LOCUS NC_017295:15 19415 bp DNA linear BCT 07-SEP-2013 DEFINITION Clostridium acetobutylicum EA 2018 chromosome, complete genome. ACCESSION NC_017295 SOURCE Clostridium acetobutylicum EA 2018 chromosome, complete genome. COMMENT locus start: 3472797; locus end: 3492211 COMMENT n1_4mer:GRV/n1_4mer:RV = 3.164649; n0_4mer:D = 19.242461; n0_4mer:PS = 35.442807 FEATURES Location/Qualifiers source 1..19415 /organism="Clostridium acetobutylicum EA 2018 chromosome, complete genome." gene complement(1..900) /gene="" /locus_tag="" /db_xref="3472797..3473696" CDS complement(1..900) /gene="" /product="hypothetical protein" /translation="MENNQGTSCPTSFCNASVLKAHTLEQAENWPVRPGKYKVPVVLS EFVIQIDVEAKVKLNEPAYEIKRIEKQVFLTECRYVGGTDKVFIEGYIRKNIEYASRH CTTKSGIGGVINDTTVHIPFRCVTRVEFNGARPRVFPNFQPDVARYFDQKRMGKNIRE ADRASYEIFNEPVYCELEWSEIYDADIDDRGCPIDHFLNEEEFQEFTDKSVVYIAIKL LQKQQVGHTHHGHYDEKEGFEKEGFEKEGYKKEGFENQGFENQGCGKEGFSKEGFKKE EFGKEYGYKGKGEWNGMIDKYKK" gene complement(1102..1596) /gene="" /locus_tag="" /db_xref="3473898..3474392" CDS complement(1102..1596) /gene="" /product="Thiol peroxidase, TPX" /translation="MKVKFKGKEVTLEGTEIKVGDTFPDFVAVNSSLEPVMLKNTNRV RVFLAVPSVDTPVCDLEVKTFNARASEIDGVSIYTISMDLPFAQSRWCGAEGIKNVTT LSDYRDRAFGKNTGTYIKELGLLARAVFVVDSSNKVTYANYLEEVSGYPNYDEVLQAA QAAK" gene complement(1825..2739) /gene="" /locus_tag="" /db_xref="3474621..3475535" CDS complement(1825..2739) /gene="" /product="TPR-repeats containing protein" /translation="MPLSYYEKGIMYKRKNFMGPAVKCFEEARKLEEKVGSKASLELA KIYAYFKDYEEAYKYCKEAISKSNYIEAYYLMVRILLLSNTPINEILKKAGKVKIHNS LLADIFCFEGNYEVALKIIDTCLKEDEVTRDLELIKIKCLLKLKQYDKCKDYIDNFSQ SYLYFFKIRMYKVICCVLLEEYRLAWKIIDEFDYKKLSLYNKNKLKAYINFYNAALDI RGITPHENDEEYYSCIFEIIDILLATKEIKCLKKLIQTISKYDGGYLELAELYSNYGY VSEAKKLIVLYIKKFEVVNNKMIYILQK" gene complement(2745..4526) /gene="" /locus_tag="" /db_xref="3475541..3477322" CDS complement(2745..4526) /gene="" /product="Glycosyltransferase fused to TPR-repeat domain protein" /translation="MSNEISLCMIVKNEEKYLFQCLDSVKDIVDEIIIVDTGSTDKTV EIAKKFGAEIHYFMWNNSFSDARNESLKYATKDWIFIMDGDDEFSKDDKEKFKELVKN NLKEDCLYYFETLSYCGEFVDSSNISVNLNPRLFKNNYGYKYEGIVHNQLINTEKEIK NVIYNIRIYHYGYLEDVSKKKNKRGRNIPLLKKQLKENPDDRFAHFNIGNEYYAIGDL QKALTHYCEAYKDFNPSSGFGFVLITRLIVTNFGIGKHEKAIEFADIGLEYYPNATDI YFLKALIYEATRRPTLAIKALKRCIEMGEPPSNLKLYYGTWSFKALYELVNIYMGLKD YEEAYKYCIETIKAKNDFVNPVYVIGHILKERKTPIEEFKVELEKLFSDYPKAYFFIA NILYDEGYFNEALEYTDKCEKEGLNSDAILDLKLKAMIRAQKFNECAEANYFAKESVF YFNASMYKVLSLVLIGKFKEALKDLEIFKDGKLKRQDKKELEVYSQFVKLFMNEETKV LSEDKEDKEYTGFILDICDILLSNKLYDEFEKALNLFNLISDENVLLNLSKLYYKHGI ESMAKKEAIRSIKEFEVFDNEILDILR" gene complement(4672..5319) /gene="" /locus_tag="" /db_xref="3477468..3478115" CDS complement(4672..5319) /gene="" /product="membrane protein" /translation="LGTVNRVAGVATITRLGVLGTVNAVSTVGTIARLGILGTVNRVA GVATITRLGVLGTVNAVNTVGTIARLGILGTVNRLAAVGTLTRLGVLGTISGDVNSRI VGSGVYATVQDIAVSSTGTYTNFIDISQYSATGWYIKKISNVPATLTARIALVPSTNR AVYTPYIDLPVGTITSDITKALVLDRTQYLKYAAVNLISSSTTIPTVQVVFDAKN" gene complement(5306..6340) /gene="" /locus_tag="" /db_xref="3478102..3479136" CDS complement(5306..6340) /gene="" /product="membrane protein" /translation="LANSIVFQNAASQLRSAIYGYDGTNYQPVKVNSTGELQINVGTI NAVGTITRLGVLGTVNAVGTVTRLGVLGTVNRVAGVATITRLGVLGTVNAVGTVGRLG VLGTVNRVAGVATITRLGVLGTVNAVSAVGTVGRLGVLGTVNRVAGVATITRLGVLGT VNAVGTVGRLGVLGTVNRVAGVATITRLGVLGTVNAVGTVARLGVLGTVNRVAGVATI TRLGVLGTVNAVGTVARLGVLGTVNRVARVATITRLGVLGTVKAVGTVGTVGVLGTVD RVARVATVARLAVLGTVRAVGTVATVGVLGTVNRVARVATVARIAVLGTVRSSKHSRN SSKIRSTGHS" gene complement(6498..7811) /gene="" /locus_tag="" /db_xref="3479294..3480607" CDS complement(6498..7811) /gene="" /product="UDP-glucose 6-dehydrogenase" /translation="LKQESLAQKIKNKTAVVGVIGLGYVGLPLAVQSAVKGYKVVGFD VQSKKVDMINNGQNYINDIPNDTLKEVVKKDKLKATFNFEFIKSTDIVLICVPTPLDK YQQPDISYVRNSTEVVGKYLNKGMLVVLESTTYPGTTEELILPTLQKESGLKCGRDFY LAFSPERVDPGNVKYKTENIPKVVGGVQKESTKIAAAFYENILEVKVHEVSSPKIAEM EKILENTYRNINIGLINEMAIICNKMNIDIWEVIEAAKTKPYGFQAFYPGPGLGGHCI PLDPYYLTWKAREYNYHTRLIETSGEINNCMSMYVVERATKILNRFNKPLKDSKILIL GIAYKKDIDDYRESPAIRIIENFELEGAKVSFYDPHISVYKYKNKEHYGIDISKSKLM