LOCUS NC_019976:3 18471 bp DNA linear BCT 16-MAR-2013 DEFINITION Natronococcus occultus SP4 plasmid 2, complete sequence. ACCESSION NC_019976 SOURCE Natronococcus occultus SP4 plasmid 2, complete sequence. COMMENT locus start: 63260; locus end: 81730 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.529489; n0_4mer:D = 29.575024; n0_4mer:PS = 28.371300 FEATURES Location/Qualifiers source 1..18471 /organism="Natronococcus occultus SP4 plasmid 2, complete sequence." gene 1..1113 /gene="" /locus_tag="" /db_xref="63260..64372" CDS 1..1113 /gene="" /product="biotin synthase" /translation="VVYETGNRTIDDAVRRVLDGERLDRTDGLALLAQPVETLAAGAD LVRRNFSDGTVDACSIVNAKAGNCAEDCGFCAQSAHFDTGIDSYGFLEPEAILEAAKR AEADGAQRFGIVVAEKGVSKKKRPDEWDDVIRAVRLVRDETSVEIDASLGLLTQEEAD ELAAEGLNHYNHNIETSRRYFPEIIGTHTFEDRLKTLRRAKNAGMDLCAGVILGMGES PTDRVDAAVELQEIGISSLPVNILNPIEGTPLGERDRAAISKTEIIETIAVYRFLHPE SRVRLTGGREVNLAEDEQHLPFEAGADGILTGDYLTTDGQTPDDDLEIIERAGLEPNR AVNDFDPAAVATQHKTSDPKTAAGTATSNATTKTDD" gene 1115..2143 /gene="" /locus_tag="" /db_xref="64374..65402" CDS 1115..2143 /gene="" /product="hypothetical protein" /translation="MHEIKFAVLGTGGIGRRTLEYATAKDGLTPVAACDRHGVAVDHG GLDVNELLAATEGNIASDGGVTAVKQSGETSGVAASSQAEPTETPIADIIAESDGIDA VLIALPNLEHDFIPRVADRFAEAEYDGVLVDVLKRSRVIDMLDDRIDSFNDAGITFVC GAGATPGLLTGAAALAAQSFVDIESVEIWWGVGLKSGYEDNRGTVREDIAHLDGYDTE TARSMSDAEIEQVIDEHDGRLEFTDMEHADDVLLERAGICDAEDVTVGGILDARSDEK PTTTTVRVTGTTFDGERGTNTFQLDDNTSMEANVNGPALGYLQAGVRRNRNGEYGVFG PAELMPGF" gene 2145..3344 /gene="" /locus_tag="" /db_xref="65404..66603" CDS 2145..3344 /gene="" /product="7-keto-8-aminopelargonate synthetase-like enzyme" /translation="MQRHHSLGFDLETRLRERERSGLRRDLVPIDSVDARARTAADPK GEPANFGAERLIFASNDYLGLAGDPRVAETAVRAARDVGTGAGASRLVVGDTSTHRSL ERRLATEKNAERALTFSSGYAANVGTITALAPDVIFSDALNHASIIDGARLSDATVEV YDHCDADALAQRMAERFSDGVTDESWLVVTDSVFSMDGDVAPIEALCDVAEEYGAWVM VDEAHATGVYDGGIVNERGLENRVQVQLGTLSKALGAQGGFVAGDETLIEYLLNAARS FVFSTGLAPPAAAASERALALAPDRRDALWTNVERLRTGLEALGYEVLGDTHILPVLV GNRDEAVALADRITEAGIVAPAIRPPTVPEGTSRIRLTPKATHTDTHIEQCLTAFETA MTKGGCP" gene 3341..4024 /gene="" /locus_tag="" /db_xref="66600..67283" CDS 3341..4024 /gene="" /product="dethiobiotin synthase" /translation="MTIAIVGTDTGVGKTVITAGLVAYLRDEGYDARAIKPVQTGFPA DDDAGYVRRVCGNESAATRLRTFEEPLAPAVAARRAESRLEFDSLVDDVHKALKTTGI GIIEGAGGVRVPLSNDPPREIIDLVATLETPALIVARSGLGTLNHTALTVQALRARDV PIAGIALNRYQGHSVAERTNPDELERMCSCQVQPLPELSSEDPEAVCRLGSRVAELCT QTRSLALSR" gene complement(4067..4434) /gene="" /locus_tag="" /db_xref="67326..67693" gene complement(4555..4854) /gene="" /locus_tag="" /db_xref="67814..68113" CDS complement(4555..4854) /gene="" /product="hypothetical protein" /translation="LLYLKVSERTTFIAGFDERLNPDQNECIEQLFIGADVEPPEEAV GEDPDDEIEDDEIDLEEPVDDAEDDDPEHDSGVNGEDDETPDEPGLTMIPPSKSF" gene 5045..8305 /gene="" /locus_tag="" /db_xref="68304..71564" CDS 5045..8305 /gene="" /product="DNA/RNA helicase, superfamily II" /translation="MTDIGNRVIDNNAGLLAEHKEGSVRDVFEHYLTKAIEEDRDNSF RLDVGTGFLFFSGFEAIADRFEELIETGSVSRIEDPEWGTEAPIRVVMGPETSNRTKS ILLSLVTDQVIEYDDEAIDILRRFVEKGVVDFRVITERNFHPKFYSFYLRSEVPDDIW AGSANFSKGGLQSNIELSVQMQAGNQDRELFREWFDKLWEQGEEDLDVLEVIENVQQS DYVYQPPSVFFAKLIRYLDRDYLLDSSVSTSGSPLLEYQNLTYNIVMERLQRFGGYIL SNSVGTGKTYVAAQTAATYQRRFPDNEILVVAPSNVTEEWEDVFDEFNVASETEFLSM GMLQKQPLEEATAGDRVFDYREYTDRFSLLIVDEAHNYRNDSNRRNNLEDIIRQNGDS DVLLTTATPINISPEDLFSLIDLFYRAGRVHQFETAGLKSHYENTRQRLKKLNKYDDL SSSLIRDIKTIENELSIKITWRIIQEEFQEDLRELAGDDVEYDDPEITEEEYDYPTRY QSEVFEEIVPFLDQLNYEPSKLWDGQGYQNFDNLIFRQKWRLYKRLESSLKAFHDSID NLHKRFILYYEAITRDTAIEEGDVSSHVTSIDPQEAATATDFERLETVVTTYRSLDSD LQETVLTNLRSDIDLIEQMGDRIESSFGTTETVPYPGDNKVAKLQSIVADKLGEEKPV VIFSQYSDTVEYLYQSLSDEHTGVRRIHGGLSEDKEAFVSSFNRGEFDVIITTDMLAE GVNLPRADAIVNFDLPYNPITLIQRTGRALRITNPKQVEVHNFRPTDSIDRELELYEK LDARLDTILDIVGLDFIVWLMDKKKIEQLHEEEREEYLESLDEYNETMASSNPSDIAP