LOCUS NC_017297:23 18147 bp DNA linear BCT 07-SEP-2013 DEFINITION Clostridium botulinum F str. 230613 chromosome, complete genome. ACCESSION NC_017297 SOURCE Clostridium botulinum F str. 230613 chromosome, complete genome. COMMENT locus start: 3546467; locus end: 3564613 COMMENT n1_4mer:GRV/n1_4mer:RV = 2.011565; n0_4mer:D = 18.385214; n0_4mer:PS = 35.521988 FEATURES Location/Qualifiers source 1..18147 /organism="Clostridium botulinum F str. 230613 chromosome, complete genome." gene complement(1..1149) /gene="" /locus_tag="" /db_xref="3546467..3547615" CDS complement(1..1149) /gene="" /product="putative R-2-hydroxyglutaryl-CoA dehydratase subunit" /translation="MNKLPDFIKDFSEAKRNAFVKMKEIKDEGGKIVGVYCGFAPWEV IAASGAVGAWLCGMDEEPIEDAEKHLPRNLCPLIKSSYGFALTEKCPFYYFSDMLLGE TTCDGKKKMYEALSKMKPMHVMNIPQTPYGKDSYNYYKKAIIKLKEELEKNLNVEITE EKLKEKIKLRNRERMALRDYYSLSKLCPPPMTGYNLRRVIQGTLYLSDKEKEIEDINN IIRETMKKYNEGERPVSKEAKRILVTGCPLGESTEKVIEAIEANGGVVVCYENCSGAK DESLLVDEEKNPIDALTERYLRTACACMSPNDNRIEYLDYLIDEYRVEGVVEVILQAC HTYNVESHRIKTFVTNNKKVSYLKIETDYSKRDLGQLKTRVEAFIEML" gene complement(1261..1593) /gene="" /locus_tag="" /db_xref="3547727..3548059" CDS complement(1261..1593) /gene="" /product="hypothetical protein" /translation="MKVAYVLESPHAQNILTNMIIPQMEKEMHGADVVGMFFIMDNTY FLIEGTETAERLKKLSEKTGLVLLACDKCAKERKIEDKLIKEAAIGCFPVCYAALDSA GVDHIITI" gene complement(1760..2518) /gene="" /locus_tag="" /db_xref="3548226..3548984" CDS complement(1760..2518) /gene="" /product="ATPase-like protein" /translation="MRLEIKDVSKSYINNKKKNKVLDNVSFNIEEGEFVTLLGPSGCG KTTLLTMIAGFHNSDSGEIILNDNRVMKPGPDRGFVFQNYALFPWMTVKDNIMYPMKQ QKIPKKESIDRLNYLLEMSKLKGKENLYPNQLSGGMKQRTAVVRALASKPEVLLMDEP LGAIDFQMRQMMQEELESLWLKDKTTVIMVTHDVDEAVYLSDRVIVFSAKGGKIIEDM KISLPRSRNRDNHKYLELKKELTSILKDSLSQNL" gene complement(2518..2655) /gene="" /locus_tag="" /db_xref="3548984..3549121" CDS complement(2518..2655) /gene="" /product="hypothetical protein" /translation="MVEAQTKMQTDMLVALMILAALIGFFIDRGLLQLNKLLTKWRYV Q" gene complement(2695..3237) /gene="" /locus_tag="" /db_xref="3549161..3549703" CDS complement(2695..3237) /gene="" /product="glycine betaine/proline ABC transporter permease/substrate-binding protein" /translation="MMVILIIVWYLLAEHYGNELILPTPKRTGKAFIKCLTSSEIMTN LLITLNRVLKGFMYAMIIGVPLGLFMGAFKMANNLIGGFIDSIRQVPIMAWVPLTIVW FGIGDGPTIFLITFSGIFPVILNTIAGVKNISKDYYNAARSMGAGPWSIFSNIILPAS IPDILTGARIAISGGWMSVI" gene complement(3285..3821) /gene="" /locus_tag="" /db_xref="3549751..3550287" CDS complement(3285..3821) /gene="" /product="hypothetical protein" /translation="MCPEAAKNLIENDDRFEIICPLVSNSDIFVLKNENKIKKIAMTQ NRFYQEKIIKDEYGEKVQIYPMIYSSLPYTLEKGRVDGIIIDSIKALKLNGEKKALSI NKNYTSYVLVIKKKFKKDKKFKEFITNYNKSVMELKRKDRIKNSIEDYKKINLSNEEV EQWLKLKVKFFLIPQQEY" gene complement(3873..4091) /gene="" /locus_tag="" /db_xref="3550339..3550557" CDS complement(3873..4091) /gene="" /product="hypothetical protein" /translation="MKYLKKIIITLTILIIFILVLNKLPDESLNSKIKIGVSDDSSGL VINYMINNNRLKNADLDENFEPYFIKDC" gene complement(4100..4240) /gene="" /locus_tag="" /db_xref="3550566..3550706" CDS complement(4100..4240) /gene="" /product="hypothetical protein" /translation="MYFFCSEEHYRNWVKESNINEDNIFCLDTQEAVCVAKMLFSVTD LK" gene complement(4247..4813) /gene="" /locus_tag="" /db_xref="3550713..3551279" CDS complement(4247..4813) /gene="" /product="hypothetical protein" /translation="MLTLEKNNLLDKEIDLNVIKHYEKERLIINSIDSKLSYLEKKVR IYIMDYIIEEKRPYNLKNLDYNFICNIGVAKDEFINIVLSLKDKKVLVMDEKENINFI YPVSAFDTNYKVKLEDGREINAMCAVDSIGTAFTFKQNIKIESSCIMCNDSIEIIIEN GEIKKCIPENLRVLHVDLNKNDSWASSC" gene complement(4841..5941) /gene="" /locus_tag="" /db_xref="3551307..3552407" CDS complement(4841..5941) /gene="" /product="putative lipoprotein" /translation="MKKRKIIGLLCTLVLGTALIATGCSKGSKETSAEKDKDYTVNLG YYNCDHMTSACVAKDAGIFDKMGLKVNVSGNGKVPQAMAAGKMDVGYIGYAGLIRGLA KGSPITVAANNHLGGSMYLVVSNKIKDPKDLKGKKLGIGTKPEESETWLMCAKKLGIP TEGKNYDCVEFGSDKDAYLALKAGKIDGFTCCDPWGSMAEYEKTGHIIATADKIVGED KWGECCVYSMNTKFEKEHPELAKKMIQAHVEAMKYCYEHPIKAAKIFAENYQVPEEVA IMTIYKKTVGEGRTITWKMNDDYFKTEIDTLMKYKLIEEEPDYDKLISKKIYEEAKVA DFDKFIKENVDSVFPVGMKYEEWKVKAMEIDK" gene complement(5959..6423) /gene="" /locus_tag="" /db_xref="3552425..3552889" CDS