LOCUS NC_019972:1 18889 bp DNA linear BCT 16-MAR-2013 DEFINITION Methanomethylovorans hollandica DSM 15978 plasmid pMETHO01, ACCESSION NC_019972 SOURCE Methanomethylovorans hollandica DSM 15978 plasmid pMETHO01, COMMENT locus start: 110500; locus end: 129388 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.741398; n0_4mer:D = 17.116063; n0_4mer:PS = 27.601819 FEATURES Location/Qualifiers source 1..18889 /organism="Methanomethylovorans hollandica DSM 15978 plasmid pMETHO01," gene complement(38..523) /gene="" /locus_tag="" /db_xref="110537..111022" CDS complement(38..523) /gene="" /product="hypothetical protein" /translation="MGFFGELLQDVTGKSKRPEIKGGRFENFVSDEIFTDKLFDLVEM TRDFNSNSERFEERSMNPDFLFRDKRTREEFWIEAKYRTGLFRNDKGQLVCEICKSWQ LDRYRDVEKTSGKKVYICLGLGEDPRYPETVHLIPVFGAYPQLFQSKLKETLIWRNPD I" gene complement(886..1074) /gene="" /locus_tag="" /db_xref="111385..111573" gene 1500..1736 /gene="" /locus_tag="" /db_xref="111999..112235" CDS 1500..1736 /gene="" /product="hypothetical protein" /translation="MLGYLSQPRDKSRRERMLPCETCAHGRNITEGHIRVNVKTSAKD EVMDKIEQQKRCGQLVFGDYVQCKNVSATKYKGS" gene 2062..5292 /gene="" /locus_tag="" /db_xref="112561..115791" CDS 2062..5292 /gene="" /product="DNA/RNA helicase, superfamily II, SNF2 family" /translation="MLLDNRTNGKVGEELRKHIEKGSHLSVVSGLFSIFGYSELKKEL EKIDHFRFLLPQNSVELKNQKVNDFFIKGLTGSEMERKFRNNLNISQIAHECAIWLTK KAEIRTSATLIPQSLYHITKPNGEEIAIHGSSPFSAEGFGFTPSDSFDITFCFTTGEE TKNLLKWFDSIWNNQQNTNDIKSILITQLEKIYSDKSPSFIYFIVLFNVFKEYLGEIK EENIIKTKTGIKDTLIWNKLYRFQRDGVLGAIDKIERYNGCIIADSVGLGKTFEALAI IKYYELRNDRVLVLCPKKLRENWTLYTVNDKRNILAADRFNYDVLNHTDLTRSKGYSG EINLETINWGNYDLVVIDESHNFRNNPPRKDGLTRYSRLMAEIIKAGVRTKVLMLSAT PVNNRMNDLKNQVLFITEGVDHALEPQGIISIEQTLKMAQARFNQWLKLKEADRTTES LLDTLNFDYFKLLDLLTIARSRKHIEKYYDVAEIGRFPIRAKPINIKAYIDTENRFPA LGEINRDIRRLNLSAYAPLKYVLPQYMDKYSRKYDMKLAGGSVFKQIDREESLIHLMR VNLLKRMESSINSFSLTVEKLLSEVRRIIELLDSHDDLEFKELDIEEIEIENEEFSLY AVGNKVKVLIQDVDRIRWKQELQEDEELLQKVLFAAKQIDPNRDAKLLQLKDLINKKV SDPINENNHKIIIFTAFADTARYLYNNVADWSKTSLGLHCAIVTGTGDNKTTMPGIRK DMASIITSFSPISKERSLISPELSDEIDILIATDCISEGQNLQDCDFLVNYDIHWNPV RIIQRFGRIDRLGSKNEVIQLVNFWPNMELDEYINLEARVSGRMVLLDISATGEENVI EYSDAGKMNDLEYRRKQLERLQEEVVDIEDLGGGISITDLTFNDFRMDLAEYMKINSR VLEHMYPGMFSVVSLDDIGEEGLKPGVIFCMRNENNAIKTDSTYALSPIYLVYVSDNG EVLLNFTHAKRILDLFKKISINRSIPDRTAVSLFNGYTHNGTNMSHYRNLFGKAVAAI TGKAEEYGVESLFHRGGTVINKDSFKGIDDFEVIAYLIILDKEVLK" gene 5289..6107 /gene="" /locus_tag="" /db_xref="115788..116606" CDS 5289..6107 /gene="" /product="hypothetical protein" /translation="MNDILVSMIDLPESAYLGKRVSKKLFFDNGALTTADKKLFQDDV ESIVWQYGLKPNNIQVKPYTDEQREYLEVAILDIVLRSPKSYKRLAEVIHRTIPYPLL LVFSLNQVASTQDLQVEDDLESRFISNGSKISLSVAPKRFSLAEKGAIVAEEFFTTEW MDMESLTDIERLFLENLNIKDLPHTDFFDLYDALIDRFIAFDCASFSGEFRLNGKHDP EMLREQLAMCHELKGKISDMRKKLSSETQFNNKLEINMKIKQMETQLKAISIGL" gene 6159..6293 /gene="" /locus_tag="" /db_xref="116658..116792" gene 6365..7102 /gene="" /locus_tag="" /db_xref="116864..117601" CDS 6365..7102 /gene="" /product="hypothetical protein" /translation="MEIKEYRVPFNGKIFRSIEFNFRNNPSDKLTLDSLIEKGIILAK KVNPILARDSSLARDNNMKIKDCIGGAIAEYCWRTWLNQYFELNRIDMKAQETSFENA KNQIDIQIINNRGDIKTVEVRSSFAYKGVDAAISHNFKILGPYYNEIKKYEYTKDYHV MVVYSFSKDLLKSQLESGDFKVYLVGGATRILLQNSPFAFNRDLAPQDDITERLNQRA TYRVIEPIANGYDTIKISELIASMSQL" gene 7183..9075 /gene="" /locus_tag="" /db_xref="117682..119574" CDS 7183..9075 /gene="" /product="adenine specific DNA methylase Mod" /translation="MIQKLDLKIDNKSMNIVSANIEQLKYIFPEVFTDGKIDFDVLKA LLGEYIEDRDERYGFNWNGKSKARMISQTPSIGTLRPCPAESIEWDTTQNLFIEGDNL EILKLLQKSYYKKVKMIFIDPPYNTGNEFIYPDKYQDNLSTYLHYTGQIDNEGFKFST NSETSGRYHTNWLNMMYPRMKLAKNLLKDDGVIFISIDDNEVANLRNICDEIFGEENF VAKIPWRKRTAKSDVPFGVSQDYEWILCYAKTDQFKASKKGSPRKYYESPDFPNKPWR IHDMTKQTSASERPNSYFTMVNPKTGEEYPANPNNVWRITKDTFQKYYEESRIIFPGD YAFLKISNPVLRYFKEDDQKNAGDLFGFVPLSTHLPTTVGMTQDGTKEMNQLFQSKNF PFPKPVNLIKYFIECVSAIDKSAIIFDFFAGSCTTAHAVLDLNKEDGGNRKFIMVQLP