LOCUS NC_018607:19 18655 bp DNA linear BCT 10-OCT-2012 DEFINITION Brachyspira pilosicoli B2904 chromosome, complete genome. ACCESSION NC_018607 SOURCE Brachyspira pilosicoli B2904 chromosome, complete genome. COMMENT locus start: 2184832; locus end: 2203486 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.601762; n0_4mer:D = 13.436284; n0_4mer:PS = 22.932148 FEATURES Location/Qualifiers source 1..18655 /organism="Brachyspira pilosicoli B2904 chromosome, complete genome." gene 1..513 /gene="" /locus_tag="" /db_xref="2184832..2185344" CDS 1..513 /gene="" /product="methionine aminopeptidase" /translation="MFIKSNTTDIVKPSIKDEKAIENIKKAAQIAQEAIDLAFEYSLS GTRASKIDKDVEKFIKSKGAYPANLEVPEYGFSTSISIGNEIAHGRPTNKKILVQGDI ICIDIGVKYNGYYADCARTMVVKGNQLSSTNKKAYKLIKACKESLEHAIYKLRPNILL STYGREVEKK" gene 636..797 /gene="" /locus_tag="" /db_xref="2185467..2185628" CDS 636..797 /gene="" /product="methionine aminopeptidase" /translation="MVLALELMITEGSDKYIIENDGWTISTADYSFAAHFEHTVLIKK NGVEILGID" gene complement(1002..1583) /gene="elaC" /locus_tag="elaC" /db_xref="2185833..2186414" CDS complement(1002..1583) /gene="elaC" /product="phytochrome sensor protein" /translation="MYETINNILAKDYFPINLEQFGASIKFEPFYEGKKINYGNMTVE ALWVNHPCYTLSYKITSNDKTLVYLTDHEPYKKRLHIQHPSLDHYNNNANLLHARLID YVRGANVLIIEGEYTKSEYINGHVGWGHSTLNDAIQVGLDADVPYVIIHHHNQDRTDA QIKLIYNKLLAFLRKENIDLQLAFAKESSYIII" gene complement(1688..1885) /gene="" /locus_tag="" /db_xref="2186519..2186716" CDS complement(1688..1885) /gene="" /product="phytochrome sensor protein" /translation="LKVRFLGSRGSIPTPGTSFSEYGGNTSCIQVIDDEGNYIILDAG SGLKNLGYYALKSEKKKVLFY" gene 2046..2906 /gene="rarD" /locus_tag="rarD" /db_xref="2186877..2187737" CDS 2046..2906 /gene="rarD" /product="RarD permease" /translation="MGKSIFLFVGVTALSMSAIFARLANAPSSITAFYRLLFSFIIIL PILLIRNLEELKKISKKDFLLSLVSGIALAGHYSLWFQSLKYTSVASSTVIVTLQPLF SIVAGYFIFKERYTKLAILGFIIAIIGSVIIGWGDFQVSTTALIGDVLAFISAGLISA NFLLGQYIRKRLSALTYTGLTYFASAVFLFFVVIFTNTPLTGYPLYTWINILGLTLIS TMLGHVVFMWLLKWFSASVVSMTILGEAVGACILGYFILKESISINQLIGIIIILFGI GLFLKEHKQN" gene 2920..3381 /gene="" /locus_tag="" /db_xref="2187751..2188212" CDS 2920..3381 /gene="" /product="YbaK/prolyl-tRNA synthetase associated domain-containing protein" /translation="MISEKVLKVLNELGIEHKEFEEKGATKTVEDAAKSLNIEKGQVA KSILLKPVKKDFFMLIASGDKKISSKKTKEYFGCKTNFASAEDTYNLTGFTFGGVCPF GIDERITVLVDKSMKRFDDLYIACGSDSSLAKMSYDEIINKISNIEVDLTE" gene 3489..3920 /gene="" /locus_tag="" /db_xref="2188320..2188751" CDS 3489..3920 /gene="" /product="hypothetical protein" /translation="MIKKILSSLIVLAIFSTSILFADMVVPASALPKQAATFIKKIYP NAQIWKVERDGGKFDVELSNGASIDFLTNGDWVNIDGEYNGVPFSVLPQAVANTVKKT YPQAMITSVEKEWGNYKIKLNNMMEMFISSDGSLMGQQFDD" gene 4212..5537 /gene="flgE" /locus_tag="flgE" /db_xref="2189043..2190368" CDS 4212..5537 /gene="flgE" /product="flagellar hook protein FlgE" /translation="MMRSLFAGVSGLQNHQTRMDVVGNNISNVNTYGFKKGRVTFKDM ISQSLSGAAKPQEDRGGINPQQVGLGMQVATIDTIHTQGALQVTGVNTDLAIQGEGFF IEKKGNSSYYTRNGAFSIDKNGYLVNPSNGYKVQGWNAVLNPETGMMELNTAAGVEDL IIPVGSKDPARATQNTKFFCNLQKNSDTHQADLTIYDSTGIPRQLRATFNRTDVNRWD MVIEIPEATEGSVSVSAGDPVENGGNNTFQLVFNDAGSLISVSDGTNTQTEGVLMPNV SFTYTGTDGEVNQTINLTMGEVGLFNGITQFESPSTTKAIEQDGYTMGMLEGFSFDDS GQITGVFTNGNRKTLGQVALAKFANAGGLEKAGDTLFVESNNSGAANIGVAAAEGRGS IKAGTLEMSNVDLSEQFTDMIVTQRGFQANARTITTADQLLQEVIALKR" gene 5601..5825 /gene="flbD" /locus_tag="flbD" /db_xref="2190432..2190656" CDS 5601..5825 /gene="flbD" /product="flagellar family protein" /translation="MIYVTRFDGSVLYINPHQIEFMEETPDLVITMLSGRKVLTKDSY ETVLNRIVEYRTRILNEDSTKKPSFYGNED" gene 5868..6659 /gene="motA" /locus_tag="motA" /db_xref="2190699..2191490" CDS 5868..6659 /gene="motA" /product="flagellar Motor Protein MotA" /translation="MDIIVPLGFLLVIGINLFGIISGGGNVGHMVDIASAVVTGLGGT TSLFVANDIGTILGVPKAIKVLLNKPNYDEAQIIITLISFSEKARREGLLVLEDDIQE VSDPFLKKGMQLVVDGTDPELVKNILNTEIDNVEARHDTVRKVFEDAASLYPAWGMIG TLIGLVIMLRSLGGGGGVEAIGSGMAVALITTYYGSVIANGFALPIAGRLAARHASEA IVQSIMLEGILSIQAGDNPRIVKDKLVSFLPPPQRQKVNEQVGDR" gene 6678..7478 /gene="motB" /locus_tag="motB" /db_xref="2191509..2192309" CDS 