAKPKLLLLDEPVTMTGPGTKQEVLDVIKNVKKELNIPIIVVSHLPELHMY ISDRLIYLEDGHIIEEGKTETVLKHFLKDMQPQVEISSLGKKETIIKVKDINKRLTLI RVGEVLNFKNLSLDINRGEIVSLIGQSGAGKTTLLKMIEGLTSPASGEILYLHDGEWI DITNFNPRRMELRKKISIMHQEFTLSPHSTIGQQIGFRMQIKGPGSLEYARKKAKELE VSEEILDMLYTLPDMAEEEKDKIMNQMQITPEIYAKLFPKVTFEDVKEHASKIFEALD LPLGILYKTPYQISGGEHVRAYIALALTTHPEILMLDEPFGDLDPVTLRDVTNALKRI NREFGTTMIIVSHHMDFVKEVSHRVVLIDEAKVVMDGDPVEVSNCLIEMSHAKYLERN IESLIS" ORIGIN 1 gtgaaaaaga tcgcattgct acagagcttt gtagacgaaa taccaaactt attttgtagg 61 cttgaaattc atggttatta tgttcacaca agttttcttc ttgaagaaaa tataatcgat 121 gagatcaaaa gaaaccaata tgatgcattt ttactggatc tgtccggtac gccgatcgaa 181 gaattaagga aaaatcatta cctttctgaa ataagtggtc atatccctgt cattttgatc 241 gctccttatg tggactatcc cttactggag tcgttaggta atgtacacat ctcaggatgt 301 ttgatacctc cattctcaga tgagcaattg tgctcgacca ttgaattggc atgccataat 361 cacaacattc taaaaacaaa tgcctatgac atgaaaaata ccctgtttga gaaggagaga 421 agttatgcta tgcttctctc gaatctgcct ggtatggcat ataggtgtga taatgatcag 481 gaatggacca tgcgatttgt ttcagagggc tgttacaagt taacaggtta tgattccgaa 541 gctcttttgc acaatcggga tatctcttat aatagactga tcactcctga aaaccaggcg 601 catatctgga aaaaatatca ggaaatgctc gccagaaaag aaacattcca ggatgagtat 661 accataacta ccgcaatcgg agaggttaaa tgggtatggg aacagggaaa aggagtttat 721 gccgataatg gtgagctaat agctattgag ggttttattg ccgatatcac agagaagaag 781 aaagtacagg aaacacttag ggaaagcgag tcacgctatc gcagcctgtt tgaaaacaat 841 cactctgcca tgctggtcat agatcctgaa ataggttcaa tcatagatgc aaatccggca 901 gcagtatctc tctatggctg gacacgtgaa gaactcagaa gtaagaccat caaagagatc 961 aacgcattgt ctcctttcga ggtaaaagag gaaatggacc gtgcagttaa aggccagcgt 1021 atccgtttct tttttaaaca tagtctcgca gatggttctg tcagagatgt ggaagttttc 1081 agcagtccta ttcttatgga cagaaaaatg cttctctact ccattataaa tgatatcaca 1141 gagcttaaca ggatggaaca ggaacttctc ctgaaccggt tctgtattga tcattcagtt 1201 gtggggatat tccgtattga agagcctgat ggcagaatag taagtgtgaa tgatcatgcg 1261 tgccaatccc tgggatattc ccgtgaggaa ctctgttcaa tgacggtatt ggatattgat 1321 cctacattta ctcctgagac atggattgaa cacaggaaaa atgtacgaaa gctgaaatcg 1381 ggaactatcg agacaattct ttgcaaaaag gatggcacag aatttcctgt agagattact 1441 attaacgata tggagcatga ggggaaagta ttctatcttt cttttgcaaa ggatatcacc 1501 aaacgcaagg ttgcagaaca ggcgctcaag gagagtgaag agttcttcag gatcactttg 1561 tacagtattg ctgacggggt cattaccact gatattaacg ggaatttaag gcaaatgaac 1621 catgttgctg aaaagctgac cggctggaat gaggccgaag ccaggggaaa aaaggtcgag 1681 gaaattttca atatcttcaa tgaagataca cgacagcagg ttgagatacc cgtgcgcaga 1741 gtactgaggg aaggccgggt aatgggccag gcaaatcata aactgttgat ctctaaagat 1801 aatagggaaa tccccattgc tgatagtggc tcgcctattg tgaatgagaa gggtgagata 1861 atcggagttg tgctggtgtt ccgtgaccag agcgaagaaa ggaaggccca gaggtctctc 1921 cgggaaagtg aagcacgttt caggcagctg gtcgagaatg cacctgaagc tattttcgtt 1981 caggctaatg gttgttttgc ctatgtcaat ccagcagcat tgcgtctttt cggggttgat 2041 tcggccagcc agttaatagg gaagcctgtt