complement(5959..6423) /gene="" /product="putative lipoprotein" /translation="MRNIKIFFVFAIVFLLFGCSSNINELKESKNMGVKSDNERLLYF QHKYKDKEVLKCAEKDLNNDNKLDLIVIYKENNDKNSMVVVLSDKEKYKITNEVSAPI ENQKIEFKDIDKKPPIEFVVSGSKNGSFGYAIYRIEKGKIINLFGEDMKDCC" gene complement(6992..7531) /gene="" /locus_tag="" /db_xref="3553458..3553997" CDS complement(6992..7531) /gene="" /product="" /translation="MFIYYIKKILLTSINLLNGASTWLIFSFILAGLLHNILAPDKFQ KMLGNKKISSLIKATLSGMLLPICSCGVIPLGLSLYYSGAYLGPTLAFIASTPIINPI AVFLSYGLLGPKIATIYLVVGFTVPLIIGAIGNKLGGPELKAPGVEEQIQKRMEEIEL EEDQTSIFEKIKNGNCVVF" gene complement(7531..7791) /gene="" /locus_tag="" /db_xref="3553997..3554257" CDS complement(7531..7791) /gene="" /product="hypothetical protein" /translation="MKKILVEFVNTCPCCDEYSEFVKEACLKHSSEVECKIYYAGKDI DYIKKYGMILKGTLILNEKKKIDKLSKEIIESEIEKAIGDNK" gene complement(8194..8271) /gene="" /locus_tag="" /db_xref="3554660..3554737" gene complement(8296..8370) /gene="" /locus_tag="" /db_xref="3554762..3554836" gene complement(8399..8475) /gene="" /locus_tag="" /db_xref="3554865..3554941" gene complement(8501..8577) /gene="" /locus_tag="" /db_xref="3554967..3555043" gene complement(8582..8659) /gene="" /locus_tag="" /db_xref="3555048..3555125" gene complement(8665..8739) /gene="" /locus_tag="" /db_xref="3555131..3555205" gene complement(8747..8822) /gene="" /locus_tag="" /db_xref="3555213..3555288" CDS complement(8747..8822) /gene="" /product="tRNA-Gly" /translation="CGSGSVVERHLAKVNVASSNLVFRS" gene complement(8888..8972) /gene="" /locus_tag="" /db_xref="3555354..3555438" gene complement(8987..9063) /gene="" /locus_tag="" /db_xref="3555453..3555529" gene complement(9066..9141) /gene="" /locus_tag="" /db_xref="3555532..3555607" CDS complement(9066..9141) /gene="" /product="tRNA-Gln" /translation="LGCRQAVRHSTLTATRVGSNPAIPA" gene complement(9145..9221) /gene="" /locus_tag="" /db_xref="3555611..3555687" CDS complement(9145..9221) /gene="" /product="tRNA-His" /translation="GGHSSVGRAPDCGSGCQGFESLCSP" gene complement(9236..9312) /gene="" /locus_tag="" /db_xref="3555702..3555778" gene complement(9317..9394) /gene="" /locus_tag="" /db_xref="3555783..3555860" gene complement(9400..9474) /gene="" /locus_tag="" /db_xref="3555866..3555940" gene complement(9482..9557) /gene="" /locus_tag="" /db_xref="3555948..3556023" CDS complement(9482..9557) /gene="" /product="tRNA-Gly" /translation="CGSGSVVERHLAKVNVASSNLVFRS" gene complement(9624..9708) /gene="" /locus_tag="" /db_xref="3556090..3556174" gene complement(9723..9799) /gene="" /locus_tag="" /db_xref="3556189..3556265" gene complement(9802..9877) /gene="" /locus_tag="" /db_xref="3556268..3556343" CDS complement(9802..9877) /gene="" /product="tRNA-Gln" /translation="LGCRQAVRHSTLTATRVGSNPAIPA" gene complement(9881..9957) /gene="" /locus_tag="" /db_xref="3556347..3556423" CDS complement(9881..9957) /gene="" /product="tRNA-His" /translation="GGHSSVGRAPDCGSGCQGFESLCSP" gene complement(9964..10041) /gene="" /locus_tag="" /db_xref="3556430..3556507" gene complement(10047..10121) /gene="" /locus_tag="" /db_xref="3556513..3556587" gene complement(10128..10204) /gene="" /locus_tag="" /db_xref="3556594..3556670" gene complement(10349..10819) /gene="" /locus_tag="" /db_xref="3556815..3557285" CDS complement(10349..10819) /gene="" /product="phosphodiesterase" /translation="LKIGVISDTHRYIGDATSLVNSLGNVNLIIHLGDNVEDVKMLSS VYKGKIINVRGNCDFSKETPSELIENIGGKRFFITHGNRYDVKYDLAKLRYRALELEA DIALFGHTHVSQIEYIDGIWFINPGSPTLPRNGVRSVAIIGIEGDKVVPIIKKI" gene complement(10836..11435) /gene="" /locus_tag="" /db_xref="3557302..3557901" CDS complement(10836..11435) /gene="" /product="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase" /translation="MKKEVIVASNNKDKIREIKEILKKFNIDALSMKEAGIDIDIEED GNTFMENAYKKAATIYEILPNYMVIADDSGLMVDALNGAPGIYSARFAGEHGNYKKNN EKLLKELDGKKVEERKAKFVCSIVFIIDKDNVIRVQGEINGVIGEKEIGEDGFGYDPL FYIPEYKKNFAQMDSQTKNSISHRGEAFRKLKCELEKYI" gene 11539..12912 /gene="" /locus_tag="" /db_xref="3558005..3559378" CDS 11539..12912 /gene="" /product="hypothetical protein" /translation="LKYIGPFLRMNTLDPSNIYSQMNFLAKESLQNIILHSNCGICMP