EQAPPEETRTDRILRRAIDTYNLSSDDVLAVSPSIRRPIYTVVESSDYQDQETEAHDA TVRDTPLSNFAVLGETGGDPSIWTPLHRSVKAGSDAAGLTESDKQTIEKIREERQEQY NRERVTAGQLGRAASQLVDQVEEVMDLVSDPEMRGTLDAVRERLEADTYTVPQRNALA DSLSSIQEEVYGWMANPDTEIRNAPEWQTVIHMSEKGRAESGESELKAVIKYQNND" gene 8298..11915 /gene="" /locus_tag="" /db_xref="71557..75174" CDS 8298..11915 /gene="" /product="Eco57I restriction endonuclease" /translation="MINVTNSPSLLDATPERGDTGDYGYDFLVDAGYFEAPTSDTVTY DTDCEVTYRFSIEGSVRIAYFEFPMAAVPQDTPKKITQELKRRTRLQYFWFFDPETNR VQVFRASRGNFQFIYNPDLHKGTTAGSKLDKLEQVPEDINVLFDYKDVVDRFYRELWD HRSDLAGSLTTNGDYTLSKQEELLSAQRIIDRLIFLYFLVERGVITPVNDSKEMVPGK TDRVFSTLVDEHDDFWVFLRTVFFDRLNSHNTDAIKFTGSYWLHVPYLNGGLFQPEEL ATTDGTTISEDDELIVEDFDWDALISELNEYNWLLDGLEGTDDDAAETVGNLTPAVLG YIYEKFVISVSKIGDDVRLSDLGASERNDLLSEGNSEVGAYYTGEDITDFKARRALWE GVLEKVDQDLAEGTAPVELRSDDLYRPGEDRSAEIESTQKGGFDILYEKYRSSPEVLQ YLDSKLTELRVCDPAVGSGSFALAVANTLFEWRSMCRPDTDEYVLRRQIIAQNIFGVD VLEGATEICKLRLWLWLISATPVDTTEGTAVDERDEIPPLPDITFNIRTGNSLLGFTE TAAVAGQQHTLGSTTMEDRLRKYGQDVRNYRESADPERETKRTLERRHDELKKDLDEW YAGAQSDSNNNRLTIADHVDDVGAAWNSLNAAPQSSTTLSITVPDGIPEAIDEYLGER GFTTYKYKARLDSPTLEKRGVETIFHRFRQHFSDPEEWSVLVEREYAEQDFRRDKLNA CHWPLEFPLVFIENGGFDVVISNPPYGASLSPEEEPLLKNEANYECQGTNDSCEWFYE RALDLAHDHGVISYIVNKSIAFYSSWSDIREKLLEETEFKHVFDVGLGFVGVNLETIA IVNTMGGDGQSRIPTVHRSRDLRSTTANQPVHLGWVEQEFMMDSKTIIFRPITDEQSD VLESLRSHDRRLGDVMSTEDTTRQLYIPDSKKKRLDEGDDHYINKNPWVQEFYVEDIW HKDLSDYRDSVDEYAVPRVMLKVLRGTRLRAWIDEGGDVVGTEKLVNVPLEESTPEEI AFVYAALNHPCASYYLQKAIFSETTESARVMDGQYSKPIPIPEASTETEITVAQLAWA LTLARQLDHDSTRDLSERVTTLQSGLNAILTGLYLNAQPETITHWCGAANSAGTESER VHEVFREFYSKRFATRNGNPEQCWDEIEAVVDSTVDMVSEWETDQLLGSHEMAVVEDV L" gene complement(11932..12543) /gene="" /locus_tag="" /db_xref="75191..75802" CDS complement(11932..12543) /gene="" /product="hypothetical protein" /translation="MPSKKLAKEDATEVLFVKEALGDDPTFGVNVERLVNHPEMGWVV FEFLKLGGPFTDPPYKWREILAIDESHPNNYWHRNGRKFVSLWQLTQELGGVLFLVNY SVKEAETEDGVPDNCLPQPYVRIPPGTDAEEKVYYYIAKGKGAHVLQVTDIDLDAAFD DSDATPIETRPIPESEGGMSWDAFSDWFRRINRESSSDPRTLR" gene complement(13032..14129) /gene="" /locus_tag="" /db_xref="76291..77388" CDS complement(13032..14129) /gene="" /product="esterase/lipase" /translation="MTDNSDRTTTPRRAFLAGTAGTAVLGTAGAATGADDHRNEAERT NDKRRAGRQDREIASWKPTAHDLTMDDCHRLRVWERTTAADPDEAVIFVHGMTYGALP MFDPPVAEDFGWLRYAADQGLAAFAPDMRGYGDTELPAEFRSQPEANAPPLSFEREAL DLLEVTRWLREDCGFDRIHYVGLSGGTWRGRAVYALGEPDYATVTLAGGSFDTLEVGT DPDGPAYLPHTREEFVEAWTGEIPTDADLDRWIGGDEYTADEVLDAVWKAIVESNQAI EDEPETIINPLVVQDREYHPEQITDPTFVVRPSSDETISRAGALNLYDAVGAEDDRKQ YAEIAGGTHFMFLERKREEFFDAVNHFQDQY" gene 14750..14905 /gene="" /locus_tag="" /db_xref="78009..78164" CDS 14750..14905 /gene="" /product="hypothetical protein" /translation="MPHDQDVEGDTSDISSEYECLQCGKIVRAETSPGECAECGGEFQ NRAKSLE" gene complement(14950..15222) /gene="" /locus_tag="" /db_xref="78209..78481" CDS complement(14950..15222) /gene="" /product="hypothetical protein" /translation="MSNASVQTTNAPSVPNQGMTPVVAVVVAVADAAGTDPLELPPLH EAINPEALNELIDCDRESGLQSISFEYAGYDVVVSGTGDVHVTLSE" gene complement(15367..16044) /gene="" /locus_tag="" /db_xref="78626..79303" CDS complement(15367..16044) /gene="" /product="putative DNA binding protein" /translation="MSVVAEFTIPADAFALDHTLEAVPDATVEIERLATHSREWVMPF LWVTSDDIEDVGSVLENDPDIETVRTLNLADGTGYFNVHWSEEIQQLIDEIVDQRGIM QEAEAKDGRWYLKLKFVDQTVLEEFQAHFQKRDYMFELQRLHRGIGPKERRYDLTPSQ REVLTVAQEMGYFDVPRETQIEELATELGVSTNSVSQRLRRATDNLVRNTLTVAPPKG MTESDGV" gene complement(16149..16622) /gene="" /locus_tag="" /db_xref="79408..79881" CDS complement(16149..16622) /gene="" /product="hypothetical protein" /translation="MSIRTEADMFERELQKLYHAELEILDLNGDLSEAAASEEIQELF AGHREDTVAQITRIEEIFELTDLPLEERGSPIMEGLLAEKDEFVSEVESDELRDLDAI GIGTINERIEITLLDRLILLAETLDHPESVVSRLEQNRSEAESALQKMQAYRRAD" gene