LOCUS NC_019970:6 18302 bp DNA linear BCT 16-MAR-2013 DEFINITION Thermoanaerobacterium thermosaccharolyticum M0795, complete genome. ACCESSION NC_019970 SOURCE Thermoanaerobacterium thermosaccharolyticum M0795, complete genome. COMMENT locus start: 743497; locus end: 761798 COMMENT n1_4mer:GRV/n1_4mer:RV = 2.738652; n0_4mer:D = 21.074497; n0_4mer:PS = 39.651602 FEATURES Location/Qualifiers source 1..18302 /organism="Thermoanaerobacterium thermosaccharolyticum M0795, complete genome." gene 1..3435 /gene="" /locus_tag="" /db_xref="743497..746931" CDS 1..3435 /gene="" /product="DNA-directed DNA polymerase III PolC" /translation="MFVHLHVHSEYSLLDGSCRIKELVKRAKELDMDSIAITDHGVMY GAIEFYKEAKSQGIKPIIGCEIYVAPRSLYDKEYGIDNLNYHLILLCKNMTGYENLMK IVSKASIDGFYYKPRVDHEYLKNHSEGLIALSSCLGGEIPSYLLSDDYEKAKDTAILY NSIFGKGNFYLELQYHGLSEQEKVNSELIKLSKELDIPIVATNDVHYLDRDDHMAHEV LLCIQTGKNMDDADRMSFPTDEFYLKSSDEMYEMFSYCREALENTEKIAEMCNLEFEF NKTKLPKYDVPNGMTSAEYLRKLCIEGLNKRYANPSQEVIERLNYELSVIEKMGYVDY FLIVWDFIKFARDNGIMTGPGRGSAAGSLVAYCLGITKIDPIKYNLLFERFLNPERVS MPDIDSDFCYERRQEVIDYVVKKYGEDKVAQIITFGTMAARAAIRDVGRALNFPYAEV DAIAKMIPFEPGMTIDKAIGLNPELKEKYENDEKIRQLIEISRSLEGLPRHASTHAAG VVISSEPLVKYVPLQKNEGSIVTQFTMTTLEELGLLKMDFLGLRTLTVIRDTLNIIKE TRSIDVDIDNIDFEDKEVYALISKGDTEGVFQLESSGMKQFMTELKPEKLEDIIAGIS LYRPGPMDQIPRYIENKNHPENIKYEHPLLKPILDVTYGCMVYQEQVMQIVRDLAGYS LGRSDLVRRAMAKKKMKVMEEERKNFIYGIKDESGNYVVPGAINKGVDEATANRLFDE MIDFANYAFNKSHAAAYAVVAFQTAYLKRYYPVEFMAALLNSFVDNTDKVAFYVQVLK KMGIQVLPPDINESYSHFSVVNGKIRFGLAAVKNVGINATLEIVEDRKKNGRYTSIVD FFERIDDKQLNKKAVESLIKAGAFDSFGVYRSQLLAVYEDIMDSIHKNRERNIKGQMS LFGSEIERNEVKYSLPDIKEFSQDMILSMEKETMGLYISGHPLDEFQEDIQRVANCTT RDLKNGDDTFVKKSIFDNQDVVLAGIIESKKIKFTKNNNMMAFVNLEDLYGTIEVIVF PTVYERYSKFLREDLPVIIKGKVSLKEEEEPKILCDEIEPLTHKVREKLWLNVKEQKD IEKIKGVLSRYRGNIPVFIKYTNKSLAAKKDLWVNGTNELLDELVSILGKENVKIV" gene 3509..3706 /gene="" /locus_tag="" /db_xref="747005..747202" CDS 3509..3706 /gene="" /product="hypothetical protein" /translation="MWTVIYMAHSMEIAEKVKDILTKEGFLVKLKPLKKNVDNSEGYC EVMVPNSEAQDAQNTIIEYGL" gene 3777..4742 /gene="" /locus_tag="" /db_xref="747273..748238" CDS 3777..4742 /gene="" /product="6-phosphofructokinase" /translation="MKTIGVLTSGGDAPGMNAAIRAVVRCGIYNGLTVKGIMRGYQGL IDDEIEDMTLSSVGDIIQRGGTILRTARSAEFKTKEGRAKAAEVLKKHGIEGLIIIGG DGSFRGAQLLSNEHGVNTIGIPGTIDNDIPCTDYTIGFDTACNTAIDAINKIRDTATS HERANIIEVMGRNAGYIALYAGLAGGAEIIIIPEVKFDIDEVCDKISYGIKRGKLHHI IVLAEGVMSGLELSKMIQERLPKLDLRHTTLGHIQRGGAPSVMDRIIASQMGARAVEL LLENKSQRIISIRNNQIVDDDIDTALAMRKEFNFKLYELSKILSI" gene 4754..6505 /gene="" /locus_tag="" /db_xref="748250..750001" CDS 4754..6505 /gene="" /product="pyruvate kinase" /translation="MRRTKIICTIGPASEKYEILRELIESGLNICRLNFSHGDHEEHG SRIDNIKKIREELQLPIAIMLDTKGPEIRTGKFKNGVAELKEGQTFTITSRDVEGDDT ICSVTYKGLPQDVERGSRILIDDGLVSLKVNDVKGEDIICIVENSGTIGDHKGVNVPG TKLNLPAITQKDVDDIEFGIKKGIDMIAASFVRKAADVIAIRRLLEDNDAGHILIISK IENREGVENIDEIIKVSDGIMIARGDLGVEIPIEEIPIVQKRIIEKCNKAGKPVVTAT QMLDSMIRNPRPTRAEVTDVANAILDGTDAIMLSGETAQGKYPVEAFKTMSKIAEKIE TYINYKENMDKNFDYNISMTNAISHATCTTARDIGATAIITSTISGYTARMVSRYRPS APIIAVTPDKGVARRLSIVWGVYPLISQEVSSTDEMIEVSVNTALNEGLIRNGDIVVI SAGIPVATTGTTNMLKVHIVGDVIVKGTGIGTKSISGVVSIIHDPYKDKDKFREGDII VAQKTERDYMPIIEKASAIITEEGGLTSHAAIVGLNYGIPVIVGCEGVTAKLKDGMTV TLDAARGLVYKGIVNIK" gene 6550..6990 /gene="" /locus_tag="" /db_xref="750046..750486" CDS 6550..6990 /gene="" /product="acyl-CoA thioester hydrolase, YbgC/YbaW family" /translation="MNTFDAKIRVRYGETDKMGIVYYANYLNWFEIGRTEFFRSLGMT YKELENNKIMLPVIEANCKYIWSAEYDDVIIIRTKIDFLKGTRIRFAYDIIRENDNKL LAQGMTEHPFTTLDKKPVNIKKVLPHVYEMLNKCYSCTIDTGDR" gene 7203..9311 /gene="" /locus_tag="" /db_xref="750699..752807" CDS 7203..9311 /gene="" /product="glucan 1,4-alpha-glucosidase" /translation="MSRKLIKYLPLLMLASSVLSGCFNNVSSIKIDRFINISAVNGPG EEDTWASAQKQGVGTANNYVSKVWFTLANGAISEVYYPTIDTADVKEIKFIVTDGKSF