6678..7478 /gene="motB" /product="flagellar motor protein MotB" /translation="MATIKFGKKAKKAGDKAQVPGPSAPLWLQTYGDFVTLVLTFFVL LLSTMSESISDSTMQLLATAFQGSFGNLSGGVTLSQSKLVAGGANVDALPAMDRGYSM GRSVDKAVSVLESEIKNNKIRVSEDERGFVITLGADQYFESASTNIVNTQNNTETFIK IASVLSTLPNDIRIEGHTDSGAILEGSITEQWFGNNWGLSTARAIVVLEKLFESDQTG KLDINKYSVAGYADTRPVASNDLPDGRALNRRVDIVVVRNDVTYYNQK" gene 7487..8359 /gene="" /locus_tag="" /db_xref="2192318..2193190" CDS 7487..8359 /gene="" /product="SAM dependent methyltransferase" /translation="MIVARDWKDYKILDAGNGEKFENIGGFLVSRPDSQIIWQKQLNK WNNLDAIYHRSDKGGGYWQYINSPKENFIIKYKDLSFKIEFTNFKHIGLFPEQAVNWQ FIIDKIKEKKSSTHKNKEIKALNLFAYTGGATVACAYADCDEIVHVDASKKIVGHAKT NIEINNFQNKKVRFIIEDVIKFVLREVRRERKYDVIIMDPPVYGRGPNGELWQIETSL TRLVEECVKLLSPSPILFLINCYTASFSHISLKNILQTQIKNNGFFESGEIALPIENT DLILPSGIYARFFT" gene 8453..9946 /gene="" /locus_tag="" /db_xref="2193284..2194777" CDS 8453..9946 /gene="" /product="hypothetical protein" /translation="VNTIEEYTPTTSKYELYTHLSEQIVSGKIRTFSEIFTYASNVNF EKINDHNNILKGLFNLIRKINWGFFNNLDKEMYPKLWDQFVIENPKYSFAGDLKLSLT IADIYIAMLDIHGYTKFCEENKNNLSKMHALDDLLQNKISELTRFYNVISHRKQGDEI VMMCPSATDALSATMAIIGALSKKRILTECPDIDTSIFPEFKVSAGIAGGMSNNSLII TEDGDLSGFLINNAARMQARANMLSPKDTKIIVTKNLQFNFLKENSKVKSEIFEKNII SFYDNGMISFKGTEIPIVEAIFNPNEKYKEAFFNEMEELVKSIKGNLWKQRLFTSILD LISKAVSSMPKFQINKRVNEYISAYDNKTIYDLCNSANGAYVVKENYKEAIDTFALII KLLKTIPDFDPMVLEYAESICNGYEKVLPIYDIVIKKEIEMNLTEIFPANHVPIFQNV QKANETYNKLMKYALDSNALKRRKSIWYGILEKELNNLVINMYSGKK" gene 10035..10760 /gene="" /locus_tag="" /db_xref="2194866..2195591" CDS 10035..10760 /gene="" /product="hypothetical protein" /translation="MYIKKVFLSLIVLSIFFVSCSNTKTTNSSDSLAYLQGGEGEWVL KVDDFTINQTNFNKDYKVFLNSMKAQGATPEQIAMIESDNRYKQNYAEDLINQILLLK KAETDKFFETEEAKSTIDATIRNIKAQYYYQKLIEQAASNVPAPTPEQAKAFFDQAKD QLQLAQYGITEYNTQTAPYIADIYKRVYAEQNVQREIIDLKDKAVIERNNAVLGEPTI VPPTTMPNTQGQVTNNLLPRATN" gene 10836..13166 /gene="infB" /locus_tag="infB" /db_xref="2195667..2197997" CDS 10836..13166 /gene="infB" /product="translation initiation factor IF-0" /translation="MPQINESNDKNQQNLSSDNKPKKVIINKKSNNSNNTEESQASAT VKKIKKVVVKKIIIRNKMEKQDSAKTENVQTPEQRKPFNNNKFNNNRDNSNNNRERYN KGFNKESNNRDFSRDKQYKNTQITPPPVEEVSFKKDNKKDNKKRDYEKKEKEYDKKSS QKDSKAEAAQRQENKIFNKLQAKKLQQEQRLASVEKEISIMETITVGDLAKKMNLRAS DIISKLMGMGTMARVNDIIDSDTATIIADDFGCKVNVISLQEEATIEIKEDKPEDLKP RPPVVTIMGHVDHGKTSLLDAIRHSNITSKESGGITQNIGAYKVKIPSGEIAFIDTPG HAAFTMMRARGAKSTDIVILVVASDDGVMPQTLEALNHAKEANVPIIVAVNKMDLPNA SMDKVKAALSEHGLTPEEWGGDTQYIGVSALTKQGINDLLEAIILQAEMLELKANPNR EAIGIVLEASLDQGRGPVGTVLVQNGTLKIGDYFVCGLSVGKVRAMVNDLGQRVTKAL PSTPVEVLGFEKTPEAGESFNVMLDEKEAKAIADKRVQLKQQEALKANVKVTLENLYE KIASDAMKEFKVIIKADVQGSAEALRDALNKIQSDKIRFVSIYSASGAVTESDVNLAH ASNAIIIAYRVRPSGKARELAEKLGIPIERYDIIYEAIESIQNAMKGSLERLKKEVDI GIVEVRDVFHVPRVGTIAGCYVTSGKIERNAGVRVMRDNVLIYTSKISSLRRVKDDVK EVATGYECGASIENFNDIKKGDLLEIFKIEEITQEL" gene complement(13163..13954) /gene="" /locus_tag="" /db_xref="2197994..2198785" CDS complement(13163..13954) /gene="" /product="hypothetical protein" /translation="MIDDDFFNNIEEYIKKTDIEFDILFVDSITKDKIALLVNKILIK YKIEKYYEDVIYILMELITNAIKARYLHLISLKVLNEMYPNYSLDEYYSNPDIMKKYS DIFRDDESREKLKNILKNENKFLSDNNNNIDNFYNDVLLLNENTKSKFIIKLFIHITK NNVEFDIVNDSPLIMLGRTRIDSKRLTFKEYYNNDMVESFFLEQLDNTESAGFGLALC DLRLYNIGLEPTKHLEIYNDNNKTHSKLIIPIKGVFSHLIFHNKY" gene complement(13957..15078) /gene="" /locus_tag="" /db_xref="2198788..2199909" CDS complement(13957..15078) /gene="" /product="lipid-A-disaccharide synthase" /translation="MRIFIATGEVSGDIQGALIANEIKKLAPQTIIDGFGGVEMKKAN VNILSDMSTLSTMGIFEGINPKFAFKKLGAFNILKEYLKNNKVDVMLLVDNQGVNLIL AKYCKKNNIPYIYYFPPHVGIWGEWNAKRLLSAKKIITPFQFDYDVYKKYNCNVVYSG HPFADINYNRKVSPLNMDKKEYTVGVLFGSRYQEIKKLAPVFIKSMKILNDMLFGNIR FIIPVAYPEYREPIENIIDNYKDLLNGICYSVIENKDDVYIYSDALIMSSGTASLIAA CYGKPMVICYKISHLTFLLGKFFTNIKYVGMPNVMLNEEAAPELLQRDCNPNAISSHI IKYLTDKEYYDKTSSNLIRVRELLGDKNVLERVAKEIIN" gene complement(15100..15894) /gene="lpxA" /locus_tag="lpxA" /db_xref="2199931..2200725" CDS complement(15100..15894) /gene="lpxA" /product="UDP-N-acetylglucosamine