complement(16670..17236) /gene="" /locus_tag="" /db_xref="79929..80495" CDS complement(16670..17236) /gene="" /product="hypothetical protein" /translation="MTDRKNAMLTTEDRRWLTGEKSYEGEHAKQQRYQRRRDIRKRVH NTILDFTILFEHLEDAEREKLFECLEDDESDDEFEAGLRDGLAFILYNAGITETMLEE CSHGTESTAERLLREAVDAAGKRDEILIEDVAISIDATRAPIASIVAELKAGNEVSPA ELCLLLESEAVDTDAARDCLRELVVDAE" gene 17434..18471 /gene="" /locus_tag="" /db_xref="80693..81730" ORIGIN 1 gtggtttacg aaactggcaa tcgaacgatc gacgacgcag tacgacgagt gctcgacggc 61 gagcgcctcg atcggaccga cggactcgcg ttactcgccc agcccgtcga gaccctcgct 121 gccggcgccg atctcgttcg tcgtaacttc tctgatggga cagtcgacgc ctgtagtatc 181 gtgaacgcga aggcgggaaa ctgcgccgag gattgtgggt tctgcgcgca gtcggcccac 241 ttcgataccg gtatcgactc ctacggcttc ctcgagccgg aggcgatact ggaagccgcg 301 aaacgagccg aagccgatgg tgcgcaacgg ttcggtatcg tcgtcgccga aaaaggcgtc 361 tcgaaaaaga aacgtcccga tgagtgggac gacgtcatcc gggcagttcg actcgtccgc 421 gacgagacca gcgtcgaaat tgacgcctcc ctggggctgt tgacccagga agaggccgac 481 gaactcgcgg ccgagggcct caaccactac aaccacaaca tcgagacctc caggcgatac 541 tttcccgaaa tcattgggac gcacacgttc gaggaccggc tgaaaacgct tcgtcgtgcc 601 aagaacgcag gtatggacct ctgtgctggc gttatccttg gaatgggtga gtctccgacc 661 gaccgagtcg atgcagccgt cgaactccag gagatcggca tttcctcgct cccggtcaat 721 atcctcaatc cgatcgaagg aacgccactg ggagaacgcg atcgggcagc catctcgaaa 781 accgaaatca tcgaaacgat cgctgtctat cggtttctcc acccagaatc gcgagtgcgg 841 ctgaccggtg gccgcgaggt caacctcgcg gaggacgaac aacacctgcc gttcgaggca 901 ggtgctgacg gcatcctgac tggtgattat ctaacgacgg acgggcagac gcccgatgat 961 gatctcgaga tcatcgaacg cgccggattg gagccgaacc gggcggtcaa cgacttcgat 1021 ccagctgcag ttgcgaccca gcacaaaacc tcggatccga agactgcagc gggaacggca 1081 acgagcaatg cgacgacaaa aaccgacgat tgagatgcac gaaatcaaat tcgcggttct 1141 tggcaccggt gggatcggtc gacggacact cgagtatgcg acggcaaaag acggtctgac 1201 gcctgtggcc gcgtgtgatc gacacggcgt tgcagtcgac cacggggggc tcgacgtgaa 1261 cgaactgctc gcagcgactg aaggcaatat cgcgagtgat gggggcgtca cggcagtcaa 1321 acagtcgggc gagacgagcg gcgtcgcagc ctcgtcgcag gccgagccga ccgaaacacc 1381 gatcgccgat atcatcgccg aatccgacgg tatcgacgcg gtactcatcg ccttaccgaa 1441 cctcgagcac gatttcatcc cgcgcgtcgc cgatcggttt gcagaggccg agtacgacgg 1501 cgtcctcgtc gacgttctca agcgctctcg cgtcatcgat atgctcgacg atcgcatcga 1561 ttcgttcaac gacgctggta ttacgttcgt ctgtggcgca ggcgcaacac ccggtcttct 1621 gaccggtgca gccgcactcg cagcccagtc gttcgtcgat atcgagtcgg tcgagatctg 1681 gtggggtgtc ggactcaaat ccggctacga ggacaaccgt ggcaccgtcc gcgaggacat 1741 tgcccacctc gacggctacg ataccgaaac cgctcgaagc atgtcggatg cggagatcga 1801 acaggtaatc gacgagcacg acggccgtct cgagttcacc gatatggaac acgctgacga 1861 cgttttgctc gagcgagcag ggatctgcga tgccgaggac gtgacggttg gcggaattct 1921 cgacgcgcga tcggatgaga agccgacgac gacgacggtt cgcgtgactg ggacgacctt 1981 cgacggtgag cgggggacca acacgttcca gctcgacgat aacacaagca tggaggccaa 2041 cgtcaacgga ccggcactcg gctacctaca ggcaggcgtt cgtcggaacc gaaacggcga 2101 gtacggcgtc tttgggccgg cggagttgat gcccggattc tgagatgcag cgtcaccact 2161 ccctcggctt cgatctcgaa acgcgtctcc gggagcgaga acggtccggt ctccggcgcg 2221 atctcgtacc catcgacagc gtcgacgctc gcgctcgcac cgctgccgat ccgaaggggg 2281 agccagcgaa cttcggggcg gagcggctga tcttcgcctc gaacgattat ctcggactgg 2341 ccggtgatcc gcgggtcgcc gagaccgcgg tgcgtgccgc tcgcgacgtc gggactggtg 2401 cgggggcctc gcggctcgtc gtcggcgata cgtcaacaca ccgatcgctc gagcggcgtc 2461 tcgccacaga gaagaacgca gagcgagcgc tcacgttctc gtcggggtac gcagcgaacg 2521 ttggaacgat caccgcgttg gcgccggatg tgatcttctc cgacgcgctc aaccacgcga 2581 gtattatcga cggcgcgcgc ctctcggacg cgaccgtaga ggtctacgac cattgtgatg 2641 cggatgcgct ggcacagcgg atggctgagc gcttctcaga cggagtgaca gacgaatcgt 2701 ggctcgtcgt aactgactcc gtcttctcga tggacggtga cgtcgctccg atcgaagccc 2761 tctgtgacgt agccgaagag tacggcgcgt gggtgatggt agacgaagcc cacgctacgg 2821 gcgtctacga cggcggcatc