DFDLVIITTDHSKYDYKFIQQNSNFIFDVRNATKNLKDRSNIELL" gene complement(8007..9755) /gene="" /locus_tag="" /db_xref="3480803..3482551" CDS complement(8007..9755) /gene="" /product="TPR-repeat domain fused to glycosyltransferase" /translation="MKKKKIAFFVKQGLDNFLKDIIEGLRDQYEVKKIIVLDYKQINE EMSSADICWFEWCDELIGYASKLKMASFKKIIVRLHSYEAFTGYIYDVKWENVNKIIF VSEHLRDIVLNKVKNLDKLKTEIISNGIDLEKFKYADRGSGFNVAYVGYINFKKGPML LMHAFKAIADIDSRYKLYIAGEFQEERYVLYFNQMISEMGLQNRVIYSGWQKNLDSWL NDKNYILCTSLLESQNVSVMQAMSKGIKPLIHNFVGAKTIYPKKYVWSSIDECTKMVK DKEYNSREYRSYIENGFSRNTEKDKILKLFNQLLIEEDSSKNISDYLKKVNLKGGNKF KDIKTLTLITKRNLHEAKINTENTIIANEGDIILPYMDEFNENTLNYLNKDYVMVAPR YVFNLNDKNQIFNYYDRNFYKDAPAAYVLKTFFTTGEMSCMNLGSIYRTKEILNNSTN EAFEGALDYIMLSRVFSKALNKKVKITEEYAYFRKVKQIEKDKRSILLQLISLTVSGY YCVKNNIVSFKDAKQTILDRGKLVEKINGCGYEYSKLIVKCLSKEISEEDFIKEVLKE NIAELPSEFSKLRKFL" gene complement(9848..11515) /gene="" /locus_tag="" /db_xref="3482644..3484311" CDS complement(9848..11515) /gene="" /product="hypothetical protein" /translation="MKIGILSNVNISSIAGKIDDSFEVYKPDGYGVWVQEITDIKSAL YKFKPEGIFLILDGKELIRNKELWDIEDKKNELLRNLEYIEQAVVKNKDIRFFISDID IETKKIKVEKDCEEETIIQLEWLNRLSELKNKYSNMSIFPLKRLIEVEGRKSCYCNKL WYLSGIKFSVKGEEIIKAEIESLAVAMSGRRKKCLVLDLDNTLWGGIIAEVGVDGIEL SEYKEGARYKEFQKRIKEIKDTGVLLCICSKNNEKDVDEVFFKHPHMVLKKSDFTCTK INWLSKVENIKKICSELNLGADSLVFIDDSPIERELVKNNVEGIIVPDFPEDTYMLED FIIDIYNRYFRIVETSTEDLNRTEMYKENLEREIEKKETESLEAFLKNLRMEITVRKA SGHDILRISQLTQRTNQFNLTNKRYTRTDVSSLIKNKSFDVFAVEVKDKFGDNGVVSV IIVERKNLKEIFVDTFLMSCRVMGRKIEEQLISFVEDFYRSSGFEKIFTYYNASKKNK PVEKFYENMGYKVISLDENGSKFYGEKIVKLKNVKRSIYGKLKLSGF" gene complement(11512..11739) /gene="" /locus_tag="" /db_xref="3484308..3484535" CDS complement(11512..11739) /gene="" /product="Acyl carrier protein, ACP" /translation="MEQRLIKVVSRTLKEKKERLSLTSSRKSLPKWDSLCHLQIILAV EKEFNINIPMKEVFSIDKIKDFIKFIRSDER" gene complement(12751..13347) /gene="" /locus_tag="" /db_xref="3485547..3486143" CDS complement(12751..13347) /gene="" /product="Nitroreductase family protein" /translation="MSKDFYEAVKKRRTIYGIGKESPISDERIKEIVELLVKETPSSF NSQSSRVVVLFGKNHDKLWEITKETLRKIVPEGNFSSTEEKINSFKSGYGTILYFEDQ NVIKSLQDQFQLYKDNFPVWSEQSSGMLQINIWNALSLEGLGASLQHYNPLIDDAVRD EWHIPQNWKLIGQMPFGKPTADPGDKDFIPIDSRVKFF" gene complement(13572..15446) /gene="htpG" /locus_tag="htpG" /db_xref="3486368..3488242" CDS complement(13572..15446) /gene="htpG" /product="heat shock protein 90" /translation="MAVKQFKAESKRLLDLMINSIYTNKEIFLRELISNASDAIDKCY YRSLVDTNITFNKDDFYIRISADKENKTLTITDTGIGMTKDDLENNLGTIAKSGSFAF KSENEAKEGVDIIGQFGVGFYSAFMVADDVTVISRSVDSEEAYKWESKGVEGYTIEKC EKETPGTEIVLKIKENTDDEKYDEFLDEYKLRSLIKKYSDFIKYPIKMMTKKTRPKKD NDKETEEYLEDETLNSMVPIWRKNKNELKQEDYDNFYMDKHFGFEKPLKTIHSNVEGV VSYNTLLFIPASAPYDFYTKEFEKGLELYSNGVMIMQKCGDLLPDYFSFVQGLVDSPD LSLNISRELLQHDRQLKFIAKKIKEKIKSELLSMAKNDRENYVKFFNSFGRQLKYGVY SDFGSNKEVLQDLLMFYSSTEKKLVTLDEYVSRMKEDQKYIYYAAGESNEKIEKLPQT EVVKDKGYEILYFTDDVDEFAIKMLMKYKEKEFKSVSNKDLGFEADEKESKKETEENK DLFDFMKEVLDGKVKEVRASSRLKSHPVCLSNDGELSIEMEKVLKMMPDNNNVKAEKI LEINTNHEMFNSIKAAFKDDKDKLKKYASLLYNEALLIEGLPIEDPVQFANDVASLMK" gene complement(15627..17159) /gene="" /locus_tag="" /db_xref="3488423..3489955" CDS complement(15627..17159) /gene="" /product="putative cardiolipin synthase (phospholipase D family)" /translation="LRFFIKFIFHRATFVVISALIQLFVLIFVIIKFNEYFVFFYGIS IVVSIIAVLYILYNNSNPAYKIVWIIPILVFPLFGGLFYLFFGGSKLSRRTRKKMECI VAKSRAVLIKGEVIINEIRNNNETAANQSSYIQNYSLFPPYKYTKAEYFSTGEETFNE LIEQLKKAKQYIFLEYFIIKEGVMWNSVLQILRDKVQEGVEVRVIYDDIGCMFTLPNG YHKELEKIGIKCCVFNPLIPMVSFKFNNRDHRKIAVIDGLVGFTGGINLSDEYINKYQ KYGYWKDTAIKVEGKAAWNLSVMFLSMWSFLRGIDEDFNTFKKNIEKEFSSREGYVQP FADSPLDGEPVGEIIYMNLISKATKYVYITTPYLVIGNEMVTALTSAAKGGVDVRIIT PHIPDKKIVHSVTKSYYKVLIESGVKIYEYMPGFIHSKTYVCDNEYGVVGSINMDFRS LYLHFECGVWMYKTNTVYDIKKDFMDTLDKSKEITLEEINKVKWYSTLWRVVLRVFAP LM" gene complement(17311..17604) /gene="" /locus_tag="" /db_xref="3490107..3490400" CDS complement(17311..17604) /gene="" /product="Spore coat protein F (CotF) family protein" /translation="MSTILGSIVKGNTDIDDQVIAGVMMDGAKSSAGAYLNATLISTT PELRAVYSSSLNQLIGSNAAINELSVNKGWTKPYDPSAQQLSEVVAKSNEILD" gene