atggaacgtt tccatccgga tttccgtgat 2101 attgtccgtg aacgcatcca tcttattaat gatatgcacg aagaagtacc taatatcgag 2161 aagatctacc tgaggcttga cggcacacct ttcaatgtag agatatccag agtgccaata 2221 atctatgatg gtcttaacgg atctctggtc tttttcaggg atgtcaccga acgcaagcgg 2281 gtggaaagag ctctcatcag ggcaaagatg gtttcggatg aggctaatcg cagtaagacc 2341 gaattcctgg ccaataccag ccatgaactg aaaacccctt tgaattctat tatcggcttt 2401 tcggagctta tgcttgccgg cgagctggga aagatcagca agcaacagaa aaaatacatt 2461 gggactatac ttgaaagcgg ttgtatgctc cttaatatcg taaacaagat attggatata 2521 tccagtatcg actatggccg aatggatctc agttatacta aattcaatct ttgcgatgct 2581 attcaggaca cctgtgcaat gatgcaggca gctgcaaaca ggaaatccat aaaacatgta 2641 gttgatattg atccacagat caatgggata aatgctgatg ccatcaagtt caaggagata 2701 gtttacaatc ttgtggataa ttccataaag ttcacgcctt atgggggaat tgtgatcatc 2761 actgccactc agaatgaaag ccacgtgaag atatctgtca cagataatgg tattggtata 2821 gcaaaagaga atattgagag aatatttgat cccttttacc aggtggatag ttccacaaca 2881 cgcaggtatg gagggacagg gcttggactt gcccttataa aacagttcat aaaaatgcac 2941 ggtgggaaca tttgggtgga aagtgaaccc ggtaaaggca gcactttcac ttttaccatt 3001 cccctagact atggggaaca accgatacgt atgttgcagg tttctgaaga tcaggacctc 3061 gatttttgtt catgaccggg attaattgct tctgattatt gctgcgggaa cgcaatggtc 3121 attttctatt cccgttgagg gtttccacta tctccttaaa gctttccagc cctgcttcga 3181 tattctctat gatctcgttg gcgagtatgt cagggtctgg caggttgtcc aggtctgcca 3241 ggcttttgtc cttgagccag aagatgtcca gattggtttt atcccttgat gctatttcct 3301 cgtaggtgaa tctgcgaaac ctgccttcgg gatcttcccg gctccatgtt tccttgcgct 3361 ggaaacggtt ctcggggtta tagcaacgga tgaagtcttc aaggtccgtg aacctgagag 3421 ggttcttttt cagggtgtgg tgtacgttgg tgcggtaatc gtagatccat atttccctgg 3481 tccagggttc tttggatgcg ggttttgcct cgaagaacag tacattggcc tttaccccgt 3541 gggcgtagaa tatgccggtg ggcaggcgca ggatggtgtg caggtcggtg gtctccagga 3601 gctttttgcg gacagtttcg cctgctccgc cttcaaagag cacgttgtcg ggcaggacta 3661 ctgctgcctg ccccccggtt ttgaggatgg tatgaatgtg ctgcacgaaa ttaagctgct 3721 tattgctggt agtgacccag aagtcctggc ggttataggt gaggtcttct ttctcctgct 3781 cgccttcgtc gttggtgaag gtcatgctgc tcttctttcc gaagggcggg ttggtgagca 3841 cgtagtcgta tctgatgtta ggatcggcta tgagggcatc ggaattggag atcatgggct 3901 ctccgtctat ttctccgatg ttgtgcaaaa agaggttcat gagtgccagc ctgcgggtcc 3961 cggccactat ttcattgccg ccgaaggtct ttgctttcag gaagcggctg tggtcgcggt 4021 caggctcgta attgtttgtg aggaagtcat aggccgccag gaagaaaccg cctgtaccgc 4081 agcagggatc gccaatggtc ttcataggtt ccgggcgcag gcactgcacc atggctttga 4141 tgagcgggcg gggtgtaaaa tactggccgg ctccgctttt agtgtcttct gcgttcttct 4201 gcaggagacc ttcgtagatc tcgccctttg tatccactcc catcatgacc cagctttcct 4261 tgtcgatcat atcaatgacc ttgtacagca tggcagggtc gctgatcttg ttctgcgcct 4321 tgaggaagat ctgcccgagc atgccgggct ttttgcccag ctcctccagc agctccttgt 4381 aatgggtatc aagctctgca ccgcgctttt gttttaacac atcccatgtg tacttctccg 4441 ggatgcctat atcccggctg tatggcggtt