FSELKLKHDFADPKNFSSCTPLLCVYKKANPKLINSNKKLTWNDGKFKKEVNILGNSF MVLSILQLIEYYEQFKDKDKNLYSYTKLYNKLCKKQLEFFATYLRNEEGVFVNKLDAS DNMLSDINFKEKNKKFNFSNQCFLMCAYYGTSLLDKDDYCSNYKDFSLDILNMFLEYK DELYTLSTDEISKLCLGMNIFYKYSKNDDSKVLLLDLSELLQEKLKEKDLNIEKKVDT HCLAYIDFMLTFDNLGILKFKNLSKRMYKSLTKLYNDNLSMFIKNTDKKEIKYSCDEL ILYLLVLLNEYKNDKENYDKNLLLKFYKNQIINSGIILSWPEEPTLNSIERYKNFSLK SEDLLDEKCFRMGSIPSPEAIEIAPVLAKYVEYNTKKQEFTNCRNSFDSNKNFFLWFL TLYTLKN" gene 13025..13180 /gene="" /locus_tag="" /db_xref="3559491..3559646" CDS 13025..13180 /gene="" /product="hypothetical protein" /translation="MNITCSEKCKNNKNGRCILNYISPFLSIREENANCAYFLPIKSS KNKTTIK" gene complement(13183..14745) /gene="" /locus_tag="" /db_xref="3559649..3561211" CDS complement(13183..14745) /gene="" /product="family 5 extracellular solute-binding protein" /translation="MKKIICFLLSFTLIFFSGCVEKNKEVTSDEGIRDYLIYNIETMP KDLIMLEDDSQREKDLLLSLFDGLVGLDKNNNIVPELAEKWEVSKDGIDYKFYIKDNL FWSNGKEIAARDFEKFFKDILIYCKENNIRFNELNSVYGVKDYLTNGNLDNIAIKAKE DNILEIRLNNKDPYFLSTLSKPKYKLRKIDKKNKNYKKSFNEIPYTGAFCINKIEKDQ ITINKNNRYWDKENIKINRIVLKSIQNSEEALAHLKTSKLDLFMNPPIAEINNLNKEG LISKKLSLETGNIIFNKKDYIDLNLRRAIDSCISREDMCSKLLYGKSVPAIAYVPNNI AENDDISYGKNYFSLNKNLQRAKEFLDKSEYKKEKKDLKIISIEDPISNKIANSIIGE LKESLDINLNLVNCKDENELEQKIKNGDYDLAFVRNKAKNNDPLFFLLNFTSDSLQYQ DFLNKIKLEDNMWKKREYINKAQDVLAEDLYTIPVCFFYDMLCKRSRVQGQYITIDGN VIIKKITLAPYN" gene complement(14900..16330) /gene="" /locus_tag="" /db_xref="3561366..3562796" CDS complement(14900..16330) /gene="" /product="glutamyl-tRNA(Gln) amidotransferase subunit B" /translation="MDFEAVIGLEVHAELSTNTKIYCGCTTEFGGQPNTHVCPICLGL PGSLPQLNKRVVEYGIKAGLALNCSINKVCRMDRKNYFYPDCPKNYQITQDEVPICRD GYIEIELENGEKKKIGIERIHMEEDAGKLLHTNAGTLVDYNRAGVPLIEIVSRPDIRT PEEATKYLEKLKSILSSIEVSDCKMEQGSLRCDGNISVMPKGSEKFGVRSEIKNMNSF KALEKALSYEYDRHVEAVTKGEILEQETRRWDEANSVTVLMRSKEKANDYRYFPEGDL VTLNISDEWIEEVRKTIPELPHEKAERFVNEFRIPKYDAMVLTLTMDMAKFFEETALK SEDAKATSNWLMGDISRLMNEKTIEVKDLKFNPEQLAELIKLINAGTISNNIGKKVLD DMFKSGKSPKDIVEEKGLVQNNDEGAILEVVKKIIENNPQSIEDFKNGKKRALGFLVG LVMKETKGKANPQIVNKLVSEEANKM" gene complement(16366..17823) /gene="gatA" /locus_tag="gatA" /db_xref="3562832..3564289" CDS complement(16366..17823) /gene="gatA" /product="glutamyl-tRNA(Gln) amidotransferase subunit A" /translation="MDLTKLTAHELKDMLSNKEVKAEEITKAFLDRINLVDNKLGAYL YVSEEEAIKKAKEIDVKIEKNEELKALSGIPVGIKDNINVKGMQNTCASKILEGYTSP YDAHVTEKIKQEEGIILGKLNMDEFAMGSSTENSAFKLAKNPWDLERVPGGSSGGSAV AVAGSEATLSLGTDTGGSVRQPASFCGVVGLKPTYGRISRSGVVAFGSTLDQVGPMGK DVEDCALLTSAIAGLDKKDFTTADKEVPDYKKSLTKDIKGKRIGIPKEFFGDGLDKNV RKSVEEAIKVLEANGAEVKPCSLPLMDYALSAYYIISSAEASSNLARFDGIRYGYRSK NFKDAKDIYLKSRSEGFGDEVKRRIMLGTYVLSAGYYDAYYKKALKVRKLIKDDFQRV FKEFDAIVSPTSPTTAFKVGEKKDDVMSMYLSDIYTVPISVAGVPAISLPCGMVDGLP VGLQIISDYFKEDVLFNLAYNYEQSVDFHKMRADF" gene complement(17860..18147) /gene="gatC" /locus_tag="gatC" /db_xref="3564326..3564613" CDS complement(17860..18147) /gene="gatC" /product="glutamyl-tRNA(Gln) amidotransferase subunit C" /translation="MSVSKKDVEYVAELARLEFKEEEKDNFVNDLNKILNYMEKLDEL NTDDVDIVVNPYYIENKYREDNVEKSMELKEVIDNAPESLEEYVIVPKVID" ORIGIN 1 ttataacatt tctataaaag cctccactct agtttttagt tgtcctaaat cccttttaga 61 ataatctgtt tctattttta aataagatac ttttttatta tttgtaacaa aagtttttat 121 tctatgagat tctacattat aggtatggca tgcttgtaat ataacttcta ctacaccctc 181 caccctatat tcatctatta aataatctaa atattctatc ctattatcat taggactcat 241 acaagcacag gctgttctta aatatctttc tgttaatgca tctattggat ttttttcttc 301 atctactaat aaactttcat cttttgcacc actacaattt tcataacaaa ctactactcc 361 cccattagct tctatagcct caattacttt ttcagtagac tctcctagag gacaacctgt 421 tacaagtatt cttttagcct ctttagaaac aggcctttca ccttcattgt attttttcat 481 tgtttctctt attatattat ttatatcctc tatttccttt tccttatctg ataaatataa 541 agttccctgt attaccctcc tcaaattata acctgtcata ggtggtggac aaagcttaga 601 taagctataa taatctctta atgccattct ttctctattt cttaatttaa ttttttcttt 661 tagcttttct tccgtaattt ctacattcaa attcttttct aattcctctt taagctttat 721 aattgctttc ttgtaataat tataagaatc ctttccataa ggagtttggg gtatattcat 781 aacatgcata ggtttcattt tacttaatgc ttcatacatt ttcttttttc catcacaagt 841 agtttctcct aaaagcatat ctgaaaaata ataaaatggg cacttttctg ttaatgcaaa 901 accataactt gattttatta gtgggcataa atttcttggc aaatgttttt