gtcaacgaac gtgggcttga aaaccgggtg caggtgcaac 2881 tcggaacgct ctcgaaagcg cttggtgccc aaggtgggtt cgtggctggc gatgagaccc 2941 tcatcgaata cctactcaac gctgcccggt cgttcgtgtt ttcgactggt ctcgcgccgc 3001 cggctgcagc cgcttcggaa cgtgcactgg cgcttgcacc cgatcggcgt gacgcgctgt 3061 ggactaacgt cgagcgactg cgaacggggc tcgaagcgct cgggtacgag gttctgggtg 3121 atactcacat ccttccggtg ctcgtcggca accgcgatga ggcagtcgca ctggccgatc 3181 gaattaccga ggctggtatc gtcgcaccag caatacggcc acccacggta ccggagggga 3241 cgagtcgtat tcggctcacg ccgaaagcga cacacaccga cacccacatc gagcagtgtt 3301 tgaccgcctt cgaaacggcc atgacgaagg ggggctgccc atgacgatcg ccatcgtcgg 3361 gacggatact ggtgtcggca aaacggtcat cacggcaggg ctcgtcgcat accttcggga 3421 tgaagggtac gacgctcgag ctatcaagcc tgtacagacc ggtttcccgg cggacgacga 3481 tgccggatac gtccggcggg tctgtggtaa cgaatcggct gccacgagac tccgaacctt 3541 cgaagaaccc cttgctccgg ccgtcgcagc acgacgggcc gagagtagac tcgagttcga 3601 ttcactcgtc gatgacgtcc acaaggcact caaaacgact gggatcggaa ttatcgaggg 3661 agctggtgga gttcgtgttc cgctttcaaa tgacccacca cgcgagatta tcgacctcgt 3721 tgctacactc gaaactccgg cactgatcgt tgctcgctcc ggacttggta cgttgaatca 3781 cacggccttg accgtccaag cgcttcgtgc acgtgacgtc ccgattgccg gaatcgcctt 3841 gaataggtat cagggacact ccgtcgccga acgaacaaac cccgacgagc tggagcggat 3901 gtgttcctgt caggttcagc cgcttccgga attgtcgtcc gaagacccag aagcagtctg 3961 tcgtctcggc agtcgagttg ccgagctctg tacacaaacg agatcgctgg cactgtctcg 4021 ttgagccagt ttgagggacg accccaggag cgaacccgga caaccttgtc ccgaaatccg 4081 ctgtcttcac gcaacctcgt ggccggtacc gttccgaaat ccgaatcgat ggtggatagc 4141 tcacggttct gaggacggta cgcacgaccc actggtcgag ttcctcgata accctctctc 4201 accctcggcc ggcactcgtg agcggatact caacccgaac tggcttcgtc tcgagaacgc 4261 gtcgctcacc gattccctgt tcctcgagat cggttagcga ctcggaaagc acctttcccg 4321 agatgccgtc gatccgctct ttgaggttgc caaaccttgc ggtccggcgt tcagcaattg 4381 gtggacgatt gtcggacgcc acttccgtcc gaggacggcc gacgctacga tcaacgggtt 4441 gtccgtcagt gctcaccagt tctcgagacc gctcttctgc tgtcgacatc gctggtaatt 4501 acccccggat ccgtatgtcg taacaggggt agcgataccg accaaaatga gattctagaa 4561 ggatttactg ggcggtatca tcgtcagtcc gggttcgtcg ggtgtttcgt catcctcacc 4621 gttcacgcca gaatcgtgct cggggtcgtc gtcctcggca tcgtcgaccg gttcttcgag 4681 gtcaatttca tcgtcttcaa tctcgtcatc cggatcctcc ccgaccgctt cctccggcgg 4741 ttcgacgtcg gcgccgatga agagttgttc gatacactcg ttctggtccg ggttgagccg 4801 ctcgtcgaaa ccggcgatga acgtcgtcct ctcactgact tttaagtata gcaagaatat 4861 aacggtagta taccaaatga agccctccgg ctgggtcgtt aatgccgcta cacctccaca 4921 tattcatgtc tacgagtagg gatcgaaatc gtacgaaaga acgtcctggg gagcccatag 4981 tggaagatga ccacacgtct cttggctcgg tcgtcgactc tctactgaaa gagcgcgaaa 5041 actgatgacg gatatcggta atcgggttat cgacaacaac gccggactgt tagctgaaca 5101 taaagaaggg agtgtccgtg acgtatttga gcactacctt accaaggcga tcgaggaaga 5161 tcgggacaat agcttccgac tggacgtcgg gactggattc cttttctttt ccggattcga 5221 agcgatcgct gacaggttcg aggaactaat tgagaccggc tccgtcagtc gaatcgaaga 5281 tccggagtgg ggaacggaag cacccattcg ggtagtcatg ggtccggaaa cctcgaaccg 5341 aaccaaatct atcctgctct ctttggtcac tgatcaggtt atcgagtacg atgacgaagc 5401 tatcgacatc cttcgacggt tcgtcgagaa gggggttgtc gatttccggg ttattacgga 5461 acgtaacttc cacccgaagt tctacagctt ttatcttcgc tccgaggttc cggacgacat 5521 ctgggctgga tcggctaact tcagcaaagg cgggcttcag agtaatatcg aactctcggt 5581 gcagatgcag gcgggaaatc aggatcgaga gctgttccgt gagtggttcg acaagctttg 5641 ggaacagggt gaagaagatc ttgacgtact agaggtcatt gagaacgtcc aacagagtga 5701 ctacgtctac cagcctccat ccgtcttctt tgccaaactc atccggtatc tcgaccgtga 5761 ctacttactg gacagcagcg tctcgaccag tgggtcaccg ctactggagt atcagaatct 5821 aacgtacaac atcgtgatgg agcggctcca gcgctttggc ggatacatcc tctcaaacag 5881 tgtcggtaca ggcaaaacgt atgtcgccgc acagaccgct gcgacctacc aacgacggtt 5941 tcccgataac gaaattctgg tcgttgcccc ctctaatgtg accgaagagt