VSDETNDTISKVEKFTDKSLGYKLVNTDKKGRYRITKEIFTDVKRNSLIMKAKFEALE GSINDYKLYLAYDPHIKNQGSYNEGYVIKANNNEMLMAKRDNIYTALSSNIGWKGYSI GYYKVNDIMTNLDENKQMTKHYDSARGNIIEGAEIDLTKNSEFEIVLSFGGSDSEAAK TALETLGEDYNNLKNNYIDEWTKYCNTLNNFNGKANSLYYNSMMILKASEDKTNKGAY IASLSIPWGDGQSDDNTGGYHLVWSRDLYHVANAFIAAGDVDSANRSLDYLAKVVKDN GVIPQNTWISGKPYWTGIQLDEQADPIILSYRLKRYDLYDSLVKPLADFIIKMGPKTG QERWEEIGGYSPATMAAEVAGLTCAAYIAEQNKDYESAQKYQEKADNWQKLIDNLTYT ENGPLENGQYYIRIAGLPDPNADFTISIANGGGMYDQKEIVDPSFLELVRLGVKSAED PKILNTLRVVDSTIKVDTPKGPSWYRYNHDGYGEPSKEELYHGVGKGRLWPLLTGERG MYEIAAGKDATPYLKAMENFANEGGIISEQVWEDTGLPTDSASPLNWAHAEYVVLFAS NIEHKVLDMPDIVYKRYVSK" gene 9411..10769 /gene="" /locus_tag="" /db_xref="752907..754265" CDS 9411..10769 /gene="" /product="23S rRNA (uracil-5-)-methyltransferase RumA" /translation="LQNVNIGDIYEVYIDNMAHEGQGVGRLDGIAVFVRGALKGERVL AKIDEKHKNYLNAHVEKILLPSQERIMPKCIYAGKCGGCTLQHLSYKGQLEFKKQVVD DSLSRIGKINTIVYDTIGMDNPLYYRDKAEYPVGIEDGNIKSGFYASKSHNIIAIDSC MIQSDYSIEAMKTVREWANNYKISIFDEKSGKGLLRHIITKVGFTTKEVMVILVINGI DIPYKDELINTLKKNIKELKSIVLNINKSRSRLVMGSQNIVIYGDGYITDYIGDKKFE ISPLSFFQVNPIQTKVLYEKALEYADLKGDEIVIDVYCGIGTISIFFAKYVKHVYGIE VVSDAVEDAKRNAAINNVDNADFIAGKAEDVMKDLCNKGLKPNVIVFDPPRKGLDKDV VETSIKMNPKKIIYVSCNPTTLARDLRIFEDNGYKTEKVQPVDMFPYTYHVECVVLMS RL" gene 11092..11685 /gene="" /locus_tag="" /db_xref="754588..755181" CDS 11092..11685 /gene="" /product="hypothetical protein" /translation="MTGTEKLEALIKSSKGVITSKQATNHNIHREYLSEFVRQGKLER IAHGIYITPDVWEDKMLIHQLRKSKMVYSHETALFLHDLTDRDPVAYCVTVPTGYNTS RLKQDGLIVYTIKKELLDLGICTKQTTFGNDIRVYNMERTICDILRDRKNQDVVVVSD ALKRYIRRPDKDLNRLMKYAGILRVEKVLRNYLEVLL" gene 11682..12539 /gene="" /locus_tag="" /db_xref="755178..756035" CDS 11682..12539 /gene="" /product="hypothetical protein" /translation="MNTSTQLKALIRNLSKEKSVQAEIILRNFMLERLLERISLSPFR DKFILKGGMLIAAMVGIDTRSTMDMDATIRGIPLSETALEEVMKAILTCPVDDGVKMT LKGFENIRDESEYPGIRVSIEAILDKTRQVMKVDITTGDRITPRAVEYSFKLLFENRS ISILAYNIETVLAEKLETILSRSTANTRMRDYYDVYILTTLRAQDINWNLLPEAFKNT AEERGSYNHLMETGDDIMGEIEQSQVLAYLWRRYQQKNSYADDLTWAQVIASVKELYI KAFDRDANK" gene complement(12634..13761) /gene="" /locus_tag="" /db_xref="756130..757257" CDS complement(12634..13761) /gene="" /product="transposase" /translation="MMEEEVTQYVGPKGKHNSERKAYRHGKEQGQIVLGGRKVKIEHP RVRTIDGKELVLQTYKMFHDEDILGQMAMERMLYGLSTRQYSKGLEPVGSSLDVKDIS KSTISRHFIERTKTALSEMLTRRLDSLDIVALYIDGVVMADHTVIVAMGLDSDGYKHI LGLWEGATENATICKQLLTDLVDRGLCSDKGLLVIIDGSKALRAAVRDTFGQNALVQR CQVHKKRNVLDHLPENQHDWVKRKLDKAWNIEDASRAEKELKALANELHKDYPGAAAS LLEGLEETLTVKRLGLPDLLTRTLSSTNPIESAFDIVRSLSRNVKRWKNGEQVLRWSA AGLLEAEKHFHRINGYKDIPILREALSWNIDGIKSHEGALA" gene complement(13758..13928) /gene="" /locus_tag="" /db_xref="757254..757424" CDS complement(13758..13928) /gene="" /product="hypothetical protein" /translation="MEVYHNTKVVDKNISPQIMAAACPNINQEQINNLLQAVKEGLLA FSVTVASMLSRP" gene 14116..14538 /gene="" /locus_tag="" /db_xref="757612..758034" CDS 14116..14538 /gene="" /product="ADP-ribose pyrophosphatase" /translation="MKYEISCGGVVFTRKNGKVLYVIIKSPEGYYGFPKGHMEDNETE EQTAIREIYEETGLKVKIIPGFKTIDEYPIPQKEGVMKRVMYFAAEYDNQEISYQKEE LLGAYLMTYEEAMDIFQFESSKRILREVNDFIISGKWK" gene 14900..15154 /gene="" /locus_tag="" /db_xref="758396..758650" CDS 14900..15154 /gene="" /product="prevent-host-death family protein" /translation="MPNIKPISDLRNYNEVLRSIEEGSPVFLTKNGRGRYVVMDMREY EKMQAKLKLLTELAKGEKAGQENGWLTIDELEASLEVTDG" gene 15147..15479 /gene="" /locus_tag="" /db_xref="758643..758975" CDS 15147..15479 /gene="" /product="addiction module toxin, RelE/StbE family" /translation="MVNLKISPKAQKDMLEIKEYISEELGNPTAATNLLAKITKRFRD LMEFPLIGVPLSSVIKIETSYRYLVCGQYTAFYRYENDTVYVDRVLYGRRDFMRILFG DVAKEEDN" gene 15942..16154 /gene="" /locus_tag="" /db_xref="759438..759650" CDS 15942..16154 /gene="" /product="" /translation="LRMLHMSLKHDKPLISGYVEAIEDKIAEGEKANRNLDIILDETK QMSSLVYSMLDLPVLDQGNHQTDYVW" gene complement(16194..17069) /gene="" /locus_tag="" /db_xref="759690..760565" CDS