EPCDKDSEASKAGYKTIAEIGKERIRRAIKKIKEESPDYKGDLGFKVFKLDSTNIKPW DVDEDNLQTILEDYISNIKDGRSEHDVLYEILLKYGLDLTLPVEERKIAGKNVFVIGA GALIICLDDDITLDVVEGIVKLKEELQPEIVRVVFKDLGFKGDVVKTNTLQILKLAGI DDVKSI" gene 9085..12087 /gene="" /locus_tag="" /db_xref="119584..122586" CDS 9085..12087 /gene="" /product="restriction endonuclease" /translation="MKIHFDPNLDFQHEAISAITGIFEGQEICKTNFTVAPLKYDPQM KLPNEPQKDLGIGNRLLLLEEDIHNNVRSIQLRNGLAPSESLKSFDFSVEMETGTGKT YVYLRTIFELNKLYGFTKFIIVVPSVAIKEGVYKSLQITEEHFKALYDNVAFDYFVYD SQKLGQVRNFATSDTIQIMVINIDAFRKSFSDPEKEDKANIIHRPHDRMTGSRPIEFI QATDPIVIVDEPQSVDRTQKSKEAIASLNPLCTLRYSATHVDKHHMVYKLDSVDAYER KLVKQIEVAGIEVQDSHNKAYIKLLKVDNTKGKINAQIELDIQQKDGSVKRTNKTVHQ GDDLLEISNGRSVYDGYIINDIYCEKGNEYIDFTSKPEILRLEQIVGNVNPDEYKLLQ IRKTIEEHLEKELRLTSKGIKVLSLFFIDRVANYRSYDEHGNPEKGKFAKMFEEEYIK TISKPKFRALLNGNDPEVACQGVHNGYFAIDKKKDSSGNEILKDSSGEGKTQADENAY QLIMRDKEKLLSFDSKLKFIFSHSALKEGWDNPNVFQICTLNETQSAMKKRQEIGRGL RIAVNQNGERVHGFEVNTLTIMANESYEKFAEALQKEIEEEEGIKFGVVEKHLFANII IPAETNTVTHLGFEASEQIWQHLKSKGYIDVKGKVQNKLISDLKTGSLDIPEKFKDNA DKIGTALKKVAGNLNIKNAADKKKISLKRAVLDSQEFKELWDRIKYKTTFRVDFDSDK LIQICAEEIKKSLSVGKARFKFRKAKTEIDRGGVHANLISETSHTYESKDFVLPDIIT YLQNETNLTRKTLVQILLQSERLSEFSNNPQKFIEQVSAIIKNQMRLFIVDGIKYEKI GDEHYYAQELFEEKELCGYLNKNMLQSKKSVYDHVVYDSDVEAEFAKSLELNQDVKVY AKLPDWFKIDTPLGSYIPDWAVLVDKDGQMKLYFVVETKGSILNNALRPTEQGKIDCG REHFKALGTNVGFTVASNYESFENELSK" gene 12241..13563 /gene="" /locus_tag="" /db_xref="122740..124062" CDS 12241..13563 /gene="" /product="hypothetical protein" /translation="MPITLDNSSKEILIENMTISNPDVFNFLCDKDNREEWIERALIV GCAGLKQMILTDNVDYVEKKFNDFLQQARDVFKEQSEEVTQKIDDTFSLEKNTSPLYK LQSLILDYFDEDNGKFKVLVDGYFNKDGGEVRKLLDQSFDLKNTDSPFYQLIKNIEEA TGKDENAIKELLDPHKTDSPAEKLKREIFLKFKELKEQEMQQLNERIKEMREQELKDI RDVVLKAEAVAEEKERGTAKGFDFEELVYNSLLEMSSSFEDEVEAVGRSAGRSAKKGD IVIDIDGDEKCRIVVECKDAGGYTAKKTMEEINEAIDNRNAAYGIFLFAKQEQMPSQF NCVKITDSYLITYMDNENLHFAYRLARTLLKHQQTHTYSVETAKISSEVQKIEELIKN INTMQGKVTQIINSGEYLKVELKKLYEGVDFSLNRIDSYLGSEKAVAE" gene 13645..13869 /gene="" /locus_tag="" /db_xref="124144..124368" CDS 13645..13869 /gene="" /product="hypothetical protein" /translation="MHKTRNYYSMKSAHIFKNPRRSGSKKDAPKTIYPSEDSLDPAFV KEVEHRRQEVQNGKGIRFDTAEDLFTNLEK" gene 13866..14129 /gene="" /locus_tag="" /db_xref="124365..124628" CDS 13866..14129 /gene="" /product="addiction module toxin, RelE/StbE family" /translation="MTYQIILSPDFEKDTKVLFKKDPALYDRFKKTVYNILENPFCGK PLRNVLKGLRRVHVGHFVLIYELDETHRTITLLSFTHHDKAYK" gene complement(14196..15326) /gene="" /locus_tag="" /db_xref="124695..125825" CDS complement(14196..15326) /gene="" /product="hypothetical protein" /translation="MNRYPYDSLEILAQAEWHFKKDTAFDRAMACIAFDNSIEFSITT YLQQDYSPDEKYIQYDNNYETYLSSHEQKLEFFAEYLQKNDLQCDFTIDDFKKMHVHA GWFFVPNPHYPGYFDTPAKEWAEAYRKAAIQVFNAFYGADTENLLLRMEQEYGKEMNY RMSNKMNLGISSDIVEVTKTLKDLEAYLKFALSVMEIVPYNSELSLLALWRLFFTHVE SASEEMDNAVFRAVSIEKALEYEGSVNLRMQIIHNIMDEVNKIVAFVKDYPMSSNIVH ELRQRHSRWLRPEIIAVHIVQKPCVVLLETKTYSDQTETITRENLSDIMSSFSAKSTA VENAKIFMDLDSCSISMVTKLLVPEAEKEIAEIYNTKFYNIM" gene complement(15548..18889) /gene="" /locus_tag="" /db_xref="126047..129388" CDS complement(15548..18889) /gene="" /product="molecular chaperone of HSP90 family" /translation="MTNVIYDVIREENIGLYGTAVNEYGPTLLTELYSEKTHFIYELL QNAEDAYERLNKEDTRIKSVHFELYNDRLEIRHNGIPFDEEDIKGICRLASGTKKQDI SQIGKFGIGFKSVYAYTKSPEIYSGHYCFCIKNYVHPYSINQRNDIIKGQTLFVIPLN NDKINQKDSYLEIKSKLIGLGARTLLFLKNIEEITWKIDGTYGKYYKKSNHETTYSRA ILYSESNVSVISIENWLKFSRTISNECNNKSSVEIAYLVQNDENSKKEQIISADNTQL VVFFPTDKKTGLSFLIQGNFQTTTSRDNIFSNDWNKLLIEEIAILTAESLDRIKEMEL LDVSFLQTLSIDINALRYNSTFLPISKKIKEKFLGDNALLPTYNGGYVTAKQAILANS QSLRELLSSKQISDLLHRENLQWLDGTITKDKTPELRSYLITELSVPEIDPDKFARDF SVDFIEKQSDEWVKKFYIFLLDQKALWKKYYQKGPLLSKEIIRLDNNSHVIPFSEEGK PNAYFPSEFRERFPTIKDNIANDPKAKEFLEELELQKPDDIAEIIDIILPFYKEDKNL PIDKEVHLQHIEWISKTILSSINSDRKRELLEILRTTPILYAKNICTGEILLKKPLEI YLGEKYTGHRDIETFFEENSNIYLLDSLYSNLNLDRIIFKKLGCKSQINITCKCSEWG