complement(17619..17822) /gene="" /locus_tag="" /db_xref="3490415..3490618" CDS complement(17619..17822) /gene="" /product="hypothetical protein" /translation="MRRLSEAEMLSLSGLLKAENDGLAVSRAMESIIKDEDLKKQAEA GILEAEGRIKGLQQFINENSVIR" gene 18078..19415 /gene="" /locus_tag="" /db_xref="3490874..3492211" CDS 18078..19415 /gene="" /product="Signal transduction histidine kinase" /translation="VENFSDKDELIHKWDSFIGTVEKNPTLRPLTMESWKRCKNMGVN PKHIKLKTLSHNELNDKISNNLHLIKIVKPYFDYLFLRVTNIPFLIALADSKAWIINI SGNVNDFGEKKFRFCLGSNCSEKYIGNNGIGTCLTCGKPIIIYGREHFVNAYASFTCI GVPIKVNKKIVGAIDVCIPNKYAHPSIFDLTISCVESIQSTLSIIDRSSIKNSPNMNL SRTSKLLATAVHDLKNPLSVIRGLGQLGKLTSDKAKADYYFDKVIKQADELNTMVVEL LSIFSPPKIKPMEISKIIKDVIEEFEPQCNSKKISLNIINSNSSYANISEPLFKRAIR NLISNAIQAIDIDGSIEIKIKQENKHIILSITDTAGGIPEELRDNLFEPFTFKRSGGT GLGLFMVYHTITNTHNGEMWFHTTPGNGTTFFIKLPIANPTSDLDMDKYNLMM" ORIGIN 1 ctacttttta tatttgtcaa tcattccatt ccattcgcct tttcctttgt agccatattc 61 cttgccaaac tcttcttttt tgaagccctc tttactaaat ccttccttgc cacaaccttg 121 attttcaaag ccttggttct caaagccttc ttttttgtaa ccttcttttt caaagccttc 181 tttttcaaag ccttcttttt catcataatg tccatgatga gtgtgtccta cttgttgttt 241 ttgaagtaat tttattgcaa tataaacaac tgacttatca gtgaattctt ggaactcttc 301 ttcatttaag aagtgatcta ttgggcatcc tctatcatca atatctgcat catatatctc 361 agaccattca agttcacaat atacaggttc attaaatatt tcatagcttg ctctatcagc 421 ttctcttata tttttaccca ttctcttttg atcaaaatat ctagctacat ctggctgaaa 481 attagggaac actctagggc gagctccatt aaattccact cttgtaacgc atctaaatgg 541 aatatgaact gtagtatcat tgataacacc gcctatacct gattttgtag tacagtgtct 601 tgaagcatat tctatattct ttcttatata gccctcaatg aataccttgt cagttcctcc 661 aacatatctg cattcagtaa ggaatacttg tttctcaatt ctctttattt cataagcagg 721 ttcatttaat ttaaccttag cttctacatc tatttgaata acaaactctg aaagaacaac 781 aggtacttta tactttccag gtcttacagg ccagttttct gcctgctcaa gtgtatgagc 841 ctttaaaacc gatgcattac aaaatgaagt tgggcatgaa gttccttgat tattttccat 901 ttgtatctct tctcctttac cataacatgg gatattttac accctgatat atagtattct 961 gctaagataa aaaatgtact atgctaaccc aatttttttt actttaagcc tatatattaa 1021 actacttttg tgtaaaataa gagccctgaa agctaaacct ttcagggctc tattatatta 1081 tattgcatac tcttaaacta attatttggc agcctgagct gcttgtaaca cttcatcata 1141 gttaggatat cctgatacct cttctagata attggcatat gtgactttat tgctgctatc 1201 tactacaaaa acagctcttg ctaaaagtcc taactcttta atataggtac cagtattttt 1261 accaaaggct ctatctctat aatcagataa tgttgttaca ttcttaattc cttcagctcc 1321 gcaccatctt gattgtgcaa aaggtaaatc cattgaaata gtataaattg aaactccatc 1381 tatttctgat gctcttgcat taaaggtctt tacttcaaga tcacatacag gcgtatcaac 1441 agatggaact gccaaaaata ctcttactct atttgtattc tttaacatca ctggctcaag 1501 agaactattt accgcaacaa aatctggaaa tgtatctcca acctttattt ctgttccttc 1561 taatgtaact tcttttccct taaattttac tttcatagca tactgtttat tttatttaaa 1621 ataatatata aggaaattaa cgactagaat tttgctatat atcagggggg atatcaatca 1681 caatatagtg ttaatttcct catataagtt gcatttaaat aaataaacta ctcacctctc 1741 ttatataata tttattatta agtaatatct attatatatt actataatac tacctaaaac 1801 ctaaattgta aatatattat tgcattactt ttgcaaaata tatatcattt tattatttac 1861 aacttcaaat ttttttatat acagtactat taattttttt gcttcagata catatccata 1921 gtttgaatat aattctgcca attctaaata tccaccatca tatttagaaa tagtttgaat 1981 gagttttttt aggcatttaa tttctttagt tgctaacagt atatctatta tttcaaaaat 2041 acatgaataa tattcctcgt cattttcatg tggagttata cctctaatat ccaaagctgc 2101 attgtaaaag tttatatatg cctttagctt atttttgtta tataagctaa gctttttgta 2161 atcaaattca tctattattt tccacgctaa cctatattct tcaagcagta cacagcaaat 2221 aaccttatac attctgatct taaaaaagta taaataactt tgagaaaaat tatctatata 2281 atctttgcac ttatcatact gttttaattt taataagcat tttattttaa ttagttcaag 2341 gtcacgtgtc acttcatcct ccttaagaca cgtatctata attttgagag caacttcata 2401 attgccctca aaacaaaata tatctgctaa caacgaatta tgaatcttaa cttttccagc 2461 tttctttaaa atttcgttta ttggagtatt tgataataac aatattctaa ccattaaata 2521 ataggcctca atatagttgg atttactaat tgcctcctta caatacttat aggcttcttc 2581 ataatcttta aagtaagcat atatcttggc taactctaaa gaagctttac tccctacctt 2641 ctcttcaagc tttcttgctt