acyltransferase" /translation="MKKDIHETAIISESAKIADNVKIGPYAVIEGNVTIGENTVIGAH SVIKEYTNIGKNNIIHDNVVLGDLPQDIHFDRNTVTFLEIGDNNEIREFANLHRASKE NAKTIIKNNCYIMATGHVAHDCEINDNVIICNGALVAGHVKVGKGAFISGNCVVHQFC SIGEYAMISGMSAVGRDILPYALTAHAGEAIIYKLNLVGMRRAGFTSEQISQAEEAYD LWYNWNKTKQEFLDTYLNDNSLNDIAKKIVVFISESRRGITPRKTV" gene complement(15910..16374) /gene="" /locus_tag="" /db_xref="2200741..2201205" CDS complement(15910..16374) /gene="" /product="(3R)-hydroxymyristoyl-ACP dehydratase" /translation="MENINITKIMDLLPHRYPFLLVDKVISIEEGKIHSLKNVTFNEP QFTGHFPESPIMPGVLMVEALAQTSGIYCYMKLLKPEEIGNKFMFFAKIDNVKFKNPV IPGDVMDMFVTVEAFNGTLLKTHGEVRVGDSLACSADLGLFLVDREAMKINK" gene complement(16458..17588) /gene="" /locus_tag="" /db_xref="2201289..2202419" CDS complement(16458..17588) /gene="" /product="iron-sulfur cluster-binding protein" /translation="MSKVVIIKCDNYDLDMVKSAINRGIDLLGGIDLFVQSNDKVLLK PNLLAAETADKSVTTHPVVFEAIASILQERGCKVSYGDSPGVGKGSSVALKAGIDEVA SRLNVEYADFDEPVGVNFPDGVQEKSFTVAKPVTEADVIISLPKLKSHALTVMTGAVK NQFGCIPGFRKAEYHLKLPDFEDFSTMLLDLNKYVNPKLYIMDAILAMEGNGPRSGNP RKVNALLFSTDAVALDYIASQIISFDYNNIPTIKMGFKHNFSNKDDIEVLGDDIESIK VVDFKKPHKRIGIGRSLMKFANFPIVKKIFSFIIPKPVIDKNKCVKCGVCVKVCPVTP LALNFDKKGKNYPPEYYYDKCITCYCCQELCPHKAIFLKRKF" gene complement(17666..18655) /gene="" /locus_tag="" /db_xref="2202497..2203486" CDS complement(17666..18655) /gene="" /product="hypothetical protein" /translation="MKIITLILLNIFILFSSNTLFSQDITFRVTGISGVAFIEKSDKS LRVFRGSEIHEGYKLTTKSNTTVEITVLKDGNNIGSVSLNEKSIMMVNSSISDEYSYI SLSLLHGYFTVSIEDDYQVHTANVSSMVTYNNAAAKIEVAFSEDGSTIVIPINTKVNV YADNDERIVNPREVYIAEFNGNNRVVKQGSDTDPLVFLNNGEENARLDSTSTIESLIS AMEDISQSDAASVSRVSLTDVDNGEKDIYALEMKRNRMIAGNEGYYSSIVRLINSDSV SKNEMIPYARKSLGLYSANQRAINKMDSALTRTRDKFNRIKKEFDSKMYGVSE" ORIGIN 1 atgtttatta aaagcaatac aacagatatt gtaaagcctt ctatcaaaga tgaaaaagct 61 atagaaaata ttaaaaaagc agctcaaata gcacaagaag ctatagactt agcttttgaa 121 tattctctat caggaacaag agcttcaaaa atagataaag acgttgagaa gtttataaaa 181 tctaaagggg cataccctgc caatttagaa gtgcctgaat atggtttttc tacaagcata 241 tcaataggaa atgaaatagc acatggcaga ccaacaaata aaaaaatatt agtgcaaggc 301 gatattatat gcattgatat aggagttaaa tataacggct actatgctga ctgtgctaga 361 actatggttg ttaaaggcaa tcaattaagt tcaacaaata aaaaagcata taaattaatt 421 aaagcttgta aagaatcttt agaacatgct atatataaat taagaccaaa tatactttta 481 agcacctatg gaagagaagt tgaaaaaaag taaatgaata tggatacagc ataataaaat 541 ctcttacagg tcatggtgtt ggatatgagt atcatgaagc tccttatata tataattttt 601 atcacccaaa taatgatgta aaactagaag agaatatggt tttggcatta gaattaatga 661 taactgaagg ctctgataaa tacataatag aaaatgatgg ctggactata tctacagccg 721 actactcttt tgcagctcat tttgaacata ctgttttaat taaaaaaaat ggtgttgaaa 781 tattaggaat agattaattt ataacaactc tgctctaaaa ctttttatac ataaataatt 841 atattctatt atatgatttt tattttattc aactttttct cgtagcaaaa agttgcaaaa 901 agtacaaata ctttagcttt atatcttata aatatttata aaataaataa tacaaatatt 961 ttagccaaaa aatgcggttc ttttgcttct tttatatata cttaaataat aatataagaa 1021 ctttcttttg caaaagctaa ttgcaaatct atattttctt ttcttaaaaa agctaaaagt 1081 ttattgtaaa ttaattttat ttgtgcatca gttctatctt gattatgatg gtgaataata 1141 acataaggca catcagcatc aagccccacc tgtatagcat catttaaagt agaatgcccc 1201 cagccaacat gcccattaat atattcgctt tttgtatact ccccttctat aattaaaaca 1261 ttagcccctc tcacataatc tattagccta gcatgaagca aattagcatt gttgttataa 1321 tggtctaatg atgggtgctg tatatgaaga cgttttttat aaggttcatg gtctgtcaaa 1381 tatactaaag ttttatcatt agaagtgatt ttgtatgaca aagtatagca agggtgatta 1441 acccataatg cttctactgt catatttcca taatttattt ttttgccttc atagaagggt 1501 tcaaatttaa tagaagcacc aaactgctca agattgatag gaaaataatc tttagctaat 1561 atattattaa ttgtttcata catttcctca tgattatctt tagggccgta tattgtaaag 1621 ctatatttat tagaataaaa tggtgcgaaa aaaggtattc ctataatatg gtcccaatgg 1681 aaatgtgtta ataaaataat actttctttt tttcactttt aagagcataa tatccaagat 1741 tttttaatcc gcttccagca tcaagaataa tatagtttcc ttcatcatct ataacttgta 1801 tgcaagacgt attaccgccg tattcactga aactagtacc aggggttggt atagagcctc 1861 tgcttcccaa aaatctaact ttcaaattgt actcttaaat aaatttttat atataaatca 1921 tacactataa agtaaaaaaa tcaatctaat aataatacaa