ttctgtattc ctctgccatc ttgaggaata 4501 tgagaaaggt cagctgttcc agataatcgc catagctcac gcctccgtct cgcaggacat 4561 tgcagaagct ccagactttg gaaacgatgg atgatgtgtt ctcagacatg gtctttatct 4621 ctgggtttgg aatagtattt ttaatctttt tagttgaatt tgatactcaa aagcagtgtt 4681 caacttgcgg ggtaacttgc agggtagctt gcggggtcag tccttcacca tcccggatga 4741 tgctcttcag ttgctcggat atcatgatct gccttgtatc ctttgttctt tcctataatt 4801 caagctgtga tgaaataagt tactttattt ttgtgcttct ctcatctctt ttttcatttt 4861 tcttttctgg atatgttcaa atgtccaccc gatggcattg tagagcggat tgaccggtac 4921 gttcacatag tatttcgttt tcgggtcaag ccagcctttt tctttccagt aggtatgatc 4981 ggctggcgag atatgtgcca gctctccaaa ggttgctttc tgcccgcgga aaatgaatac 5041 atccctaagc cccggagatc tacgtgcttt cttcataagg gcatcgtgaa atataactgc 5101 tgcttgctta agcttccgtt cattttcaag ttctgttttc ataggtaatg gcacgcgggt 5161 tataatgcct accttgtgag atatctcgaa gccccatata cctgcaacca gctcaagata 5221 atcaaggaca tccctgtgac ccatcagccc ggtactacag aggagcagcg ccttcttatc 5281 aaaaaagcga ggtctatgga atatatatga aaagcgatca ataaaagtct tcatctgtgc 5341 agaaacgttc atgccataaa caggtgttgc aaatataact ccgtcagcat catgcatttt 5401 ctgctcgatg agaggtgcat cgtccttgaa aggacaatga tcctctcctt ccccaaaaca 5461 gacaagacat ccacggcact gtgacaggtt tgcatctttg agcatcaggt actcaaattc 5521 aacatcaccc attgaatgca tgacctcttc tatctttttg gcagcccgat aggtattgcc 5581 cttgcgcgga cttcccatga tcaccaggat tttcatattc tctacacctc cctttaatat 5641 ttgtacagta caaggtatta tatttttatc tttacgattt ctgctccatt ttttgtttca 5701 tttcctgtct caggaaataa ccacccgttt ttggcggacc ttcaaatgtg accaatttag 5761 ctattttttg taaatctctg cgtatggtag ctattgatac attcaactca tttgataatt 5821 catttgaatt tctgcctgga ttttgataaa gtaacaatat gatttttgag agtctcagtt 5881 ttactgtatc acttactgta tcacttactg tatcacttac tgtatcactt actgtatcac 5941 ttactgtatc acttaaagaa ccaccaattc tttttagttt tgtattttgt gtcattcctt 6001 ctttaataag tccttcaggt atcggaataa ttgtcttaaa tgtactacct tcaataaact 6061 gaggagtgcc actacctgcg tattccttaa taaagcgatt tacgtttaaa acaccagaac 6121 ccagttcatc tactcttcca agttgcatga agaattttac tatcgcgggg ttttttggga 6181 acggagcaaa cctttccgga tcgatctgtc cttctccatg tggattgttg gcgttttcag 6241 cttcgatccg gtctgcatag attataaatg tgcaggggta ggcgttcatg tattccctgt 6301 ggactatcaa atttgcaact acttctctga atattttatt tctaagactt acccgctgat 6361 cgccttctat ataaaatttg tcaggcaaat gcttgcctac aaatgtcatt agctgttcgt 6421 aggcttctat caggttcgtc tggatgtatt cgcggtcatc gtagcggtaa atgtcttcaa 6481 tacggacaag agcatcgatt ttaaagtaag gaagaatttg ctggattact tcgtcttttc 6541 caagcagcaa agctgctgca agtgtatagc cttcttgtgc acttttgagg tctcgcttcc 6601 acagacctgc tttttccagc atctgctggt cgttcagtgc cagccaggga tggttgtaat 6661 tgtagcttct gataagattc tttatttttg ggaacaggtc ggctttgaag tcttcaaagc 6721 gcagtgcggg ataaattatg ccttctgtat aatgcgctgt tttgtgatta taaatttccg 6781 ctatctgctg tggctgtatg actttgaaat ccccgtcatt actgcggttg aacactgtat 6841 tggcggtctt atgtatctgt gagctggcag gaacctggat