cttcaaagca cttcactgca ggccccataa aattttttct 2701 tttgtacata attcccttct cgtaatacga tagaggcata tatatcacct caatatatct 2761 aaaatctcat tatcaaatac ctcaaattcc tttatagatc ttattgcctc tttttttgcc 2821 atactttcaa tgccatgttt ataatatagc tttgaaagat tcagtagtac attttcatca 2881 cttattaaat taaacaaatt aagagctttt tcaaactcat catataattt attcgaaagt 2941 agaatatcgc aaatatccaa tataaaacct gtatattctt tatcttcctt gtcctcggat 3001 aaaacttttg tttcttcatt cataaatagt tttacaaatt gagaatatac ttcaagctcc 3061 tttttatcct gccttttaag cttaccatct ttaaatatct ctagatcttt aagcgcctct 3121 ttaaattttc ctatcaaaac taagctcaaa accttataca tagaagcatt aaaataaaat 3181 acactttctt ttgcaaaata attagcttct gcacattcat taaatttttg agctctaatc 3241 atagccttaa gctttaagtc taatattgca tctgaattaa gtccttcttt ttcacatttg 3301 tccgtatatt caagtgcctc attaaaatat ccctcatcat aaagaatatt tgctataaaa 3361 aaatatgctt tggggtaatc agaaaatagc ttttctaatt caactttaaa ttcttctatt 3421 ggcgtctttc tttcctttaa tatatgtcct ataacatata caggatttac aaagtcattc 3481 ttagccttta tggtttcaat acaatattta tatgcttctt cataatcctt caaacccata 3541 tatatattaa caagttcata taaagcttta aaactccatg tcccataata tagctttaaa 3601 tttgagggag gttctcccat ctcaatacat cttttaagag cctttattgc aagcgttgga 3661 cgtctagtag cttcatatat aagtgctttt aaaaaatata tatctgttgc attaggataa 3721 tattcaagcc ctatatctgc aaactctatt gctttttcat gtttaccaat accaaagttt 3781 gtaactatta accttgtgat tagtacaaat ccaaaaccag aacttggatt aaaatcttta 3841 taagcttcac agtaatgagt taatgctttt tgtaaatcac ctatagcata atactcgttt 3901 ccaatattaa aatgagcaaa tctatcgtct ggattttcct taagctgttt ctttaaaaga 3961 ggtatgtttc ttcctctttt attcttcttt ttagatacat cctccaaata tccgtaatga 4021 tatattctta tattataaat tacattcttt atttcttttt cagtattaat caactgattg 4081 tgaacaatac cttcgtactt atatccataa ttatttttaa agagtctcgg attcaaatta 4141 acacttatat tactactatc tacaaattct ccacaatagc tcaaggtttc aaagtaataa 4201 agacaatctt cttttaaatt attcttcaca agctctttga atttttcttt gtcatcctta 4261 gagaattcat catccccatc cattatgaat atccaatcct tagttgcata tttaagggac 4321 tcgtttcttg catcgctaaa gctattgttc cacataaaat aatgaatctc agctccaaac 4381 tttttagcta tctcaaccgt tttatcagta gagcccgtat caactataat tatttcatca 4441 acgatgtcct taacactatc caggcattga aataagtatt tttcttcatt tttcactatc 4501 atacacaaac ttatttcatt actcataaaa tcactccaaa atatatgaca ggtgacaaac 4561 ctaaattgca cataccatgg tttgccacct gaaattttta atttaaaaat tcagcctaaa 4621 atcaacttat gcatatctta tacataagtt gataatctta gctacactaa attagttttt 4681 agcatcaaaa acaacttgta ccgttggaat tgttgtacta ctagaaatca aattaactgc 4741 agcatatttt agatattgag ttctatctaa aactaatgct tttgttatat ctgaagttat 4801 agttcctact ggtaaatcaa tatacggagt atacactgcc ctatttgtgc ttggtacaag 4861 agctattcta gctgttaaag ttgcaggtac atttgaaatt ttcttaatat accatccggt 4921 agctgaatat tgagatatat ctataaaatt ggtgtaagtg cctgtagatg aaactgctat 4981 atcttgaaca gtagcatata ctccacttcc aactattcta ctattgacat ctcctgatat 5041 agttcctaat actccgagtc ttgttaatgt tcccactgct gctaatctat taactgtacc 5101 cagtattccc aatcttgcta ttgttcctac tgtgtttact gcgttaactg ttcctaatac 5161 tccgagtctt gttattgttg ctactcctgc tactctatta actgtgccca gtattcccaa 5221 tcttgctatt gttcctactg tgcttactgc gttaactgtt cctaatactc caagtcttgt 5281 tattgttgct actcctgcta ctctattaac tgtgcccagt actcctaatc ttgctactgt 5341 tcctactgtg cttactgctc ctaactgttc ctaatactgc tattcttgct actgttgcta 5401 ctcttgctac tctattaact gttcctaata ctcctactgt tgctactgtt cctactgctc 5461 taactgttcc taatactgct agtcttgcta ctgttgctac tcttgctact ctatcaactg 5521 ttcccagtac tcctactgtt cctactgttc ctactgcttt aactgttcct aatactccaa 5581 gtcttgttat tgttgctact cttgctactc tattaactgt tcccagtact cctaaccttg 5641 ctactgttcc tactgcgtta actgttccta atactccaag tcttgttatt gttgctactc 5701 ctgccactct attaactgtg cccagtactc ctaaccttgc tactgttcct actgcgttaa 5761 ctgttcccaa tactccgagt cttgttattg ttgctactcc tgccactcta ttaactgtgc 5821 ccagtactcc taaccttcct actgttccta ctgcgttaac tgttcctaat actccaagtc 5881 ttgttattgt tgctactcct gctactctat taactgtgcc cagtactcct aaccttccta 5941 ctgttcctac tgcgcttact gcgttaactg ttcctaatac tccaagtctt gttattgttg 6001 ctactcctgc tactctatta actgtgccca gtactcctaa