complement(16194..17069) /gene="" /product="nitroreductase" /translation="MDAIDLLKNRRSCRNFSDIPIDDDVLNDILEVGLNAASGGNTQP CTIIKIRDKDRKSKLKDLLGQNFIEKSDTVLVFLLDFYKQKRWCEINKAPYGRNRSFL EFIISLEDVMCVAQSIECACTLKGIGSVYLGTPNLRYEEIKELLELPELTIPVLAMCL GNVKGTLNSRKKLQKDAVIFDEKYKKLNDDEIERYYEEKYQNNNTYINDKNSYLIDEL YNIASMVGGKDFADKVKANVEKNGYINPAQKLFGLHYNPIEMIGMNQWIWNFFKEQGF DFLDETFHINRLDVK" gene 17403..18302 /gene="" /locus_tag="" /db_xref="760899..761798" CDS 17403..18302 /gene="" /product="protein of unknown function (DUF1848)" /translation="MIISASRRTDIPAFYSDWFYNRIKEGYVLVRNPFNLHYVSKVPL SLELVDCFVFWSKNPANMIDNLHIIDRYPYYFQFTLNPYDDKIEKNVPKKSKIIDTFK RLSDKIGPNRVIWRYDPIIVTKAISKEYHYKYFEVLASKLQGYTSKCIISFVDFYPKA KKSLEKIGAFDISDEDKIRIARRIGEIAEAYSLKIETCAEEIDLSQFGIEHGKCIDPN LIKEISGRNIKDEKDKNQRKACGCASSVDIGAYNTCMHRCIYCYANYSSNVVNDNMTR YDVNSPLLCSSITDEDVIAEKNS" ORIGIN 1 atgtttgtac atttgcatgt tcacagtgaa tatagccttc ttgatggttc ttgtagaata 61 aaagaactag ttaaaagagc aaaagaatta gatatggatt ctatcgctat tacagaccat 121 ggagttatgt atggtgctat agaattttac aaagaggcaa aatctcaagg gattaagcct 181 ataattggat gtgaaattta cgttgctcca aggtcattgt atgacaaaga gtatggcata 241 gataacttga actaccattt aatattgttg tgtaaaaata tgactggata tgaaaattta 301 atgaagatcg tatcgaaggc atctattgat ggattttatt acaaacctag agttgaccat 361 gagtacctga aaaatcatag tgaaggatta attgcactaa gctcttgcct gggtggggaa 421 attccgtcat atcttctctc agatgattat gaaaaagcta aagatacagc tattttatac 481 aattctattt ttggaaaagg caatttttat ttagagcttc agtatcacgg cttaagtgaa 541 caagaaaaag taaattctga attaataaag ttatcaaaag agctggatat acccattgtt 601 gcaacaaacg atgtgcacta tcttgataga gatgaccaca tggcacatga agttttatta 661 tgcatacaga caggcaaaaa tatggatgat gctgatagaa tgtcatttcc aactgatgaa 721 ttttacttaa agtcatcaga tgaaatgtat gagatgtttt catattgcag agaagctctg 781 gaaaatactg aaaagatagc ggaaatgtgc aatttggaat ttgaatttaa taagacaaaa 841 cttcctaagt acgacgttcc aaacggcatg acatcggcgg aatacctacg gaagctttgc 901 attgaagggc ttaataaaag atatgcaaat ccaagccaag aggtaattga aaggcttaat 961 tacgaattat ctgtcataga aaagatggga tatgttgact attttcttat cgtgtgggat 1021 tttataaaat ttgcccgcga taatggtatt atgacggggc ctggcagagg ttctgctgct 1081 ggaagccttg tggcatactg ccttgggata acaaagatag atcccataaa atacaacttg 1141 ctttttgaaa gatttttaaa tccagagaga gtcagcatgc ctgatataga ttctgatttt 1201 tgttatgaga gaagacagga agtaattgat tatgttgtaa aaaagtatgg cgaagataaa 1261 gtggcacaga taatcacatt tggtacaatg gctgccagag cagcaatcag agatgtaggg 1321 cgagcattaa attttccata cgctgaagtt gatgccattg caaaaatgat acctttcgaa 1381 ccgggaatga ctatagataa ggcaatcgga ttaaatccag agctaaaaga aaagtatgaa 1441 aatgatgaaa agataaggca gttaatagaa atatccagat ctcttgaggg acttccaaga 1501 catgcttcaa cccatgcagc aggtgtcgtc atatctagtg aaccacttgt aaaatatgta 1561 cctttgcaaa agaatgaagg atctattgtt acacagttta caatgacgac tctggaagaa 1621 ttgggtctat taaagatgga ttttttgggt ttaagaactc taacagttat tagagataca 1681 ttaaacatca taaaagaaac tcgaagtata gatgtagata ttgataatat agactttgaa 1741 gataaagaag tctacgcgtt aataagcaaa ggcgatacgg aaggtgtttt ccaacttgaa 1801 tcgtctggaa tgaagcaatt tatgacagag ttgaagccag aaaaacttga agacataata 1861 gcagggatat ctctatacag acctggtcct atggatcaaa tacctagata tattgagaat 1921 aaaaatcatc ctgaaaacat aaaatacgag catcctctac taaagccaat acttgacgtt 1981 acttacggct gtatggtata tcaagaacag gttatgcaaa ttgtaaggga tcttgcaggg 2041 tactcactag gaaggtctga tttagtccgc cgtgccatgg caaagaaaaa aatgaaggtt 2101 atggaggaag agagaaaaaa ctttatatat ggaataaagg atgaaagcgg aaactatgta 2161 gtacctggtg ccataaataa aggtgtcgat gaggcgactg ctaataggct ttttgatgag 2221 atgattgatt ttgccaatta cgcatttaat aaatcacatg cagctgctta tgctgttgta 2281 gcatttcaaa cagcctattt gaagaggtat tatcctgtgg aatttatggc tgctttatta 2341 aatagctttg ttgataatac agataaagta gctttttatg tacaggtttt aaagaagatg 2401 ggcatacaag tattgccgcc agacataaat gaaagctatt cccatttcag cgttgtaaac 2461 