LOCUS NC_017179:1 23411 bp DNA linear BCT 04-SEP-2013 DEFINITION Clostridium difficile BI1, complete genome. ACCESSION NC_017179 SOURCE Clostridium difficile BI1, complete genome. COMMENT locus start: 281069; locus end: 304479 COMMENT n1_4mer:GRV/n1_4mer:RV = 6.070418; n0_4mer:D = 23.237328; n0_4mer:PS = 43.802690 FEATURES Location/Qualifiers source 1..23411 /organism="Clostridium difficile BI1, complete genome." gene 1..1266 /gene="" /locus_tag="" /db_xref="281069..282334" CDS 1..1266 /gene="" /product="sugar-phosphate kinase" /translation="MKKLPIKTVVQRLLDLQEEGKSATLLGIGPMSPNLLQASFELAK DDDFPLMFIASRNQVDADELGGGYVNGWNQETFTKDIKKIADKVGFDGLYYLCRDHGG PWQRDKERNDHLSVDEAMELGKKSYLADIEAGFDLLMIDPTKDPFEIGKVIPLDVVLE RTVELIEYCENERKRLNLPDIGYEVGTEETNGGLTSTETYETFITRLKVELDNRGLPM PTFIVGQTGTLTRKTEQVGTFNFRNAYDLAQMAKKYGVGLKEHNGDYLDDVTLLEHIP SQIIATNVAPQYGTEETRAYLKLAEVECKLEKEGLVDKTSNIRHVLLVNAIECGRWRK WVVGEQKNLTTEEIFKNEVLSNEILDIAGHYTFNNDDVKKEIEVLYDNLSKNNIDGQR FVVDHIKRPLRDYAECYNLKGVTTRILNK" gene 1354..2070 /gene="" /locus_tag="" /db_xref="282422..283138" CDS 1354..2070 /gene="" /product="hydrolase" /translation="LINLIFDVDDTLYNQLTPFYTAYNKVFSSIKDISIEDLYMSSRK YSDEVFHMTENGEMPIKEMHIYRIMKAFEELGNSITEKDAQSFQDEYIYQQSQITLIP EVERILNFSKERNINLGIITNGPSNHQRMKLKQLNIENWVDKSNIFISSEVGFSKPDT NIFRVAENVMNLDRENTYYVGDSYRNDVLGAKKAGWKSIWLNHRGHEVEELFYKPDFV ILEHKDLISLFIKICSYKNM" gene complement(2265..2558) /gene="" /locus_tag="" /db_xref="283333..283626" CDS complement(2265..2558) /gene="" /product="spore coat protein" /translation="MRNMIENLIKNNTYIDDKVIMLSMLSSAKASANMYLNSALTSST PELRAIYSASLTQMVEGHTALTELSINKGWVKPYDKPIQQLTCSYKESQNVID" gene complement(2564..2779) /gene="" /locus_tag="" /db_xref="283632..283847" CDS complement(2564..2779) /gene="" /product="hypothetical protein" /translation="MRTLSETEKISLAAVIKMESDGLLMQRAINMLISDEDLKRQSES SILATEGRIKAIQQFIVENEILISEEV" gene complement(3324..3836) /gene="" /locus_tag="" /db_xref="284392..284904" CDS complement(3324..3836) /gene="" /product="nitroreductase" /translation="MLEVIKNRRSIRTYIDKNIEEDKITEILKSAMQAPSSKNAQPWE FIIVDDKELLKELSKSQHRAKHIEFAPLCIVVLGNRDKFLKPGKWIQDLGACTQNLLL EVTNQGLAACWAGVFPKNKVVNKVKQILDLPVKLVPYALISIGYSEEKNEFIDRFDEN KIHRNVYKNR" gene 4286..4762 /gene="" /locus_tag="" /db_xref="285354..285830" CDS 4286..4762 /gene="" /product="phosphoribosylaminoimidazole carboxylase catalytic subunit" /translation="MKVAVVMGSKSDYPKLEEGIKLLEKYGIEVVARALSAHRTPEQL SIFLKEIEDDTDVIIAAAGKAAHLPGVIASQTLIPVIGLPIKSSTMDGLDSLLSIVQM PKGIPVATVTIDLGLNAALLALQIMTLKYPKLKEDLKSYREEMAQKVLEDDKNLRG" gene 4768..5466 /gene="" /locus_tag="" /db_xref="285836..286534" CDS 4768..5466 /gene="" /product="phosphoribosylaminoimidazole-succinocarboxamide synthase" /translation="MLLYEGKAKQVYSTDNENEYVVYYKDDATAFNGEKKAEISSKGI LNNKISTIIFEMLKENNINTHFIKSLSDREMLVKKVEILPLEVIVRNIAAGSICKRVG LEEGVVFDEPIFEISYKNDAYGDPMLNDDYAVAMKLATREELKFLREETLKINELLKA FFLKLNLKLVDFKIEFGKDSEGNIILADEVSPDTCRLWDVNTNEKLDKDRFRKDLGDL VEGYTEVLSRMNNK" gene 5478..6845 /gene="" /locus_tag="" /db_xref="286546..287913" CDS 5478..6845 /gene="" /product="amidophosphoribosyltransferase" /translation="MCGVLGIYSNKDVTKELYYSLYSMQHRGQESCGLALLDDGEIKY KKDMGLVGDVFKENELSKLKGNIGIGHVRYSTAGGSHVSNCQPLVGSCRKRQLAIAHN GNLVNANYLKDMLEEDGYMFQTNSDTEVILYILARYYKGDIVESLKVTMDYIKGAYAL VIMSQEELVAVRDPHGFRPLVLGKKGDEYIFASENCAIDILGGEVIRDVEPGEIIVVK DGELKSYFYSENYKPVKKSCIFEHIYFARNDATIDNVNAYEFRIKCGERLAQNETVKA DMVVPVPDSGWPGAIGYANASGLKISEGLVKNRYVGRTFIKPTQEEREIAVKIKLNPL STIIKGKSIILVDDSIVRGTTSKQLVKSLREAGAKEIHLRITSPPVAYSCYYGIDTPN RSKLIASSNNVEEMREYIGCDSLKFLDIEGMLDATEHKSTFCKACFDGEYPVKKIDKE ELLSC" gene 6839..7915 /gene="" /locus_tag="" /db_xref="287907..288983" CDS 6839..7915 /gene="" /product="phosphoribosylformylglycinamidine cyclo-ligase" /translation="MLTYKESGVDIDEGNRAVDLIKGKIKGTYDGNVVGDLGNFSGLY SLKDFVGMKEPVLLASTDGVGTKLKIAQMMDKHDTVGIDLVAMCVNDLICQGAKPLFF LDYIALGKLVPEHIEKIVGGIADGCKMSGCALIGGETAEMPGMYGEDDYDLAGFSVGI ADKEKIVSGNNVKSGDVLVGISSSGVHSNGFSFIRKIFLETYNYKMEQYVEELGMTVG EALLTPTKIYVKLALDVLAKHDIKAIAHITGGGLIENITRVIPKGLGLDINKKSWEKP PIFKMIEGFNAVDERELHKSFNMGIGLVLIVDKENADDVVNFINNRENDNAAYVDKKY SELLEDKAYIIGEVVDSHEGVELC" gene 7909..8502 /gene="" /locus_tag="" /db_xref="288977..289570" CDS 7909..8502 /gene="" /product="phosphoribosylglycinamide formyltransferase" /translation="MLNIGVLISGGGTNLQAVIDGTESGEIKGQVKVVISSKQGAYGL ERAKNHNIKAICETDEDKIIEILKENKIDLVVLAGYLKIISPKLVNEFRNKMINIHPS LIPSFCGAGFYGEKVHQGVIDYGAKVTGATVHFVDEGADTGPIIMQDVVKVNQDDDAK TLAKRVLEVEHRILKESISLFCENKLKLQGRRVFINE" gene 8495..10027 /gene="purH" /locus_tag="purH" /db_xref="289563..291095" CDS 8495..10027 /gene="purH" /product="bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase" /translation="MSKRALISVTDKTGVVEFAKELNKLDYEIISTGNTFKTLKENGV NVMQVEDVTNFPEILDGRVKTLNPYIHGGILYKRDKESHVETVNEHKIHSIDLVAVNL YDFEGTLKAGKSHDEIIENIDIGGPSMIRSAAKNYKDVIVVVDIKDYDSIIEKLKTDT MTLEDRKKLSYKAFSTTGRYDALISSYFAGEVGDTYPDILNLTFQKEQTLRYGENPHQ NGFLYSQSNAKNPILNYEQLGGKELSFNNLNDLHGCLEVMREFKDSEEVVSVAIKHAN SCGVGLGKDAFEAYTKCYEADKVSIFGGIVGITSTIDKATAEKLNEIFLEIVVAYDFE