ccttcctact gttcctactg 6061 cgttaactgt tcctaatact ccgagtcttg ttattgttgc tactcctgct actctattaa 6121 ctgtgcccag tactcccaat cttgttactg ttcctactgc gttaactgtt cctaatactc 6181 cgagtcttgt tattgttccc actgcattga ttgttcctac atttatttga agttctcctg 6241 tactattaac tttaacaggt tgataattag ttccatcata tccatatata gctgatctta 6301 gttgacttgc tgcattttga aatactatac tatttgccaa agtttttcac tccccattgt 6361 ttatcaaaaa ttccatataa aagttagact tatacagtag atgtataagt tctaaccaaa 6421 atggatttta tcttcttaga tttaaatatt aagctacagt tatattatat ggtggacaac 6481 caatttagtg atggttttta caaaagctcg atattgctcc tatccttcaa attcttcgtt 6541 gcatttctaa catcaaaaat aaagtttgaa ttttgttgta taaacttgta atcatacttg 6601 ctgtgatctg tagttatgat aaccaaatca aaatccataa gcttgctctt acttatatca 6661 attccgtaat gttctttatt tttatactta taaactgaaa tatgaggatc ataaaaagac 6721 acctttgctc cttctaattc aaaattttct attatcctaa ttgcaggact ttccctataa 6781 tcatctatat cctttttgta ggctatacca agtatcaata ttttagaatc tttcaagggt 6841 ttattaaatc tattcagtat ctttgtagct ctttctacaa catacatact catacaattg 6901 tttatttctc cagaggtttc tataagacgt gtatggtaat tatattctct tgctttccaa 6961 gttaaataat agggatcaag aggaatacaa tgcccaccaa gtccgggacc tggataaaat 7021 gcctgaaaac catatggctt agttttagca gcttctataa cttcccatat atctatattc 7081 atcttattgc atatgatagc catctcattt ataagaccta tatttatatt tctatacgtg 7141 ttttcaagga ttttttccat ctctgcaatc tttggacttg aaacttcatg cacttttacc 7201 tctaatatat tttcataaaa agctgctgct atttttgtac tctctttttg cactcctcct 7261 acaaccttgg gtatattctc agttttatac ttaacattcc ctggatcaac tctttcagga 7321 gaaaatgcca aatagaaatc tctcccacac ttaagtccag actccttttg aagtgtagga 7381 agtataagct cctctgttgt acctggatag gttgtacttt caagtactac taacattccc 7441 ttattaagat attttccaac tacctctgta gaatttctaa catagcttat atcaggctgt 7501 tgatacttat ctaatggggt tggtacgcat atcaaaacga tatccgtact ctttataaat 7561 tcaaagttaa aggttgcttt aagtttgtcc tttttaacaa cttcttttaa cgtatcattt 7621 gggatatcat ttatatagtt ttgtccatta tttatcatat caactttctt actttgaaca 7681 tcaaacccta caaccttata ccctttaact gcactttgaa ctgcaagtgg aagccctaca 7741 tatcctagac caattactcc cacaacagct gttttattct ttattttttg cgctaaactt 7801 tcctgtttca atataaccac ttccaaaatt ttaatataac ggactgcgct ctatacataa 7861 tatgttttaa agagaatttt gttatttcat aaaaactgga tcttatataa aaatcaaaat 7921 gccctcctta taataaacag ctaaaatatt gaagctgttt acataaagat ggcattttaa 7981 atataaatac tactcttaaa gagttattat aaaaattttc taagtttact aaattcactt 8041 ggaagctccg ctatattttc ctttagcacc tctttaatga aatcctcttc tgaaatttct 8101 tttgaaaggc attttacaat taattttgaa tattcgtatc cacagccatt aattttttct 8161 actaatttcc ccctatctaa aatggtttgt tttgcatcct taaagctaac tatattgttc 8221 ttaacacaat aatatcccga aactgtaaga gatataagtt gaagtaaaat gctgcgcttg 8281 tctttctcta tctgttttac ctttctaaaa taagcatatt cttcggttat cttaactttt 8341 ttatttaaag ccttggaaaa aactctagag agcataatat aatccaaagc accctcaaat 8401 gcttcgtttg tagaattatt taaaatttct ttagttctat aaatactccc taaattcata 8461 caggacattt cccctgttgt aaaaaatgtt ttcaatacat atgctgcagg agcatcctta 8521 taaaaatttc tatcatagta attaaatatt tgattcttat catttaaatt aaaaacatac 8581 cttggagcaa ccataacata atccttgtta agataattta gcgtattttc attaaattca 8641 tccatataag gaagaataat atcaccttca ttagcaataa ttgtgttctc cgtatttatt 8701 ttagcttcat gtaaatttct tttagtaatt agggttaacg tctttatatc tttaaacttg 8761 tttccacctt ttaaatttac tttttttaaa taatcagaaa tatttttaga actatcctct 8821 tctattaata actgattaaa aagctttaat attttgtctt tttcagtgtt tcttgaaaat 8881 ccgttttcta tataacttct atattctctt gaattatatt ctttatcctt aaccatttta 8941 gtacattcat ctatactgct ccacacatat tttttaggat aaatagtttt agcccctaca 9001 aaattatgaa ttaaaggctt tataccttta ctcatagctt gcataacact tacattttga 9061 gattcaagca aactagtaca gagtatataa tttttatcat ttagccaaga atccaagttc 9121 ttttgccacc ctgaataaat tactctattt tgaagtccca tttcacttat catctgatta 9181 aaatataata catatctttc ctcttgaaat tctccagcta tatacaattt atatctagaa 9241 tctatatccg ctattgcttt aaaggcatgc atcaatagca ttggtccttt cttgaaattt 9301 atatatccaa cataggctac gttaaaacca ctgcctctgt ccgcatattt aaacttttct 9361 aaatctattc cattacttat aatttcagtc tttagcttat ctaaattctt aaccttatta 