ctgcatcctc 961 tataggttcc tcatccattc cacaaagcca agcccccact gctcctgatg cagctatcac 1021 ttcccaggga gcaaatccgc aataaactcc cactattttt ccaccttcat ctttaatttc 1081 tttcattttt acaaatgcat ttcttttagc ttcactaaaa tccttaataa aatctggtaa 1141 tttattcata taatatcccc ctctagataa aaataggatg cctcaaaata ggcttaattt 1201 tatatttgcg attttaaaat taaatctatt tcattttgag acacccattc ttttctttta 1261 ttatattgtt attatatggt ctactcctgc agaatctaat gctgcataac atactgggaa 1321 acaacctatt gccgcttctt taattaactt gtcctcaatt tttctttctt tagcacattt 1381 atcacaagct aataaaacaa gcccagtttt ttcacttaat ttttttaatc tttccgctgt 1441 ttcggtaccc tctattaaaa aatatgtatt atccattata aaaaacattc caactacatc 1501 tgcaccatgc atttcctttt ccatttgtgg aataatcata ttggttaaaa tattttgagc 1561 atgtggtgac tctaatacat aagctacttt catcttaaaa tcctcctaat tacttttaat 1621 ttaatatatt tatccaatga ctacccgctc taatactccc atcttcttca aagtgggaat 1681 aaagaacggt tacgtccctg gataacgatt tctaagcttc agtgggagta aaaactccct 1741 ctgaagccaa gaactctgtt tataaatttt ggcttaatga atcctttaat atgctagtta 1801 attccttttt taattctaga tatttatggt tatccctatt tcttgatctt ggtaaactaa 1861 ttttcatatc ttctataatt tttcctccct tagctgaaaa aacaatcact ctatcactta 1921 ggtatactgc ttcgtcaaca tcatgagtta ccattataac tgtagtttta tcctttaacc 1981 ataaactttc taactcttct tgcatcattt gcctcatttg aaaatctata gcacccaaag 2041 gctcatccat aagtaatacc tctggtttac tagctagtgc tcttactact gcagttcttt 2101 gtttcatacc acctgataat tgattagggt ataaattttc ttttcctttt agcttagaca 2161 tctctaataa ataatttaac ctatctatag attccttttt aggaattttt tgttgtttca 2221 tagggtacat tatattatct tttacagtca tccatgggaa taatgcataa ttttgaaaaa 2281 caaagcctct gtctggacca ggtttcatta ccctattatc atttaaaatt atttcaccag 2341 aatctgaatt atgaaaacct gcaatcatcg ttaaaagtgt tgtttttcca caaccggatg 2401 gacctagtaa tgttacaaat tctccttctt ctatattaaa acttacatta tctaaaactt 2461 tatttttttt cttattattt atgtaagatt tactaacatc ctttatttct aacctcatta 2521 ttgaacatac ctccacttag taagtaactt atttaattga agtagtcccc tatctataaa 2581 gaatccaatt aaagctgcta atatcattaa tgcaactaac atatctgttt gcatttttgt 2641 ttgagcttct accatagaga aaccgagacc ggcactcgtt gctataaact ccgctcagat 2701 tacagacatc catcctccac ttatagctat tctagctcct gttaatatat caggtataga 2761 agctggtaat attatattac taaatatgct ccaagggcct gctcccatac ttctagctgc 2821 attataataa tctttagaaa tattttttac tccagctata gtatttaata ttactgggaa 2881 tattcctgaa aacgtaatta aaaatatggt aggtccatcc cctattccga accatacaat 2941 tgtaagagga acccatgcca ttataggaac ttgccttatg gaatctataa atcctcctat 3001 aagattatta gccattttaa aagctcccat aaaaagacct aatggaacgc ctattatcat 3061 ggcatacata aaacctttta aaaccctatt taatgtaata agtaaattgg tcataatttc 3121 actactagtc aaacacttta taaaagcttt tcctgttctt ttaggtgttg gtaatattag 3181 ttcattacca taatgttctg ctaacaaata ccaaactatt attaaaataa ccatcataat 3241 taatttgtac attaattctt taatcttatt tttactggtt tcttttaata ttcctgttga 3301 ggtattagaa agaactttac tttcaatttc agccattgtt ccacctcctc attagataag 3361 ttaatttttt tataatcttc tatagagttt ttaattctat cttttctttt taattccata 3421 acagacttat tataattagt tataaactct ttaaattttt tatccttttt aaattttttc 3481 ttaataacta atacatagct tgtataattt ttatttatac ttaaagcttt tttttctcca 3541 tttaacttta atgcttttat tgaatctatt ataatcccat caaccctacc tttttccaat 3601 gtataaggca aagatgaata tatcatcgga tatatttgta ctttttctcc atattcatct 3661 ttaataattt tttcttgata aaatctattt tgtgtcatgg ctattttttt aattttattt 3721 tcattcttta aaacaaatat gtctgaatta ctaactaaag gacatattat ttcaaatcta 3781 tcatcatttt caattaaatt tttagctgct tctggacaca ttattgctat atctaaaaca 3841 tctgagctta aagcccattg agaagtatta cctcagcagt cctttataaa atatggttca 3901 aaattttcat ctaaatctgc attctttaat ctattattat taatcatata atttataaca 3961 agtccagatg aatcatctga aactccaatt tttattttgg aattcaaaga ttcatctggt 4021 aatttattta gtactaaaat aaatattatt aatatagtta aagttataat aatttttttt 4081 aaatatttca tatacatccc tattttaaat cagtaacact aaataacatt ttcgctacac 4141 atacagcttc ttgggtatct aaacaaaata tattgtcttc attaatattt gattctttaa 4201 cccagtttct ataatgttct tcactacaga agaaatacat tatatttcaa caactagagg 4261 cccaactatc atttttattt aaatctacat gtagtactct taaattttca ggtatacatt 4321 ttttaatttc accattttca ataataattt ctatagaatc attacacata atacaactag 4381 attctatttt tatattctgt ttaaatgtaa