PEALEVLKQKKNLRILKLAKIEDSLQPYEMKYLDGKLLIQDRNNILAEKSENVTKAKP TDAQLKDMEFGMRVVKNMKSNAIAIVKNGQTLALGCGQTSRIWALKNALENNKDKDFT GAVLASDAFFPFDDCVTLAHEYGISAVVQPGGSIKDKDSIEACDKYDMVMVFTGIRHF KH" gene 10038..11288 /gene="" /locus_tag="" /db_xref="291106..292356" CDS 10038..11288 /gene="" /product="phosphoribosylamine--glycine ligase" /translation="MKILVVGGGGREHAICWKLSKEKNVEKVYCAPGNAGITNVAECV NIGDTNIEELLKFAKENEIGLTIVGPEVPLVMGIVDEFEKEGLRVFGPNKKCAQLEGS KAFSKEFMIKHNIPTAKYKEYTNLEEAISEIDSFGYPVVIKADGLAAGKGVVIPENRE DAIATLKEMMSDKKFGAAGDKIVIEEFLKGIETSILAFVDNDTIVPMASAKDHKKVNN YEQGPNTGGMGTFSPSEIYTEELANKVKETVLEKTLEGFKKDGLNFKGILFVGLMITE DGEKVLEYNVRFGDPETQSVLFRLETDLHEIMETILDNKLKDIEINYSDDEAVCVMLT SGGYPDSYEKGKIITGLENLDDDIVVFHSGTKMLDGNLVTNGGRVIGITAKSTTVKDA AEKVYENIKKINFEGMHYRTDIGR" gene 11313..15119 /gene="" /locus_tag="" /db_xref="292381..296187" CDS 11313..15119 /gene="" /product="formylglycinamidine ribonucleotide synthetase" /translation="MLNTENKDSMVRRVLVEKREGFDLEAKALKKDLVESLHIDNIEN LRILNRYDVEGISEEVYENAAKTIFSEPNLDVVYYEEIPKLNDERVFAIEFLPGQYDQ RGDWAAQCVQIVNQGIRPAINTAKVYILSGKITDEEFSKIKDYCINPVDSREASLEKP ETLKMETEIPTTVEVLDGFIDLDENGLRTFVSEKGLAMTLGDLQHVQKYFKDTEKRNP TITEIKVLDTYWSDHCRHTTFMTEIENVKIEDGKFNDIVKEAYQMYLNSRDNVYVNRH KDICLMDIATVAVKELKKNGKLNDLDESEEINACSINVDVEVDGKMEKYLVMFKNETH NHPTEIEPFGGAATCLGGAIRDPLSGRSYVYQAMRVTGSADPRTTLEDTLPGKLMQRK ITTEAAHGYSSYGNQIGLTTGQVAEVYDENFVAKRMEIGAVIAAVPKENVVRERPEAG DVIVLLGGKTGRDGCGGATGSSKEHSEESILTCSAEVQKGDAPNERKIQRFFRNKEVA QMIKRCNDFGAGGVCVAIGEIADSLDINLDLVPKKYDGLDGTELAISESQERMAVAIK KENKDKFIQLAVEENLEATHVATVTDTGYLRMFWNGKAIVDINREFLDTNGVKQTTDV HVTKVDEENTFFSSNEIVKDVKCASMKDKFTKVLSDLNVCSQKGLVEMFDNTIGGNTV LMPFGGKYQATPTQGMVAKIPVLGGETNTSTIMTYGYNPKVGKWSPFHGALYAVVESV CKLVAIGGNYSTTRLTFQEYFEKLGNNPEKWGKPFSALLGAFYAQSKFEIPAIGGKDS MSGTFKDIEVPPTLVSFAVDTVDAKKVVSPEFKKADSKVVMLCVNKAENDVVDFEELK RNLDKVRELIHGNKVLSTYALGFAGVGEAISKMAFGNKIGFKFSEEAEKTFTDDKLFE ASYGNIVLELANDDLCMLEGYNYVVLGSTTKEASIFIKGEELALDELYKAHCSTLEPI FPTKTEEVKSKIETISYISQGEAKKSSLSIATPRVFIPAFPGTNCEYDSARAFERVGA NANIRVFKNLTYKDIEDSIDTIVNEIKSSQIIMLPGGFSAGDEPDGSGKFIATVFRNP RVQEAINEFLTQKDGLMLGICNGFQVLIKLGLVPYGEIRVPSESAPTLTYNNIGRHQA KIARTRISSNKSPWLAQTNVGDIHNIAISHGEGKFVASEDVMRELIANGQVATQYVDF NNEATYDIEFNPNGSFYAVEGITSADGRVFGKMGHSERIGEEVFKNIIGEKDQKIFES GVKYFR" gene 15325..16197 /gene="" /locus_tag="" /db_xref="296393..297265" CDS 15325..16197 /gene="" /product="dtdp-4-dehydrorhamnose reductase" /translation="MKILITGSNGQLGKELVSQLEAINQSINQPKYVILATTRNDLDI SNQTNIDNFILHNKPDVIVNCAAYTKVDACEDNIEIAYKINALGVRNLAIASEKVNAK LVHISTDYVFNGFSKYPYREDNKTEPNSVYGKSKLMGEKFVEQFSHKYFILRTAWLYG NGNNFVKTMIKLSLENKEVNVVNDQFGTPTSTVDLAKIIIRIMETEHYGVYHATCEGE CSWYDFAKKIFELKNIDIKVNPIKSNEFKCKAQRPLYSVLDNFMLKLIGLNSFRKWEE SIEEYLERYDINEK" gene 16306..17187 /gene="" /locus_tag="" /db_xref="297374..298255" CDS 16306..17187 /gene="" /product="glucose-1-phosphate thymidylyltransferase" /translation="MKGIILAGGSGTRLYPITKCISKQTLPIYDKPMIYYPMSVLMLA GIQDILIISTPRDIKAFEELFGDGSSLGLKITYAIQEKANGIAEAFIIGEEFIGNDRV SLVLGDNIFYGYGFSERLENAVKRKGATIFGYHVSNPNSFGVVEFDKDFNVLSIEEKP TVPKSNYAIPGLYFYDNDVVEIAKLVEPSDRGELEITSINSEYLKRGKLKVELLGRGM AWLDTGTHKGLLDASNYVEVVQTRQGLYIACLEEIAYTKGYISREQLMKLAKPLIKTE YGQYLLKLASEDMQYGR" gene 17224..17781 /gene="" /locus_tag="" /db_xref="298292..298849" CDS 17224..17781 /gene="" /product="dtdp-4-dehydrorhamnose 3,5-epimerase" /translation="MGKINVIKTKIEGLYIVEPNVFCDERGYFMESYNKKDFIEQGLD MCFIQDNESSSRKGVLRGMHFQVRYPQGKLVRVTEGEVFDVAVDLRKDSQTFGKWEGV ILSDKNKKQFYIPEGFAHGFLVLSEKAVFNYKCTNYYYPEFEHGFIWNDKQISIEWPL KGIEEIFLSEKDKKQKSFKDICIRR" gene 17819..18802 /gene="" /locus_tag="" /db_xref="298887..299870" CDS 17819..18802 /gene="" /product="dtdp-glucose 4,6-dehydratase" /translation="MKKILITGGAGFIGSNFVHYMLNKYVDYFIVNLDLLTYAGNLET LIEIQDSSNYKFVKGDISNREQMYKLFEEERFDIVVNFAAESHVDRSVENPDLFIKTN IIGTQVLLDASIKYGVKRYHQISTDEVYGDLPIDRKDLFFTEQSPINPSSPYSASKAS ADLLVSSYYRTYGLLTTISRCSNNYGPYHFPEKLIPLMILNALENKQLPVYGNGENVR DWLHVYDHCTAIDLIIHKGNIGEIYNIGGHNERSNLEVVKMILNLLDKSEELISYVND RPGHDLRYAIDATKIENELGWKAKYDFDLGIKETVKWYIENESWWKAVLSV" gene 18841..19509 /gene="" /locus_tag="" /db_xref="299909..300577" CDS 18841..19509 /gene="" /product="transglycosylase" /translation="LNEISSLINILALTQLSGSNTTNQCNCTYNSSSGFDMIMMTLLK ALSQNNQQTSNGYNLSSNSENLFDELGSVVNNTASRFIDVDTKDKSVKSRIENAIEQA SKKYNVDSNLIKAIIKVESDFNPNTVSSAGAKGLMQLMPENCRDLGVTDPFNIEQNID AGTRHIKEYIDMFGGSIEMGLMAYNGGPGRMKSRGVESISDLYKMPKETQNYIPKVMK YYRG" gene 19518..19946 /gene="" /locus_tag="" /db_xref="300586..301014" CDS 19518..19946 /gene="" /product="hypothetical protein" /translation="MGINIDKLNISPSINMEVKKLKESNKFSDKLNSLKQSSSLEDIK RNLESVKKAGERLVLTQNYGDISIYKNAVKEYLKSVVDNMYSLDKNSSFWEHQYYKNV KIVDSKLEDMTSKLISEEKENIDIVSTVDMIQGLLIDMYR" gene 19970..20284 /gene="" /locus_tag="" /db_xref="301038..301352" CDS 19970..20284 /gene="" /product="flagellar motor switch protein" /translation="MNSKKEDIYELNFGQLIEEKSGVIEENQNVFNAKVNVAVSIGNT TETIKNILDLKEGSIIKLSKNVDEKLDIYANDRLFAYGESIITNEKLSVRLSKIEDSD VN" gene 20436..20711 /gene="" /locus_tag="" /db_xref="301504..301779" CDS 