NVTISSMHGWHKRSLNGFDPDSEIEGLEHALKNITVQKAHILWSILENNSKIISGTVE SSSRQDYSNSTKSEEYSKAGKLLTEHQWIPDKENNFHLPSDLMLSDLPDEFNIKSPKA KTLAEKLKLKAQFMLEVAEYLKEKCPELEGIINEIQSLDEEDRMKLPELIASLKKTKQ SQKKSSIYSLLGNETESTLEEHKQLSKKSSFSHLSGTQNESTLEKQENLPKKSSPSDI RKKFEKSLSKHGKTYFKNTNNSGWDNSVSPEEEEKIRQKYSDKFHKRLDGIKIKRKNS HLIKTEIYDSIDPKQFLFEQYRGHCQLCNTKLNIGSNQPYFSIYRIVETENAHEWTNM EFNVICLCPNCHALMKNHPNRNLDNILKIAKKILNYEVAPEEVKERKGDYYIIDVVVG GKKQYLYYKPIHMQKIAAFVEKTNN" ORIGIN 1 aactacaaat taattgagtg tagaaaattc aaaaatttta aatatcagga tttctccaaa 61 ttaatgtttc tttgagctta ctttggaata attgaggata agcaccaaag acaggaatta 121 gatggacagt ttcaggatat ctgggatcct cgccaagacc caggcagata tagacttttt 181 tgccgctggt tttctctaca tctctgtatc tgtctaattg ccaggatttg cagatctcac 241 agacaagttg tcctttatca tttctgaaaa gccctgttcg atatttggct tcgatccaga 301 actcttcgcg ggttctttta tccctgaaga gaaaatcagg gttcatactt cgttcttcaa 361 atctctcgct atttgaatta aagtctcttg tcatttccac aaggtcaaat aatttatcag 421 tgaatatctc gtcagaaacg aaattttcga atctgccgcc tttaatttca ggtcttttac 481 ttttgcctgt tacgtcttga agtaattctc caaagaaacc catttttgat accttcgttt 541 ttaggattaa atacattcac aaggagttta aattgaatct cattctattt atattattca 601 gttggtttcg tttttccttt tcatacatga ggatatattt ctatgataaa agggtagatc 661 tctagtggag tttctgggct tgaataatcc agataaaaat tgatcaaaaa atagattcat 721 gtaactaaag cagggaacta cgaagtcttt agtttcctgg acgaaatagg ctcatagaaa 781 aagtatctaa actgccctat catgtaaaca gtaaatgtgt gaaaaagccc atttgcaaca 841 tagctatagc ttaaagaagg gacattttca tttaatccaa tttatttata ttctgcactg 901 agtttttaag tttgtaaatt tacaaatttt gaaacaacga ttattctaat tgaactgcct 961 tataagctct gtctttccca ctcttctctt tcctgttatc aataaaaaat aggaactgtt 1021 ctaattaagc agtcgcgtga gtgccagttc tttttctctg ttgtagaatt gcataatcat 1081 tacttttgta atcatttgtt agatctaggt gatctctgag aaagctaggt atgtaattga 1141 atcggttctg catgaattcc agcaaagaca agtggttaat ttcttatgaa tttcattatg 1201 gatcaaggga cctctgaata atacgaatcc agatcatact gatcatgttc tgtaatttca 1261 ttaatcaaac tcaagagacc agtatcagaa agtataattt gctcatatat cattcagaca 1321 gatagcaaaa ctagtctcat aaagattaaa cggtcgatta aaagtttact tcttcatagg 1381 tacgttttct gaatagaagc gcaatagcaa tcactattat tcgagcattg catgatcttt 1441 ttatttcgac cagtgcctgc tatctccgga aaagaccgca gacataatcg aaaagattaa 1501 tgctaggtta tctatcccag ccacgggata agtcccggcg tgagagaatg cttccctgtg 1561 agacatgtgc acacggaaga aatatcactg aagggcacat ccgtgtaaat gtaaagacct 1621 cggctaaaga tgaggtcatg gacaagatcg aacagcagaa aaggtgtggg cagctagtgt 1681 tcggggatta tgtgcaatgt aaaaatgtga gtgctacaaa atataaaggt agttagtaaa 1741 aatatgactc ctttacatca aattgttttg aactgtaatt ttgaataata agaagaactg 1801 actataatag atagattgtg ccctttcaaa agtacacttt taaaagcatg tactataaat 1861 caaaagagtg actgaatttt ataataataa tgcattgcca tacttctcca ttaatttgaa 1921 gggtaaatct acttttaact atttatagat agcaaattta tatataataa aagcaatagt 1981 gttttaaacg atagtacttc taaactaaat tctcattaac attattggat actacttaga 2041 actgcaaagg aaacataaat catgttatta gataacagga caaacgggaa agttggtgaa 2101 gaacttcgaa aacacattga aaaaggctcc catttgtcag tagtatcagg gcttttctct 2161 atatttggtt attctgagct taaaaaagaa ctagaaaaaa tcgaccattt tcgttttctt 2221 cttccacaaa attcagttga acttaaaaat caaaaagtga atgatttttt tataaaagga 2281 cttactggct cagaaatgga aagaaaattt cgtaataatc tgaatatttc acagattgca 2341 catgagtgtg ccatatggtt aactaaaaaa gcagagatca ggacatcagc tactctgatt 2401 ccgcaaagcc tttatcatat tacgaaaccc aatggagagg aaatagccat acatggtagt 2461 tctccttttt cagcggaagg ctttggattc actccttctg attcttttga tatcaccttc 2521 tgttttacta caggagaaga aaccaagaat cttctaaagt ggtttgattc aatttggaac 2581 aatcaacaga atactaatga tataaagagt attcttatta cacaacttga aaaaatatat 2641 tctgataaat caccatcgtt catttatttt attgttcttt tcaatgtgtt caaagaatat 2701 cttggagaaa ttaaggaaga aaatataata aaaacaaaaa ccggaataaa ggatacactg 2761 atatggaaca aactttatag atttcaacgt gatggtgttc ttggagcaat cgataaaatt 2821 gaaagatata acggttgcat aattgcagat agtgttggac ttggaaaaac