tttataatat tttgattatt 1981 gaaaaataca aaaaaaatat tataattttt agaaaataaa ttattaatat ataattttta 2041 tagtaatggg aaaaagtata tttttatttg ttggagtaac agcattatca atgtctgcaa 2101 tatttgcaag acttgctaat gccccttctt caataacagc attttataga ttattatttt 2161 cttttataat aattttgcct atacttctaa taagaaattt agaagagtta aaaaaaataa 2221 gtaaaaaaga ttttctatta tcattagtat caggcatagc attggcaggt cattattcat 2281 tatggtttca atctttaaaa tatacttcag ttgcaagctc taccgtaata gtaacgcttc 2341 agccattatt ttctatagta gcaggttatt ttatttttaa agagagatat accaaattag 2401 caatacttgg ttttattata gcaataatag gttctgttat aataggctgg ggagattttc 2461 aagtaagcac cactgcatta attggagatg ttttagcatt tatatcagca ggactcatta 2521 gtgctaactt tttacttggg caatatataa gaaaaagatt atccgctctc acatacacag 2581 gtttaacata ttttgcatcg gctgtatttt tattttttgt agtaatattt actaatacac 2641 ctcttactgg atatccatta tatacttgga ttaatatatt aggtttaact ctcatatcta 2701 caatgcttgg acatgtggtg tttatgtggc ttttaaaatg gttttctgct agtgttgtat 2761 ctatgactat attaggagag gctgttggtg cttgtatatt aggatatttt atattaaaag 2821 agagtattag tattaatcag cttattggta taataataat tttatttgga ataggattat 2881 ttttaaaaga gcataaacaa aattaaatgg agaatattta tgattagtga aaaagtatta 2941 aaagttttaa atgaacttgg catagaacat aaagagtttg aagagaaagg agctaccaaa 3001 acagttgaag atgctgctaa atctttaaat attgaaaaag gtcaggttgc aaaatctata 3061 ttactaaaac cggtaaagaa agattttttt atgttaatag catcaggtga taaaaaaata 3121 tcttcaaaaa agactaaaga atattttgga tgcaaaacaa attttgcaag tgcagaagac 3181 acttataatt taacaggttt tacttttgga ggagtatgtc cttttggaat agatgaaaga 3241 attaccgtat tagttgataa aagcatgaag agatttgatg atttatatat agcttgcgga 3301 agtgacagtt ctcttgcaaa aatgagttat gatgaaataa taaataaaat ttcaaatata 3361 gaagtagatt taacagaata aaatcataaa atatattgac ataaattaaa attttgttta 3421 tattaatctt gtaaagataa tttacaagta tataaaaaat atagcagtaa attatagagg 3481 agtttaatat gataaaaaaa atattatctt cattaatagt attagcaatt ttttctacat 3541 caattttatt tgctgatatg gtagttccag cttcagcatt gcctaaacaa gcagcaacat 3601 ttatcaaaaa aatatatcct aatgctcaaa tatggaaagt agaaagagac ggcggaaaat 3661 ttgatgttga attatcaaat ggtgctagta tagatttttt aactaatggc gactgggtaa 3721 atatagacgg agaatataac ggtgtacctt tcagtgtatt gcctcaagct gttgctaaca 3781 cagtaaaaaa gacatatcct caagctatga ttacaagtgt agaaaaagag tggggaaatt 3841 ataaaataaa actcaacaac atgatggaaa tgtttatatc atctgatgga tcattaatgg 3901 gacagcaatt tgatgattaa ttatataaaa ggtttatgaa aagtattatt tttaaaaggt 3961 gctgcgaaat gtagcatctt ttttttatgt ttaaaaagtt attattcttt acaacatttc 4021 aagaaagatt tttatttctc attattatca attaattaaa acaataattt ttctcattat 4081 tttttagatt ataagaatta aatgctaata aaaaaatatt aagcaaattt taattatacc 4141 gaaaatatta taagaaaata ataaatattt aataaataca ataataatta ctttatggag 4201 gaattcgcct tatgatgcgt tcattatttg caggtgtatc tggattacag aatcaccaaa 4261 ctagaatgga tgttgttggt aataacatat ccaatgtaaa tacatacggt tttaaaaaag 4321 gtagagtaac tttcaaggat atgataagcc aatctttgag cggagcagct aagccgcagg 4381 aagatagagg cggtatcaat cctcagcagg ttggtcttgg tatgcaggta gctactatag 4441 atacaataca tacacaagga gctttacaag ttactggtgt aaatacagat ttagctattc 4501 aaggagaagg tttctttatt gagaagaaag gaaatagttc ttactataca agaaatggag 4561 ctttctctat agataaaaat ggttatttag ttaacccttc aaatggttat aaagtacaag 4621 gttggaatgc tgtacttaat ccagaaacag gaatgatgga attaaatact gctgcaggcg 4681 tagaagattt aattatacca gtaggttcaa aagacccagc acgtgctaca caaaatacta 4741 agttcttctg taacctacaa aaaaatagtg atactcacca agcagattta actatttatg 4801 attctacagg aatacctcgt caattaagag caacatttaa tagaacagat gttaatagat 4861 gggatatggt aatagaaata ccagaagcaa cagaaggaag cgtaagtgtt tctgccggag 4921 accctgttga aaatggagga aataatactt tccaattagt attcaatgat gctggttctt 4981 taatttctgt aagcgatggt actaatactc aaactgaagg cgtattaatg cctaatgtat 5041 ctttcactta tacaggtaca gacggagaag taaatcaaac tattaacctt actatgggag 5101 aagttggttt atttaatggt attacacaat ttgaatcacc ttctacaact aaagctatag 5161 aacaagatgg ttatactatg ggtatgcttg aaggattcag ctttgatgac agcggtcaaa 5221 ttactggcgt atttacaaat ggaaatagaa aaactttagg acaggttgct ttggctaaat 5281 ttgcaaatgc cggcggttta gagaaagcag gagacacttt