20436..20711 /gene="" /product="negative regulator of flagellin synthesis" /translation="MDIKNVSSNIVVNNYLKNTSGVKKVEEVKKINKTDKIELSKFAK EMASVSNMSDENIRNKKVDEIKNALENGTYKIKPKEIAKKMIEDMRG" gene 20716..21132 /gene="" /locus_tag="" /db_xref="301784..302200" CDS 20716..21132 /gene="" /product="flagellar biosynthesis protein" /translation="MITDLKVIIYEEKNIISKMMELLKEQFDYIVEKDLENLNMLNPK LEDISRELASIEIKRRQLFGDDISMSEVVENSNDRYLKEIYTDLKHILALAKNQQESN DSLIKKELIFTKKMINFIKPADKQTATYNSYGNIRK" gene 21150..22460 /gene="" /locus_tag="" /db_xref="302218..303528" CDS 21150..22460 /gene="" /product="putative flagellar hook-associated protein" /translation="MAGLFSILNTANSGMNAHQKAIQTISHNISNLDTDGYSRQRTEF ATNSPMYMPSLSNSIARGQLGTGVHVTDVTRARNSFYDYQFRAEAHKYGNTVSKYDYY NTIETIINEPSDYGISAGIDDFFKGWESLAKDINSDSKKSLVVENASNLATLISESYK KLNKLKGDIDDNINSEIKQINDMLKSLEDLNKSIDVISGSGSTPNDLLDERDRILDDL SFKLDLENSDVKNMLSDGKLELNELKNADGTWKTGVSGTLQGLFEMHGKIDTYKSDLK DVSDGLAKQINDVYNTSAGITVTDFFITSNVDGEDIIKVNPAIKSNPNELKLTADEAS KIAKLKDEKIDIGVAGGKVSTISDHYKAFAESVGLDSQKVNQDEVNQRKIINNIDNSR MSVSGVSLDEEMTELIKIQRSYQASAKVMSTAVQLLDVVINGII" gene 22479..23411 /gene="" /locus_tag="" /db_xref="303547..304479" CDS 22479..23411 /gene="" /product="flagellar hook-associated protein" /translation="MRVSTGMMSSNYLNSLQDNLQRLDKVNRQVNTTKEINKLSDNPY KAIKILNSKSEIKTMETYVENCKDTGNWLETTDTALDQLGKLLSDIKKTLVASGDGAY SDDELKTLSNETNEKMKEIANALNATHEGKYIFSGSNTGVPPVECIDNADGSVSLKFN SSLNLNKLNDSLSMDIAQGISVDYNVKLSSLGFDPTKTDPFEELNNISKKLANPDADA IKELTTTCLGDMEQLIENTVNVRSIYGTKANTVEAMKEKNDDSLIQLKDILSQNEEID YGEKLVQLKAAELTYQASLQTGGKLFNVSILDYI" ORIGIN 1 atgaaaaaat taccaataaa gactgtcgta caaagattac tagacttaca agaagagggg 61 aaaagtgcaa ctcttttagg aattggtcct atgtcaccaa acttgttaca agcaagtttt 121 gaactagcaa aagatgatga ttttccttta atgtttatcg caagtagaaa tcaagtagat 181 gcagatgaac taggtggcgg ttatgtaaat ggttggaatc aggaaacttt tacaaaagat 241 attaagaaga ttgccgacaa agttggattt gatggtttat attatttatg tagagaccat 301 ggtgggccat ggcaaagaga taaagagaga aatgaccatt tgtctgttga tgaagcaatg 361 gagttaggaa aaaaatctta tttagcggac attgaagcag gttttgacct attgatgatt 421 gaccctacaa aagacccatt tgaaattgga aaagtaattc cactagatgt agtactagaa 481 agaactgtag aattaattga gtattgtgaa aacgagagaa aaagacttaa tctaccagac 541 ataggttatg aggttggtac agaggaaacc aatggaggtc ttacttcaac tgagacgtat 601 gaaacattta taactagact aaaggttgaa cttgataata ggggtttgcc aatgccaaca 661 tttatagttg gtcaaactgg tactttaact agaaagacag aacaagtagg aacttttaat 721 tttagaaatg cttatgattt agctcaaatg gctaagaaat atggagttgg tttaaaagag 781 cataatggcg attacttaga tgatgtaact ttattagaac atataccatc tcaaattatt 841 gctacaaatg tagctcctca atatggtact gaagaaacta gggcatattt aaaattagca 901 gaagttgagt gtaaattaga aaaagagggc ctagttgata aaacttctaa tatcagacat 961 gttcttcttg ttaatgcaat tgaatgtgga cgttggagaa aatgggtagt aggagaacaa 1021 aaaaatctaa ctactgaaga gatatttaag aatgaagttt tatctaatga aatactagat 1081 attgcaggac attatacatt taataatgat gatgttaaaa aagaaataga agtgctttat 1141 gataatttaa gtaagaataa tattgatggt caaagatttg ttgtagacca tattaaacgt 1201 cctttgcgtg attatgcaga atgctataac ttaaaaggtg ttactacgag gattttaaat 1261 aaataatagg acttatagtg gtgagtattg ttatactagg tatttatagt tataattata 1321 cttaccacta ttaaatttag gaggactaat attttgatta atttaatttt tgatgtagat 1381 gatactttat ataaccaatt aacgcctttt tacactgcat ataataaagt gttttcttca 1441 ataaaggata tttctattga agatttatat atgagtagta gaaagtatag tgatgaggta 1501 tttcatatga ctgaaaatgg agaaatgcca atcaaagaaa tgcatattta taggataatg 1561 aaagcttttg aggagttggg aaattctatt acagaaaaag atgcacaaag ttttcaagat 1621 gagtatatat atcagcaatc acaaattaca ctaataccag aagttgagag gattttaaat 1681 ttttctaaag aaagaaatat taatctagga attataacta atggcccatc aaaccatcaa 1741 agaatgaagt taaagcagtt aaatattgaa aattgggttg ataaaagtaa tatttttatt 1801 tctagtgagg ttggattttc taagccagat actaatattt ttagagtagc tgagaatgtt 1861 atgaatttag atagagaaaa tacatattat gtgggtgatt cttatagaaa tgatgtatta 1921 ggtgctaaaa aagctggttg gaagagtata tggttgaacc atagaggaca tgaggtagaa 1981 gagttgtttt ataaacctga ttttgtaatt ttggaacata aggatttgat atctttattt 2041 ataaaaatat gtagttataa aaatatgtag taaaaaaatg ttaataatag aattgtataa 2101 aataattaat aataactata taaaattata tgtttagatt gtgagcaatc tattttatgt 2161 taaaaataga ttatttagaa gaaggggaaa tcttaaaaaa atttgaatat ccccttttta 2221 ttatttaatt aaaatgaaat agttagaaat atattttatt tagtttagtc aataacattt 2281 tgggattctt tataactaca tgttaactgt tgaataggct tatcatatgg tttaacccat 2341 cctttattaa tacttaattc tgtaagtgct gtgtgacctt ctaccatttg agttagtgaa 2401 gctgaatata tagctcttaa ttcaggtgta ctacttgtta atgcagaatt aagatacata 2461 ttggcagatg ctttagcaga tgaaagcata cttaacatta ttactttatc gtctatataa 2521 gtattgttct taattagatt ttctatcata tttctcatgt tatctatacc tcctcagaaa 2581 ttagtatttc attttcaact ataaattgtt gtatagcttt aattcttcct tctgttgcta 2641 atatactaga ttctgattgt ctttttaggt cttcatctga tattaacata tttattgctc 2701 tttgcataag taatccgtca gactccattt ttataactgc tgctaaagat attttttcag 2761 tttctgaaag tgttctcatt taatcatctc ctatattgta atttatgctt taatagtatg 2821 tctttctttt