atttgaagct 2881 cttgctatca taaaatatta tgaattgaga aacgatcgag ttcttgtact ttgcccaaag 2941 aagttacgtg aaaattggac actttatact gtcaatgaca agcgtaatat tctggcagct 3001 gatcgtttta attatgatgt gttgaaccac accgatctta ctcgctccaa aggttattct 3061 ggcgagataa atcttgaaac aattaattgg ggtaattatg atctagttgt gatcgatgaa 3121 tcacataatt ttaggaataa tccaccgcgt aaggatggac ttacccgtta ttctagattg 3181 atggccgaaa taataaaagc aggagtcaga acaaaagttc tgatgctttc tgcaacacca 3241 gtaaacaatc gcatgaatga cctaaagaac caggttcttt ttatcacaga aggagtagat 3301 catgctcttg agcctcaggg tattataagt atagaacaaa ctcttaaaat ggcacaggca 3361 cgttttaatc agtggttgaa acttaaagaa gcagaccgta ccactgaatc attgcttgat 3421 actctgaatt tcgactactt caagcttcta gacctgctca ccattgcacg ctctaggaag 3481 catattgaaa aatactacga tgttgctgag attggcaggt ttcctatacg cgcaaaaccc 3541 atcaatatca aagcttatat tgacacagaa aacaggtttc ctgccctcgg agaaataaac 3601 cgtgatatcc ggaggctgaa tctgagtgca tatgcacctt taaaatatgt tcttcctcag 3661 tatatggata aatacagccg caaatatgat atgaaacttg ctggtggatc tgtttttaag 3721 caaatcgatc gtgaggaaag cctcatacat ctcatgcgtg tcaatctttt gaaacgtatg 3781 gaaagttcaa tcaattcttt ttcacttacc gtggaaaaac tgctatctga agttcgtcgt 3841 ataatagaac ttcttgattc tcatgatgat ttggaattca aagagctgga tattgaagag 3901 atagagatag aaaatgagga gttctcactt tatgctgtcg ggaataaagt aaaggttctc 3961 atacaagatg tggaccgtat acgctggaaa caggagcttc aggaagatga agaactgttg 4021 caaaaggtgc tttttgcggc taagcagata gaccctaaca gggatgctaa actcttgcag 4081 ttaaaagatc tgataaataa aaaagtatct gaccctataa acgagaataa ccataagatc 4141 atcatcttta cggcttttgc tgacactgca aggtatctct acaacaatgt tgccgattgg 4201 tcaaagacct cattaggtct tcattgtgca atagtcacag gaactggtga taataaaaca 4261 actatgccag gaatacgcaa ggatatggca tctataatta cttctttttc acctatttcg 4321 aaagagagaa gtctaattag ccccgaactt tcggatgaga ttgatattct aattgctaca 4381 gattgtatct ctgagggtca gaacctgcag gattgtgatt tcttagttaa ttatgacatc 4441 cattggaatc cagtacgtat aatacagaga tttgggcgta tcgatcgtct tggctcaaag 4501 aacgaagtga tacagcttgt caacttctgg ccgaatatgg agcttgacga atatataaat 4561 cttgaagcaa gggtttcagg aaggatggta cttcttgata tctctgcaac cggtgaagag 4621 aacgttatcg agtattcaga tgctggtaaa atgaacgatc ttgaataccg tcgtaaacag 4681 ctagaaaggc ttcaggaaga ggttgttgat attgaggatc tgggtggggg tatctctatc 4741 actgatctca cgttcaatga ttttagaatg gaccttgctg aatatatgaa gataaattca 4801 agagtccttg agcacatgta tcctggaatg ttctctgtgg tcagcttgga tgatataggt 4861 gaggaagggc tgaagcctgg tgtgatattt tgtatgcgta atgagaacaa tgcaattaaa 4921 actgacagta cttatgcatt atcacctatt tacctcgtat atgtttctga taatggtgaa 4981 gtgttattga acttcacaca tgcaaaaagg atactggacc ttttcaagaa gatctctatt 5041 aacagatcga taccagatag aactgctgtt tcattgttca atggctatac acacaatgga 5101 accaatatga gccattatag gaatttattt gggaaggctg ttgcagcaat cactggcaaa 5161 gcagaggagt atggtgttga gagtcttttc cacaggggag ggaccgtgat caacaaggat 5221 tctttcaagg gtattgatga ttttgaggta attgcttatt tgataatact tgataaggag 5281 gttttaaaat gaatgatata ctggttagta tgattgacct tcctgaatct gcttatctgg 5341 gtaagcgggt atcaaagaaa cttttttttg ataatggtgc acttacaaca gctgataaaa 5401 agctctttca ggatgatgta gaatcgattg tgtggcaata tggtcttaaa cctaataaca 5461 ttcaagtaaa accatatact gatgaacaaa gagaatatct tgaagtggct atactggata 5521 tagtgctacg ttcaccgaaa agctataaac gattggctga ggtgatccat cgaacaatac 5581 cctatccttt attattggta ttttctctaa atcaggttgc ttctacacaa gatttgcaag 5641 tggaagatga tctggagtca cgttttataa gcaatggatc aaaaatatcg ttaagtgtag 5701 ctcctaaaag attcagtttg gcagaaaaag gagcaatagt ggctgaagag ttcttcacaa 5761 ctgaatggat ggacatggaa tcactaactg acatcgaacg gttgttcctt gagaatctga 5821 acatcaaaga tcttccacat actgatttct ttgacttgta tgatgcactt atcgaccgtt 5881 tcattgcatt tgattgtgct tctttcagcg gtgaattccg gcttaatggc aaacatgacc 5941 ctgaaatgct acgggagcaa cttgctatgt gtcacgaact caaaggaaag atatctgaca 6001 tgcgtaaaaa gttgagttct gaaacgcaat tcaataacaa acttgaaatt aacatgaaaa 6061 taaaacaaat ggagacgcaa ttaaaggcta tatcaatagg