gtggatcacc tattttcctt 6901 tgatttcata ggtttgcgga aacagtatga acggtgggtc aagcttttgc gggttgtttg 6961 aaagattgac cagattggca accatgtttt cgatctctga ctgctcaact cctattatat 7021 tgccattatc atcggctccg agaatgatgt cccctccatc ccggttgagc atggcgcaga 7081 tggtttcaaa caagttcctt ggcaaagctg tacgcgcttc cttaaactcc agacgtatgc 7141 cttcctgttc tttgagtaat ctcttaagcc gttccagtcc caatctgctc acctcttttc 7201 ctttccttct tttttcactt taattctttc cagcaacaca tccgcaggct cccagtcctc 7261 cgccatccgc acctcagcaa gctccctttc gctcagcagc ttcccctcaa acgccttttt 7321 caaaatactc tgccgaagcg cctctgcctt ctccagagcc tcatcaatat cctgcgcaat 7381 cttatcacac accgaaagcc gcgtttcaat ttcctgaacg atggcttgtt gttcggggag 7441 aggtgcaact gggatgcata aagatgctat ttttgaaagg ttcaatgtgt atagacctga 7501 tgtagaacta gcaactttag taatctgatt tctgccgtca aatgaaagca accaataaag 7561 tataaacttc ctaattttta caatttcaaa tcttacctta attatatgat tttgatgtat 7621 gcatggagat atttttccat tccatatggc aactctacca atttgattaa cgcttccgtt 7681 gccttctaca attaaaaggt ctccttcttt cagtaaaact cgtgaaacct cctgttcttc 7741 aatgcctata tattttaaat catctaatct aagttcatta gaataaacat tagcaactct 7801 gaggtaaggc aaagttgtag atattgcatt tcttttggag ttctttgtaa ggccgcctgt 7861 tacttccccg agttcctcta tcttcaccca tccccacccc tctggcagcc ctggaaattc 7921 cacaatttca tcttctgtga ggggttttac aggcttcatt ttcttgccgg aatattttgc 7981 agcttcttct ctttcctttc ggatatgttc cagcaaatcc cgcgcatccg gcagatcggt 8041 ctgctgctcc cgccattttc tggtaagttc accctcaaac gctttcttca gcaccgcctg 8101 cctgtaaact ttaagttgtt cctgtgccag ccttaggttg gcgataccgt tgtcaagctc 8161 gctgaaaagc tgctcgatct tggagacaat ggcgcgctgt tcggggaggg gtgggagagg 8221 gaatggatat tcttgcagat attttgttga aactcttggc aaatttacgc cacttgagtt 8281 atgtgtcata tcacttacaa acttacgtga caaaaagaaa tatttagaat agttaagatt 8341 ggaaatacta gcagatttaa aaacaagaat gtctgtagaa caaactccat cttcattagc 8401 taaatacact ttattcaaat aaggtctaag ttttccgtag agcagatcac cttttttaaa 8461 actatttttt atagtagtga ttgtatcgat tttaacatct tgtgttaatg ttcctctatc 8521 tttctcaata tgttctaaac caatgtaaaa taaggattct cctgagccat tgtgtttatc 8581 ggactttaaa atgtgagctt ccccaagccg cacccattgc catccttctg ataatcttgg 8641 taaattctct attccagcat tattgaaaga tatcgagtta ttcattttaa gcatctaatg 8701 cctcaatatt tactgtcaga ttatagttaa acactcatgg tttgtaactt atgaacggta 8761 aaatcaaatt caataggtag ttatgtcaat actataagtt tcaaacaaaa ggttaacaac 8821 tataatctat tacttcccaa tgtccacctt ttgcaggacc gatgcgtttt atctttcctt 8881 cagctttcaa tttccgaaga ttccattcaa caccttgtat ggacaagcct gtgatctgac 8941 acagttcttc acgggtaaca gtgggattat ccctgattgc ctcaagtatt atttctgcat 9001 ttttcccctt agttttctcc gaactttcac ccaaatctgc ctcagaagtt ctgtcaagtt 9061 ttcggaaaat aacagaaaaa ccgctattgt attcaaattc cacagacgat tttttgttct 9121 cgtccactgc ctgtataatt cggcttatgc ccgtacccac tttttcaatg tagtttatac 9181 gatgcagcaa agaagcgatc agagggttac gtgtgacact cttacgtccg aactcggaag 9241 gtctaagacc gcttggcagc cctccgggat tggatatctg caccctgtca