caaggaaata accattacac ttttttacag tattttatat tctctttata 2881 tcaaagttta gtcaacttaa tatattaata taattttgta ggatatttat cattaaatat 2941 ctataaaata aattatttga atattcataa atcaaaattt atttgtatgt acttcttcaa 3001 gagtcaatat gaattttttc aaaaaattaa ttttgatgat aatcattaag ggctatattt 3061 ttcctaaagt tgtgattatc attattaatt tactaaaata ctttaatgaa aaatagctaa 3121 ctttaattgt aggatattct taatatattt gaaataaata aaaatattga aggatataat 3181 attcaattgg tatataaata ataaatgata gttaagattt accttagagg ctaattaggt 3241 gttcagtcaa aattaatgcc tttagaatac aaatgtattc taaaggcatt tttactatgt 3301 attttcattt atattactaa acattatcta tttttatata catttctatg tattttattt 3361 tcatcaaatc ggtctataaa ttcatttttt tcttcactat atccaataga tataagtgca 3421 taaggaacta attttactgg taagtctaaa atttgtttaa ctttatttac tactttattt 3481 ttaggaaata ctcctgccca acaagcagct agaccttgat tagtaacttc taataataaa 3541 ttttgtgtgc aagcacctaa atcttgtatc catttaccag gttttaagaa tttatctcta 3601 tttccaagca ctactataca taatggtgca aattctatat gctttgctct atgctgtgac 3661 tttgagagct ctttcagcag ttccttatca tctactataa taaattccca aggttgagca 3721 ttttttgatg aaggtgcttg catagctgat tttagtattt cagttatttt atcttcttct 3781 atatttttat ctatatatgt tcttattgaa cgtctatttt ttataacttc taacatacag 3841 attctccttt aaataaaatt atttctattt atataatatc attactttaa gttttagcta 3901 ttacttatat aaagaataaa ctttgtgttg gttttatcta agtaaaagta acattcagaa 3961 ctaaaaaaca agactataaa tccaagatat taattaaaaa agaagtaata aaaaataata 4021 tacaagattt aaaaaagagt attgagctta aaatttaatt agaaaaccaa ttttgagata 4081 atctgttttt tattttaaca aaaaaacata aataaagttc gatacgtagc gaatgaaaaa 4141 aatacaagaa atattttttt taaaaaattt caaaaaagag ttgataatat atgtatatta 4201 atataaaatt taaggtgtat aattcgtata ataatacgaa tgatttgtag tgtaaaataa 4261 cttataaacg gagaggggaa gtctaatgaa agtagcagta gttatgggtt caaaatcaga 4321 ttatccaaaa ttagaagaag ggataaaact gcttgaaaaa tatggaatag aggttgtagc 4381 aagagcatta tcagctcata gaacaccaga acaactttca atattcctaa aagaaataga 4441 agatgatact gatgtaataa tagcagcagc aggaaaagca gcacacttac caggtgtaat 4501 agcttcacaa acattaattc ctgtaatagg attacctatt aaatcatcaa ctatggatgg 4561 actagactca cttttatcaa tagttcaaat gccaaaagga atcccagttg caacagttac 4621 aatagactta ggtttaaacg cagctttatt ggcattacaa ataatgactt taaaataccc 4681 aaaattaaaa gaggatttga aatcatatag agaagagatg gcacaaaagg tgttagaaga 4741 cgacaagaat ttaagggggt agcagaaatg ttattatatg aaggaaaagc aaaacaagta 4801 tattctacag ataatgaaaa tgaatatgtt gtttattata aagatgatgc aacagcattt 4861 aatggagaaa aaaaagcaga aatatcttca aaaggtatac taaataataa gatatcaaca 4921 ataatctttg aaatgttaaa agaaaataat ataaatactc actttataaa aagtttatca 4981 gatagagaaa tgttagttaa aaaagtagag attttaccat tagaagtaat agtaagaaat 5041 attgctgctg gttctatctg taaaagagtt ggtcttgaag aaggtgtagt tttcgatgag 5101 ccaatttttg aaataagtta caaaaatgat gcttatggtg acccaatgct aaatgatgat 5161 tatgcagtgg caatgaagtt agcaactaga gaagagttaa aattcttaag agaagaaact 5221 ttaaaaataa acgagttact aaaagcattt ttcttaaaat taaacctaaa gttagttgac 5281 tttaaaatag aatttggtaa ggattctgaa ggaaatataa tattggcaga tgaagtatca 5341 ccagacactt gtagactttg ggatgtaaat acaaatgaaa agttagataa ggacagattt 5401 agaaaagacc ttggagacct tgtagaaggt tatacggaag tactttcaag aatgaataat 5461 aaataggagg caaatgtatg tgtggagttt tagggattta ctctaataaa gatgtaacta 5521 aagaactata ttattcttta tattctatgc aacacagggg gcaagaaagc tgtggtttag 5581 ctcttttaga tgatggagaa attaagtaca aaaaagatat gggattagtt ggagatgttt 5641 ttaaggaaaa tgaattatct aagttaaaag gaaatatagg gattggacat gttagatatt 5701 caacagctgg aggaagtcat gtttctaact gtcaaccttt agttggaagt tgtagaaaaa 5761 gacaattagc catagctcat aatggaaatc tagttaatgc aaattattta aaagatatgc 5821 tagaagaaga tggatatatg ttccaaacta attcagatac agaagtgatt ttatatatac 5881 ttgctagata ttacaaaggg gatatagtag aaagtttaaa agtgacaatg gattatataa 5941 aaggtgcata tgctcttgta ataatgagtc aagaagaatt ggttgcagtt agagacccac 6001 atggattcag acctcttgta cttggtaaaa agggtgatga atatatattt gcatcagaaa 6061 attgtgcaat agatatactt ggcggagaag ttataagaga tgtagagcca ggagagataa 6121 tagtagtcaa agatggagaa ctaaaatcat atttttattc agaaaattat aaaccagtta 6181 agaaaagttg tatatttgaa cacatatact ttgcaagaaa tgatgcaact atagacaatg 6241 taaatgcata tgaatttaga attaaatgtg gtgagagatt agctcagaat gaaactgtaa 6301 aggcagatat ggtagttcca gttccagatt caggttggcc aggagctatt ggttatgcaa 6361 atgctagtgg attaaaaata agtgaaggct tagttaaaaa tagatatgta ggaagaacat 6421 ttataaaacc tacacaagaa gaaagagaaa tagcagtaaa aataaaatta aatcctcttt 6481 caacaataat aaaaggaaaa tctataattt tagtagacga ctcaattgta agaggaacta 6541 catctaaaca attagtaaaa tctttaagag aagcaggagc aaaagaaatt catcttagaa 6601 taacttctcc tccagtagct tactcttgtt actatggaat agatactcca aatcgctcta 6661 aattaattgc atcaagtaac aacgtagaag aaatgagaga atatattgga tgtgatagtt 6721 taaaattcct agatatagaa ggaatgttag atgcaacaga acataagtct actttctgta 6781 aagcttgttt tgatggagaa tacccagtta agaaaattga taaggaggaa ctactttcat 6841 gttaacatat aaagaatcag gtgtagatat agatgaagga aatagagcag tagaccttat 6901 aaaaggtaaa ataaaaggaa cttatgatgg aaatgtagtt ggagatttag gtaacttcag 6961 tggattatac agtttaaaag attttgtagg