actttgatgg aggaaataga 6121 ggatgcaaaa acttgacgca aaaacagatg gtaaaagcat ggatgttgtt gaaggtattg 6181 tcaaatgaag gaagaattgc agcctgagac agtgcgggtc gtgttcaagg attcgggatt 6241 caaaggagac atgcaagact aacttcacag tagtactgct caaatatgaa tattagataa 6301 aacttgagca taacagagaa ttttttcaaa agcagtacca tacattaaca cctagagtga 6361 tttgatggag ataaaagaat atagagtccc tttcaatggg aagatatttc gcagtattga 6421 atttaatttt agaaataatc catccgataa gttgacattg gatagtttaa ttgaaaaggg 6481 tataattttg gctaaaaaag taaatccaat acttgcacgc gattcaagct tagctagaga 6541 taataatatg aaaataaagg attgtatagg aggagctatt gctgaatatt gttggagaac 6601 ttggctaaat cagtatttcg aattaaatag gatagatatg aaagcacaag aaacttcttt 6661 tgaaaatgct aaaaaccaaa ttgatatcca aattattaat aacagaggag atattaaaac 6721 cgttgaagta cgttcatctt ttgcctataa aggtgtggat gctgcaatta gtcataattt 6781 taaaattttg ggaccatatt ataacgaaat taaaaaatat gaatatacaa aagactatca 6841 tgttatggtt gtttattcat tttctaaaga tttattaaaa tcacaattgg aatctggtga 6901 tttcaaagta tacctggtag gaggcgcaac tcgaatttta ttgcaaaatt caccttttgc 6961 tttcaatcgc gatttagctc ctcaggacga cattacggaa agattaaacc agcgtgctac 7021 ttacagggtc atcgaaccaa ttgcgaatgg ctatgacact attaaaattt ctgaattaat 7081 cgcaagtatg agtcaattat aattctattt tgtagaactc aaaaagaata ctcggagaac 7141 taattatagg atatatctac agcatatgaa tggaggatac taatgattca aaaacttgat 7201 ttaaaaatag acaataaaag catgaacatt gtttctgcaa atatagaaca attaaagtat 7261 atctttccgg aggtgttcac tgacggaaaa atagactttg atgtacttaa agcgctactt 7321 ggtgaataca tagaagaccg tgacgagcgt tatggtttca actggaatgg aaagagcaaa 7381 gctcgtatga tctcccagac tccaagcata ggaacactgc gcccatgtcc tgccgagtct 7441 attgaatggg ataccactca aaacctcttc atagaaggtg ataatctcga aattcttaaa 7501 cttctccaga agtcctacta caaaaaggtc aagatgatat ttatagatcc tccttacaat 7561 accggtaacg agtttattta tcctgacaag tatcaagata atctctctac ttatctccac 7621 tacaccggtc agatagacaa tgaaggtttc aaattctcta ccaactccga gacttcagga 7681 cgctatcata ctaactggct gaatatgatg tacccacgta tgaaactagc aaagaatttg 7741 ctgaaggatg atggtgtgat tttcatttct attgatgata atgaagttgc aaatttgaga 7801 aatatttgcg atgagatttt tggtgaggag aattttgttg caaaaatccc atggagaaag 7861 agaactgcaa aatctgatgt accatttggt gtttcacaag attatgaatg gatattatgt 7921 tatgcaaaaa ccgatcaatt caaagcatca aaaaaaggat caccaaggaa atattacgaa 7981 tcgcccgatt ttccaaataa accgtggcgc atacatgata tgacaaaaca aacaagtgca 8041 agtgaaaggc ctaatagtta ttttacaatg gtaaatccaa aaactggtga agaatatcct 8101 gcaaatccta ataatgtatg gagaattacg aaggatacat tccagaaata ttatgaagaa 8161 agtagaatta tattccctgg cgattatgca tttttaaaaa tctcaaaccc cgtactaaga 8221 tattttaaag aagatgacca aaaaaacgct ggtgacttgt ttggatttgt acctttaagt 8281 actcacttac caacaactgt tggtatgacc caagacggaa caaaagaaat gaatcaatta 8341 tttcagagta agaattttcc atttccaaaa cctgttaatt tgattaaata tttcattgaa 8401 tgtgtcagcg caatcgataa atctgctata atctttgact tcttcgccgg ttcctgtacc 8461 acagcccatg cagtcctgga ccttaacaaa gaggatgggg gcaatcgcaa gtttatcatg 8521 gtacagcttc cagagccttg tgataaggat tctgaagcat ccaaggcagg ttataagaca 8581 atagccgaga ttggaaaaga gcgtattcgc cgtgctatta agaaaatcaa agaggaatct 8641 cctgattaca aaggggacct tgggttcaag gtattcaagc tggattctac caacatcaag 8701 ccgtgggatg tggatgagga taacctgcaa actatacttg aggattatat aagtaacatc 8761 aaggacggac gcagtgaaca tgatgtgctt tatgagatct tgcttaagta tgggctggac 8821 ctaacgctac ctgtagagga aagaaaaatt gcaggaaaga atgtgtttgt gataggagca 8881 ggagcactta tcatttgtct ggatgatgac attactttgg atgttgttga aggtattgtc 8941 aagttgaagg aagaattgca gcctgagatt gtgcgggtcg tgttcaagga cttgggattc 9001 aagggcgatg ttgttaagac taatactctg caaatactga agctcgcagg tatcgatgat 9061 gtgaagagca tatgaggtgt tcacatgaag atacattttg atccgaacct ggattttcag 9121 catgaagcta ttagtgcgat aacaggtatc tttgaaggtc aggaaatatg caagacaaac 9181 ttcacagtag cacctttgaa gtatgaccct cagatgaaac tgcccaacga accacagaaa 9241 gatcttggaa taggcaatcg acttctattg ttagaagaag atatccacaa taatgtaaga 9301 tccattcagt tacgtaatgg tctggctcct