tcaaagacct 9301 cgataagcac attggagctt ctgtcaaaat aatcacggtg gcagacagcg tttattatgg 9361 cttctctcag tgccacatca ggaatatccg gaatctcttc ccgctgcaca ccctcgatct 9421 tatactgcac gttggtgtgc cttttcacga aaaggatggc attatcgatg ttttcgacaa 9481 tgttctcctt gaaatccttc ttgtcaagga tatgcacctt ctccgtaccc ttgtatagca 9541 cgcataccac aatggcatga ttcatcagga aatcaatatc cttcgcaaag aacagcacgc 9601 ctgcattcgt cagttttccc tcatcattga tgcaatcgag gtttctaagc agcgacatcc 9661 tgtcaatgga cctgctgacg cctgccatgt tcaggaaatt ttcaaaagcc ctctcatcga 9721 aatcattatc gaaaaccgcc ttctcatttc tcagttcctc aaagcgaatg cgcccttcct 9781 tctggaagaa atcaatgatc tcattgcgtg taagtttctg ggagttcgcc ccgttgcgga 9841 taaagaagcc tcttgagcag gcatagggct tgtcgctgcc ctccggcacc tccacgatga 9901 taaggttatc ctgcaccctt atctcaatat caagatacag ctgcaactgc ctgagggaat 9961 cctgcaccct tgacctgaaa ctgttatcag tatgtgtacc ttttatggtt ccattatcag 10021 caacaccaag gatgaccctt cccccgccgg aattggcaaa agcgcaaacc tcctccacaa 10081 aggacttatc aaggaattcc ttgaactcta tgtggtatcc ttcgccagcc tctatgatgt 10141 ctttgatcga aaattccatt tttaagccgc cagtgcctcg ttcagttcgc tgataatgct 10201 gttcatctca tcgccaaaga gctgatacat cctgctacgg cttccttctc tatcaaaagg 10261 tctgtaatcg agatcgtcta gttccatgtg tacattgtca ataatataat cctttatcat 10321 acgcagccat tgcatctgct cctcattgaa tttcacagtt ccggcttgct ttttgaacac 10381 ccagtcccgg aagttgcggt tcaccgtcag gtcgtatgca gtaagtaccg ggtcgatctc 10441 cgtcaccctg cggatcaggg agaccagagc tgtaagctct tttttcggag agttcccgtt 10501 caccttctcc agctgctcgt aagcctgcca taccctcaaa ggcgcaaaca gcggtttttc 10561 cagtttcagc ctctccagca cttcctttat catggcaaaa gtaacatccc tgcgctggta 10621 aggctggttg tagaatatcc gaagggctgt gatctcatcc ttgtgggctt ccagatactc 10681 cctgaaatcc cgcacaagct catccgccct caccacagca tccttatccc attcggtccg 10741 tgtcactacg tcaatgttca ccgtatcaat gatctgctca tgcaccctgc gcacattctc 10801 aatatactcg ttaagctctc ccgtaaaagt gaaccttgca acatcgatca attcctgctg 10861 cgcctgcctg ctcgccttct cctgcggcat gtccggctga atctccctta tctcaaaagc 10921 ccgaccctcg atcacatccg ggttatacgc attcagcagg tctcttatgg tctggttgat 10981 ggtcttcccg ctggcctttt cagcatacac gatcttctca tcgggagtta tcatcttatc 11041 cagccgcgcc agccggttcg ccagcgagac atataggtcc tcgtcctgcg caccaaaggt 11101 cacggccgcc agcaggtcct tgagcggtgc tcctttcttc ctctcaagcg gtctgctgtc 11161 tgttttcatg gacttcgtca cgcccacagc atccacaata acaaaatgcg tcttggcaga 11221 caccaccgaa ggtgtcactt tcctcaggtc atcatacccc atgacccgcg taccgcggcc 11281 tttcatctgc tcaaagtagt tgcggctctt cacatcccgc atgaacagca ggcattccag 11341 cggctttaca tccgtacccg tggctatcat gtccacggtt accgctatcc tggggttgta 11401 gtcattgcgc agtgcagaca gcacagaatc cgcatcttcc tccgccttgt acgtcacctt 11461 cttgcagaaa gcattgccct cgccaaactc ctcccgcacg atctggataa tatcatccgc 11521 atggctgtct gtcttggcaa agatcaaagt tttcggtatc tcctgccttc ccgggaatat 11581 ctccggcagc ttatccctga acgccctgat tacattgcgt atctggctcg ggttcaccac 11641 atccctgtcc agctgcctgc cggtataggt