tatgaaagaa ccagttttgc ttgcatctac 7021 agatggtgtt gggactaagt taaaaatagc tcagatgatg gacaagcatg atactgttgg 7081 aatagattta gttgcaatgt gcgtgaatga tttaatttgt caaggagcaa aaccattatt 7141 tttccttgac tatatagctc ttgggaaatt agtgcctgag catatcgaaa aaatagttgg 7201 tggaattgca gatggttgta aaatgtctgg ttgtgcacta attggtggag aaactgctga 7261 aatgcctgga atgtatggag aagatgacta tgatttagca ggattttctg taggaatagc 7321 agacaaagaa aagattgttt ctggaaacaa tgttaaatca ggagatgtat tggttggtat 7381 atcttcaagt ggagtacaca gcaatggatt ttcttttata agaaagatat ttttagaaac 7441 ttacaattat aaaatggaac aatatgttga agaactagga atgacagttg gagaagcact 7501 tttaacacca actaaaatat atgttaaatt agctttagat gtattagcta aacatgacat 7561 aaaagctata gctcacataa ctggtggagg gcttatagaa aatataacaa gagttatacc 7621 taaagggtta ggactagata tcaataaaaa atcttgggag aagcctccta tatttaaaat 7681 gatagaaggt tttaatgctg ttgatgagag agaacttcat aagagtttta acatgggtat 7741 tgggctagtt ttaatagtag ataaagaaaa tgctgatgat gttgtaaact ttataaataa 7801 tagagaaaat gacaatgctg cttatgtaga taaaaaatac agtgaattat tagaagataa 7861 agcgtatata attggtgaag tagtagatag tcatgaaggt gtagaattat gctaaatata 7921 ggagttttaa tatctggtgg aggaacaaat ttacaagcag ttatagatgg cactgagtct 7981 ggagaaataa aaggtcaggt taaagtagtt atctcaagta agcaaggtgc ttatgggcta 8041 gagagagcta aaaatcataa cataaaagca atttgtgaaa ctgatgaaga caagataata 8101 gagattctta aggaaaataa aatagattta gtagttttgg ctggttattt aaaaataatc 8161 agcccaaagc tggttaatga gtttagaaac aaaatgataa acatacatcc atcattaatt 8221 ccttcatttt gtggagctgg gttctatgga gaaaaagttc atcaaggtgt tatagattac 8281 ggagctaaag taactggtgc tacagttcat tttgttgatg aaggtgctga tactggacca 8341 atcataatgc aagatgtagt taaggtaaat caagatgatg atgcaaagac acttgcaaaa 8401 agagtgttag aagttgaaca taggatttta aaagaaagta taagtctttt ttgtgaaaat 8461 aaattaaaac ttcaaggtag gagagtgttt ataaatgagt aagagagctt taataagtgt 8521 aactgacaag actggtgtag tggaatttgc taaggagtta aataagttag attatgaaat 8581 tatatctaca ggaaatacat ttaaaacatt aaaagaaaat ggtgttaatg taatgcaagt 8641 tgaagatgtt acaaattttc cagaaatatt agatgggaga gtaaaaacat taaatccata 8701 tatacatggt ggtatacttt ataaaagaga taaagaatct catgtagaaa ctgtgaatga 8761 gcataaaata cattcaatag atttagtagc tgtaaatcta tatgattttg aaggaacttt 8821 aaaagctgga aaaagtcatg atgaaataat tgaaaatata gatattggtg gaccatctat 8881 gatacgttct gctgccaaaa actataaaga tgtaatagta gtagtagata taaaagatta 8941 tgattctata atagaaaaat taaaaacaga tacaatgaca ttagaagaca gaaaaaaatt 9001 atcatataaa gctttctcaa ctacaggaag atatgatgcg ttaatatcta gttattttgc 9061 tggagaagtt ggagatacat atcctgacat attaaattta actttccaaa aagaacaaac 9121 tttaagatat ggagaaaatc cacatcaaaa tggtttctta tattcacaat caaatgcaaa 9181 aaatccaatc ttaaattatg agcaattagg cggtaaagaa ctttctttta acaatttaaa 9241 tgatttacat ggatgtttag aagtaatgag agaatttaaa gatagtgaag aagtagtttc 9301 agtagctata aaacatgcta attcatgtgg ggtaggtcta ggaaaagatg cttttgaagc 9361 atatacaaaa tgttatgaag cggataaggt ttcaatattt ggaggaatag taggaataac 9421 ttctactata gataaagcta cagcagagaa attaaatgaa atattcttag agatagtagt 9481 agcatatgat tttgagccag aagctttaga ggtacttaaa caaaagaaaa atttaagaat 9541 attaaaatta gctaagatag aagatagttt acaaccatat gaaatgaaat atttagatgg 9601 aaaattatta atacaagata gaaataatat attagcagaa aaaagtgaaa atgtaacaaa 9661 agcaaaacca acagatgcac aacttaagga catggaattt ggtatgagag tagtaaaaaa 9721 tatgaaatca aatgcaattg cgatagtaaa aaatggtcaa actttagctt taggttgtgg 9781 acaaacatca agaatttggg cattaaaaaa tgctcttgaa aataacaaag ataaagattt 9841 tacaggagct gttttagcgt cagatgcatt tttcccattt gatgattgtg taacattagc 9901 tcatgaatat ggaatatcag cagtagttca accaggtggc tctataaagg ataaagattc 9961 aatagaagct tgtgataagt atgatatggt tatggtattt acaggaataa gacacttcaa 10021 acactaagga ggatattatg aagatattgg ttgtaggcgg tggcggaaga gagcatgcta 10081 tatgctggaa actaagcaaa gaaaaaaatg tagaaaaagt ttattgcgcg ccaggtaatg 10141 caggaattac aaatgtagca gaatgtgtaa atataggtga tactaatata gaagaacttt 10201 taaaatttgc caaagaaaat gaaataggtc tgacaatagt aggaccagaa gtaccactag 10261 ttatgggaat agtagatgag tttgaaaaag aaggattaag agtatttgga cctaataaaa 10321 aatgtgctca acttgaagga agtaaagctt tttcaaaaga atttatgata aaacataaca 10381 tacctactgc aaaatataaa gaatatacaa acttagaaga agctatatca gaaatagata 10441 gttttggata tccagtagta ataaaagcgg acggattagc tgctggaaaa ggtgttgtaa 10501 tacctgaaaa tagagaagat gctatagcaa ctttaaaaga aatgatgtca gataagaagt 10561 ttggagctgc tggagataaa atagtaattg aagagttttt aaaaggaata gaaacttcaa 10621 ttctagcatt tgtagacaat gatacaatag ttcctatggc aagtgcaaaa gaccataaaa 10681 aagtaaacaa ctatgagcaa ggtccaaaca ctgggggaat gggaactttt tcacctagtg 10741 aaatatatac agaagaatta gcaaataaag taaaagagac agtattagaa aaaactttag 10801 aaggcttcaa aaaagatgga cttaatttta aaggtatttt atttgttggt cttatgataa 10861 ctgaagatgg agaaaaagta cttgaatata atgtaagatt tggagaccct gagacacaat 10921 ctgttttatt tagattagaa acagatttac atgagataat ggaaactata ctagataata 10981 agttaaaaga tatagaaata aactatagtg atgatgaagc tgtatgtgtt atgcttacat 11041 caggagggta tccagacagt tatgaaaaag ggaaaattat aactggtctt gaaaacttgg 11101 atgatgatat agtagtattc