LOCUS NC_016822:19 17928 bp DNA linear BCT 07-SEP-2013 DEFINITION Shigella sonnei 53G, complete genome. ACCESSION NC_016822 SOURCE Shigella sonnei 53G, complete genome. COMMENT locus start: 3946500; locus end: 3964427 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.486665; n0_4mer:D = 30.599465; n0_4mer:PS = 37.702522 FEATURES Location/Qualifiers source 1..17928 /organism="Shigella sonnei 53G, complete genome." gene 262..615 /gene="" /locus_tag="" /db_xref="3946761..3947114" CDS 262..615 /gene="" /product="DNA-binding transcriptional repressor ArsR" /translation="MSFLLPIQLFKILADETRLGIVLLLSELGELCVCDLCTALDQSQ PKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWAAKIIDEAWRCEQEKVQAIVRN LARQNCSGDSKNICS" gene 669..1958 /gene="" /locus_tag="" /db_xref="3947168..3948457" CDS 669..1958 /gene="" /product="arsenical pump membrane protein" /translation="MLLAGAIFVLTIVLVIWQPKGLGIGWSATLGAVLALVTGVVHPG DIPVVWNIVWNATAAFIAVIIISLLLDESGFFEWAALHVSRWGNGRGRLLFTWIVLLG AAVAALFANDGAALILTPIVIAMLLALGFSKGTTLAFVMAAGFIADTASLPLIVSNLV NIVSADFFGLGFREYASVMVPVDIAAIVATLVMLHLYFRKDIPQNYDMALLKSPAEAI KDPATFKTGWVVLLLLLVGFFVLEPLGIPVSAIAAVGALILFVVAKRGHAINTGKVLR GAPWQIVIFSLGMYLVVYGLRNAGLTEYLSGVLNVLADNGLWAATLGTGFLTAFLSSI MNNMPTVLVGALSIDGSTASGVIKEAMVYANVIGCDLGPKITPIGSLATLLWLHVLSQ KNMTISWGYYFRTGIIMTLPVLFVTLAALALRLSFTL" gene 1971..2396 /gene="" /locus_tag="" /db_xref="3948470..3948895" CDS 1971..2396 /gene="" /product="arsenate reductase" /translation="MSNITIYHNPACGTSRNTLEMIRNSGTEPTIIHYLETPPTRDEL VKLIADMGISVRALLRKNVEPYEELGLAEDKFTDDRLIDFMLQHPILINRPIVVTPLG TRLCRPSEVVLEILPDAQKGAFSKEDGEKVVDEAGKRLK" gene complement(2530..2826) /gene="" /locus_tag="" /db_xref="3949029..3949325" CDS complement(2530..2826) /gene="" /product="hypothetical protein" /translation="MQLEEVAKALKELGHPTRLFIFKHLVKAGEQGLPVGELQKQLGI PGSTLSHHISALVSVGLVKQNRESRTLMCVSQYAMLEAIIEFLREECCVNSKIA" gene 2933..3211 /gene="" /locus_tag="" /db_xref="3949432..3949710" CDS 2933..3211 /gene="" /product="permease" /translation="MSSWLAMLQDAAEMFVFLAVELSLLFIVISAGVSLIRQKVPDHK IQQMMGARKGRGYLLAALLGAVTPFCSCSTIPMLRGLLSAKAGFCQRQ" gene 3298..4470 /gene="" /locus_tag="" /db_xref="3949797..3950969" CDS 3298..4470 /gene="" /product="integrase for IS21, orfA" /translation="MLSREDFYMIKQMRQQGAYIVDIATQIGCSERTVRRYLKYPEPP ARKTRHKMVKLKPFMDYIDMRLAENVWNSEVIFAEIKAMGYTGGRSMLRYYIQPKRKM RPSKRTVRFETQPGYQLQHDWGEVEVEVAGQRCKVNFAVNTLGFSRSFHVFAAPKQDA EHTYESLVRAFRYFGGCVKTVLVDNQKAAVLKNNNGKVVFNSGFLLLADHYNFLPRAC RPRRARTKGKVERMVKYLKENFFVRYRRFDSFTHVNQQLEQWIADVADKRELRQFKET PEQRFALEQEHLQPLPDTDFDTSYFDIRHVSWDSYIEVGGNRYSVPEALCGQPVSIRI SLDDELRIYSNEKLVASHRLCSASSGWQTVPEHHAPLWQQVSQVEHRPLSAYEELL" gene 4470..5267 /gene="" /locus_tag="" /db_xref="3950969..3951766" CDS 4470..5267 /gene="" /product="IS21 ORF2" /translation="MHELEVLLSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQ EWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGIDRKVVRELAGLAFVERSENVIL LGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYAR VLILDEIGYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAIL DRLLHHSTTLNIKGESYRLKEKRKAGVLTKNTTPISDDEMVESGQHQ" gene 5397..6068 /gene="" /locus_tag="" /db_xref="3951896..3952567" CDS 5397..6068 /gene="" /product="hypothetical protein" /translation="MTFGWKVTLLYAIIAAGVSVLASIILDSLGFERHIIASKSSSAN CCAPAKTSPGTTYTPIKVSCCSPAAKAIENPVVTCCSTKAVVSINPIKLATKDALQQF KDVLPYLLLGVLIGSFIYGFIPSAWIAAHAGADNPFAIPLSAVVGIPLYIRAEAVIPL ASVLMTKGMGLGALMALIIGSAGASLTEVILLKSMFRMPMIAAFLTVILGMAILMGYL TQLLF" gene 6331..6633 /gene="" /locus_tag="" /db_xref="3952830..3953132" CDS 6331..6633 /gene="" /product="IS600 ORF1" /translation="MSRKTQRYSKEFKAEAVRTVPENQLSISEGASRLSLPEGTLGQW VTAARKGLGTPGSRTVAELESEILQLRKALNEARLERDILKKATAYFAQESLKNTR" gene 6774..7487 /gene="" /locus_tag="" /db_xref="3953273..3953986" CDS 6774..7487 /gene="" /product="IS600 ORF2" /translation="VAHIRTRETYGTRRLQTELAENGIIVGRDRLARLRKELRLRCKQ KRKFRATTNSNHNLPVAPNLLNQTFAPTAPNQVWVADLTYVATQEGWLYLAGIKDVYT CEIVGYAMGERMTKELTGKALFMALRSQRPPAGLIHHSDRGSQYCAYDYRVIQEQSGL KTSMSRKGNCYDNAPMESFWGTLKNESLSHYRFNNRDEAISVIREYIEIFYNRQRRHS RLGNISPAAFREKYHQMAA" gene 7723..8088 /gene="" /locus_tag="" /db_xref="3954222..3954587" CDS 7723..8088 /gene="" /product="IS2 repressor TnpA" /translation="MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAAS QLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQIKELQRLLGKKTMENELLKEAVE YGRAKKWIAHAPLLPGDGE" gene 8046..8951 /gene="" /locus_tag="" /db_xref="3954545..3955450" CDS 8046..8951 /gene="" /product="IS2 transposase TnpB" /translation="VDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRS RHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALL LERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHW AVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLE PKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSAL GYRSPREYLRQRACNGLSDNRCLEI" gene 9253..10098 /gene="" /locus_tag="" /db_xref="3955752..3956597" CDS 9253..10098 /gene="" /product="hypothetical protein" /translation="MSIDFTPGIINTYHGDIYNCTTNTDNAKTPDTPKWPCDNWEEQQ PINSTFSGEGYISDQYDLVQHQLQQINACHTNTTYTNADYSKVVAQLVSLITNIETIS STQLTQQTQSILNQINNIRYEKNKSAECRIIVVANPKPDKAIITKISVEEGIPITFSV QTMFSDTNFIAEQRADLPTNIKDIQSLYQKMTKLYIEHSENKNRMKVFAGANFIDFNM TGQNLSGFVLTLSRFYFEDLLNINFTDANLGDTIFYIKNTLPPNYIKMDNILTNKSKV YFQHY" gene complement(10557..11060) /gene="" /locus_tag="" /db_xref="3957056..3957559" CDS complement(10557..11060) /gene="" /product="IS1 ORF2" /translation="MPGNCTHYGRWPQHDFTSLKKLRPQSVTSRIQPGSDVIVCAEMD EQWGYVGAKSRQRWLFYAYDSLRKTVVAHVFGERTMATLGRLMSLLSPFDVVIWMTDG WPLYESRLKGKLHVISKRYTQRIERHNLNLRQHLARLGRKSLSFSKSVELHDKVIGHY LNIKHYQ" gene complement(10979..11254) /gene="" /locus_tag="" /db_xref="3957478..3957753" CDS complement(10979..11254) /gene="" /product="IS1 repressor protein InsA" /translation="VASVSISCPSCSATDGVVRNGKSTAGHQRYLCSHCRKTWQLQFT YTASQPGTHQKIIDMAMNGVGCRATARIMGVGLNTILRHLKNSGRSR" gene 