gggaagacgt 6001 atttgacgaa ttcaacgtcg cctccgaaac agaattcctg tcgatgggga tgttacagaa 6061 acagccactc gaagaggcga ctgcaggcga ccgagtcttc gattatcggg agtatactga 6121 tcgatttagt ttactaatag ttgatgaggc acacaactac cggaacgaca gtaaccgacg 6181 taacaatctg gaagatatca tccggcagaa cggcgattct gacgttctcc tcacaactgc 6241 gacgccgatc aacatcagtc ctgaagacct gttctcttta attgacctgt tctaccgagc 6301 ggggagagtc caccagttcg agacggccgg gttgaagtca cactacgaga acacccgaca 6361 gcgattgaag aaattgaaca agtatgacga ccttagcagt agtcttattc gagacatcaa 6421 aacgatcgag aacgagttat ctatcaagat cacatggcgt attattcagg aggagttcca 6481 agaggacctc cgtgagctgg cgggagatga cgtcgagtat gacgatcccg aaatcacaga 6541 ggaggagtac gattatccca cccggtatca aagcgaggtc ttcgaagaaa tcgttccctt 6601 cctcgatcag ctcaattacg aaccctcgaa gctgtgggat gggcaggggt accagaattt 6661 cgacaacctg atcttcaggc agaagtggcg gttgtacaag cgcctggaaa gtagtctcaa 6721 agccttccac gacagcatcg acaatctcca caagcggttc atcctgtact acgaggccat 6781 tacgagagac acagcgattg aggaaggcga tgtctcctca cacgtcacca gtattgaccc 6841 acaggaagca gctactgcaa ctgatttcga acgactggaa accgttgtca ccacctaccg 6901 ttcccttgat tcggaccttc aggagacagt cctcacgaac cttcggtctg acatcgacct 6961 tatcgagcag atgggggacc gaatcgagtc ctcgttcggt accaccgaaa ccgtccccta 7021 tcccggagac aacaaggttg caaagctaca gtcgatcgtt gcggacaaac tgggcgagga 7081 gaaaccggtc gtcatcttct cccaatacag tgatacggta gaatacctct atcagagcct 7141 ttccgacgag cacaccggtg tcagacgtat ccacggtgga ctctctgaag ataaagaggc 7201 gttcgtatcg tctttcaacc ggggcgagtt tgacgtaata atcacaacgg acatgttggc 7261 agaaggtgtg aaccttcctc gcgcggacgc catcgtgaac ttcgacttgc cgtacaatcc 7321 gatcactcta atccagcgga ccggtcgggc gttgcgcatc acgaatccga aacaagtcga 7381 ggtccataac tttcgcccaa cagattccat cgatcgagag ctcgaactgt atgaaaagtt 7441 agacgctcga ctggacacga ttcttgacat cgtcggtctt gacttcattg tctggctaat 7501 ggataagaaa aagatcgaac agttacacga ggaagagcgg gaggagtacc ttgaaagcct 7561 cgatgaatac aatgagacga tggcctcttc gaacccgagt gacattgctc cggaacaggc 7621 gcccccagag gagacacgaa cggatcggat ccttcggcgg gcgatcgata cctacaacct 7681 cagttccgat gatgtgcttg cagtctcacc gtcgatacga cgcccgatct acaccgttgt 7741 ggaatcctcg gattaccaag atcaagaaac cgaagctcac gacgcgacag ttcgagacac 7801 tcccctgtcg aacttcgctg tccttggtga gacgggcggt gatccgtcga tctggacacc 7861 gttacaccgc agtgtaaagg ccggatccga tgctgcaggc ctgacggaaa gtgacaaaca 7921 aacgattgag aagattcgcg aggaacgcca ggaacagtac aaccgggagc gggttacagc 7981 agggcagtta gggcgtgctg cttcacagct ggttgatcag gtagaggagg taatggacct 8041 ggtttctgac ccggagatga gagggacgtt ggatgccgtt cgtgagcgac tggaagcgga 8101 cacatacaca gtacctcaac gcaatgctct ggcggacagc ctgtcgtcaa ttcaggaaga 8161 agtctacggc tggatggcta atccggatac ggagattcgt aacgcaccag aatggcaaac 8221 agttatccac atgtccgaga aagggagggc cgagtccgga gaaagcgaac tgaaggcagt 8281 cataaaatac cagaacaatg attaatgtga cgaactcccc gagtctactg gacgcgacac 8341 cggaacgcgg cgataccggt gattacggat acgatttttt agtcgatgct ggatatttcg 8401 aagcgccgac gtcggacacg gtaacctacg ataccgactg cgaggttacg tatcgcttta 8461 gcatcgaggg atccgtgcgg attgcgtact tcgagttccc gatggcggct gtgccacagg 8521 ataccccgaa gaagatcaca caggagctga agcggagaac tcggctacag tatttttggt 8581 ttttcgaccc ggagacgaac cgggttcagg tattccgagc gtcacgaggg aacttccagt 8641 ttatctacaa ccccgacctc cataagggaa ccacagcggg aagcaagctg gacaagctag 8701 agcaggttcc cgaagacatc aacgtccttt tcgactacaa ggacgttgtt gaccgcttct 8761 accgagagct gtgggaccac cgatccgacc tcgcgggctc gctcacgact aacggcgact 8821 acacgctgag caaacaggag gaactcctct ctgcacagcg gattattgac cgtctgattt 8881 tcctctactt tctcgtcgaa cggggtgtca tcaccccggt gaacgattcc aaggagatgg 8941 ttccggggaa aacggatcgt gtattcagta cgctcgtcga tgaacacgat gacttctggg 9001 tcttccttcg aactgtcttc tttgaccgac taaactctca caacaccgat gctatcaaat 9061 ttaccggatc gtactggctc catgtcccgt atctgaacgg aggactcttc cagcccgagg 9121 agcttgctac cacggacggc