atttgtagaa agcaataact 5341 ctggtgctgc taatattggt gttgctgctg ctgaaggaag aggttctatt aaagctggta 5401 ctttagagat gtctaacgtt gatttaagtg aacaatttac tgatatgata gtaactcaaa 5461 gaggtttcca agctaatgct agaactataa ctacagctga ccagttgctt caagaagtta 5521 tagcacttaa gagataaata aaatattaga ctttttgttt ttttttagta taatataatg 5581 gttaggagtt tcttgatatt atgatatatg taactagatt tgacggaagc gttttatata 5641 ttaatccaca tcaaatagag tttatggagg aaactcctga tttggtaatc actatgctat 5701 ctggaagaaa agtgctaact aaagatagtt atgaaactgt attaaataga atagtggaat 5761 atagaactag aatattaaat gaagattcta ctaaaaaacc ttctttctat ggtaatgaag 5821 attagaaaga aaataaaaaa taaataaaat attagagagt aaaaaatatg gatattatag 5881 tacctttagg ttttttatta gttataggta tcaatttatt tggtataatt tcaggtggtg 5941 gtaatgttgg tcacatggtg gacattgctt cagcagttgt aacaggttta ggaggaacta 6001 cttctctttt tgttgcaaat gacataggaa ctatattggg cgtacctaaa gcaataaaag 6061 ttctcttgaa caaacctaac tatgatgaag cacaaataat tattacttta ataagctttt 6121 ctgaaaaggc aagaagagaa ggtttgcttg tacttgaaga tgatatacaa gaagtttcag 6181 acccatttct taaaaaaggt atgcagcttg tagtagacgg aacagaccca gaactagtaa 6241 aaaatatttt gaatacagaa atagataacg tagaagcaag acacgataca gtaagaaagg 6301 tatttgaaga tgctgcttca ttatatcctg cttggggtat gattggtaca ttaattggtc 6361 ttgtaatcat gcttagaagt ttgggcggcg gcggtggtgt tgaagccatc ggttctggta 6421 tggcggtagc acttattact acttactacg gttcagttat cgctaacggt tttgctttgc 6481 ctatagctgg tagacttgct gcaagacatg cttctgaggc tattgtacag agcattatgc 6541 ttgaaggtat attatctata caggctggtg ataaccctag aattgttaaa gataaattag 6601 tatctttctt acctcctcct caacgtcaaa aagttaatga gcaggttgga gacagataaa 6661 taatttaagg atatataatg gctactatta aatttggtaa aaaagctaaa aaagctggtg 6721 ataaagcaca agtaccaggt ccttctgctc cattatggct tcaaacatat ggagacttcg 6781 ttactttggt acttacgttc ttcgtattac tgctttctac tatgtctgaa tctattagtg 6841 attctactat gcaattatta gctactgctt ttcagggctc tttcggtaat ttatctggag 6901 gggttacttt atcgcagagt aaattagttg ctggtggtgc taatgtagat gctttgcctg 6961 ctatggacag aggatactct atgggcagaa gcgtggataa agcagtatca gtattagaat 7021 cagaaataaa aaacaataaa ataagagtat ctgaagatga aagaggtttt gttatcacat 7081 taggagcaga ccaatatttt gaatcagctt ctacaaatat agtaaacact caaaacaaca 7141 cagaaacttt tataaaaata gcttcagtac ttagcacatt accaaatgat attagaatag 7201 aaggtcatac agactctggt gcgatattag aaggaagtat tacagaacaa tggtttggaa 7261 acaactgggg gctttctact gcaagagcta ttgttgtatt agaaaaatta tttgaaagcg 7321 atcaaacagg aaagttagac ataaataaat attctgttgc gggttatgct gatactagac 7381 cggttgcgtc taatgatttg ccagatggaa gagctttaaa tagaagagtt gatatagttg 7441 tagttcgtaa tgatgtaact tactataatc aaaaataata gactgtatga ttgtagcaag 7501 agattggaaa gattataaaa ttttagatgc tggaaatggc gaaaaatttg agaatatagg 7561 aggattttta gtatcgcgtc ctgattctca aattatttgg caaaaacaat taaataaatg 7621 gaataattta gatgccatat atcatcgctc tgataaggga ggcggttatt ggcaatatat 7681 taacagtcca aaagaaaact tcatcataaa atataaagac ttatcattta aaatagagtt 7741 cacaaacttc aaacatattg ggctttttcc tgaacaggct gttaattggc aatttataat 7801 agataaaatc aaagaaaaaa aatcatctac tcataaaaat aaagaaataa aagctcttaa 7861 tttatttgca tatacaggcg gtgctactgt agcttgtgct tatgcagatt gtgatgaaat 7921 agtgcatgtt gatgcttcaa aaaaaattgt tggacatgct aaaacaaata tcgaaattaa 7981 taattttcaa aataaaaaag taagatttat tatagaagat gttattaaat ttgttttaag 8041 agaagtgaga agagagagaa aatatgatgt tattataatg gaccctccag tatacggcag 8101 aggtcctaat ggagagcttt ggcaaataga gacaagttta acaagattgg tagaagaatg 8161 cgttaaacta ttatctccct cccctattct atttttaatt aactgctata ctgcaagttt 8221 ttctcatata tctcttaaaa acattttgca aactcaaatt aaaaataatg gtttttttga 8281 aagcggagaa atagctcttc ctatagaaaa tactgatttg atacttccat caggaatata 8341 tgctagattt tttacataaa attatgatgt aacaactatt gctttttttt atttataagt 8401 taaagtttta aatgggtttg atatatatat taatattttt taaggaaaca atgtgaacac 8461 tatagaagaa tataccccca ccacttcaaa gtatgagtta tacactcatt taagcgaaca 8521 aatagtatct ggaaaaataa gaactttttc agaaatattt acttatgcta gcaatgttaa 8581 ttttgagaag attaatgatc ataataatat tttaaaagga ttatttaatc ttataagaaa 8641 aattaattgg ggattcttta ataacttgga taaagaaatg tatccaaaat