9421 agtactatat ctcttaagtg ttctgataca aatattattt tatttacgtt ctcccattta 9481 acatcatata tataacctgt aaaggcctca taactgtgaa gccttactat aatcttttta 9541 aaacttgcca ttttaagctt tgatgcatat cctataagtt catcacacca ttcgaaccaa 9601 catatatctg ctgagctcat ttcctcatta atttgtttgt aatccagtac tattatcttt 9661 tttacctcat actgatccct aagtccctct attatatctt taagaaagtt atcaagcccc 9721 tgctttacaa aaaaagctat ttttttcttt ttcatatacc ttctcctatt aaacttacta 9781 agctacacat acacactaat tacttaaagc ttgaaattca gaaatatgta tagcttaaac 9841 tttcccttta aaatccactc aacttcagct taccatatat gcttctttta acatttttaa 9901 gttttactat tttttctcca taaaacttac ttccattttc atcaaggctt ataaccttat 9961 atcccatatt ctcatagaat ttttctacag gtttattttt tttagatgca ttgtaatatg 10021 tgaatatttt ttcaaaacct gagcttctat aaaaatcttc tacaaagctt ataagctgtt 10081 cctcaatttt tcttcccatt actctacagc tcattaaaaa tgtatctaca aaaatctcct 10141 taagattttt cctttcaact attattactg aaactactcc attatctcca aatttatctt 10201 ttacttccac tgcaaacaca tcaaaacttt tattcttaat taaacttgaa acatccgttc 10261 ttgtatatct tttatttgtc aaattaaatt gattggttct ttgtgttaat tgtgaaattc 10321 ttaaaatatc atgccctgaa gcctttctaa ctgttatctc cattctaaga ttcttcagga 10381 aggcttctaa ggattctgtt tctttttttt caatttccct ttccagattt tccttgtaca 10441 tttctgttct atttaaatcc tctgtgctgg tttcaacaat tctgaaatac ctattatata 10501 tatctataat aaagtcctcc agcatatatg tgtcctctgg aaaatcaggc actatgattc 10561 cctcaacatt gttcttaaca agctctcttt ctataggact atcgtctata aacaccaaag 10621 aatctgcacc caaattaagt tctgaacaaa ttttttttat attttccact tttgatagcc 10681 agtttatttt ggtacatgta aaatcactct tttttagtac catatgtgga tgcttaaaaa 10741 aaacctcatc tacatccttt tcattatttt tagagcaaat acacaataac actcctgtat 10801 ctttaatttc ttttattctt ttttgaaatt ccttatatct agctccctct ttatattctg 10861 aaagctcaat accatcaact ccgacttctg caataattcc tccccacaga gtattatcca 10921 agtctaaaac aaggcatttc tttcttcttc cactcatagc tacagctaag ctctctattt 10981 cagctttaat tatttcttct ccctttactg aaaactttat tccactcaaa taccaaagct 11041 tattacaata gcaacttttt cttccctcaa cctctataag tctttttagt ggaaatatag 11101 acatattgct atatttattt ttaagttcac ttagcctatt taaccactct aattgaatta 11161 tagtttcttc ctcacagtct ttttcaactt taattttttt cgtttcaata tctatatccg 11221 aaataaaaaa tcttatatct ttatttttta caactgcctg ttctatatat tctagattcc 11281 taagaagttc attttttttg tcttcaatgt cccataattc tttatttcgt atgagttcct 11341 ttccatccaa aatcaaaaaa ataccctcag gtttaaattt gtatagagct gattttatgt 11401 ctgtaatttc ttgaacccat actccataac catcgggttt atatacctca aagctatcat 11461 ctatttttcc agctatagat gatatattaa cattggaaag aatacctatt ttcatctctc 11521 atcacttctt ataaacttga taaagtcttt aatcttatct atgctaaaga cttctttcat 11581 aggaatgttt atattaaatt ctttttcaac tgccagtata atctgaagat gacaaagaga 11641 atcccatttg ggaagacttt tcctcgaaga tgtaagcgat aacctctctt tcttctcctt 11701 taaagtcctt gatacaacct ttatcaatct ttgttccata gcttacctcc gtttattcta 11761 tatttctata cttttaagat gttaggcctt atactgtttt acaaaacaca gctcatcctt 11821 atataagtgt tttttcctat ggatgtatgt cccgatattt tactcatatc caaaataaaa 11881 gtttcatcat atattttcta caaacgtgag atacacttac tacagaatca agcattccac 11941 cctttaccat ataagtgttt tcacctttaa atactgactt tctataagta ataagtacat 12001 taaaagaagc ttactgttag aatttttaca aacaaagccg ttatgttcag ctattacttt 12061 tttccataat tatcgtaagt cattatccta ctgcatccta aaatttatgc tgttcctaca 12121 cttacgttat ctactattac attgtaatca cttataataa ctgttttact ctatagcttc 12181 tttagatatt ctacttaaga acctcttcga cttaattctg ctataagcat attttctcct 12241 actacatgca tccaattaat ataatattca acgaaaattc taatgttaca aaagtacatg 12301 taggcttata taaaggaatt aatatattca taatatagat tttataatgg acgcttgaag 12361 gaaatgttta atcttgatat ttacattttg aaacctttct aagatatgtt tgcgtagaag 12421 atttttggct ataataataa gatttaaaaa taattctgtt ggaatcgtag agggtagtgc 12481 ctgtgttttt ttctaaaaat ctaaaagaaa cactagacat attctgataa aatggaactg 12541 tttgtatagg agggttaggt ataaattata ctgatgtacg gatacttaat gacattaaaa 12601 gagcctcaaa tatatttatt gaaatgtata agttgcactt tactagtctt tatgtagaat 12661 tttctttcaa aaacttttcg accttagatt taaaggattt tgtttcaaac aagtgatatt 12721 tttcacttat ttgaaacctt ccttacctta ttaaaaaaac