actaccatct cagaggacga tgagttgatc gtcgaggact 9181 tcgactggga cgctctcatt agtgagctca acgagtacaa ttggctcttg gatggtctcg 9241 aaggcacgga cgacgacgca gctgagacag tcggaaatct cactccggcc gtcctcggat 9301 acatctacga aaagttcgtc atttcagtga gtaagatcgg cgacgatgtc cgtctgagcg 9361 atttgggcgc gtccgagcga aacgacctcc tgtccgaggg taacagtgag gtcggcgcgt 9421 actacaccgg tgaggacata accgatttca aggctcgtcg tgcgttgtgg gagggtgtac 9481 tggagaaggt cgatcaggac ctcgccgaag gaacagcccc tgttgagctt cgttccgacg 9541 acctctaccg acccggagaa gaccgatctg cggaaatcga gtcgactcag aaaggcgggt 9601 ttgatatcct ctatgagaag tacaggagct ctccagaagt actgcagtat ttggattcaa 9661 aactaacgga gttgagggtg tgtgaccctg ctgtcggaag tggctcgttc gctcttgcgg 9721 tggcgaacac actgttcgag tggcggtcga tgtgccgacc cgatacggac gagtacgttc 9781 tccggcggca gatcatcgca cagaacatct tcggcgtgga cgtcctcgaa ggggcgacag 9841 aaatctgtaa gctgcgtctg tggctgtggc ttatcagcgc aactccagta gacacgaccg 9901 aggggacggc cgtcgacgaa cgtgacgaga ttccacccct gccggacatc accttcaaca 9961 tccgaaccgg aaacagcctc ctcggattta ccgaaaccgc tgctgtagcc ggtcaacagc 10021 acactcttgg ctccacgacg atggaggacc gattacggaa gtacggacaa gacgttcgta 10081 actacaggga atccgctgac cccgagagag agacgaagcg aacgctcgaa cgccgacacg 10141 acgagctaaa gaaagacctg gacgagtggt acgcaggggc tcagagtgac tcaaacaata 10201 accgcctcac gatcgctgac cacgttgatg atgttggagc cgcgtggaat agcctgaatg 10261 cggctcccca gtcctccacg acgctcagca tcaccgttcc ggacgggata cccgaagcga 10321 tcgatgagta cctgggggag cggggattta cgacgtacaa atacaaggca cggttagaca 10381 gtccgacact cgagaaacgg ggtgtcgaga cgatcttcca ccggttccga cagcacttct 10441 ccgatcctga ggagtggagc gtcctcgtcg aacgtgagta cgctgaacag gactttcgac 10501 gggacaagtt gaacgcgtgt cactggccgc tcgaatttcc gctcgtattc atagagaacg 10561 gaggattcga cgtcgtcatc agcaatcctc cctatggagc ttcactcagc cccgaagaag 10621 agccgttgct gaaaaacgag gctaattacg agtgtcaggg gacgaacgac tcttgtgagt 10681 ggttctacga acgggcactc gacctcgctc acgatcacgg tgtcatctcc tacatcgtca 10741 acaaaagtat cgccttctac agttcgtggt ccgacatccg cgagaaacta ctggaggaga 10801 ccgagttcaa gcatgttttc gacgtcggac tcgggttcgt cggagtaaac ctcgaaacca 10861 tcgcgatagt caatactatg gggggtgacg gtcagtcacg tattcctact gtacaccgga 10921 gcagggatct tcggagtaca actgcgaacc agccggtcca ccttggatgg gttgagcagg 10981 aattcatgat ggattcgaaa accatcattt tccgacccat aacggacgag cagagcgatg 11041 tcctggaaag cctgcgttcc cacgaccggc gtcttggtga cgtaatgtct accgaagaca 11101 cgacgaggca gttgtacatt ccagacagca aaaagaagag actcgatgag ggggacgatc 11161 actacatcaa caagaacccg tgggtacagg agttctacgt ggaagacatt tggcacaagg 11221 atctcagtga ctaccgcgac tccgtcgacg aatacgccgt tccgcgtgtc atgttaaagg 11281 tgctccgtgg aactcggctc cgggcctgga tcgacgaagg tggagacgtt gtaggcacgg 11341 agaagctcgt aaacgtccca cttgaggaga gtaccccgga agagatcgcg ttcgtatacg 11401 ctgcgttaaa ccacccgtgt gcatcctact acctccagaa ggcgatcttc tcggaaacca 11461 ccgagagcgc acgggtgatg gacggtcagt actcgaaacc gattccgatc ccggaagcgt 11521 ccacagaaac tgaaatcacc gtcgcccagc tcgcgtgggc gctgacgttg gcgagacaac 11581 tggaccacga ctctacccgt gacctttcgg aacgagtgac gacccttcag tcgggactca 11641 atgcaatcct cactggtctt tacctgaatg cgcagccgga aacgatcacg cactggtgtg 11701 gtgctgccaa cagcgccgga acggagagtg aacgcgtcca cgaggttttc agagagtttt 11761 acagcaagcg gttcgctacg cggaacggga acccagagca gtgttgggac gagattgagg 11821 cagtagtgga ttcgaccgta gatatggttt cggagtggga gacggaccaa ctcttgggat 11881 cacacgaaat ggcggtagtc gaggacgtcc tgtagagggt ggaaaaggcg gctaccgaag 11941 cgtccgggga tcgctactgc tttctcggtt gattcgccgg aaccagtcgc taaacgcgtc 12001 ccagctcata ccgccttcgg attccgggat cgggcgggtt tcgatcggag tagcatcgga 12061 gtcatcgaac gcggcgtcga ggtcgatgtc ggtgacctgc agtacgtggg cgcccttgcc 12121 ctttgcaatg tagtagtaca ccttctcctc cgcatcggtt ccaggaggaa ttcgaacgta 12181 aggctgcggg agacagttgt ccggaacacc gtcttctgtt tcggcctctt tgacggagta 12241 attcacgaga aagagcacgc