ggaaaaataa ggtttggact tgcagctgtg aaaaatgttg gaataaatgc aacattagag 2521 attgtagagg acagaaaaaa gaatggcaga tacacatcaa ttgtagattt ttttgaaaga 2581 atagatgata agcagttaaa taaaaaggct gttgaaagcc taattaaagc aggtgcattt 2641 gattcatttg gtgtatatag atcacaattg cttgctgttt atgaagatat tatggacagc 2701 atacataaaa acagagagag aaatataaag gggcaaatgt cattattcgg gagcgaaatc 2761 gaaagaaatg aagttaaata ttcacttcct gatattaaag aattttctca agacatgata 2821 ctttcaatgg aaaaagaaac gatggggcta tacataagcg gacatcccct tgatgaattt 2881 caagaagaca ttcaaagagt agcaaattgt acgacgcggg atttgaaaaa cggcgatgac 2941 acatttgtga aaaaatcgat ttttgataat caagatgtgg ttttagctgg aataatcgaa 3001 agcaaaaaaa taaaatttac aaaaaacaat aatatgatgg catttgtaaa cctggaagat 3061 ttatatggga cgatagaggt tatcgtattt cctacagtat atgaaaggta ttcaaaattt 3121 ttgagggaag acttacctgt gataataaaa ggcaaggtca gtttaaaaga agaggaagag 3181 ccgaaaattt tatgtgacga aattgagcca cttactcaca aagttagaga aaaactgtgg 3241 cttaatgtaa aggaacaaaa agatattgaa aagattaagg gagttttgtc aaggtataga 3301 ggaaatattc ccgtatttat aaaatacacg aataaaagcc ttgctgccaa aaaagatttg 3361 tgggtaaatg gaacaaatga gcttttagat gaacttgtca gtatacttgg aaaagagaat 3421 gttaaaattg tataatacat aaatatatat tgatattata caaaaaataa attaaaatag 3481 tagttagaat aatcaaggag gcctttttat gtggactgtt atatacatgg cgcacagcat 3541 ggagattgct gaaaaggtca aagatatact gacaaaggaa ggctttttag taaaattaaa 3601 acctctaaaa aaaaatgtag ataatagtga aggatattgc gaggttatgg ttcccaattc 3661 agaagcacag gacgcacaaa atactattat tgaatatggt ctttaattgc cccttacaag 3721 gggaactttt aataaaatgg gacgcaatag gacccggttg gtaaggagga tatattatga 3781 aaactatagg agtattaaca agtggtggag atgcgccagg catgaatgcc gcaataaggg 3841 cagttgtaag atgcggtata tacaatggac tcacagttaa aggcatcatg agaggatatc 3901 aaggacttat tgacgatgaa atagaagaca tgacattgtc atctgtaggt gatattatac 3961 agaggggtgg cacaatactt cgaacagcca gaagtgctga gtttaaaaca aaagaaggta 4021 gagctaaagc tgcagaagtt ctaaaaaaac atggaattga aggacttata atcattggtg 4081 gcgatggttc tttcagaggg gcacaattgt taagcaatga gcatggagtc aatactattg 4141 gaataccagg tactattgac aacgacatac catgtactga ctatacaatt ggttttgaca 4201 cagcgtgtaa cactgcaata gatgctataa ataagatcag agatacagct acatcacatg 4261 aaagagccaa tatcattgag gtaatgggga gaaatgctgg atacatagca ctttatgcag 4321 gacttgctgg tggagcagaa atcattataa tacctgaagt aaaatttgat atcgacgagg 4381 tctgcgacaa aatatcgtat ggtattaaga gaggtaaatt gcatcacata attgtattgg 4441 cagaaggagt aatgagcgga ttagagttat caaagatgat tcaagaaagg cttcctaagc 4501 tggatttgag acatactaca ctaggacata tacaaagagg cggtgcacca tcggttatgg 4561 atagaattat tgcaagtcaa atgggagcaa gagctgttga gcttctattg gagaataaat 4621 cacagaggat aatcagcata agaaacaatc aaatagttga tgatgatatt gacactgcat 4681 tagccatgag aaaagagttc aactttaagt tatatgaact tagcaaaata ttatcaatct 4741 aaggagtgaa gatatgcgta gaactaagat aatatgcaca ataggtcctg caagtgaaaa 4801 atatgaaata ctgagagaac taattgaaag tggcctaaat atttgcagat taaatttttc 4861 tcatggcgat catgaagaac atggaagcag aatagacaat ataaaaaaga ttagagaaga 4921 gcttcagctg ccgattgcta ttatgcttga tacaaaggga ccggaaataa gaactgggaa 4981 atttaaaaat ggagttgctg agctaaaaga gggacagacg tttacgataa cctctaggga 5041 tgttgagggc gatgatacta tttgttcggt gacatataaa ggacttcctc aagatgttga 5101 aagaggttct cgcatattga tagatgatgg gttggtatct ttaaaagtca atgatgtaaa 5161 aggcgaagac ataatatgca tagttgagaa ttctggaacg attggcgatc ataaaggtgt 5221 aaatgtacct ggaaccaagt tgaatttacc tgctatcacg caaaaagatg ttgacgacat 5281 agaatttgga ataaaaaagg gtattgatat gatagctgca tctttcgtga ggaaggctgc 5341 agatgtaatt gcaataagaa ggctattaga agataacgat gcaggtcaca tactcatcat 5401 ctctaagata gaaaatcgtg aaggtgtaga aaatatagac gagattataa aagtttcaga 5461 cggcataatg attgctcgtg gagatttagg tgtagaaata cccatagaag aaataccaat 5521 agttcaaaaa agaataattg agaagtgcaa taaagcaggt aagccagttg ttactgccac 5581 acagatgctt gattcaatga taagaaatcc taggcccaca agagcggaag ttacagatgt 5641 agcaaatgct atattggatg