catagtggca ctaagatgct tgatggtaat ttagttacca 11161 atggaggaag agtaattggt ataactgcaa agtcaactac agttaaggat gcagcagaaa 11221 aagtttatga aaacataaag aagataaact ttgaaggaat gcactataga acagacatag 11281 gaagataatt tttctaaaat ggaggataag gtatgttgaa tactgaaaat aaagactcaa 11341 tggttagaag agtattagtt gaaaaaagag aaggttttga ccttgaggct aaagctttaa 11401 aaaaagactt agtagaaagt ttacacatag ataatataga aaatttaaga atattaaata 11461 gatatgatgt agaaggaata tcagaagaag tttatgaaaa tgcagcaaag acaatattct 11521 ctgaaccaaa tttagatgta gtatattatg aagaaatacc aaaattaaat gatgaaagag 11581 tatttgcaat agaatttctt cctggtcaat acgaccaaag aggtgattgg gcagctcaat 11641 gtgtacaaat tgtaaatcaa gggataagac ctgctattaa tacagcaaaa gtttatatat 11701 tatcaggcaa aataactgat gaagagtttt ctaaaataaa agattactgt ataaatccag 11761 tagatagtag agaagcatct ttagaaaaac cagaaacatt aaaaatggaa actgaaatac 11821 caacaacagt tgaagtatta gatggattta tagatttaga tgaaaatgga ttaagaacat 11881 ttgtaagtga aaaaggatta gcaatgactt taggagactt acaacacgtt caaaaatact 11941 ttaaagatac agaaaagaga aatccaacta taacagaaat aaaagtatta gatacttatt 12001 ggtctgatca ttgtagacat actactttta tgactgaaat agaaaatgta aagatagaag 12061 atggtaagtt taatgatata gtaaaagaag cgtatcaaat gtatcttaac tcaagagaca 12121 atgtatatgt gaacagacat aaagatatat gtttaatgga tatagccact gttgcagtaa 12181 aagaattaaa gaagaatggg aaattaaatg acctagatga aagtgaagaa ataaatgcat 12241 gtagtataaa cgtagatgtt gaagttgatg gtaagatgga aaaatatcta gtaatgttta 12301 aaaatgaaac tcacaaccat ccaactgaaa tagaaccatt tggtggagca gctacttgtt 12361 taggtggagc tataagagac ccattatcag gaagaagtta tgtttatcaa gcaatgcgtg 12421 ttacaggaag tgctgaccca agaacgactt tagaagatac tttacctgga aaacttatgc 12481 aaagaaaaat aactacagaa gctgctcatg gatatagttc atatggtaac caaataggtc 12541 ttacaactgg acaagttgca gaagtatatg atgaaaactt tgttgcaaag agaatggaaa 12601 taggtgcagt tatagcagca gtaccaaaag agaatgtagt aagagaaaga cctgaagcag 12661 gagatgtaat agttcttctt ggaggaaaaa caggaagaga tggttgtgga ggggcaactg 12721 gttcatctaa agaacatagt gaagagtcaa tcttaacttg tagtgcagaa gttcaaaaag 12781 gagatgctcc taacgaaaga aaaatacaaa gattctttag aaataaagaa gttgctcaaa 12841 tgataaaaag atgtaatgat tttggagcag gtggagtttg tgttgctata ggagagattg 12901 ctgatagttt agatataaac ttagacttag tacctaaaaa atacgatgga cttgatggaa 12961 ctgagcttgc aatttcagag tcacaagagc gtatggcagt agctataaaa aaagaaaata 13021 aagataaatt tatacaatta gcagtagaag aaaacttaga agctacacat gtagctacag 13081 taacagatac aggatattta agaatgttct ggaatggaaa agcaattgta gatataaata 13141 gagagttctt agatacaaac ggagtaaaac aaactactga tgtccatgtt actaaagtag 13201 atgaagaaaa tacattcttt agctctaatg aaatagtaaa agatgttaag tgtgcaagta 13261 tgaaagacaa gtttacaaaa gtattatctg accttaatgt ttgttctcaa aaaggattag 13321 tagagatgtt tgataataca attggtggta atacagtact tatgccattt ggaggaaagt 13381 atcaagcgac tccaacacaa ggtatggttg ctaagatacc agtacttgga ggagaaacta 13441 atacttctac aataatgact tatggatata atccaaaggt aggaaaatgg agtccattcc 13501 atggtgcctt gtacgcagta gtagaatctg tgtgtaaatt ggttgctatt ggaggaaatt 13561 atagtacaac aagacttaca ttccaagagt attttgaaaa acttggtaac aatccagaaa 13621 aatggggtaa accattctca gcacttttag gagcatttta tgcacaaagt aaatttgaga 13681 tacctgctat aggtggaaaa gacagtatgt ctggtacatt taaagatatc gaagttccac 13741 caacattagt ttcatttgct gttgatacag tagatgcgaa gaaagtagta tctccagaat 13801 ttaaaaaagc agactcaaaa gtagtaatgt tatgtgtaaa caaggcagaa aatgatgttg 13861 tagattttga ggaattaaag agaaacttag acaaagtaag agaacttata catggaaata 13921 aagttttatc aacatatgca ttaggatttg caggtgtagg tgaagcaata agtaaaatgg 13981 cttttggtaa taaaatagga tttaagttta gtgaagaagc tgaaaaaaca tttacagatg 14041 ataaattatt tgaggctagt tatggaaata tagtacttga attagcaaat gatgatttat 14101 gtatgttaga aggatacaat tatgttgtgc ttggaagtac aactaaagaa gctagtatat 14161 ttatcaaagg tgaagaactt gcattagatg aattatataa agcacactgt agtactttag 14221 agcctatatt cccaactaaa acagaagaag taaaatcaaa gatagagact ataagttata 14281 tatcacaagg agaagctaaa aaatcatcat taagtatagc tactccaaga gtatttatac 14341 cagcatttcc tggaacaaac tgtgaatatg actctgcaag agcatttgaa agagtaggag 14401 ctaatgcaaa cataagagta ttcaagaatt taacttataa agacatagaa gattctatag 14461 atacaatagt aaacgaaata aaatcttctc aaataataat gttaccaggt ggatttagtg 14521 ctggtgatga gccagatggt tctggtaaat ttatagctac tgtatttaga aatcctagag 14581 tgcaagaagc tataaatgaa tttttaactc aaaaagatgg actaatgtta ggtatctgta 14641 atggattcca agtattaatt aaattaggat tagttccata tggagaaata agagttccaa 14701 gtgaaagtgc tccaacactt acttacaata atattggtcg tcatcaagct aagattgcta 14761 gaactagaat ttcatctaat aaatctcctt ggttagctca aactaatgtt ggagatattc 14821 ataatatagc aatttctcat ggagaaggta aatttgttgc tagtgaagat gttatgagag 14881 aattaattgc taatggacaa gtagcaactc aatatgttga ctttaataat gaagctactt 14941 atgatattga gtttaatcca aatggttcat tctatgctgt tgaaggtata actagtgctg 15001 atggtagagt gtttggtaaa atgggacatt ctgagagaat tggtgaggaa gtatttaaga 15061 atattatagg tgaaaaagac caaaagatat ttgaatctgg agttaaatat tttagataaa 15121 gctttgatgt ttaattgata gctagaatat ataatttaga tatttagatt taaagagatg 15181 taataatatg atgataatca tttaatatta catctctttt