cgccaagctc ttgggtcaac tgccagagtg agacgaattt 12301 ccgcccgttt cggtgccagt agttgttcgg atggctctcg tcgatggcta atatctcgcg 12361 ccacttgtac ggcggatcag taaagggacc ccccagtttc aggaattcga acacgaccca 12421 tcccatctcc ggatggttca ccagtcgttc cacgttcacg ccgaaggtag gatcatcacc 12481 cagcgcctcc ttcacgaaca gaacctccgt cgcgtcttcc ttggcgagtt tcttactagg 12541 cattctctga acgatgcggg caagccaaca taatactagg cgttgatatg agtagataga 12601 caataggaat ttactaatta cattcttctt tgttgattgg aagggctgat actcttgcca 12661 cagctgttca ctctccccga cacagtatgg gaggtgagct cgcccacgaa ctgccacaaa 12721 cgaactcgat gttcacgggg atcgctggct tcgctgcgct ccaagacgtc cattggacgc 12781 tggacagaat tccgggtggc tgcagcctgg cgaaatcgag tttacccgga gcagttctcc 12841 actactagct ccgtgaagta ccacgggcgc ggtggcccgt agcctcgtcg tttggcctct 12901 ccccgaaacg ggagcgtaac ggcagcagac gaacgtaatt cccgctgtac ttgcggagca 12961 atcgaaacga gccgcgacct gcaaaacgta ctccgttcga gcactaccac ggactgaggg 13021 gagtcaactg cctagtactg gtcctggaag tggttgaccg cgtcgaagaa ctcctcacgc 13081 ttgcgctcga ggaacatgaa gtgtgttcca ccggcgatct cggcgtactg cttccggtcg 13141 tcttcggcgc cgacggcatc gtatagattc agcgcacccg ctcgggaaat ggtttcgtcg 13201 ctcgagggac gtacgacgaa cgtcgggtcg gtaatctgtt cggggtggta ctccctgtcc 13261 tggaccacca gcggattgat gatcgtctcc ggctcgtcct cgatcgcctg gttgctctcg 13321 acgatcgctt tccagaccgc gtcgagtacc tcgtcggcgg tgtactcgtc gccgccgatc 13381 caccggtcaa ggtcggcgtc ggtgggaatt tcaccggtcc acgcctcgac gaactcctcg 13441 cgggtgtggg gcaggtatgc cggcccgtcc gggtccgtgc cgacttcgag cgtgtcgaac 13501 gaacccccag caagcgtaac cgtcgcgtag tccggttcgc cgagcgcgta taccgcgcga 13561 ccacgccacg tgccgcccga gaggccgacg tagtggatgc gatcgaaacc gcagtcctca 13621 cgaagccacc gggtcacctc gaggagatcc agggcttcgc gttcgaacga cagcggcggc 13681 gcgttcgcct ccggctggga ccggaactcg gctgggagtt ccgtatcgcc gtacccgcgc 13741 atgtcgggcg cgaacgctgc cagtccctgg tcggccgcgt accgcagcca gccgaagtcc 13801 tcggcaaccg gtggatcgaa catcgggagc gcaccgtagg tcattccgtg gacgaagatg 13861 accgcctcgt cgggatctgc agcggtcgtc cgctcccaga ctcgaagccg gtggcagtcg 13921 tccatcgtca gatcgtgggc ggttggcttc cacgaagcta tctcgcggtc ctgcctgccg 13981 gcccgtcgtt tgtcgttcgt tcgctctgcc tcgtttcggt ggtcgtccgc gcccgttgcc 14041 gcgccagctg tcccaagaac cgccgtcccg gccgttccgg cgaggaacgc tcgtctaggg 14101 gtcgttgtcc ggtcactgtt gtccgtcatg tctcgggaaa atgactgttt gagaatacaa 14161 tcatagtacc tgtgtatttc acgaactgag aaactcccga acagtggtga gcaacccatc 14221 cgatcccgat tcggagaccc cattggggtc gaccgtgtcc ttcgtctgtc gaccgcttgc 14281 tgtactggct gacgcgacgg gcgctacccg aatctggttc tcgattagtg ggagatacgc 14341 acctgaagag gtgtacctgt tgaacgataa cagggaggcg tgatccgtac ggactgttcg 14401 attaccttgt gatttatcct catagtaatc gctttcgagg ttcttgccgc aacaagacgg 14461 caatacgata tcgaacagtg ctgtctggaa ccgtcttctc tgtgaaaaat tgcgttcccg 14521 gcgacgccgt acatgcacga agttgctatc gaaagttgcg cagatccgga tttcccgtcc 14581 cgatggctcc agttcgttgg tcgtagaacg gttatcgatc ccaaaccgga agcggcgaaa 14641 cgtggctttg ggggagacac ccgtcggcgg ttccgttcca acacctctcc gagactattt 14701 cactcaagtt tgcaatcatt atttgtgtct gccccaccaa gggtgaggca tgccccacga 14761 tcaggatgtc gagggagata cgtccgacat tagctccgag tacgagtgtc tccaatgtgg 14821 gaaaatcgtt cgggccgaaa ccagtccggg agagtgcgcc gagtgcgggg gtgagttcca 14881 aaaccgtgcg aaatcgctcg agtaggagtc cgacatcgag cgctccctga cgagcatccc 14941 ggtccgctgt tactcggaga gtgttacgtg aacgtcgcca gtacccgaga cgacgacgtc 15001 atatcctgca tactcgaagg agatcgattg cagaccggac tctcgatcgc agtcgatcag 15061 ttcgttcagc gcttccggat tgatcgcctc gtggaggggc ggcaactcga gtggatccgt 15121 tccagcagcg tcggcaactg caacaacgac agcaacaact ggcgtcatcc cctgattcgg 15181 taccgacgga gcgttcgtgg tctgaacgga cgcgtttgac atagcacgga ctgccacata 15241 cctgtataaa ctactttcca aacagctttc cggtttctaa ccctcgttcg ttcggcgttc 15301 gttgacccga aaccgtgggc tttcgcctgt aacgcgacgg atgaacgcca cggtcacccg 15361 