gtacggacgc tataatgtta tctggcgaaa cggctcaagg 5701 gaaatatccg gtagaagctt ttaagacgat gtcaaagata gctgaaaaaa tagagacgta 5761 cataaattat aaggaaaata tggacaagaa ctttgattac aacatctcaa tgacaaatgc 5821 tataagtcat gctacatgta caactgcaag ggatattggt gcaacagcaa ttattacatc 5881 cacaatatca ggttacacag cgagaatggt atcccgctat agaccatcag cgcctattat 5941 agcggtgact ccggataaag gagtagcaag aagacttagt attgtatggg gtgtatatcc 6001 tttgatatcg caagaagtta gttctacaga tgaaatgata gaggtgtctg tgaataccgc 6061 acttaatgaa gggcttattc gaaatggcga cattgtggta atctctgcag gaataccggt 6121 tgctacgaca ggtacaacga atatgttaaa agtccacata gttggcgatg taatagtaaa 6181 aggaacgggt ataggtacaa aatcaataag tggcgttgtc tctatcattc atgatccata 6241 taaagataag gataaattta gagagggaga tattatcgtt gcacaaaaaa cagaaagaga 6301 ttatatgcct ataatagaga aggcatcggc gataataact gaagaaggag gccttacatc 6361 acatgcagca atagtagggc tcaattatgg aatacctgta attgtaggat gtgaaggagt 6421 tactgcaaaa cttaaagatg gcatgactgt tacgcttgat gcagcgagag gcttagtgta 6481 taagggaata gtaaatataa aatagacagg aagatttctt cttgtcttac ttttttgagg 6541 tgaaatttta tgaatacatt tgatgctaaa attcgcgttc gctacggcga aacagataaa 6601 atgggtatag tatactatgc caattatcta aattggtttg aaataggtag aacagaattt 6661 ttccgttctt taggtatgac atataaagaa cttgaaaata ataaaattat gctacctgta 6721 atagaagcaa actgcaagta tatttggtct gcagagtacg acgatgtcat aataataagg 6781 actaagatcg attttttaaa aggcaccaga ataagatttg cctacgatat cataagagaa 6841 aatgacaata agcttttggc gcagggaatg actgagcatc catttactac actagataaa 6901 aagcctgtaa atattaaaaa agttttacca catgtatatg aaatgcttaa taaatgctat 6961 tcttgtacca tcgacacggg cgatcgctaa gaaattgctt aaaagatatg ttgcaaacat 7021 agcgagaggc ggtagcataa gatttttcct cagaagatga atataattga ataagttggt 7081 tataatggta agggtagccg attgtactgt ggggcattat gcccctattt tttatttata 7141 aatatgagaa acggttgcac aaaccaagat gataatgtaa aataataaaa ggaggcgata 7201 tgatgagtag gaaacttatt aaatatttac ctttactaat gttagcatca agtgttttaa 7261 gcggatgttt caacaatgtg tcaagtatca aaatagatag atttattaat attagcgcag 7321 taaatggacc tggtgaagaa gatacatggg ctagcgctca aaaacagggt gtcggtacag 7381 caaataatta tgtatcaaaa gtttggttta cgctggcaaa tggcgctata tcagaggtgt 7441 actatccaac gatagataca gcagatgtaa aagaaattaa atttattgtc actgatggga 7501 aatcgtttgt ctcagatgaa acaaacgata caataagcaa ggtggagaag tttaccgata 7561 agtcattagg ttataagcta gtcaatacag ataaaaaagg aaggtataga ataacaaaag 7621 aaatatttac agatgtaaaa cgcaattctc tgataatgaa ggcaaagttt gaagcattag 7681 aaggaagcat aaatgactat aagctgtatc ttgcatacga cccacatatt aaaaatcagg 7741 ggagttacaa tgaaggttat gtaataaagg ctaataacaa tgagatgctg atggcaaaaa 7801 gagataacat atatactgct ttatcatcta acataggttg gaaaggatat tcgattgggt 7861 attataaagt taatgatatt atgactaacc ttgacgagaa taagcaaatg actaagcatt 7921 acgatagcgc aaggggcaat atcatagaag gggcagagat tgatttaacg aaaaacagcg 7981 aatttgaaat cgttctgtca tttggtggaa gcgatagtga agcagcaaaa acggcgttag 8041 agactcttgg ggaagattat aacaatttaa aaaataacta tatagatgaa tggactaaat 8101 attgcaatac tctcaataat ttcaatggca aagcaaattc actctattac aacagcatga 8161 tgatattaaa agcaagtgaa gataagacaa ataaaggtgc atacattgca tcactttcga 8221 ttccttgggg ggatggacaa agtgatgaca atacaggtgg ctatcatctt gtatggtcaa 8281 gggatttgta ccatgtagcg aatgctttca ttgcggctgg agatgttgat tctgccaata 8341 gatcgctgga ttaccttgcc aaagtggtta aggacaatgg ggtgattcct caaaatactt 8401 ggattagtgg taaaccgtat tggacaggca ttcagcttga tgagcaggca gatccaatca 8461 tactcagcta taggctaaaa agatacgatc tatatgatag tttagttaag ccattggcag 8521 atttcataat aaaaatgggg cctaagacag gccaagaaag gtgggaagag ataggtggat 8581 actcgcctgc aacaatggct gcagaggtag caggacttac atgtgcagcg tatatagctg 8641 agcaaaataa agattatgaa tccgcacaaa aatatcaaga aaaagcagac aactggcaga 8701 agcttatcga taatctcact tatactgaaa atggaccact agaaaatggc caatactata 8761 ttagaatagc tggattacct gatccaaatg cggattttac gataagcata gcaaatggcg 8821 gaggaatgta cgatcaaaaa gaaatagtag