ttatttatct aagaaataat 15241 aagttcaacc taagttaaaa tacaagctgt gttataatta attactaagt aaaattaaat 15301 atttattgga gggcaacata attaatgaaa atattaataa cagggtctaa tggtcaatta 15361 ggaaaagaat tggttagcca attagaagca atcaatcaaa gtataaatca accaaaatac 15421 gttatattag ctacaacaag aaatgatttg gatatatcca atcagactaa tatagataat 15481 tttattttgc ataataaacc tgatgtaatt gtaaactgtg cagcatatac aaaggttgat 15541 gcatgtgaag ataatatcga aattgcgtat aaaataaatg ccttaggagt gagaaattta 15601 gcaatagcat cagaaaaagt taatgctaag cttgttcaca tatcaactga ctatgtattc 15661 aatggttttt ctaaatatcc atatagggaa gacaataaaa ctgaacccaa ttctgtgtat 15721 ggaaaaagta aacttatggg agaaaagttt gttgaacaat tctcacataa gtactttata 15781 ttgagaacag catggttata tggtaatggg aataattttg taaagactat gataaaactt 15841 tctttagaaa ataaagaggt taatgtggtt aatgaccagt ttggaacccc aacaagtaca 15901 gtagacttag caaaaattat aataagaatc atggaaacag aacattatgg agtttatcat 15961 gctacatgtg aaggtgagtg tagttggtat gattttgcca aaaagatatt tgaattaaaa 16021 aatatagata taaaagtaaa tccaattaag agtaacgaat ttaaatgtaa ggctcaaaga 16081 ccactatatt ctgtattgga taattttatg ttgaagttaa ttggtttaaa ttcttttaga 16141 aagtgggaag aatccattga agaatattta gaaagatatg atataaatga aaagtaaatg 16201 tattattttt agaaaagaaa ataagatatt ataaaaaata taaatatttc ttttatttat 16261 ccgataatca taatatgaca aaaacaaatt taaggatgga aaaagatgaa aggaattatt 16321 ttagcaggag ggtctggtac aagactatat cctataacaa aatgtatatc aaaacaaaca 16381 cttccaatat acgataaacc aatgatatat taccctatgt cggttcttat gttggcaggg 16441 atacaagata tattaataat atctacacca agagatataa aagcatttga agaattattt 16501 ggagatggaa gttcactagg gcttaaaata acatatgcaa ttcaggagaa agcaaatgga 16561 attgcagaag cgtttataat aggagaagaa tttataggaa atgacagagt gtctcttgta 16621 ttgggggata atatatttta tggatatgga tttagtgaaa ggttggagaa tgcagttaaa 16681 agaaaaggag caactatatt tgggtatcat gtaagtaatc caaattcgtt tggagttgta 16741 gaatttgata aggattttaa tgtattatca atagaagaaa aacctacagt tcctaaatct 16801 aattatgcta taccaggatt atatttttat gataatgatg ttgtagagat agcaaagcta 16861 gttgaaccat cagatagagg tgaattagaa ataacctcta taaacagtga atatctaaaa 16921 cgaggaaaac taaaagtgga acttctagga agaggtatgg cttggcttga tactggtaca 16981 cataaaggtc tattggatgc ttctaactat gttgaagtgg ttcaaacaag acagggactg 17041 tatatagcat gtttagaaga gattgcatat acaaaaggat atataagtag agaacaatta 17101 atgaaactag ccaagccact gataaaaact gaatatggtc aatatctatt aaaattggct 17161 agtgaagata tgcaatatgg tagataaaat ttattataaa ttttattaag ggagtttgtt 17221 ataatgggaa aaatcaatgt tataaagact aaaatagaag gattatatat agtcgaacca 17281 aatgtatttt gtgatgaaag aggatatttt atggaaagct ataataaaaa ggattttata 17341 gagcagggtc ttgatatgtg ttttattcaa gataatgagt ctagctcaag aaaaggtgtt 17401 ttaagaggaa tgcattttca ggttagatat cctcaaggaa aattagtcag agttacagag 17461 ggagaagttt tcgatgttgc agttgattta agaaaagatt cacagacatt tgggaaatgg 17521 gaaggtgtaa tattgtctga taagaataaa aaacaatttt atattccaga agggtttgca 17581 catggatttt tagttttatc agaaaaagca gtatttaatt acaaatgtac aaactattat 17641 tatccagaat ttgagcatgg gtttatatgg aatgacaagc aaatatctat tgagtggcct 17701 ttaaaaggaa ttgaagaaat atttttatca gaaaaggaca aaaaacaaaa aagttttaaa 17761 gatatttgta taagacgtta ataaaaattt attagaatta acatttagga gaaaaaatat 17821 gaaaaaaata ctgataactg gaggagcagg atttattggg agtaactttg tacattatat 17881 gcttaacaag tatgtagatt attttattgt taacctagac ttgttgactt atgctggtaa 17941 tttagagaca ttaatagaaa tacaagacag ttccaattat aaatttgtta aaggagatat 18001 ttcaaatagg gaacagatgt ataagctatt tgaagaagaa aggtttgata tagttgttaa 18061 ctttgccgct gaatctcatg tagataggtc agttgagaat cctgatttat ttattaaaac 18121 aaacattata ggaacacaag tacttttaga tgcatctata aaatatggag ttaaaaggta 18181 tcatcaaata tctacagacg aagtgtatgg tgatttacca attgatagaa aggatttatt 18241 ctttacagaa caatctccta tcaatccaag ttctccatat tcagcttcta aagcatcagc 18301 agatttgttg gtaagttctt attatagaac atatggattg ttaacaacta tatctaggtg 18361 ttccaacaat tatgggccat atcattttcc tgaaaaattg atacctctta tgattttaaa 18421 tgctttggaa aacaaacaat tgccagtata tgggaatggg gaaaatgtaa gagattggtt 18481 acatgtatat gaccattgta ctgctataga cttaataata cataaaggga atatagggga 18541 gatttacaat ataggaggtc ataatgaaag aagtaattta gaagtagtaa aaatgatatt 18601 aaatctttta gataaatctg aagagttaat atcctatgta aatgatagac ctggtcatga 18661 tttaagatat gctattgatg caactaaaat agagaatgag ttaggttgga aggcaaaata 18721 tgactttgat ttgggtataa aagaaactgt taagtggtat atagaaaatg aatcttggtg 18781 gaaagctgtt ttatcagtgt aactttgaaa tttataaaat ttagaaaggg gcgttttata 18841 ttgaatgaga taagttcact aattaatata ttagcattga ctcaattatc tggtagtaat 18901 actacaaatc aatgtaactg tacatataat agttcatctg gatttgatat gattatgatg 18961 accttgttaa aagcattatc acaaaataat caacagactt ctaatggcta caatttatcg 19021 tctaattctg agaatttatt tgacgaactc ggcagtgtag taaataatac agctagtaga 19081 tttatagatg ttgatacaaa agataaaagt gtaaaatcaa gaattgaaaa tgctatagag 19141 caagcatcaa aaaaatataa tgtggattcg aatcttataa aagcaataat taaagttgaa 19201 tcggatttta atccaaatac tgtttcttct gctggtgcta agggtcttat gcaacttatg 19261 ccagaaaatt gcagagactt gggggttaca gaccctttta atatagagca gaatatagat 