tttcgatcac accccatccg attcggtcat cccctttggc ggggcgacgg tgagtgtgtt 15421 tctgacgagg ttgtccgtcg cacgacgcag ccgctgggag acggagttcg tcgaaacccc 15481 cagctccgtc gcaagctcct cgatctgggt ctcgcggggg acgtcgaagt aacccatctc 15541 ctgggcgacc gtgagcacct cccgctggct tggagtgagg tcgtaccgcc gctctttcgg 15601 cccgattcct cggtgtagac gctggagctc gaacatgtag tctcgtttct ggaagtgagc 15661 ctggaactcc tcgaggacgg tctggtcgac gaacttcaac ttgagatacc agcgaccgtc 15721 cttcgcttcg gcctcctgca tgatcccgcg ctggtcgacg atttcgtcga tcagctgctg 15781 gatttcctcg ctccagtgga cgttgaagta cccggttccg tcggcgaggt tgagcgttcg 15841 gaccgtctcg atatcgggat cgttctcgag gacgctcccg acgtcctcga tgtcgtcgct 15901 tgtcacccac aggaacggca tcacccactc gcggctgtgg gtcgcgagcc gttcgatttc 15961 gacggtcgcg tcgggcacgg cctcgagggt gtggtccagt gcgaaggcgt cggcgggaat 16021 cgtgaactcg gcaacgacgc tcatacgcgt gttctccgct cgaggaactg aaaaccgtca 16081 cctgccactg caacagacac gcgacggccc gagcgacaca cgactgtcgg tgctggcggt 16141 gtggtggctc agtccgctcg tctgtacgct tgcatcttct gtagcgccga ttcggcttcg 16201 gatcgattct gctcgagccg actcaccacc gactcggggt gatcgagcgt ctcggccagc 16261 aggatcagtc gatcgagcag cgtgatttcg atccgttcgt tgatcgtgcc gatcccgatc 16321 gcgtcgagat cgcgtagctc gtcgctttcg acctcactga cgaactcgtc tttctccgcg 16381 agcaatccct ccatgatcgg actgcctcgc tcctcgaggg gaaggtcggt cagttcgaag 16441 atctcctcga ttcgtgtgat ctgtgcgacc gtatcctccc tgtggccggc gaacagctcc 16501 tggatctcct cgctggcggc cgcctcggag aggtcgccgt tcagatcgag gatctccagc 16561 tccgcgtggt acagcttctg tagctcccgc tcgaacatgt ccgcttcagt tctgatactc 16621 ataggttctc cgtgatcggt cgtaccgcgc tgccctccat cccaatcggt cactccgcat 16681 cgacgaccag ctccctgaga cagtctcgtg cggcgtcggt gtcgacggcc tcgctttcca 16741 gcaggagaca cagctccgcg ggcgacacct cgtttcccgc cttcaactcc gccacgatcg 16801 acgcgatcgg cgcgcgggtc gcgtcgatcg aaatcgcgac gtcctcgatg aggatctcgt 16861 cgcgcttccc ggccgcgtcc acggcctccc gcaggagccg ttccgcagtc gactcggttc 16921 cgtgcgagca ctcttcgagc atcgtctccg tgatccccgc gttgtacagg atgaaagcga 16981 gcccgtcacg gagtcccgct tcgaactcat cgtccgactc atcgtcctcg agacactcga 17041 agagcttctc ccgttcggcg tcctcgaggt gctcgaagag gatcgtgaaa tcgagaatcg 17101 tgttgtggac ccgcttgcgg atatcgcgcc ggcgctggta gcgttgctgt ttggcgtgct 17161 caccttcgta ggacttctct ccggtgagcc accgacgatc ctcggtcgtc aacatcgcgt 17221 tctttcggtc cgtcatggtt gcgtcgtgtt cgttcggcca cggtcctccg gcatcggtac 17281 tatattcatc acatcctata aataggaata tatttaccca accatcgtga cgttatccca 17341 tgcgtcgaga tgacgccccg atcggtatga agattgtgct attcacgaac gtgaggcgac 17401 cgaccgccgg cgatcgatcg accgtcggga gcgatggctg acacgacgtc cgacgcggcg 17461 aaaacggagt atcgcggccg tgccaccccc gccaaactcc ttgagatcgc caggtacttt 17521 ctctttatcg gcatcgtcgg cttcggcggc ccgatggtcc acatcgcaat gatggaggac 17581 gacctcgtcg gcgaggacga cacggagtgg accgaccagt cggtgttcat ggaggggctc 17641 gcgatctgta atatgctccc gggtccggcc tcgacccagc tggggatctt catggggtgg 17701 atctacgccg gaaccaaggg ggcactcgtc gccggcttct gtttcatgct gccgacgttc 17761 gtcctcgtcg tcttcttgtc gtggctctac ttcgcctacc agcaggtgcc cgcggtcgag 17821 gcggtgttct acagagatac agcgagagtg cctcggggct tgtccccgag gtacttcacg 17881 gtggcgggct cgtactgatc cgttcatcga gaccgtggtc agcgagttcg gctggatgac 17941 cgggcgtgag ttcgtcgatg tccacgagag catcgcgatc ggccagctct ctccggcccg 18001 gtcgtgatga cgacggcctt cgtcggctac aagctcctgc ttgacgtctc gggcggaatc 18061 gtcgtcgtca ccgtgatcgg cgcgctcgtg gcaacgatcg gcgccttcgg cccctcgttt 18121 gcgttcatca tcggcttctt tccctacttc gcgaaggtcc ggaagaacgc cctcgtccag 18181 actgccctgg tcgccgtcaa cgccgccgtg atcggggcga ttctcggcgc gacggtcatc 18241 ctcgccgagg agtcgttcct cgtcgagcag ccgaccgtcc cggttccggt cgccggagcg 18301 gtcctcgatc tgttcgtcgt gttgctggcg cttgtcacct actggctgtt cgttcgcggc 18361 gtccacgccg cgtacctcat cgctgccggc gcgcggtcgg cgtcggggcg ttcttcttcc 18421 tgtagcaccc accgccccga gtacgatcga agaatcacga gtgaggtata g //