ttaactctgc tatctattgg 12781 tataaagtct ttgtctcctg gatctgctgt tggttttcca aaaggcattt gtcctataag 12841 tttccaattc tgaggaatat gccattcatc tcttacagca tcatcaataa gtggattata 12901 atgctgaagt gaggctccaa gaccttctag cgaaagagca ttccaaatat ttatttgaag 12961 cattcctgat gattgctctg accaaacagg aaaattatcc ttatacaatt ggaattgatc 13021 ttgaagactt tttataacat tttgatcttc aaaataaagt attgttccat atccgctctt 13081 aaaggaatta attttttctt ctgtacttga aaaatttcct tctggaacta tttttctaag 13141 agtttcctta gttatttccc aaagcttatc atgatttttt ccaaataaaa caactactct 13201 agagctttgt gaattaaaag atgatggagt ctccttaact aaaagctcta ctatttcctt 13261 tattctttca tctgaaattg ggctttcctt accaattcca taaatagttc ttcttttctt 13321 aactgcttca taaaaatcct ttgacattac tatcacctca ttttaatttt tctttaagat 13381 atataaaata tgcaattatt tttctttacc taataacttt tagtaagtaa ttttatataa 13441 taatatttac ctttaattac atagtacact tattaataat aaaaatcaag taatatttgt 13501 tttcatttat atatatatta tgctaaaaaa atataaaaaa atgcagaaaa ttactttctg 13561 cattttttta cttatttcat caaacttgca acgtcatttg caaactgtac tggatcctct 13621 ataggaagac cttctattaa aagagcctca ttatataaaa gacttgcata tttctttaat 13681 ttatctttat catccttaaa tgctgcctta atggaattaa acatttcatg gtttgtgttg 13741 atctcaagta ttttttcagc cttaacatta ttgttatctg gcatcatttt aagtactttt 13801 tccatttcaa tagataactc tccatcattt gaaagacaaa ctgggtgtga ttttaatcta 13861 cttgaagctc ttacttcctt aacttttcca tctaaaactt ctttcatgaa atcaaataaa 13921 tctttattct cctctgtttc ctttttactc tctttttcat ccgcttcaaa acctaaatcc 13981 ttgtttgaaa cagatttaaa ttctttttcc ttatatttca ttaacatttt tattgcaaat 14041 tcatctacat catctgtgaa atataatatt tcatatcctt tgtctttaac cacttcagtt 14101 tgaggaagtt tttcaatttt ttcattactt tcacctgctg catagtagat gtatttctga 14161 tcttccttca ttcttgaaac atattcatca agggttacta gctttttctc tgttgatgaa 14221 tagaacataa gtaaatcttg aagtacttct ttattacttc caaaatcaga ataaactcca 14281 tattttaact gtctaccaaa gctattaaag aatttaacat agttttcacg atcattctta 14341 gccattgata acaattcact tttaattttt tcttttatct tctttgcaat aaacttaagc 14401 tgtctatcgt gttgaagaag ctctcttgat atgtttaaag ataaatctgg agaatcaact 14461 aaaccttgaa caaagctaaa gtaatcagga agtaaatctc cacatttttg cattatcatt 14521 actccatttg agtaaagctc taagcccttt tcaaattcct ttgtatagaa atcataaggt 14581 gcacttgcag gaataaataa aagagtattg tagcttacta ctccctctac attagagtgg 14641 attgtcttaa gaggtttttc aaatccaaag tgcttatcca tatagaagtt atcgtagtct 14701 tcctgcttca attcattttt gttctttctc catataggaa ccatactatt taaagtttca 14761 tcttctaaat attcttctgt ttccttgtca ttatcttttt taggtcttgt ttttttagtc 14821 atcatcttaa ttggatattt tataaaatca gagtattttt taatgagtga tcttagttta 14881 tactcatcta aaaattcatc atatttttca tcatcggtat tttcttttat ctttaatact 14941 atttcagttc caggtgtctc tttttcgcat ttttcaatag tatatccttc tactcccttt 15001 gattcccatt tatatgcttc ctcagaatca accgaacggc ttattacagt aacatcatca 15061 gccaccataa atgctgaata gaaaccaact ccaaattgcc ctattatatc cactccttcc 15121 tttgcttcat tctcactttt gaaagcaaaa gaaccacttt tagcaatagt acctagattg 15181 ttttctaaat catcctttgt catacctatt cctgtgtcag tgattgttag agttttattt 15241 tctttatctg ctgaaattct tatataaaaa tcatctttat tgaaagtaat atttgtatca 15301 acgagtgaac gataatagca cttatcgata gcatcacttg cgttcgatat aagttccctt 15361 aaaaatattt ctttatttgt ataaattgag ttaatcatta aatcgagaag tcttttagat 15421 tcagctttaa actgttttac agccatttta tcatacccct tcacttgatt aatatttaaa 15481 tgcccaaaag accaaatacc ttatggtcat tggctcaata tcactatgta ttttgttagc 15541 actctatatc aacgagtgct aattttattt tagcaataat tacagttttg tcaatacgtt 15601 tttccatatt taatcaatta actttcttac atcaaaggtg caaaaactct tagaaccacg 15661 cgccataaag tactatacca cttaactttg ttaatctctt ctaaagttat ctctttactt 15721 ttatctaatg tatccataaa atccttctta atatcgtata cagtattggt tttatacatc 15781 caaacaccgc actcaaaatg aagataaaga cttctaaaat ccatatttat actgcctaca 15841 actccgtatt cattatcaca aacataagtt tttgaatgta tgaagcctgg catatactca 15901 taaattttaa ctccgctctc aattaaaact ttatagtagg atttagttac agaatgaaca 15961 atttttttgt ctggtatgtg tggggtaata attctaacat ctactcctcc ctttgcggca 16021 gaggtcagtg ctgttaccat ctcgtttcct ataactaaat aaggtgtagt aatataaaca 16081 