tgtgggatca 8701 atttgttata gaaaatccta aatatagttt tgctggagat ttaaaactta gtttaactat 8761 agctgatatt tatatagcaa tgcttgatat tcatggatat actaaatttt gcgaagagaa 8821 taaaaacaac ctttctaaga tgcatgcttt agatgatttg cttcaaaata aaataagcga 8881 acttacaaga ttttataatg ttatatctca cagaaagcag ggcgatgaaa tagtaatgat 8941 gtgcccatcg gcaactgatg cattaagtgc tactatggct attattggag ctttgagcaa 9001 aaaaagaata ttaacagaat gtcctgatat agatacttca atatttccag agttcaaagt 9061 aagtgctggt atagctggag gaatgagcaa taattctctt attatcacag aagatggaga 9121 tttatctggt tttcttatta acaatgcagc aagaatgcaa gctagagcaa atatgttatc 9181 tccaaaagat actaaaataa ttgttacaaa aaatttgcaa tttaacttcc ttaaagaaaa 9241 tagcaaagta aaaagtgaaa tatttgaaaa gaatattata tctttctatg ataatggtat 9301 gatatctttt aagggaaccg agattcctat agttgaagca atatttaatc ctaatgaaaa 9361 atataaagaa gctttcttta atgaaatgga agaacttgta aaaagtataa aaggaaattt 9421 gtggaagcag agattattta caagcatatt agatttgatt tcaaaagcag ttagctctat 9481 gcctaaattt caaatcaaca aaagagttaa tgaatatata tctgcttatg ataataaaac 9541 tatatatgat ttatgcaata gtgcaaatgg agcttatgta gttaaagaaa attataaaga 9601 agctatagat acttttgctc ttataataaa actattgaaa acaattcctg actttgaccc 9661 tatggtatta gaatatgccg agagtatatg caatggctac gaaaaagttt tacctatata 9721 tgatatagta attaaaaaag aaatagaaat gaacttaaca gagatatttc ctgctaatca 9781 tgttcctata tttcaaaatg tgcaaaaagc aaatgaaact tataataaat taatgaaata 9841 tgccttagat agtaatgctc taaaaagaag aaaatctatt tggtatggta tattagaaaa 9901 agaacttaat aatttagtga taaatatgta ttctggtaag aaataaatat ttataaaata 9961 gcttgcacta ataatacata tatgataaac tattgcaact attaagttgt attgtaaatt 10021 aaggagtatt ttttatgtat attaaaaaag tatttttatc attaatagtt ttatcgatat 10081 tttttgtatc ttgttcaaac acaaaaacta ctaactcttc agattcatta gcttatcttc 10141 aaggcggtga aggtgaatgg gttttaaaag tagatgattt tacaataaat caaactaatt 10201 ttaataaaga ttataaagta ttcttaaact ctatgaaagc acaaggagca actcctgaac 10261 aaatagctat gatagagagc gataatagat ataaacaaaa ctacgcagaa gatttaatta 10321 accaaatact tttgctaaaa aaagcagaaa cagataaatt ctttgaaaca gaagaagcta 10381 aatctacaat agatgctact atcagaaata ttaaagctca gtactattat caaaaattaa 10441 tagaacaagc agcaagcaat gtaccagctc caactccaga gcaagctaaa gcattctttg 10501 accaagcaaa agaccaattg caattagctc aatatggtat cacagaatat aatactcaaa 10561 cagctccata tatagctgat atttataaaa gagtttatgc agaacaaaat gttcaaagag 10621 aaattattga tttaaaagac aaagcagtaa tagaaagaaa caatgctgta ttaggagaac 10681 caactatagt acctcctact actatgccta acacacaagg acaagtaaca aataacttat 10741 tacctagagc aacaaattaa taaatataaa taaacacttg taagataata tgtaatttat 10801 cttgcaagtg aatactttaa aaaagaagga aaatgatgcc tcaaataaat gagagtaatg 10861 acaaaaatca acaaaactta tcttctgata ataaacctaa aaaagtaatt attaacaaaa 10921 aatctaataa ttctaataat actgaagaaa gtcaagctag tgctactgtt aaaaagataa 10981 aaaaagttgt agtaaaaaaa attattatac gtaataaaat ggaaaaacaa gactctgcaa 11041 aaacagaaaa tgttcaaact ccagagcaga gaaaaccttt taataataat aaatttaata 11101 ataacagaga taatagcaat aataatagag aaagatataa taagggtttt aataaagaat 11161 caaacaatag agatttctct agagataagc aatataaaaa cactcaaatt actccgcctc 11221 ctgtagaaga ggtatcattt aaaaaagata ataagaaaga taacaaaaaa agagattatg 11281 agaagaaaga aaaagaatac gataaaaagt cttctcaaaa agattctaaa gcagaagctg 11341 ctcaaagaca agaaaataaa atatttaata aattacaagc taaaaaactt cagcaggaac 11401 aaagacttgc aagtgttgaa aaagaaatta gcataatgga aactattact gttggagatt 11461 tagctaaaaa gatgaactta agagcttcag acataatatc taaacttatg ggtatgggta 11521 ctatggctag agttaatgat ataattgact ctgatacagc tacaattatt gctgatgatt 11581 ttggctgtaa ggttaatgtt atatcattac aagaagaagc tactatagag ataaaagaag 11641 acaaaccaga agacttaaaa cctcgtcctc ctgttgtaac aattatggga cacgttgacc 11701 atggtaaaac ttcgcttctt gatgctataa gacatagtaa tatcacttct aaagaaagcg 11761 gcggtattac tcaaaatata ggtgcttata aagtaaaaat tcctagcgga gagatagctt 11821 ttattgatac tccaggtcac gctgcattta ctatgatgag agcaagaggt gctaaaagta 11881 ctgatatagt aatacttgtt gttgcttcag atgacggtgt tatgcctcaa actttggaag 11941 ctttaaacca tgccaaagaa gctaatgtac ctattattgt tgctgttaat aaaatggatt 12001 tacctaatgc ttctatggat