aagctgttcc tatagaatca actgcacaca 4441 tagcatttat ttctctacca tcttctaatt taactttata attagtatca aaggcactaa 4501 ctggataaat aaaatttata ttttcttttt catccataac taacactttt ttatctttta 4561 atgataatac tatatttata aattcatcct ttgctactcc aatattacaa ataaagttat 4621 aatctagatt ttttaaatta taaggtcttt tttcttctat aatatagtcc attatatata 4681 ttcttacttt tttttctaaa taagataatt ttgaatctat actgtttata atcaatcttt 4741 ccttttcata atgcttaata acatttaagt ctatttcttt atccaataga ttatttttct 4801 ctaaggttaa catatattac ttccttttct acctgaactc ctatttatct atttccatag 4861 ctttaacttt ccactcttca tatttcattc ctactgggaa aactgaatct acattttctt 4921 ttataaattt atcaaaatca gctactttgg cttcttcata tattttttta gatattaatt 4981 tatcatagtc aggttcttct tctattaatt tatatttcat taaagtatct atttctgttt 5041 taaaataatc atcattcatt ttccaagtta tagttcttcc ctcacctaca gtttttttgt 5101 aaattgtcat aatagctact tcttctggga cttgataatt ttcagcaaat atttttgctg 5161 cttttattgg atgttcataa caatatttca tagcttctac atgagcttgt atcatttttt 5221 tagctagctc tggatgttct ttttcaaatt ttgtattcat agaataaaca caacattcac 5281 cccatttatc ttctccaaca attttatctg ctgttgcaat aatgtgacct gtcttttcat 5341 attccgccat tgatccccat ggatcgcaac aagtaaatcc atctatttta cctgctttta 5401 atgctaaata tgcatctttg tctgatccaa attcaacaca atcataattt ttgccttccg 5461 taggaattcc taacttctta gcacacatta accaggtttc actttcttca ggctttgttc 5521 ctattcctaa ttttttacct tttaaatctt taggatcttt tattttatta gaaacaacta 5581 aatacattga tccacctaaa tgattattag ctgcaacagt tataggtgat ccctttgcta 5641 atcctcttat taatcctgca tatcctatat atcctacatc catttttcct gctgccatgg 5701 cctgaggaac ttttccattt cctgatacat taacttttaa tcccatttta tcaaatatac 5761 ccgcatcttt agcaacacaa gcagaggtca tatgatcaca attataatag cctaggttta 5821 ctgtataatc cttatccttt tcagctgaag tttctttact tcctttagaa caacctgtag 5881 caattaatgc tgttcctaaa actaatgtac ataataagcc tattattttt ctttttttca 5941 tttttaatcc cccttaaatt agcaacaatc tttcatgtct tctccaaaca gatttattat 6001 tttacctttt tctattctat aaattgcata tccaaaactt ccatttttag atcctgatac 6061 tacaaactct attggtggtt ttttatctat atccttaaac tctatttttt gattttctat 6121 aggtgctgaa acttcatttg taatcttata tttttcttta tcacttaata caactaccat 6181 agaattttta tcattatttt ctttataaat aacaattaaa tctaatttat tatcattatt 6241 taaatctttc tccgcacatt ttaaaacttc tttatctttg tatttgtgtt gaaaataaag 6301 taatctttca ttatcacttt ttactcccat atttttgctt tctttaagtt cattaatatt 6361 actagaacaa ccaaataaca aaaatactat tgcaaacaca aaaaatattt taatatttct 6421 catttatctt cacctttatt aagctgatat tgctttactt atctttctta ttttaggaag 6481 catagctttt aaaaatagta taaacataat taatgaacaa acatacttca taggttctgg 6541 tgctgcaaat ataaatttat tagcagcctt tatagtattt tgagttctat caaaactaat 6601 aacaggttca aagttaggta atataatatt tgtaaaatac cctacaataa aagataaagc 6661 tattaatgta gtagtatata tggctactgt cctcttacct attaactttc caatacttat 6721 aagttcaggt aaatttgatg cagttcccgc cattaaaaaa gttattgctg ccccaggagc 6781 tgctccacta gctaccaatg cagcaataaa aggtatatgt cctaccgcac acacatacat 6841 aatgcaaccg attactgcta ttccaaaaat agatactgca tttggtgatc ctaagtattg 6901 ttgtatgaat tcttgtggta caagaactaa aagtattccg gctaatagca tacctggaat 6961 tacatatttt gatacagcta cagccacatc attaaaagac cacacaattc ccatttttta 7021 ttttttcaaa tattgatgtt tgatcttctt ctaattctat ttcttccatt cttttttgaa 7081 tttgttcttc tactccaggg gcttttagtt caggcccccc taatttattc cctattgctc 7141 caattattaa tggtactgta aaacctacta ctaagtatat agtagctatt ttaggtccta 7201 aaagaccata ggataaaaaa acagcaatag gatttattat aggtgtagat gctataaatg 7261 ctaatgtagg ccctaaatag gcaccagaat aataaagact taatcctaaa ggtataacac 7321 cacaactaca tatagggagc aacattccgg ataaagttgc tttaattaga gatgaaattt 7381 ttttattacc taacattttt tgaaacttat ctggtgctaa aatattatgt aataacccag 7441 ctaatataaa actaaatata agccaggtag atgcaccatt taataaattt attgaggtta 7501 acaatatttt ttttatgtaa tagataaaca ttacttatta tcaccaatag ctttttctat 7561 ttcactttct attatttctt tagataactt gtctattttt ttcttttcat taagtatcaa 7621 agttcctttt agtatcattc catacttttt aatataatct atatcctttc ctgcataata 7681 aattttacac tctacttcac tagaatgttt taaacacgcc tcctttacaa attctgaata 7741 ctcatcacaa catggacaag tgtttacgaa ttctactaaa atttttttca taaaaattcc 7801 tcctaaaatt taattcattt ttatgataac atatttccac ttatgtagtt atttgtaata 7861 aatatacgaa