tattttgtag ccttacttat caagttcata tatataattt ccccaacagg ttctccgtct 16141 aatgggctat ccgcaaatgg ctgaacatat ccctctctag aagaaaattc tttttcaata 16201 ttctttttga atgtattaaa gtcctcatct attcctctaa gaaagctcca catagataaa 16261 aacataactg ataaattcca agctgctttt ccttccactt taattgcagt atccttccaa 16321 tagccatact tttgatattt atttatgtac tcatccgata gatttattcc accagtaaat 16381 cctaccaaac catcaattac tgcaattttc ctatgatctc tattattaaa tttaaaagat 16441 accataggaa tgagaggatt gaatacgcag catttaatgc caattttctc aagttcttta 16501 tgatatccgt taggcagagt aaacatacac cctatgtcat catatataac tctgacctcc 16561 actccttctt gtaccttatc tcttaatatt tgtaaaacac tattccacat aactccttct 16621 ttaataataa agtattcaag gaaaatatat tgttttgctt ttttaagttg ttctataagt 16681 tcgttaaatg tttcttctcc tgttgaaaaa tattctgcct ttgtgtattt atatggagga 16741 aaaagagaat aattttgaat ataacttgat tgattcgctg ctgtttcatt attattcctt 16801 atctcattta ttatcacttc accctttatc aataccgctc ttgacttagc tactatacac 16861 tccatctttt ttctagttct tctgcttaac ttacttccgc caaaaaataa ataaaataat 16921 cccccaaaaa gaggaaatac taatattgga ataatccaca caattttata tgctggatta 16981 ctattattgt aaagtatata caatactgca attatgctta ctacaatgct aattccataa 17041 aagaacacaa aatactcgtt aaattttata attacaaaaa tcaaaacaaa tagctgtatt 17101 aatgctgaaa taactacaaa ggtagctcta tgaaatataa attttataaa aaatctcaat 17161 tattcatctc cccattacta tagtcctttt gcagtattta tatcagtctt attatatgat 17221 tatatgtaaa ctcttattaa cacttaaata atttctttta taagatttta agcctaaatc 17281 aaaaataaag agtcttgcga ctccttattt ttaatccaat atttcatttg atttagctac 17341 tacctctgat aattgctgag cagatggatc ataaggtttc gtccaaccct tatttactga 17401 caattcgtta attgctgcat tacttcctat aagctgatta aggcttgatg agtaaactgc 17461 tcttaactct ggtgtcgtgc ttataagtgt tgcatttaaa taagcacctg cagaactttt 17521 agcaccatcc atcataactc cagctataac ttgatcatct atatctgtgt ttccttttac 17581 tatacttcct aaaatagtcg acatgctact ttcccccttt accttataac actattttcg 17641 tttataaatt gttgtaagcc ttttattctg ccctctgctt ctagtattcc tgcctctgct 17701 tgtttcttta aatcctcatc ttttataatt gattccatag ccctagaaac tgctaaacca 17761 tcattttctg cttttaacaa tcctgataaa gaaagcattt ctgcctcaga aagtcttctc 17821 attttcaatc ctcccttcta ataatatctt tactaatccg agttagtata tgtagttatc 17881 tatatattaa acttcctatt tcataataaa tatgaagttg aaacatcaga cttttatgat 17941 atcgttaaac acaaatggtt atattttaat gtaattatat tttttgtata tttatctata 18001 cttttactta aaaaaggagt aaaattatgt aataagatat attatataat aataacttgt 18061 gtggggtgat atagactgtg gaaaactttt cagataaaga tgaattaata cacaaatggg 18121 atagctttat tggtactgta gaaaaaaatc ctacactcag accattaact atggaatcat 18181 ggaaaaggtg caaaaatatg ggcgtcaatc ctaaacatat taaattaaaa actctttctc 18241 ataatgagct aaatgataaa atttcaaaca atcttcattt aataaaaatt gtaaaacctt 18301 attttgatta tttattctta cgtgttacta acataccatt tttaattgcc ttagcagata 18361 gcaaagcttg gattattaac atcagcggta atgtaaatga tttcggagaa aaaaaattta 18421 gattttgcct tggttctaat tgttctgaaa aatatattgg taataatgga ataggtactt 18481 gtcttacttg cggtaaacca ataataatat acggaagaga acactttgtt aatgcttatg 18541 cttcttttac ctgcataggt gtgcctatta aagtaaataa gaaaattgtt ggagctatag 18601 acgtatgcat accaaataag tatgcacatc catctatatt tgaccttact atatcatgtg 18661 tggagtctat tcaaagcact ctttcaatta ttgaccgtag ttctattaaa aactcaccta 18721 atatgaatct atcgagaact tcaaagcttc tagcaactgc agttcatgac ctaaagaatc 18781 cattatcagt aataagagga ttaggacaac taggtaaact aacctctgat aaagctaagg 18841 cagattatta ttttgataaa gtaataaaac aagctgatga actaaatact atggttgtgg 18901 aacttctaag catatttagt cctccaaaaa tcaaaccgat ggaaatatct aaaattatta 18961 aagatgttat agaagaattt gagccacaat gtaactccaa aaaaatatcc ttaaacatta 19021 taaatagtaa cagcagctat gctaacattt cagaacctct ttttaaaagg gctattagaa 19081 acctcatatc taatgcaatc caagcaattg atattgatgg ttctatcgaa attaaaatta 19141 aacaagagaa taaacatata atactttcta ttacagatac tgctggtgga atacctgaag 19201 aattaaggga taatttattt gagcccttta cctttaaaag aagcggaggt acaggactag 19261 gtttgttcat ggtataccat acaattacaa atactcataa tggggaaatg tggtttcata 19321 ctactcctgg taatggtact acatttttta taaaactacc catagcaaat ccaaccagtg 19381 atcttgatat ggataaatat aatttaatga tgtaa //