aaaagcctca tccagctgct cccatctttt 11701 ccttcggctc agcttctccc ttttatccac gaattccctg gcctttatct cagcgccctt 11761 tttagtgatc tcggtctcga tggtgtacac atcataaccc acgttcacac cgtccgccac 11821 agcatcttcg tagctgtact cgctcaccac gttctcattg aaaaaaccaa aagtgcgctt 11881 atccggcgtg gcagtaagcc ctatcaggaa agcatcaaaa tagtccagca cctgcttcca 11941 caggttgtat atggagcgat ggcactcatc gatgacgatg aaatcgaact gctcgatagg 12001 cactttctca ttgtatacca caggcagcgg ctccttaggc tgccatccgc tctcggcagg 12061 attcgtttcc tcagtttcct cgtccagctc ctcacctttc aggatagaat acaaccgctg 12121 gatggtggaa atacacacct ggctgtccga agccatatag ctggaacgca gccgctgcac 12181 gttgtacagc tcggtgaact tgcggttatc gtcattgggt gtatatgcca tgaactcctg 12241 ttctgcctgc ttgcccagat ttcgtgtatc tacaaggaac aatactctct tagcatccgc 12301 atatttaagc aagcggtaaa tgaacgtaac agcagtgtat gtttttccag agccagtggc 12361 catctggatc aatgccctgg ggtgattttc cttaaatgac ctctccaggt tattgatcgc 12421 ccgtatctgg caatcatgca atccctctgt ccgaagcccc gggatatcca gcaatctgtt 12481 tctcagtgac ctttcctctt tgagccattc cctgaaggtc tccggacgat ggaatgaaaa 12541 aacaggtctt gatcttggtt tcgggtcgcg gtggtcagtg aacctcgtaa gtgtccccgt 12601 gctctcgtat acaaaaggca gagggtcatt gttcaggtat ttcagcttgc ttgtggcata 12661 ctcccctgac tgttcctcca caacagttag tctgtggcct tcttcttcct tcttggcctc 12721 tattatcccc acagggcttt tatccacgaa aagcacgtag tccgcaggtc cgacatctgt 12781 aaagtactcc tttacagcaa taccatcggc tgcactccag tctatcctgt tcctttcctg 12841 cactatccag ccggaagctt ccagtttccc atcgatcctg tttctggctt cctgctcagg 12901 gctctggtta tggctcatag gttttatcca tggatttctc cgcttatcct gtccccggga 12961 actgcatgga aaattcatgc agtttcagga atgattttat aaaagtctat gttcacattc 13021 aatataagta ttcttagttc cagttgtata cggtttgcat atctcttaac gaaaaataga 13081 gtcagttgct tcaattttgc acaaagccaa aaaacaagaa aggcccaata ggacaaaaca 13141 tggaaggttt atagaatacg aagatttttc aattatccat tgaccccgta ttagcatgct 13201 tcatgattct ttcaactaca gcatctgtat tttagactgg tcatgtaaga acccttctgc 13261 actgcggcgg ctaaaagtac ttatatactg ctgcaacata gttccacccc ggatgaggga 13321 tacatactat aatcaggact gcataaccgg tgcacgtgac catattcctg accgaagtgt 13381 cgatcttatc atcacagatc ctccatttgc cataaatggt aacaatctcc acaaacatta 13441 tcacaggaaa gaagagcatg tgttcgaagg gtatgttgag gtggatcagg aagaataccg 13501 tgatttttcc ataaagtgga tgcatgaggc ccacagggtt ctcaaggaca ctggttccat 13561 gtatgtggtc tcaggatgga gcaatcttct ggatatactg cttgctcttg aaaaaaatga 13621 ttttgaattg atcaaccata ttatatggaa atataatttc ggcgtgagta caaggcacaa 13681 gttcgttacg tctcattacc acattctcta ctgtaaaaaa tcagctgcaa aaaaagtgaa 13741 atttaatacc ttctgcagat ttggaacatc tgagaagcat gacgataaca gttctatgct 13801 ttataatgac ctggaagatg tatgggtgat caacagggat ttcaagaaag gcaggttaag 13861 gaataagaac acccttcctg cagaactgtt aaagaagatg atcctttact cctcagatga 13921 aaatgacctt gtctgtgatt ttttcctggg cagtttctcc acggcaaaga tatctaagtc 13981 tctcaacaga tattccacag gctttgaggt aaatagcgat gtgtatgatt accagctgga 14041 