tcggagtctc taaaatcgtt tgatttttca 9361 gtggaaatgg aaacaggaac cgggaagacc tatgtatatc tacgcacgat ctttgaactg 9421 aacaaacttt atggcttcac aaaattcatt atcgtggtcc catccgtggc gatcaaggaa 9481 ggtgtctaca aatctctgca aattactgaa gaacatttca aggcactcta tgataacgta 9541 gcctttgact attttgtgta tgactctcaa aaacttggac aagtacgtaa ttttgctacc 9601 agtgatacta tacagataat ggtcataaat atcgatgctt tcaggaagag cttcagtgat 9661 cctgaaaaag aggataaggc aaacataatt catcgtcctc atgaccgcat gaccggttca 9721 cgtcctattg agttcattca agccacagat cctattgtca tagttgatga accgcaaagt 9781 gtggacagaa ctcaaaagag taaggaagca atagcttccc ttaacccact gtgcacattg 9841 cgttactcag caacacacgt tgataaacac cacatggtct ataagctgga ttcagtggat 9901 gcttacgaga gaaagctcgt caaacagata gaggtagccg gaatagaggt tcaggacagt 9961 cacaataaag cttacatcaa actgctaaaa gtggataaca caaaaggaaa gatcaatgcc 10021 cagatagaac tggatatcca gcagaaagat ggctctgtaa agcgtacaaa caagacagtt 10081 catcaggggg atgacttact tgagatatcc aatgggcgca gtgtctatga tggatatatc 10141 atcaacgata tctattgtga aaaaggaaat gaatatattg acttcacaag caagccagaa 10201 attcttcgct tagagcagat agtcggtaat gttaatcctg atgaatataa actcctgcag 10261 atcagaaaga ccatagaaga gcatctcgaa aaagaattgc gtttgacatc taaaggcatt 10321 aaagtactga gtcttttctt tatagaccgc gtggctaact atcgatccta cgatgaacac 10381 ggtaaccctg aaaagggtaa atttgctaag atgttcgaag aagaatacat caagacgatc 10441 agtaaaccta aatttagagc tcttcttaat ggaaatgatc cggaagtagc ctgtcagggc 10501 gtacataatg gttattttgc cattgataag aagaaagatt cttctggaaa tgaaatactc 10561 aaggattcgt caggtgaagg aaagacccag gccgatgaaa atgcatatca attgataatg 10621 cgtgataagg aaaaactact tagctttgat tctaaattaa aattcatctt ttcacattca 10681 gctcttaagg aaggatggga taatccgaac gtcttccaga tatgcaccct caacgaaacg 10741 cagtctgcca tgaaaaagcg acaggagata ggacgtgggt tacgcattgc agtgaatcag 10801 aatggtgagc gtgtccatgg ttttgaagtt aatacactca caatcatggc taatgagtcc 10861 tatgaaaagt ttgctgaagc cctccagaaa gaaatagaag aggaagaagg aatcaaattt 10921 ggagtagttg aaaaacattt gtttgcaaac ataataatcc cagctgagac caatacagta 10981 actcatcttg gattcgaggc atctgaacag atatggcaac atttgaaatc caaaggttac 11041 attgatgtga aaggcaaggt gcagaataag ctgatttcgg atctgaaaac cggtagtctt 11101 gatataccgg agaaattcaa ggacaatgca gacaagatag gtacagcatt gaagaaagta 11161 gccgggaatt tgaacatcaa gaatgcagct gataagaaaa agattagtct gaaacgtgct 11221 gtccttgaca gccaggaatt caaggaattg tgggaccgca ttaagtacaa aaccactttt 11281 agggtagatt ttgattctga caagctcatt caaatatgtg ctgaggaaat aaaaaaatct 11341 ctcagtgttg gaaaagcacg cttcaaattt agaaaagcaa aaacagagat tgatagagga 11401 ggagttcatg caaatctgat atctgaaaca tctcatacgt atgaatctaa agattttgtc 11461 cttccagata tcatcacgta tctgcagaat gaaacgaatc tgacccgaaa aacattggtt 11521 cagatactct tgcaaagtga acggctttct gaattcagta acaatccaca aaagttcatt 11581 gaacaagtat ctgctattat aaaaaatcaa atgagattgt tcattgttga tggtatcaaa 11641 tatgaaaaga taggcgatga acattactat gctcaagagc tgttcgaaga gaaggaattg 11701 tgtggctatt taaacaagaa catgcttcaa agtaaaaagt cagtctatga tcatgtagtt 11761 tatgattcag atgtggaagc tgaatttgca aagtcccttg aacttaatca agatgtaaag 11821 gtatatgcaa aacttccaga ctggttcaag attgatacac ctttaggtag ctatattcca 11881 gattgggctg tacttgtaga taaagatgga caaatgaagc tgtattttgt ggttgaaaca 11941 aaaggaagta ttcttaataa tgctctgagg cccacagagc aaggtaagat tgattgcggt 12001 cgtgagcact tcaaagcatt aggtacaaat gtagggttca ctgttgctag caattatgag 12061 tcttttgaaa atgaactttc taagtgaaag aattgaagtg aaaaacactt caattctccc 12121 tctgctctca ttttctattt atgacttaaa tttatccaat taaaagtaat tatataaata 12181 tattaatatt tatctactat tgttcctata cttcacttat aattctacgg agacacccca 12241 atgcccataa cacttgacaa ttcttccaaa gagatcctga tcgagaatat gaccatttca 12301 aatcctgatg tctttaattt tctatgtgat aaggataaca gggaagaatg gatcgagaga 12361 gccttgatag tcgggtgtgc gggactcaag cagatgatcc tgaccgataa tgtggactat 12421 gtggaaaaga agttcaatga ctttttgcag caggccaggg atgtttttaa ggagcagtct 12481 gaagaggtca cgcagaagat cgatgatact ttcagcctgg