tcatgtaatc tataaataaa atttatagat tactttttta tttataaata 7921 agaaaaaaga gatgatctaa catcacctct ttaagctgca accccttgca ttatagccgt 7981 accatccata ttaattgttg tacctagagg tatagtaaaa ctaactacag atttatttac 8041 tccacaattt ctcaaagaaa tttatgaaat ttaattagtt tgtattactc tcataatgtt 8101 tatcattata aatttatgaa aataaaaaaa tcaagaactt aatactttaa gttcttgatt 8161 tcaaatattt atattattcg tttgattatc ttatggtgcg cccagcagga gtcgaacctg 8221 cggcctccgg attcgaagtc cgtcactcta tccagctgag ctatgggcgc cctaaataaa 8281 aaaagaccaa aaaaatggag cgggtgaagg gaatcgaacc ctcgtaacta gcttggaagg 8341 ctagcactct accattgagt tacacccgca tattacacat ttctcgtcag tttaatagtg 8401 gtcggggtga cagggctcga acctgcgacc tcatggtccc aaaccacgcg cgctcccatc 8461 tgcgccacac cccgatatat ttttaaaatc gccatcaagc tggtgcgcca tcgggggttc 8521 gaaccccggg caccctgatt aagagtcagg tgctctacca gctgagctaa tggcacttat 8581 ttggtgcgtc ttaagggatt cgaacccctg gcccacgcct tagaagggcg ttgctctatc 8641 catctgagct aaagacgcat attatggagc gggtgaaggg aatcgaaccc tcgtaactag 8701 cttggaaggc tagcactcta ccattgagtt acacccgcat atttgttgga gcggaagacg 8761 agattcgaac tcgcgacgtt caccttggca aggtgacgct ctaccactga gccactcccg 8821 caaatatcaa aacatttagt tcgttatatt ttaatccttc tgaattctat tcagaagttc 8881 atttaaatgg tgcagatgaa gggagtcgaa cccccacgcc ataggcgcta gatcctaagt 8941 ctagtgcgtc tgccaattcc gccacacctg cacgttatat aatttttggt gatccaccgg 9001 ggaatcgaac cccggacaac atgattaaaa gtcatgtgct ctaccaactg agctagtgaa 9061 tcaaatggct gggatggcag gattcgaacc tacgcgtgta gcagtcaaag tgctatgcct 9121 taccgcttgg cgacatccca ataatggggt gaacaaaggg actcgaaccc ttgacaacca 9181 gaaccacaat ctggcgctct accaactgaa ctatgcccac catattaggt ttaaatggtg 9241 cgccatcagg gattcgaacc ctgggcaccc tgattaagag tcaggtgctc taccaactga 9301 gctaatggca cttatttggt gcgtcttaag ggattcgaac ccctggccca cgccttagaa 9361 gggcgttgct ctatccatct gagctaaaga cgcatattat ggagcgggtg aagggaatcg 9421 aaccctcgta actagcttgg aaggctagca ctctaccatt gagttacacc cgcatattta 9481 ttggagcgga agacgagatt cgaactcgcg acgttcacct tggcaaggtg acgctctacc 9541 actgagccac tcccgcaaat atcaaaacat ttagtttcgt tacctttaaa tccttctgaa 9601 ctctattcag aagttcattt aaatggtgca gatgaaggga gtcgaacccc cacgccatag 9661 gcgctagatc ctaagtctag tgcgtctgcc aattccgcca cacctgcacg ttatataatt 9721 tttggtgatc caccggggaa tcgaaccccg gacaacatga ttaaaagtca tgtgctctac 9781 caactgagct agtgaatcaa atggctggga tggcaggatt cgaacctacg cgtgtagcag 9841 tcaaagtgct atgccttacc gcttggcgac atcccaaaag tggggtgaac aaagggactc 9901 gaacccttga caaccagaac cacaatctgg cgctctacca actgaactat gcccaccgta 9961 ttatggtgcg tcttaaggga ttcgaacccc tggcccacgc cttagaaggg cgttgctcta 10021 tccatctgag ctaaagacgc atattatgga gcgggtgaag ggaatcgaac cctcgtaact 10081 agcttggaag gctagcactc taccattgag ttacacccgc actcttttgg tcggggtgac 10141 agggctcgaa cctgcgacct catggtccca aaccacgcgc gctcccatct gcgccacacc 10201 ccgatattaa agagtctctc gagttattat tcattttgcc gttttcctgt ttgttcttgc 10261 aactctcaac gacataaact attctacatc atataattat attcgtcaat acattttttt 10321 attttttttt atgtttttta aaatttcatt atatcttttt tataataggc actactttat 10381 ctccctcaat acctataata gcaacacttc taactccatt tcttggaagt gtagggctac 10441 cagggttaat aaaccatatc ccatctatat actctatttg agatacatga gtatgaccaa 10501 atagggctat atcagcttct aattctaatg ctctatatct taatttagct aagtcatact 10561 ttacatcata tctatttcca tgagttataa aaaatctttt ccctcctata ttttctatta 10621 attcagatgg agtttctttt gaaaaatcac aatttcctct tacatttata attttccctt 10681 tataaacaga agacaacatt tttacatcct ctacattatc tcctaaatga attattaagt 10741 ttacattacc taaactattt acaagagaag tagcatctcc tatatatcta tgggtatcac 10801 taataacacc tattttcaaa attgcccccc cttatctata tatatttttc taattcgcat 10861 tttaattttc taaaggcttc tcccctatga cttatagaat ttttagtttg agaatccatt 10921 tgtgcaaagt tttttttata ctctggtata taaaataaag gatcatatcc aaatccatct 10981 tcacctattt ctttttctcc tataacccca ttaatttcac cttgcactct tattacatta 11041 tccttatcta ttataaatac tatagagcaa acaaatttag cttttctctc ttctactttt 11101 ttaccatcca gttcttttaa taacttttca ttattctttt tataatttcc atgctcccct 11161 gcaaatctag cagaataaat tcctggagct ccatttaaag catctaccat aagccctgaa 11221 tcatctgcta ttaccatata gttaggcaaa atttcatata tagtagctgc ttttttataa 11281 gcattttcca taaatgtatt gccatcttct tctatatcta