acaaatgcac aatatagaac gtggttacat acttaaagaa ctgtgctcca atgggggaaa 14101 tccgcatcac aaccagagga agcgctggac ggaagaagaa gcaaataagg tcattgcacg 14161 ctatgatgct attaagagtg ctgggctcac agacaaaaaa gcctaccagt tactttccat 14221 ggaatttggc cgggggtatt tctctatgat gaacattact aagaaaaaca ggaaataaca 14281 atttctcatt ccagtttttt cattatatta tagtccatga tcgtagaaac agggtatgct 14341 tttacaggaa taccggcttc tgcaatagct gagatggcat tgcttcccac tatcacaggt 14401 atgcctgctt ttcctctttc cataggtacg ttgaaaacat cttcgctggt ctcccctatc 14461 tgaagatatc cgttgatatc ggagtctttt gcaagttcca ttacctcatg tgccttttcc 14521 cttgcagaac ccggtatgtg gcgcaggtta gcaagcagct ttccattacc actttcaata 14581 taatcgagca ctgaagtaga atgcctgtta atgaatattt taataggatc tatcgatgtt 14641 ccgctgtagc ctatgatatc tacaaaactt acgggctggt gagcttccat ctgcataagc 14701 cctccatata atggagttga aggaatcccg ttcttcagaa ggataccgtc ataggtgata 14761 ctacatacat tggctattgc aaatttaccg tcaggtacga agatatcatc ttcttcagag 14821 tcctcatcca ctatccttat cctggggctt atggatattc cggcattaat tgcatatttc 14881 agcacatcca tagctttctc ataatcactt ttgtcaatga tggatacatt cactatgaca 14941 ttacctttct tttcccgaag gtcgtatgtg gtcttgtaca ccagttcttc tatccgggtg 15001 atgaccagat ccagcctgtc acttataagt gcgtcactga gttctttctg tccgtgttcc 15061 gttatggtac gcccgatata tccatgcttc ttggtgaatc ccctttcatc cagtatgcgc 15121 aggtgataac gtacagccct ttctccaatg gcataccccc tgttctgcag ttcatctgct 15181 atcaggcgag ctcctaatgg tttgtcgctc ttgctgatta tccgcattat ttcaataagt 15241 ttcctttcga cattggggtc tgtcatagtt attcctgtct gtattttgtt tcaaaggtta 15301 gtttgggatt aatggaatat atccgtcata tctataaaga ttatgtatca ggttctattg 15361 tgttttttga gcaaattgca tgatcatgtt gcatatcctt agaatatgtg ctcttatatg 15421 tttctttctt catttgtttc gtgcataaaa ctaggttact ttattatgat tgtagaaagt 15481 ttcatattct atgccattca attcttagtt tggagtagtg ggtaaaaaag cccattccca 15541 ttgaatataa aaggagtgtt ataagaaatg ttatttatgg acataagtac ttgggcaccg 15601 gaacacagag aagatatcct gaaacacttc aaggaaatta ggccaccggc gggtattcat 15661 gttgtcaatc agtggctgga ccttacaggc ggcagattct ttattctcta tgaggctgag 15721 agttcagagg catacgcagc tttcaatctg ccgtggtctg atgtttgtac catcgacagt 15781 gtgccggtca tggaggcaat tgatttcata aaacacatgg cagaacatgg attgaaattc 15841 taagttctga aaaataattg gtcggcctta aaggctgacg cacttttcta tttttcaatg 15901 catatagttc tacattgctg ctgaaagagt tatctttcta tctgaatctc ctacaagcaa 15961 gttgaaatcc ccggcaggca aagccgcagt attgtaatca tatgtgaact ttccttcatt 16021 gtcagcatct atgatctccg cagcttcaag gtagatggtc acttcttttt ctccttcctt 16081 tgcctggcca tggatggaaa tatcatattt tcctgaaggt acgttctctt ctgaataaac 16141 agcttcatca ctattagctt caaatgtcct tgtgtaggta atgaacatct tcacgctgaa 16201 actaagatcc ttggctttac ggccctttat ggtaaacttg ttcggaccat cgggtatctc 16261 tactttgtcc atattgtatt catatttccc atctatgacc ggaaccttct tttcaaaaga 16321 taccttaacc ttgaccttgg cctcaggatc agtgctacct gtaatagtaa gagtatcacc 16381 aaccaggggc aactctggta tgtgttccca attaacattc