aaagtaaaag ctgctttatc tgaacatggt cttactcctg 12061 aagaatgggg aggagatact caatatatag gtgtaagcgc tttaactaaa caaggaatta 12121 atgacctttt ggaagctata atacttcaag ctgaaatgct agaattaaaa gctaatccta 12181 atagagaagc tattggtata gtattagagg cttcacttga ccagggaaga ggtcctgttg 12241 gtactgtact tgtacaaaat ggtactttaa aaattggaga ctattttgtt tgcggacttt 12301 ctgttggtaa agtaagagct atggttaatg atttaggtca aagagttaca aaggctttac 12361 cttctacacc tgttgaagtt ttgggttttg aaaagactcc tgaagctggt gaatctttca 12421 atgttatgct tgatgaaaaa gaggctaaag ctatagctga taagagagta caattaaaac 12481 agcaggaagc tttgaaggct aatgttaaag ttactttaga aaacctttat gagaaaatag 12541 cttcagatgc tatgaaagag tttaaggtta taattaaagc agatgttcaa ggcagtgctg 12601 aggctttaag agatgctcta aacaaaatac aaagtgataa gataagattt gtttcaatat 12661 atagtgcatc aggagctgtt actgagagtg atgtaaactt agcacatgct tctaatgcta 12721 taataatcgc atacagagtt cgtccttctg gaaaggctag agaacttgct gagaaacttg 12781 gaatacctat agagagatac gacattatct atgaagcaat agaatctata caaaatgcta 12841 tgaaaggttc tcttgaaaga cttaaaaaag aagtggatat tggtattgtt gaggttagag 12901 atgtattcca tgtacctaga gttggaacta ttgccggttg ttatgtaact agcggaaaaa 12961 tagaaagaaa tgctggtgtt agagtaatga gagataacgt gcttatttat actagtaaaa 13021 tatctagctt gagacgtgtt aaagatgatg ttaaagaagt tgctactgga tatgaatgcg 13081 gtgcttctat agaaaacttt aatgatatca aaaaaggtga tttattagag atatttaaga 13141 tagaagaaat cactcaagaa ctttaatatt tattatgaaa tatcaaatga ctaaatacgc 13201 cttttatagg tattattaat tttgaatgtg ttttattatt gtcattatat atttctaaat 13261 gttttgtagg ctcaagacct atattgtata atctaaggtc gcataaagct aaaccaaaac 13321 cggcactttc agtattatct aattgttcta agaaaaaact ctccaccata tcgttattat 13381 aatattcttt aaaagtgagt ctcttactat ctattcttgt tcttcctagc ataataagag 13441 gtgaatcatt aactatatca aactctacat tattttttgt aatatgaata aataatttta 13501 taataaattt gcttttagtg ttttcattta ataataaaac atcattataa aaattatcta 13561 tattattgtt attgtcagat agaaatttat tttcattttt taatatattt tttaattttt 13621 ctctgctttc atcatctcta aatatatcag aatatttttt cattatatca ggattactat 13681 aatattcatc taaagaataa ttaggataca tttcattaag tacttttaaa ctaattaaat 13741 gtaaatatct agccttaata gcattagtaa taagctccat taatatataa ataacatctt 13801 cataatattt ttctattttg tattttatta atatcttatt tactaataaa gcaattttat 13861 ctttagtaat tgaatcaaca aaaagaatat caaactctat atcagttttt tttatatatt 13921 cttctatatt attaaaaaaa tcatcgtcta tcatttttaa ttaataatct cttttgcaac 13981 acgttctaat acatttttat cgccaagtaa ttctcttacc ctaattaaat tagaactagt 14041 tttatcataa tattctttat ctgttaaata ttttattata tgactgctaa tagcatttgg 14101 attgcaatct ctctgaagaa gttcaggagc agcttcctca ttaagcataa cattaggcat 14161 gccaacatat tttatattag taaaaaactt accaagcaaa aaagttaaat gagatatctt 14221 ataacatata accataggct ttccataaca agctgctatc aaactagctg taccgctgga 14281 cattataaga gcatcagaat atatataaac atcatcttta ttttctatca cagaataaca 14341 tattccattt aacaaatctt tataattatc aataatattc tctataggct ctctatattc 14401 aggataagca acaggtataa taaaccttat atttccaaat agcatatcat taagtatctt 14461 catagatttg ataaacacag gagcaagttt tttaatttcc tgatacctgc ttccaaataa 14521 tacaccaaca gtatattctt ttttatccat atttaatgga gatactttcc tattataatt 14581 aatatcagca aaagggtgtc cgctgtaaac cacattacaa ttatacttct tataaacatc 14641 ataatcaaat tgaaaaggtg taattatttt tttagcagac aataatcttt tagcattcca 14701 ttctccccat ataccaacat gaggcggaaa gtaataaata taaggaatat tatttttttt 14761 acaatattta gccaatataa gattaactcc ctgattatct acaagaagca ttacatcaac 14821 tttattattt ttaagatact cttttaatat attgaaagct ccaagctttt tgaaagcaaa 14881 ttttggatta ataccttcaa atatacccat agtagataat gttgacatat cagacaaaat 14941 attaacatta gcctttttca tctcaacacc gccaaatcca tctattatgg tttgaggtgc 15001 taattttttt atctcatttg caatcaaggc tccctgaatg tcgccagata cttctcctgt 15061 agctataaat attcgcatat atattttatt tactatcttt tatactgttt ttcttggcgt 15121 tatgcctctt ctagactctg atataaaaac aactattttt ttagctatat catttaaact 15181 attatcgttt aagtatgtgt ctaaaaactc ttgctttgtt ttattccaat tataccataa 15241 gtcataggcc tcttcagctt gactaatctg ttctgaagta aaaccagctc ttctcattcc 15301 aactaaatta agtttatata taatagcttc gccagcatga