acccaagttt tctggagctt gtaaggcttg 8881 gagttaaatc ggcagaggat cctaaaatat taaatacgtt aagagttgtt gatagcacaa 8941 ttaaagttga cacaccaaag ggaccgtcgt ggtacagata taatcatgat gggtacggtg 9001 aaccatcaaa ggaagaacta tatcacggcg taggaaaggg aagattgtgg cctcttctta 9061 ctggtgagag aggcatgtac gaaattgccg caggaaaaga tgcgacaccg tatttaaaag 9121 caatggagaa ttttgcaaac gaaggtggca taatatctga gcaggtttgg gaggataccg 9181 gtcttccaac tgattccgca tcacctctta attgggcaca tgcagaatac gtagtattat 9241 ttgcgtcaaa tatagaacat aaagtgcttg atatgccgga tattgtttat aaaaggtatg 9301 tttcaaagta aagcgcggat tttccggata aatatatccg gggaatctat tttttattac 9361 ttaaatgaag tataattgtg tatgagaata tggatttgga gtgataatta ttgcaaaatg 9421 taaacattgg cgatatatac gaagtataca ttgataatat ggcgcatgaa ggacaaggag 9481 tcggaaggct tgacggaata gctgtttttg taaggggcgc tttaaaggga gaaagggtct 9541 tagctaaaat agatgaaaaa cacaaaaatt atttaaacgc acatgtagaa aaaatcttat 9601 tgccatcaca ggaaagaatt atgccgaagt gcatctacgc tggcaagtgc ggcggttgca 9661 cattacagca tttaagttac aaaggacaat tggaatttaa aaaacaagtc gttgacgaca 9721 gcctatcaag aatcggaaag ataaatacta ttgtatatga tactatagga atggataacc 9781 cactttatta ccgcgacaag gcagaatatc cagttggcat tgaagatggc aatattaaat 9841 ctggatttta tgcttcaaag tcccacaaca tcattgcaat tgattcatgc atgattcaaa 9901 gcgattatag tatagaagcc atgaaaactg taagagaatg ggcaaacaat tataaaatat 9961 caatatttga tgaaaaatcg ggtaagggtt tgctaaggca tataataacg aaagttggat 10021 ttacaactaa agaggtcatg gttatcctag ttataaatgg gatagatata ccttacaaag 10081 atgagcttat aaatacactg aagaaaaata ttaaagaact taaaagtatt gttttaaaca 10141 taaacaaaag ccgttctagg ctggttatgg gaagtcaaaa tattgtcatt tatggtgacg 10201 ggtacattac agactacata ggagataaaa agtttgaaat atccccactg tctttttttc 10261 aggttaaccc tattcagact aaagtattgt atgaaaaagc attagaatat gcagacttaa 10321 aaggcgatga aattgtcatt gatgtatact gtggaatcgg cacaatatca atattttttg 10381 caaaatatgt aaagcatgtc tatggaatag aagtagtaag cgatgccgta gaggatgcaa 10441 agagaaatgc tgctataaat aacgtggata atgcagattt tatagctgga aaagcagaag 10501 atgtcatgaa ggatctttgt aataaaggct taaagccaaa tgtcatagtg ttcgacccac 10561 cgaggaaagg attagacaaa gatgttgtag aaacatcgat aaagatgaat cctaaaaaaa 10621 taatttacgt ctcctgcaac ccgactacat tggcaaggga tttgaggata tttgaagata 10681 atggatataa aacagaaaaa gtacagcctg ttgacatgtt tccgtacact tatcatgtgg 10741 agtgcgtggt gttgatgtca aggctgtaag cctttatttt actaggtttc cggaagtaca 10801 tccaagttgt ctactcaacc taaaggttca aaatacgtac atgggaacat atcgagggta 10861 aatttttgtg tgaaatttga gtccaaaatt aggcagggtt gagttgacag gttagataac 10921 gattatattt gtataggttg aggagatagg atggatgtta tataaacttg attctcatcc 10981 ttgaaattcc tcatgatttg tgacattgtg gcaaatgatt ccaacattaa cttgacaatt 11041 atgcttttat tgattataat ttaagcaaaa ttgtcaacag aggatgatag gatgactgga 11101 acagaaaagc tggaggcttt gattaaaagc agcaagggcg taatcacttc caagcaggca 11161 actaatcata atattcatag ggagtacttg agtgaatttg tcaggcaggg caagcttgaa 11221 cgtattgctc acggtatcta tattacaccg gatgtatggg aggataaaat gctgatccac 11281 caattgcgta aaagcaaaat ggtgtattcc catgaaactg ctttattttt acatgattta 11341 actgatagag atccggttgc ttattgtgtg acagttccaa caggatacaa taccagcagg 11401 ctaaagcagg atggactaat tgtgtatacc attaaaaaag aattgcttga tcttggaatt 11461 tgtacaaagc agactacctt cggaaatgac atcagggtat ataatatgga gcgcaccatt 11521 tgcgatatac ttcgggatag aaaaaaccag gatgttgtag tagtatcgga tgcgcttaaa 11581 aggtatatac gcagaccgga taaggatctg aacagattga tgaaatatgc cggtatttta 11641 agagttgaga aagttttaag aaattattta gaggtgctgc tatgaacaca tcaactcaac 11701 tgaaggcact gatacgaaat ctatcaaagg aaaaaagcgt gcaagctgaa attattttaa 11761 gaaactttat gcttgagcgg ctattggaga ggatatccct gtcccccttc cgtgataaat 11821 tcatattgaa agggggcatg ctgatagctg caatggtcgg tattgatacc cgatccacaa 11881 tggatatgga tgccaccata aggggaattc cgttatctga gacagcgctg gaggaagtga 11941 tgaaagcaat attgacttgt cctgtagatg atggagtaaa aatgactcta aaaggatttg 12001 aaaatattcg