atattgttag tactgatatc 16441 aagatcacgg tattttggac gatttatagt tttcagcaaa ttaagaaaag agctcttttt 16501 ttttttagta ttgctcacta tttcccccca cagaccttaa aatatatgga tacaatggaa 16561 gatttactct tcctgttcct ttttcatttc ttcttctgat tcagcttcct tttctacttc 16621 ttcagtttct tcctttttct cgccgatcat ctcatcaagc ttattctgaa gctgctgcat 16681 ctgttctttc agaattttga ggtcatcctt tttcacgact tctgcacgct tgaatgtttc 16741 ctggaccttt gcattgatct ttttttccat ctcttcagtc tgttttttct gctcttcgag 16801 gacttcttta acgaatttct taccttcctt cttattcatc tctccactat cgattagctc 16861 ctttgaaatc tcgttgatct tatcctcagt aagggcccac aggccaattc caaaaaggcc 16921 aacttttttt agagtatctt tcatactatt ttacctcgtt atgagttgta ttctgatgaa 16981 ataaatatct ttgtacaaga tacgcatgag cacagctatt tcttgtggaa caaaaaagaa 17041 aagtaatatt gattttcaga attgtatcaa tttcaggaaa taagagattc tatattcctt 17101 tccaagtact tggcatggct catctctata aggcaatttg acacttccac agggtctcca 17161 tccattacta cctttgcttc atctataagg accaccctgt gagatacctc tttcacgaag 17221 tccatatgat ggctaacgat tatcatagta gtcccgaact ccctattaat ccttttgaga 17281 gcattcgtaa catccctaag tgtcacaggg tccaggtcac cgaacggctc gtcgagcata 17341 agtatttccg gatgtgtggt aagggcgaga gcgatgtagg cccttacatg ttccccgccg 17401 cttatctggt aaggtgtttt ataaaggatg ccaaggggca ggtccagagc ttcaaatatc 17461 tttgatgcat gttccttaac atcttcgaag gtgaccttag ggaaaagctt ggcatagatc 17521 tcaggtgtta tctgcatctg attcattatc ttatccttct cttcctctgc catatcaggt 17581 aatgtgtata gcatatccaa tatctcttca gatacttcca gctctttcgc ttttttacgg 17641 gcatattcca gggatcctgg accttttatc tgcattctga acccgatttg ctggccgata 17701 gtggaatgtg gagaaagagt aaactcctga tgcattatac ttattttttt tctcaattcc 17761 atccttctgg gattgaaatt agtgatgtct atccattctc catcgtgcag atatagtatt 17821 tctccggaag caggtgacgt aagtccttcg atcatcttaa gcaaagtagt tttgccagcc 17881 cccgattgcc caatgaggga tactatttct cctctgttta tatcaagtga gagatttttg 17941 aagttcagca cctctcctac tcttataagg gtaaggcgtt tgttgatgtc ttttactttg 18001 atgatggttt cttttttccc taaagaactg atctctacct gtggctgcat atccttgaga 18061 aaatgtttca gtacggtctc ggttttccct tcctctatta tatgtccatc ttccagatat 18121 atgaggcgat cagaaatata catgtgcagc tctgggaggt gggaaacgac tataatcggt 18181 atgtttagct ctttttttac gttttttata acgtcaagaa cttcctgttt tgtgcccggc 18241 cctgtcattg tcacaggttc atcaagcaat aacagctttg gttttgcaac gatctgacgt 18301 gcaagaataa ggcgttgttt ctctccaccg ctaagagcgc ttgtcgcatg caaggcttta 18361 tgttcaagac ctacaagctt aaggtattcc atcgattcct cgtacatctc atcgtaatac 18421 ggtgaatcac tttcaggtaa tccttcatgt ccctcgtttc tggagtttat cttgcgtatg 18481 atgttctcta tggcaggtcc gttccacaag ccgaaattac gctgcagatg aattgcagtg 18541 ttctgtataa gatccatcat gtcatcttta tcagaatccg ggaaaaactg tttcccttca 18601 agctcgataa cgccttcatc aaaactctcc acacctcgga gtattcttaa caatgtactt 18661 tttccgcttc cgctttttcc cgttatgccc aggatctctc catcatttac agtaaaactg 18721 ataccttcga gtactctctt tcgttcatcc agtacattat agtccttcgc aagatttttt 18781 actctaagca t //