tatcaatacc tgcttctttc 11341 atcgataaag catctatatt aaattttttt aatatttctt ttatttctct tattttatct 11401 ttgttattac ttgcaacaat aacttctttt ttcatatgtt aatcctccaa acaaattaaa 11461 tattttattt atgtatcact aaattgccct tgtataacat attataatat aagaattaat 11521 ttatggtagg tgtgtttttt gaaatatata ggtccttttt taagaatgaa taccttagat 11581 ccaagtaata tttactctca gatgaacttt ttagctaagg aatctctaca aaacataata 11641 cttcattcca attgtggtat ttgtatgccc tttagtgaat taaaactaaa gcatgatttt 11701 gctgacccta aaaattttag ctcttgcaca cctttattgt gtgtctataa aaaagctaac 11761 cctaaactta taaattcaaa taaaaaacta acatggaatg atggtaaatt caaaaaagaa 11821 gtaaacatat taggtaatag ctttatggtc ttatccattc ttcaattaat agaatattat 11881 gaacaattta aagacaagga taagaattta tactcttata ctaaattata caataaattg 11941 tgtaaaaaac aattagaatt ctttgcaact tatcttagaa atgaagaagg agtttttgtt 12001 aataagctag atgcatcaga taatatgtta tctgatataa atttcaaaga aaaaaataaa 12061 aaatttaatt tttcaaatca atgcttttta atgtgtgctt actatggtac atctttatta 12121 gacaaggatg attattgttc taattataaa gatttttctt tagatatact taatatgttt 12181 ttagaatata aagatgaact ttatactctt tccacagacg aaatatccaa attatgttta 12241 ggaatgaata tattttataa atattctaaa aatgatgata gtaaagtatt attactagat 12301 ctatcagaac ttttacaaga aaaattaaag gaaaaagatt taaatatcga aaaaaaagtt 12361 gatactcatt gtttagctta tatcgacttt atgcttacct ttgataattt aggaatatta 12421 aagttcaaaa atctaagtaa aagaatgtat aaatcattaa caaaattata taatgataac 12481 ttaagtatgt ttattaaaaa tacagataaa aaagaaataa aatattcctg tgatgagtta 12541 atattatatc ttttagtatt acttaacgag tataaaaatg ataaagaaaa ttatgataag 12601 aatctattgc ttaagtttta taaaaatcaa ataataaatt ctggaataat actaagttgg 12661 cctgaggaac ctacattaaa tagtattgaa agatacaaga acttttcttt aaaatcagaa 12721 gatttattag atgaaaagtg ttttagaatg ggatctatac catctcctga ggctattgaa 12781 atagcaccag tactagctaa atatgtagaa tacaatacaa agaaacaaga gtttactaat 12841 tgcagaaatt cttttgacag taataaaaat ttcttcctat ggtttttaac tttatataca 12901 cttaaaaatt aatatgagga tattgcaatg caatatcctc atattaattt attttttgga 12961 tataataaac atacatcaat aagtacaagc attggtaata aaatacttta taggagggct 13021 ttgtatgaat ataacttgtt ctgaaaaatg taaaaataat aaaaatggaa gatgcatatt 13081 aaattacatc agtccctttt taagtattcg cgaagaaaat gctaattgtg cttattttct 13141 tcctattaaa tcatctaaaa ataaaaccac tataaaataa tattaattat agggtgctaa 13201 ggttattttc tttataataa cattaccatc tatggtaata tattgccctt gtaccctact 13261 tcttttacat aacatatcat aaaaaaaaca aacaggtatt gtatacaaat cctcagccag 13321 aacatcttgt gctttattga tatattctct ctttttccac atattatctt ctaatttaat 13381 tttatttaaa aaatcttggt attgcaaaga atcactagta aagtttaaga ggaaaaataa 13441 aggatcgtta tttttagctt tatttctaac aaaggctaag tcataatctc catttttaat 13501 tttctgttct aattcattct catccttgca attaaccaaa ttaagattta tatctaaact 13561 ctcttttaat tcccctatta tactattagc tattttatta gaaataggat cttctattga 13621 tataattttt aaatccttct tttctttttt atattcactt ttatctaaaa attcttttgc 13681 tctttgtaaa tttttattta aactaaaata atttttacca taacttatat catcattttc 13741 tgctatatta tttggtacat aagcaatagc tggcactgat ttcccatata gtaacttcga 13801 acacatatcc tccctactaa tacagctatc tattgccctt cttaagttta gatctatata 13861 atctttttta ttgaatatta tatttcctgt ttctaaagat aactttttag atattaatcc 13921 ttctttattt aaattattaa tttcagctat aggaggattc ataaacaagt ctaatttgga 13981 agtctttaaa tgagccaatg cttcttcact gttttgtata gatttaagta ctatcctatt 14041 aatctttata ttttctttat cccaatatct attatttttg ttaattgtta tttggtcttt 14101 ttctatttta tttatacaaa atgctcctgt atatggtatt tcattaaaac tttttttata 14161 atttttgttt ttcttatcta tttttcttaa tttatattta ggcttagaaa gagtgcttaa 14221 aaaatatgga tctttattat ttagtcttat ttctaatata ttatcttctt tagcttttat 14281 agctatgtta tctagatttc cattagttaa gtagtcctta actccatata cagaatttag 14341 ttcattgaat cttatattat tttccttaca atatataaga atatctttaa aaaatttttc 14401 aaaatcccta gctgctattt ccttcccatt gctccaaaat aaattatcct taatataaaa 14461 tttataatct ataccatctt tactaacttc ccacttttct gccaattctg gaacaatgtt 14521 attattttta tctaacccta ccaatccatc aaatagactt aataataagt ccttctctct 14581 ttgtgaatcg tcttctagca taattaaatc cttaggcata gtttctatgt tatatattaa 14641 gtaatctctt attccctcat ctgaggtgac ttctttgttt ttttctacac aaccgctaaa 14701 aaaaattaat gtaaaactta ataaaaaaca