19321 gctggaacta gacatattaa ggaatacatt gatatgtttg gagggagcat agaaatggga 19381 ttgatggcat ataatggtgg tcctggaaga atgaaaagta gaggagtaga atcaatctct 19441 gacctgtata aaatgccaaa agaaacacaa aattatattc ctaaggttat gaaatattat 19501 agagggtagg ctttattatg gggataaata tagataagct aaacataagt ccaagtataa 19561 atatggaggt taaaaaacta aaagagagta ataaattttc tgacaaatta aactctttaa 19621 aacaatcttc ttcattggaa gatataaaac gaaatttgga aagtgtaaaa aaggcaggag 19681 aaaggcttgt acttactcaa aactatggcg acattagtat atataaaaat gcagtaaaag 19741 aatacctaaa atctgttgta gataatatgt attcacttga taaaaatagt agcttttggg 19801 agcatcagta ttataagaat gtaaagattg ttgatagtaa acttgaggat atgactagta 19861 agttaattag tgaagaaaaa gaaaacatag atattgtttc tactgttgat atgatacaag 19921 gcttgttgat agatatgtat agataaggtt atacaaggag aaaagtttta tgaatagtaa 19981 aaaagaggat atatatgaat tgaattttgg gcaattaata gaagaaaaat ctggtgttat 20041 agaagaaaat caaaatgttt ttaatgcaaa agtaaatgta gctgtttcta taggaaatac 20101 aacagaaaca ataaaaaata tattagattt aaaagaaggc tctataataa aactaagtaa 20161 gaatgtggat gaaaaattag atatatatgc aaatgataga ttgtttgctt atggagaaag 20221 cattattaca aatgagaagt tatctgtaag attatctaaa atagaagatt cagatgtaaa 20281 ttagtatttt aaatagtatc cctttaggct atgatgtatg agtttagcta aggggatatt 20341 tttataaaaa atttaaaata tgcgtgaatt atataaatgt ttttatttta tgagcgataa 20401 ttaaattata agtatgtaat tttggaggtg aaactatgga tattaaaaat gtaagttcaa 20461 atattgtagt gaataattat ttaaagaata catctggtgt aaaaaaagtg gaagaagtta 20521 aaaaaattaa taaaacagac aagatagagc tatctaaatt tgcaaaggaa atggcaagtg 20581 tgtcaaatat gagtgatgag aatattagga ataaaaaagt cgatgaaata aaaaatgcat 20641 tagaaaatgg aacttacaaa ataaaaccaa aagaaattgc gaaaaaaatg atagaggata 20701 tgcgaggata aagtcatgat tacagactta aaagttataa tatatgaaga aaaaaatata 20761 attagtaaga tgatggaatt attaaaagaa caatttgatt atatagttga aaaagactta 20821 gaaaatttaa atatgttaaa tcctaaacta gaagatatta gcagggagct tgcatccata 20881 gaaataaaga gaagacaact ttttggtgat gatatttcaa tgagtgaagt tgttgaaaat 20941 agtaatgata gatatttaaa agaaatatat acagacttga aacacattct tgctttagct 21001 aaaaatcaac aagaatcaaa tgattctcta ataaagaaag aacttatttt tacgaaaaaa 21061 atgattaatt tcataaaacc agctgataag caaactgcaa cttataattc ttatggaaat 21121 attagaaaat aaatattagg aggagaaata tggcaggatt attttccatt ttaaatacag 21181 ctaattcagg aatgaatgcg caccaaaaag caatacagac aatttctcat aatataagta 21241 atctagatac agacggttat tctaggcaaa ggactgagtt tgctacaaat agtccaatgt 21301 atatgcctag tttgagtaat tcaattgcaa gaggacaatt agggactgga gtacacgtaa 21361 cggatgtaac aagagctaga aatagttttt atgattacca atttagagca gaagctcata 21421 agtatggtaa tacagtttca aagtatgact attataatac tatagaaact ataataaatg 21481 aaccatcaga ctatggaata tctgcaggta tagacgactt ttttaaagga tgggaatcat 21541 tagcaaagga tataaatagt gatagtaaaa aaagtctagt ggtagaaaat gcatcaaatc 21601 tagcaacttt aataagtgaa agttataaga agcttaataa gttaaaggga gatatagacg 21661 ataatataaa ctctgaaata aaacagataa atgacatgtt aaaaagtctt gaagatttga 21721 ataaatctat tgatgttata tctggttctg gctctactcc aaatgattta cttgatgaaa 21781 gagatagaat attagatgac ttaagcttta aattagacct tgaaaatagc gatgttaaaa 21841 atatgctttc agatggtaaa ttagaactta atgaattaaa aaatgcagat ggaacttgga 21901 aaacaggtgt atcaggaacc ttacaaggct tgtttgaaat gcatggtaag attgatacat 21961 ataaaagcga tttaaaagat gtatctgatg ggttagctaa gcagataaat gatgtttata 22021 atacatctgc tggaataaca gtaacagatt tttttataac ttcaaatgta gatggtgaag 22081 atatcataaa ggtaaatcca gctataaaga gtaacccaaa tgaattaaaa cttactgctg 22141 atgaggcttc aaagattgct aagttaaagg atgaaaaaat agatattggg gtggctggtg 22201 gaaaagtaag tacaataagt gaccactata aagcctttgc agaatcagta ggtttagatt 22261 ctcaaaaagt gaatcaagat gaagtgaatc aacgtaaaat tataaataat attgataact 22321 cacgaatgag tgtttcaggc gtatctttgg atgaagaaat gacagagctt ataaaaatac 22381 aacgctccta tcaagctagt gcaaaagtta tgtcaacagc tgtgcaactg ttggatgttg 22441 taataaatgg aataatttaa tagaaggggg aatttataat gagagttagt acaggtatga 22501 tgtctagcaa ctatctaaac tcactacaag ataatctaca aagattagat aaggttaata 22561 gacaagttaa tacaacgaaa gaaataaaca agctatcaga taatccatat aaggcaataa 22621 aaatattgaa ctcaaaaagt gaaataaaaa ctatggagac ttatgttgag aattgtaaag 22681 atacagggaa ttggttagaa actactgata ctgcattaga tcagcttgga aaattattat 22741 cggacataaa gaaaactttg gtggcaagtg gtgatggtgc atattcagat gatgagctaa 22801 agactcttag taatgaaact aatgaaaaga tgaaagaaat tgcaaatgcc ttaaatgcaa 22861 cacatgaagg aaagtacata ttttcaggtt caaatacagg tgtaccacct gttgaatgta 22921 tagataatgc tgacggttca gtgagcttaa agtttaattc tagtttaaat cttaataaat 22981 taaatgactc tttgagtatg gatatagctc aaggaataag tgtagattat aatgttaaat 23041 tgagtagcct tggatttgac ccaacaaaga ctgacccatt tgaagagtta aataatatat 23101 caaagaaatt agcaaatcca gatgctgatg ctataaaaga gctgacaaca acttgtttag 23161 gcgacatgga acaattaata gaaaatacag taaatgttag gtctatatat gggacaaaag 23221 caaatacagt agaggctatg aaggaaaaaa atgatgatag tttgatacag ttaaaggata 23281 ttttgtcaca aaatgaagaa atagattatg gagaaaaact cgttcaatta aaggcagcag 23341 agttaactta tcaagcttca ctacaaacag gaggaaagtt atttaatgta tctatattag 23401 attacatata g //