gcagttaaag catatggcaa 15361 aatatcccta ccaacagcag acattccgct aatcatagca tattcgccta tagaacaaaa 15421 ttgatgcaca acacagttac cagaaataaa agctcccttt cctaccttta catgtccagc 15481 aaccaaagca ccattacata taataacatt atcattaatc tcacaatcat gagcaacatg 15541 cccagtagcc attatataac aattattttt tattatagtc tttgcatttt cttttgatgc 15601 tctatgcaaa ttggcgaact ctcttatctc attattatca ccaatctcta aaaatgtaac 15661 agtattccta tcaaaatgta tatcctgagg caaatcaccc aaaacaacat tatcatgaat 15721 tatattgttc ttacctatat tagtgtattc ttttataaca ctatgagcac ctattacagt 15781 gttctctcct atagttacat tgccttctat tacagcataa ggacctattt ttacattatc 15841 cgctatttta gcagactctg aaataatagc agtttcatgt atatcttttt tcatcttttt 15901 gttatccaat tatttattaa tcttcatagc ttctctatct actaaaaata atcctaaatc 15961 agcagaacaa gctaaactat cccctactct aacttcacca tgtgttttaa gtaaagttcc 16021 gttaaaagcc tcaacagtaa caaacatatc cattacgtct cctggtataa caggattttt 16081 aaacttaaca ttatctattt tagcaaaaaa cataaattta ttgccaattt cttcaggttt 16141 taataatttc atatagcaat atattccaga agtttgtgcc aatgcctcaa ccattaaaac 16201 accaggcatt ataggacttt ctggaaaatg acctgtaaat tgaggttcat tgaaagtaac 16261 attttttaga gaatgtattt taccttcttc tatgcttatt actttatcta caagtaaaaa 16321 aggatatcta tgcggaagaa gatccattat tttagttata ttaatatttt ccatttatca 16381 ttacctttta aaaaaaattc tacttattat tatatatagt ataatgatac cataatatta 16441 actaaacttc aagcaattta aaactttctt tttaaaaata tagccttatg cggacataat 16501 tcttgacaac agtagcaagt aatacattta tcataataat attcaggagg ataattttta 16561 ccttttttat caaagtttaa agccaaagga gtaacaggac aaaccttaac acatactccg 16621 cattttacac atttattttt atctataaca ggcttaggta taataaaaga aaatatcttt 16681 ttcacaatag gaaaattagc aaacttcatc aaacttcttc ctatgcctat tctcttatgc 16741 ggctttttaa aatcaacaac cttaatactt tctatatcat ctcccaaaac ttctatatca 16801 tctttattag agaaattatg cttaaaaccc atttttatag taggtatatt attataatca 16861 aaagatataa tctgtgaagc aatataatct aaagcaacag catcagtaga aaataataat 16921 gcatttacct ttctaggatt accacttctt ggtccgttac cttccatagc aagtatagcg 16981 tccattatat ataattttgg atttacatat ttatttaaat ccaaaagcat agtagaaaaa 17041 tcttcaaaat caggaagctt caaatgatat tcagcctttc taaaacctgg tatgcatcca 17101 aattggtttt ttacagcacc agtcatcaca gttaaagcat gagattttaa ttttggcaaa 17161 ctaattataa catcagcctc tgtaacaggc tttgctacag taaaactctt ctcttgaaca 17221 ccatcaggaa aattaacacc aacaggctca tcaaaatcag catattctac attaagcctg 17281 ctagcaactt catcaatacc agctttcaaa gcaacactgc ttcccttccc aactccaggt 17341 gaatcaccat aagaaacttt acagcccctc tcttgcaaaa ttgatgctat agcctcaaaa 17401 actacagggt gagttgttac agatttatca gctgtttccg ctgctaacaa attcggtttt 17461 aataatacct tatcattact ttgaacaaat aaatctatac cgccaagtaa atctataccg 17521 cgattaatgg cagatttaac catatccaaa tcataattat cacatttaat tataactacc 17581 ttactcatct aatcccttta taatataacg attttttaat aaatattaga aataaaaaat 17641 tataagctta aaaaaattat tataactatt cagaaacgcc gtacattttg ctgtcaaatt 17701 cttttttaat tctgttaaac ttatcacgtg ttctagttaa tgcagaatcc attttattaa 17761 tagctctttg atttgcactg tataacccca atgactttct tgcataaggt atcatctcat 17821 tcttacttac agaatcagaa ttaataagtc ttactataga gctataatat ccttcattac 17881 ctgctatcat tctatttctt ttcatctcta aagcataaat atctttttct ccattatcta 17941 catctgtaag agatactcta gaaactgaag ctgcatcact ttgagaaata tcttccatag 18001 cagaaattaa gctttctata gtagaagtag aatctagtct tgcattttct tcgccattat 18061 tcaaaaaaac taaagggtct gtatcactac cttgttttac cactctatta ttaccattaa 18121 attcagctat ataaacctct ctaggattaa caatacgttc atcattatca gcataaacat 18181 ttactttagt gttaatagga ataacaattg tagaaccatc ttcagaaaat gccacctcaa 18241 tctttgcagc agcattatta tatgtaacca tagaagaaac atttgctgta tgtacttgat 18301 aatcatcttc tatacttaca gtaaaatatc catgaagtaa agataatgat atataagaat 18361 attcatctga aatagaagaa ttaaccatca taatactttt ttcatttaaa gacacacttc 18421 caatattatt tccgtctttt aatacagtaa tctctactgt tgtattactt tttgtggtta 18481 atttatagcc ttcatgtatt tcactgcctc tgaaaactct taatgactta tcagattttt 18541 ctatgaaagc taccccagat atacctgtaa ctctaaaggt tatatcttga gaaaaaagtg 18601 tattactgct aaagagtata aatatattca gtaaaattag tgtaattatt ttcat //