11500..12066 /gene="" /locus_tag="" /db_xref="3957999..3958565" CDS 11500..12066 /gene="" /product="outer membrane lipoprotein" /translation="MNMTKGALILSLSFLLAACSSIPQNIKGNNQPDIQKSFVAVHNQ PGLYVGQQARFGGKVINVINGKTDTLLEIAVLPLDSYAKPDIEANYQGRLLARQSGFL DPVNYRNHFVTILGTIQGEQPGFINKVPYNFLEVNMQGIQVWHLREVVNTTYNLWDYG YGAFWPEPGWGAPYYTNAVSQVTPELVK" gene 12222..12752 /gene="" /locus_tag="" /db_xref="3958721..3959251" CDS 12222..12752 /gene="" /product="putative DNA-binding transcriptional regulator" /translation="MFLIITRDTMFFTAMKNILSKGNVVHIQNEEEIDVMLHQNAFVI IDTLMNNVFHSNFLTQIERLKPVHVIVFSPFNIKRCLGKVPVTFVPRTITIIDFVALI NGSYCSVPEANVSLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNL KRINELVRHQHIDYLV" gene complement(12794..13441) /gene="" /locus_tag="" /db_xref="3959293..3959940" CDS complement(12794..13441) /gene="" /product="putative Mg(2+) transport ATPase" /translation="MTAEFIIRLILAAIACGAIGMERQMRGKGAGLRTHVLIGMGSAL FMIVSKYGFADVLSLDHVGLDPSRIAAQVVTGVGFIGAGNILVRNQNIVGLTTAADIW VTAAIGMVIGSGMYELGIYGSVMTLLVLEVFHQLTFRLMNKNYHLQLTLVNGNMVSML DWFKQQKIKTDLVSLQENEDHEVVAIDIQLHATTSIEDLLRLLKGMAGVKGVSIS" gene complement(13505..13843) /gene="hdeB" /locus_tag="hdeB" /db_xref="3960004..3960342" CDS complement(13505..13843) /gene="hdeB" /product="acid-resistance protein" /translation="MGYKMNISSLRKAFIFMGAVAALSLVNAQSALAANESAKDMTCQ EFIDLNPKAMTPVAWWMLHEETVYKGGDTVTLNETDLTQIPKVIEYCKKNPQKNLYTF KNQASNDLPN" gene complement(13947..14279) /gene="" /locus_tag="" /db_xref="3960446..3960778" CDS complement(13947..14279) /gene="" /product="acid-resistance protein" /translation="MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLA VDESFQPTAVGFAEALNNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGE WDKIKKDM" gene 14534..15106 /gene="" /locus_tag="" /db_xref="3961033..3961605" CDS 14534..15106 /gene="" /product="acid-resistance membrane protein" /translation="MLYIDKATILKFDLEMLKKHRRAIQFIAVLLFIVGLLCISFPFV SGDILSTVVGALLICSGIALIVGLFSNRSHNFWPVLSGFLVAVAYLLIGYFFIRAPEL GIFAIAAFIAGLFCVAGVIRLMSWYRQRSMKGSWLQLVIGVLDIVIAWIFLGATPMVS VTLVSTLVGIELIFSAASLFSFASLFVKQQ" gene 15905..16432 /gene="" /locus_tag="" /db_xref="3962404..3962931" CDS 15905..16432 /gene="" /product="DNA-binding transcriptional activator" /translation="MIFLMTKDSFLLQGFWQLKDNHEMIKINSLSEIKKVGNKPFKVI IDTYHNHILDEEAIKFLEKLDAERIIVLAPYHISKLKAKAPIYFVSRKESIKNLLEIT YGKHLPHKNSQLCFSHNQFKIMQLILKNKNESNITSTLNISQQTLKIQKFNIMYKLKL RRMSDIVTLGITSYF" gene complement(16749..16865) /gene="" /locus_tag="" /db_xref="3963248..3963364" CDS complement(16749..16865) /gene="" /product="hypothetical protein" /translation="MAAAFSADLSSQAVSIAPQNNNGINSFLLLFILVPENS" gene 16771..17928 /gene="" /locus_tag="" /db_xref="3963270..3964427" CDS 16771..17928 /gene="" /product="multidrug efflux system protein MdtE" /translation="MNRRRKLLIPLLFCGAMLTACDDKSAENAAAMTPEVSVVTLSPG SVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELN SAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAV EQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQD FLRMKEEVASGQIKQVQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIF PNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIE ASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESKQ" ORIGIN 1 ttagccactg gctaatagta ttgaaccgtt agatgtgggc attctcactc cagccagagc 61 caccaactca ggctgaagag taaaaaaccg acgcaaagtc ggttttttta cgtcctgatt 121 caaaccgcct ttcaaatgaa tagccaactc aaaattcaca cctattacct tcctctgcac 181 ttacacattc gttaagtcat atatgttttt gacttatccg cttcgaagag agacactacc 241 tgccacaatc aggagcgcaa tatgtcattt ctgttaccca tccaattgtt caaaattctt 301 gctgatgaaa cccgtctggg catcgtttta ctgctcagcg agctgggaga gttatgcgtc 361 tgcgatcttt gtactgccct cgatcagtcg cagcccaaga tctcccgcca cctggcattg 421 cttcgtgaaa gcgggctatt gctggaccgc aagcaaggta agtgggttca ttaccgctta 481 tcaccgcata ttccagcatg ggcggcgaaa attattgatg aggcctggcg atgtgaacag 541 gaaaaggttc aggcgattgt ccgcaacctg gctcgacaaa actgttccgg ggacagtaag 601 aacatttgca gttaaaaatt tagctaaaca catatgaatt ttcagatgtg ttttatccgg 661 gaggcattat gttactggca ggcgctatct ttgtcctgac catcgtattg gttatctggc 721 agccgaaagg tttaggcatc ggctggagtg caacgctcgg cgcagtactg gcgttagtta 781 cgggcgtggt tcatccgggt gatattccgg tggtgtggaa tatcgtctgg aacgcgacgg 841 ctgcgtttat cgccgtcatt atcatcagcc tgctgctgga tgagtccggc ttttttgaat 901 gggcggcgct gcacgtctca cgctggggta atggtcgtgg tcgcttgctg tttacctgga 961 ttgtcctgct cggtgctgcc gttgccgccc tgtttgccaa tgatggcgcg gcgcttattt 1021 tgacgccgat tgtcatcgcc atgctgctgg ctttaggatt cagtaaaggc acgacgctgg 1081 cgttcgtgat ggcggccgga ttcattgccg ataccgccag cctgccgctt attgtctcca 1141 acctggtgaa tatcgtttcc gctgatttct ttggcctcgg ctttcgcgaa tacgcctcgg 1201 tgatggtgcc ggtggatatc gccgcgattg ttgccacgct ggtgatgcta catctctatt 1261 ttcgcaaaga tattccgcag aactacgata tggcgctgct gaaatctccc gcagaagcga 1321 tcaaagatcc tgctacgttc aaaactggct gggttgtttt actgcttctg ctggtgggat 1381 ttttcgtcct ggaaccgctc ggcattccgg tgagcgccat tgcagctgtg ggcgcgctga 1441 tattatttgt cgtcgctaaa cgcggtcatg cgattaatac gggtaaagtc ctgcgcggtg 1501 ccccctggca gattgtcatc ttctcgctcg gcatgtatct ggtggtttat ggcctgcgca 1561 atgccggatt aacggaatat ctttctggcg tactcaacgt gctggcggat aacggcctgt 1621 gggccgcgac gctcggcacc ggattcctca ccgccttcct ctcttctatt atgaacaata 1681 tgccgacggt actggttggc gcgttgtcca ttgatggcag cacggcatct ggcgttatca 1741 aagaagcgat ggtttatgcc aatgtgattg gctgcgattt gggaccgaaa attaccccaa 1801 ttggtagcct ggctacgcta ctctggctgc acgtactttc gcagaagaat atgactatca 1861 gctggggata ttacttccgt acagggatta tcatgaccct gcctgtgctg tttgtgacgc 1921 tggctgcgct ggcgctacgt ctctctttca ctttgtaatg agatactgat atgagcaaca 1981 ttaccattta tcacaacccg gcctgcggca cgtcgcgtaa tacgctggag atgatccgca 2041 acagcggcac agaaccgacc attatccatt atctggaaac tccgccaacg cgcgatgaac 2101 tggtcaaact cattgccgat atggggattt ccgtacgcgc gctgctgcgt aaaaacgtcg 2161 aaccgtatga ggagctgggc cttgcggaag ataaatttac