agacgaatca gaatatccgg gaatccgtgt atctattgaa gcaattcttg 12061 acaaaacaag acaggtcatg aaagtagata ttacgacggg cgataggatc actccgcgag 12121 cagtggaata ttcctttaag ctgctgttcg aaaacagaag catcagcatc ttagcctaca 12181 atattgaaac ggttctggct gaaaagctcg aaaccatatt atcaagaagt accgccaaca 12241 caagaatgcg tgattattat gatgtctaca tactaacaac actaagggct caggatatta 12301 actggaactt gttacccgaa gcttttaaaa atacagcaga agaaagaggc agttataatc 12361 acctcatgga aaccggagat gatatcatgg gagagataga gcagtcacag gtgcttgctt 12421 acctatggag gcggtatcag cagaaaaaca gttatgcaga tgatttaacc tgggcgcaag 12481 tgatagcaag cgtaaaagaa ttatacatca aagcctttga cagggatgcg aacaaataaa 12541 ttttatatgg tgagccatgt tcgtttaaat tataattacc cgaggttgtc ccaaacgtcg 12601 tagaatttct gtagcgcatc ctacctcatt atttcatgct aatgctcctt catgggattt 12661 tatcccatct atattccaag acaacgcttc ccttaagatt ggtatatctt tgtaaccatt 12721 tatcctgtga aagtgttttt ctgcttccaa tagccccgct gcactccatc ttagcacctg 12781 ttcgccattc ttccaccgtt ttacatttcg gcttaaactg cgtactatat caaacgctga 12841 ttctatcgga ttagtggaag acaatgtcct ggttaaaaga tcgggtaacc ctaaacgttt 12901 cactgtgagg gtttcttcta aaccttctaa aaggctggct gctgcccctg gatagtcttt 12961 gtgcagttcg ttagctaatg cttttagttc tttttctgct cttgaggcat cttctatgtt 13021 ccatgcttta tccagcttgc gtttaaccca atcatgttgg ttttcaggta aatggtccag 13081 cacattgcgc ttcttatgta cctggcaacg ctggaccaag gcattttggc caaacgtatc 13141 tctaacagcg gctcttaagg cttttgaacc gtctattata accaacagtc ctttatcgct 13201 acatagccct ctatccacta aatctgttaa tagttgttta caaatggtgg cattctccgt 13261 agccccttcc cataaaccga gtatatgttt atacccatcg ctatctagcc ccatagccac 13321 tattactgta tgatcagcca ttactacgcc gtctatgtat agagccacta tatctagact 13381 atctaaacgc ctggttaaca tctccgataa tgctgttttt gtgcgttcaa taaagtggcg 13441 gcttattgtg cttttagata tgtcttttac atccaacgag cttcctacag gctccaatcc 13501 tttgctgtat tgcctggtgg atagtccata taacatgcgt tccatagcca tttggcctaa 13561 tatatcttca tcgtgaaaca ttttatatgt ttgtaacacc agctccttac catcaatagt 13621 gcggacccgt ggatgttcta ttttgacttt acggccaccc aatactatct gtccctgttc 13681 tttgccatga cgatacgctt tgcgctctga gttatgtttg ccttttggtc ctacatattg 13741 ggttacttct tcttccatca tggtcttgat aacattgagg caacggttac cgagaaggca 13801 agaaggcctt ctttgacagc ttgcagcagg ttatttattt gttcttggtt aatgttaggg 13861 caagctgccg ccataatttg gggcgaaata ttcttgtcaa cgaccttagt attgtgatat 13921 acttccatta aacggttcct cctctttttg tatttctact aggtatatta tataccttta 13981 gaggcaggaa ccgctacttc aaattccacg gaatttcgga catcttcaat tacccggaat 14041 gcggtgaaaa gtatgattcc tatccgtggg tattagaaga acgttgaaaa aattgaggtt 14101 aggagaaatg attaaatgaa atatgaaatt tcatgtggtg gagtagtatt tactcgtaaa 14161 aatggaaagg ttttatatgt aattattaaa tcaccagagg gttattacgg ttttcctaaa 14221 ggtcatatgg aggacaatga aactgaagag caaacagcta tccgagaaat ctatgaggaa 14281 accggactaa aagttaaaat tatccccggg tttaaaacca tagatgaata tcctattccg 14341 caaaaagaag gtgtgatgaa aagagtaatg tatttcgcag cagaatatga taatcaagaa 14401 attagttatc aaaaggaaga attgctgggt gcttatttaa tgacatatga ggaagcgatg 14461 gacatttttc aatttgagag ctccaaaaga atactgcgtg aagtgaatga ttttattata 14521 tctgggaaat ggaaataaag gaaagtaatt cttaataaat aattgattat actgatatgt 14581 tcccttgaac ggtgactttt caaaaatcac cgaaaaattg gttgacatgt tccctcgaac 14641 agacgatttc taaaatagct tacagacatt aattccatca actcgaacca tgtggagtgt 14701 gtggtatcgc ttaaaagaaa ccaaaaccca taaagtcttg tggcgcaagg ttttatgggt 14761 tttaggaaaa aagacagcgg ctacattgaa gatatgaggg cttcaggtat aagtattcta 14821 agtcccttca tcattgctgt tgtattttac gaagaatatt gctataataa taacaacaaa 14881 aggagaaagg agatttatta tgcctaacat taagccgatt tccgatttaa ggaattacaa 14941 tgaagtgttg cgcagcatag aggaaggttc accggttttt ttaacaaaaa atggccgtgg 15001 acgctatgtg gttatggata tgcgggaata tgaaaaaatg caggcaaaat taaaattgct 15061 tactgaactt gctaaaggtg aaaaagcggg acaggaaaat ggatggctaa ccattgatga 15121 actagaagca tccctggagg taacggatgg ttaatcttaa