agaagaacac gagtcctctc 12541 tacaagcttc aaagcctgat cctggattat tttgatgagg ataacggcaa gttcaaggtc 12601 ctggtggatg gatatttcaa taaggatggt ggcgaggtcc gcaagcttct ggaccagtcc 12661 tttgacctta agaacactga cagtcctttc taccagctga tcaagaacat tgaagaggcc 12721 acaggcaaag atgagaatgc cataaaagag ctcctggacc ctcacaagac agattccccg 12781 gctgaaaagc tcaaaaggga gatattcctg aaattcaagg aactcaaaga gcaggaaatg 12841 caacagctga atgaaaggat caaggagatg agagagcagg agcttaaaga tatccgggac 12901 gtagtgctca aggcagaggc ggttgcagag gaaaaagaaa gaggaactgc taaaggtttt 12961 gactttgaag agcttgtcta caactcgctc ctggagatga gttcaagctt tgaggatgaa 13021 gtagaagcgg ttggcagatc tgcaggtagg tcagccaaga aaggagatat tgtcattgat 13081 atcgatggtg atgaaaagtg caggatagtt gtcgaatgta aagacgccgg aggctatact 13141 gcaaaaaaga ccatggaaga gatcaatgag gccatagaca acaggaacgc tgcctatgga 13201 atattcctct ttgccaagca agagcaaatg cccagccaat tcaactgtgt caagatcaca 13261 gattcatacc taataacata catggataat gagaacctgc actttgccta caggcttgca 13321 agaacgctgc taaaacatca gcaaacacat acatattcag ttgagacagc caagatctcc 13381 tcagaggtcc agaagataga ggaacttatc aagaatatca acactatgca aggcaaggtt 13441 acccagatca tcaactcagg cgagtacctc aaggtggagc ttaagaaatt gtatgagggc 13501 gtggacttca gtctgaacag gatagattca tatctgggga gtgagaaggc tgttgcggag 13561 taaaaatatc attaacaact gatttaggtt actttatttt attcttgaaa aacaagtatt 13621 catacaaaac atcaatatgt ttatatgcat aagactcgaa actactatag tatgaaaagt 13681 gctcatattt tcaaaaatcc tcgcagatca ggaagtaaaa aggatgcgcc aaaaacaata 13741 tatccttcag aggattcttt ggatccggca tttgttaaag aggtcgagca cagaagacaa 13801 gaagtccaga atggaaaagg tattagattt gataccgcag aagacctttt tacaaacctt 13861 gaaaaatgac ttatcagatc atcttatctc ctgattttga gaaagataca aaagtcttat 13921 ttaaaaagga tcctgctcta tatgatcgtt ttaagaaaac ggtttataat atattggaaa 13981 atccgttttg tggaaagcca ctacgcaatg tgctaaaagg gcttcgcaga gttcatgttg 14041 ggcactttgt actcatatac gaactcgatg aaacccatag gactatcaca cttttgagct 14101 tcacacatca cgataaagca tataaataac aaaaaacgct atgcttaagt atgttttcac 14161 aaattcgtat cttctctatt tttgatggtg taaaatcaca ttatattgta aaactttgta 14221 ttatagatct cagctatttc cttttctgct tcaggtacca gcagtttggt caccatggag 14281 atagagcaag aatccaggtc catgaaaatc tttgcgtttt ccactgcggt agattttgca 14341 gaaaaagagc tcatgatatc cgataggttc tctcttgtta ttgtttcggt ctgatcagaa 14401 taagtctttg tttccaaaag gacaacgcac ggtttctgca caatgtgcac tgcgattatt 14461 tctggtctca accaccggga atgcctttgt cgcagttcat gtacgatatt ggatgacatg 14521 ggataatctt tcacaaaagc aacaatctta ttgacctcat ccatgatgtt gtggataatt 14581 tgcatgcgca gattcacact gccctcatat tccagagctt tttctatgga aactgccctg 14641 aaaactgcat tatccatctc ctcagatgca ctttcgacgt gggtgaagaa cagtctccac 14701 aatgcaagca aagaaagttc cgagttgtac gggacgatct ccattacaga aagagcgaat 14761 ttcaggtatg cctccagatc tttaagcgtt tttgtaactt caacgatatc cgaggaaata 14821 cccaggttca ttttgttgct catcctgtaa ttcatctctt tgccatactc ctgctccatg 14881 cgaagaagga gattctcagt atctgctccg tagaatgcat tgaatacctg tattgcagct 14941 ttcctgtaag cttctgccca ctccttagca ggagtatcaa aataccccgg ataatgagga 15001 ttaggcacaa agaaccatcc ggcgtggaca tgcatctttt tgaaatcatc aatggtaaag 15061 tcgcattgca gatcattctt ctgcagatat tcagcgaaga attcgagctt ttgctcatga 15121 ctgctcaggt aagtttcata gttgttgtca tattggatgt acttttcatc aggcgagtag 15181 tcttgctgca ggtaagtggt tatcgagaac tcgatggaat tgtcgaatgc tatacaggcc 15241 attgccctgt caaaagcagt atcttttttg aaatgccatt cagcctgtgc taatatttcc 15301 agagaatcat atggatatct gttcattttt aaccctccag ccctgaaaga aagacaatgt 15361 atgtttttca tcgttttttt ggtaatgatt tatatttatg agttaataga tagtatatta 15421 tagtgaatag taagtatata attttatcta tttgtgttta caatttaaga gtatatctaa 15481 aacgaatgta tatgaagact actctaacat caataaaatt atactgcaat aggtttagta 15541 ataaatctta attatttgtt ttttcaacaa aagcagctat tttttgcata tgtatgggtt 15601 tataatatag atattgcttt ttgcctccaa caacaacatc gattatataa taatctccct 15661 ttctttcttt aacttcttca ggtgcaactt cataattcag tatttttttt