tataatcttt ttcattttat ccccccgctt 14761 tgaagaatca tatactatat ttaattattt acacttatag gttaaaataa acaatatttt 14821 ttaaacttta catataattc aaactatttt tcataaaaaa atccccacat ttttatgtga 14881 ggatctttta ttctaatatt tacattttat ttgcttcttc acttactaat ttatttacta 14941 tttgaggatt agccttaccc tttgtttctt tcattacaag acctacaagg aagcctaagg 15001 ctcttttctt tccatttttg aagtcttcta tagattgagg attattctct ataatctttt 15061 taaccacttc taatatagca ccttcgtcat tattttgaac caaacctttt tcttcaacta 15121 tatctttagg acttttacct gacttaaaca tatcatctaa aactttttta cctatattat 15181 tagatatagt tccagcgttt attaatttaa ttaactctgc taattgttca ggattaaatt 15241 tcaaatcttt aacttctata gttttttcat tcataagtct tgaaatatca cccattaacc 15301 agttagaagt agcttttgca tcttcactct ttagggcagt ttcttcaaaa aatttagcca 15361 tatccattgt taaagttaat accatagcat catatttagg tattctaaat tcatttacaa 15421 atctttcagc tttttcatgt ggtaactctg gtatagtttt tcttacttct tctatccatt 15481 catctgaaat atttaatgta actaaatctc cttctggaaa gtatctataa tcattagctt 15541 tttctttgct tcgcataagc actgtaacag aattagcttc gtcccatctt cttgtttctt 15601 gctctaaaat ttctcccttt gttacagctt ctacatgtct atcatattca tatgataaag 15661 ctttttccaa agctttaaaa gaattcatat tttttatttc tgatcttact ccaaattttt 15721 cgctaccttt aggcattaca gatatattac catcacatct taaggaacct tgctccattt 15781 tacaatctga tacttctatt gaagatagta tactctttaa tttctctaag tattttgtag 15841 cttcttctgg agttcttata tctggtcttg atactatctc tattaatggt actcctgctc 15901 tattgtaatc taccaatgtt cccgcattag tatgaagtaa ttttccagca tcttcttcca 15961 tatgtattct ttctatgcct atttttttct tttcaccgtt ttctaactct atttcaatat 16021 atccatctct acatattgga acttcatctt gagttatttg ataattttta gggcaatctg 16081 gataaaaata attttttcta tccattctac aaactttgtt tatagaacaa tttaaagcta 16141 atcctgcctt aattccatac tctactactc ttttattcaa ttgaggtaga gaacctggta 16201 atcctaaaca tattggacaa acatgagtat taggttgacc accaaattct gtagtgcatc 16261 cacaatatat tttagtattt gttgaaagct cagcatgaac ttctaatcct ataactgctt 16321 caaaatccat ctatgttttt cactcctttg tttttaacta tatacttaaa aatccgctct 16381 cattttatga aaatctactg attgttcata attatatgct aaattaaata atacatcttc 16441 tttaaaataa tctgatataa tttgaagtcc tactggaagt ccatctacca taccacatgg 16501 taatgatata gctggtactc ctgctacact aattggaaca gtatatatat ctgaaagata 16561 cattgacatt acatcgtctt tcttttctcc tactttaaat gctgtagttg gtgatgttgg 16621 tgatactata gcatcaaatt ctttaaatac tctttggaaa tcgtctttta taagttttct 16681 tacttttaat gctttcttgt agtaagcatc atagtatcct gctgataata cataagttcc 16741 aagcattatt cttctcttaa cttcatctcc aaagccttca cttctagatt ttaaatatat 16801 atctttagca tctttaaagt tttttgatct ataaccatat cttataccgt caaatctagc 16861 taaatttgat gaagcttctg cactagatat tatgtaataa gctgataggg cataatccat 16921 taatggtaga gaacatggtt taacttctgc tccatttgcc tctaatacct ttatagcttc 16981 ttctacagat tttcttacat tcttatctaa tccatctcca aagaactctt ttggaatacc 17041 aattctttta ccctttatat ctttagttaa acttttttta taatcaggaa cttctttatc 17101 tgctgttgta aaatcctttt tatctaatcc tgctatagct gatgtgagta atgcacaatc 17161 ttctacatct tttcccattg gacctacttg atctaatgta gaaccaaaag ctacaacccc 17221 tgatcttgat attcttccat atgtaggttt taaaccaact actccacaaa aggatgcagg 17281 ttgtcttaca gaaccaccag tatctgttcc taatgataaa gtagcttcag atcctgctac 17341 cgccactgca gatccacctg aagatccacc tggtactctt tctaaatccc atggattttt 17401 ggctaattta aatgcactat tttctgtaga tgatcccata gcaaactcat ccatgtttaa 17461 tttgccaagg attattcctt cttcttgttt tattttttct gttacatgag catcataagg 17521 tgaagtataa ccttctaata ttttagatgc acaagtattt tgcattcctt ttacatttat 17581 attatctttt atacctactg gtatacctga taaggccttt aactcttcat ttttttctat 17641 ttttacatca atttctttag ctttttttat agcttcttcc tctgatacat ataagtatgc 17701 tcctagctta ttgtctacta aatttattct atctaaaaaa gcttttgtta tttcttctgc 17761 tttaacttct ttatttgaaa gcatatcttt taattcgtgt gctgttaatt tagttaaatc 17821 cattttcttt cctccctttt ccagaaaaca aaagaattat taatctataa ctttaggaac 17881 aattacatat tcttctaagc tttctggtgc attatctata acttctttta attccataga 17941 cttttctaca ttatcttctc tatatttgtt ttcaatataa tatgggttta ctactatatc 18001 cacatcatcg gtatttaatt catccaattt ttccatatag tttaatattt tgtttaagtc 18061 atttacaaaa ttatcttttt cttcctcttt aaattctaac cttgcaagtt ctgctacata 18121 ttctacatct ttttttgaaa ctgacat //