aatctcgccc aaagcgcaaa 15181 aggatatgct ggagataaaa gaatatatct ccgaggaatt aggtaatcct acagcagcaa 15241 cgaatttgct ggccaaaatc accaaacgat tcagagatct tatggaattc ccgttgattg 15301 gagtaccctt gtcttctgtc attaaaattg aaacaagcta tcgttacctt gtgtgtgggc 15361 aatatacagc tttttaccgt tatgaaaatg atactgtata tgtggacaga gtgctatatg 15421 gtagacgaga ttttatgcga atcctctttg gggatgttgc aaaggaagaa gacaactgat 15481 tatcaaatat aagactatag tatgttattt aattaagaca aaaaagaaaa agagaaacat 15541 aaaggcaggt agtataatag aaattttcat acctatttta gagttttgcc aaaatatttt 15601 taaaaacaga ggtttcatgt gttatcatat gccaaaatat gtttattggc gatggaaaca 15661 aagaataaaa tactctgttt ttttatttgc ttaaatgtat aagaagaaaa agttcatata 15721 attgcatatg tgcctgatgt gcaaagtgat tgttaaaaga gtttcatata ttttataaac 15781 gtattttaac aatacaaaat tacctggtcg taacctcaac atctattcaa catctaagtg 15841 tgccgtatat gcaatagata agtattattt ttatatttta agtcaacaaa tctgcagctt 15901 gaaaaagaaa taaaaattga tcaaatgaga acaaaatttc attgcgaatg cttcacatga 15961 gcttaaaaca cgataagcct cttataagtg gatatgtaga agcaatagaa gataaaattg 16021 cagaaggtga aaaggctaac agaaatcttg atatcatttt ggatgaaact aaacaaatga 16081 gcagtcttgt atattcaatg ctcgatttac cggttcttga ccaagggaat catcaaacag 16141 actatgtgtg gtaaatttat taaatattag tggctgtaaa aataaaaacg taattatttc 16201 acatccagtc tattaatgtg aaatgtttca tctagaaaat caaagccttg ttctttgaaa 16261 aagttccata tccactgatt cattcctatc atttctatag gattgtaatg aagaccgaat 16321 aatttttgag ctggatttat gtagccattt ttttcaacat ttgctttcac tttgtctgca 16381 aagtcttttc ctccaaccat tgaagcgata ttgtaaagtt catctatcaa atagctattt 16441 ttgtcattga tgtatgtgtt gttattttgg tatttttctt cataatatct ttcaatttcg 16501 tcatcgttta atttcttgta cttctcgtca aaaatgactg catctttttg aagctttttt 16561 ctggaattta gcgtaccttt tacatttcca aggcacatag cgagaacagg gattgtaagc 16621 tctggcaact ctaaaagctc ttttatttcc tcatagcgta gattcggcgt acctaagtaa 16681 acactgccta taccttttaa agtacatgca cattcaatgc tttgtgcaac acacattaca 16741 tcctctaaag agatgataaa ttctaagaaa gatctgtttc gcccgtaagg cgccttattt 16801 atttcgcacc atcttttttg cttataaaaa tccaaaagaa atactaaaac agtatcagac 16861 ttttcaataa aattttgtcc gagcaaatct ttaagctttg attttctatc tttgtccctt 16921 attttaatta tagtgcatgg ctgagtattg cctccactgg cggcatttaa accaacttct 16981 aatatgtcat ttaaaacatc atcgtcgatg gggatatcag aaaaatttct gcagcttctc 17041 ctattcttca ataagtcaat tgcatccatc tgccaatcct cctattatcc tttaaaacaa 17101 attgttgcat agcactatac tatttatagt attatattaa cgctaaagtc aagtatttta 17161 tttaataagt ttttataaac taatgattga tgagaaagat aactatttaa agactgactt 17221 attacatgga tttcatgatt tgagaagata ttttaaattg acaaaggcta taatgaaaag 17281 tataattctt ttacaaggta aaaacacaga tttgagtagc agtttgtatg caatatgttg 17341 gaaattataa gaagtatgta atttgttatc acagcggtct ttataaaaag gaagattaat 17401 atatgataat aagtgcaagc agaagaacgg acatacctgc attttatagc gattggtttt 17461 acaatagaat taaagaaggc tatgttttgg ttaggaatcc ttttaattta cattatgtaa 17521 gcaaggtacc tttatctttg gaattagttg attgctttgt gttttggagt aaaaatccgg 17581 caaatatgat tgataatctt cacatcattg atagatatcc atactatttt cagtttacat 17641 tgaatcctta tgatgacaag attgagaaaa atgttccaaa gaaatcaaaa ataattgata 17701 catttaaaag attatcagat aaaataggac ccaatagggt catttggagg tatgacccta 17761 tcattgtaac taaagctatt agcaaggaat atcactataa atattttgaa gtattggcat 17821 cgaagcttca aggttataca tcaaaatgta tcataagctt tgtggatttt taccctaaag 17881 caaagaaaag ccttgagaaa ataggtgctt ttgacattag tgatgaagat aaaataagga 17941 tagccagaag gattggagaa attgcagaag cgtattctct caaaattgaa acatgcgcag 18001 aagaaataga tttgtctcaa tttggaatag agcatggaaa atgcatcgat cctaatctga 18061 ttaaggaaat ttctggacgt aatattaagg atgaaaaaga caaaaatcaa agaaaagcat 18121 gtggttgtgc ctctagtgtg gatataggag cttataatac gtgtatgcat aggtgtatct 18181 attgctatgc aaattacagt agcaatgttg tcaatgacaa tatgactagg tatgatgtca 18241 attctccatt attgtgcagc agtataacag atgaggatgt aatagcggaa aaaaacagtt 18301 ag //