gcaattttta 15721 aaatattgtc cagatttctg tttggatgat ttttcattaa agcatggcaa tttggacata 15781 aacatataac attaaactcc atattagtcc attcatgagc attttcggtc tcaacgattc 15841 tataaatgga aaaatacggt tgattgctac ctatatttaa ttttgtgtta cataactggc 15901 aatgtcctct atattgttca aataaaaact gttttggatc gatgctatca tatatttcag 15961 ttttaattaa gtgactattt tttcttttga ttttaattcc atcaagccgt ttatggaatt 16021 tatcactata tttttgacgg attttctctt cctcttctgg agaaacacta ttatcccacc 16081 cggagttatt tgtatttttg aaataagttt ttccatgttt actaagagat ttttcgaact 16141 tcttccgaat atcggatggt gatgatttct ttggtaaatt ttcttgtttc tccaatgtgc 16201 tttcattttg agttccagac agatgagaaa atgaggattt ctttgataat tgtttatgtt 16261 cttctagtgt gctctcagtt tcgtttccaa gtagactata tattgatgat ttcttttggg 16321 actgctttgt ttttttcaaa gatgcgatta gttctggaag tttcattcta tcttcttcgt 16381 caagtgactg gatttcatta ataattccct caagttctgg acatttttct tttaagtatt 16441 cagctacttc taacataaat tgagccttta gtttaagttt ttctgcgaga gtcttagctt 16501 ttgggctttt tatattgaat tcatctggca aatctgataa cattaagtct gatggaagat 16561 ggaagttatt ttctttgtcg ggaatccatt ggtgttcagt tagtaactta cctgcttttg 16621 aatactcttc tgattttgta gagttcgaat agtcttggcg acttgaagat tcaactgttc 16681 cagaaattat tttggaatta ttctctaaaa tactccataa gatatgtgct ttctggacag 16741 tgatattttt taaagcatgt tctaatcctt caatctcact atctggatca aatccattta 16801 aacttcgttt atgccagcca tgcatactag aaattgtaac atttccccat tcgctacatt 16861 tacaggtaat atttatttga gatttacacc ccaacttttt aaatataatt ctgtctaaat 16921 tcaaattgga atataaacta tctagaaggt aaatattaga attttcttca aaaaaagtct 16981 ctatatccct gtgacctgta tatttttcac caagatagat ttctaaaggc ttctttaata 17041 aaatttctcc tgtacagata ttttttgcat ataatattgg cgttgttctt aatatctcca 17101 acaactctct ttttcggtct gaatttattg atgatagtat cgtttttgaa atccactcta 17161 tatgttgtaa atgtacttct ttgtcaattg gcaagttttt atcttcttta tagaaaggca 17221 atattatatc aattatttct gctatatcat caggtttttg taattccaat tcttcgagaa 17281 attcttttgc ttttgggtcg ttggcaatgt tatcctttat agttggaaaa cgttctctga 17341 attcggatgg gaaataagca ttaggttttc cttcctcact aaagggaata acatgggaat 17401 tgttgtctaa ccttatgatt tcctttgata gaagagggcc tttttgataa tatttcttcc 17461 acaatgcttt ttgatctaaa agaaaaatat agaacttttt tacccattca tctgactgct 17521 tctcaataaa gtcaacagaa aaatccctcg caaacttgtc tgggtcgatt tcaggaacag 17581 aaagttcagt aattaaataa gatcgaagtt caggagtttt atcttttgta atagttccat 17641 caagccattg aagattttca cgatgcaaca aatcacttat ctgttttgaa gataataatt 17701 cccttaatga ttgtgagttg gctaatattg cttgttttgc agttacatat ccaccattat 17761 atgtcggaag gagagcatta tcaccgagga atttttcttt tattttcttg gatataggca 17821 aaaaagtaga attataccta agtgcgttga tatctattga aagagtttgt aaaaaagaga 17881 cgtcaagtaa ttccatttct ttaattctat cgagactctc tgcagtaaga atagcaattt 17941 cttcaattaa taatttattc cagtcattac taaatatatt atcacgggaa gtggttgttt 18001 gaaaattacc ttgaatgagg aaactaaggc cagttttttt atctgtaggg aaaaaaacca 18061 ctaactgagt gttatctgca gaaataatct gttctttttt tgagttctcg tcattttgaa 18121 ctaaatatgc aatttctaca ctcgatttat tattacactc atttgaaatt gttcggctaa 18181 atttaagcca gttttcaata gatattacac ttacattaga ctctgagtaa agtatggctc 18241 ttgagtatgt tgtttcgtgg ttcgattttt tataatattt tccatatgtt ccatcaatct 18301 tccacgtaat ctcctctatg ttttttagga ataaaagtgt ccttgctcca agaccaatta 18361 atttagattt aatttccaaa taggaatctt tttggttaat tttatcgttg ttcagaggta 18421 ttacaaagag agtttggcct ttaattatgt catttctctg atttattgaa tacggatgca 18481 cgtagttttt aatgcagaaa caataatgtc cactgtatat ctcaggtgat ttggtatatg 18541 cataaacaga tttaaaacca attccaaact tcccaatttg agatatatct tgttttttag 18601 ttccactggc caatctgcag atgcctttta tgtcttcttc atcaaagggt attccattat 18661 gtcttatctc taatcgatca ttatataact cgaaatgaac tgattttata cgtgtgtctt 18721 ccttatttaa tctctcataa gcatcctcag cattctgtaa aagttcatat ataaagtgag 18781 ttttttcact ataaagttct gtcagtaatg taggtccata ctcatttaca gccgtaccat 18841 aaagtccaat attttcttct ctgataacat cataaataac attagtcat //