tgacgatcgg ttaatcgact 2221 ttatgcttca gcacccgatt ctgattaatc gcccgattgt ggtgacgccg ctgggaactc 2281 gcctgtgccg cccttcagaa gtggtgctgg aaattctgcc agatgcgcaa aaaggcgcat 2341 tctccaagga agatggcgag aaagtggttg atgaagcggg taagcgcctg aaataaagcg 2401 gcgatatcca ctgccgatag ttggtaaagt gcgctttgtt tatgtcggat gcgacgctaa 2461 cgcgtcttat ccgacctaca aaaccgtgca aattcaatat atggcatgaa atatgtagag 2521 cgtagcgcat caggcaattt tgctatttac gcagcactcc tcgcgtaaga attcaattat 2581 cgcttccagc attgcgtatt gcgaaacaca catcagcgtc cgactctcac ggttttgttt 2641 gaccagtcct accgatacca gtgctgatat atggtggctg agtgtggagc caggtatccc 2701 aagctgcttt tgcaactcac cgaccggcaa cccttgttcc ccggctttga caagatgttt 2761 aaatatgaac aaacgggtcg ggtgacctag ctctttcagc gctttagcga cttcttccaa 2821 ctgcatatga cacccctctg tctggttgat atttcgataa taccagaaat atcttgatct 2881 gaatttcatt tcgattattc tggaaatata gatttatcca atgaggttac gtatgagtag 2941 ttggcttgcg atgctgcaag atgccgcaga gatgtttgtg tttctcgccg tcgagctttc 3001 gttgctgttt atagtgatta gtgccggtgt cagcctgata agacaaaagg tgccagacca 3061 taaaatccag cagatgatgg gggccagaaa agggagaggc tatctcctgg ctgctctgtt 3121 gggagccgtt accccgttct gtagttgctc gacaataccc atgttacgtg gattgttgtc 3181 agcgaaagcc gggttttgtc agcgccagtg atataagacg gtaattcgcc atttggattg 3241 tccgctccac ccaacatgtt gtttccttaa ggttctcaca ccagaaagga catcaacatg 3301 ctgagcagag aggactttta catgataaag caaatgcgcc agcagggcgc gtacatcgtc 3361 gatattgcga ctcagattgg ttgctctgaa cggacggtca gacgctacct caaataccct 3421 gaaccgccag ccagaaagac ccgccacaaa atggttaagc tgaaaccgtt tatggattac 3481 atcgacatgc gcctggcaga gaatgtctgg aatagcgagg ttatcttcgc ggagattaag 3541 gcaatgggtt atacgggcgg acgttccatg ctgcgttact acatccagcc caaacgtaaa 3601 atgcgtccgt caaaaagaac agttcgcttc gaaactcagc ctggatacca gctccagcat 3661 gactggggcg aagttgaggt ggaggttgcc gggcaacggt gcaaagttaa ctttgcggtt 3721 aatacgctgg ggttctcccg cagcttccat gtcttcgccg caccaaaaca ggatgctgag 3781 catacctacg aatcactggt tcgcgccttc cgctacttcg gtggttgtgt gaaaacggtg 3841 ctggttgata accagaaggc tgcggtgctg aagaataaca acgggaaagt cgtgttcaac 3901 tccggattcc tgttgctggc tgaccactat aacttcctgc cacgggcatg ccgtccacgc 3961 agggccagaa caaaaggtaa ggttgagcgg atggtgaaat acctcaagga gaacttcttc 4021 gtccggtacc gcaggttcga cagcttcact catgtcaatc aacaactgga gcaatggata 4081 gccgatgtgg ctgacaaacg ggagcttcgc cagttcaaag aaacgccgga acagcgcttc 4141 gcgctggagc aggaacatct gcagccgtta ccggatacag acttcgatac cagttacttc 4201 gatatccgcc atgtgtcctg ggacagctat atcgaggttg gtggtaatcg ttacagcgtt 4261 cccgaagcgc tgtgtggtca gccggtatcg atacgaatat cgctggatga cgagttgcgg 4321 atctacagta atgagaaact ggtggcctca catcgcctct gttcagcatc gtctggctgg 4381 cagacagtgc cggagcatca cgccccgctc tggcagcagg tcagtcaggt ggaacatcga 4441 ccactgagtg cctatgagga gctgttgtga tgcatgaact ggaagtcctg ctgagtcgcc 4501 tgaaaatgga gcatctgagt tatcacgttg aaagcctgct ggaacaggca gctaaaaaag 4561 agctgaacta ccgggagttc ctgtgcatgg cgctacagca ggaatggaac ggcaggcatc 4621 agcgcggtat ggagtccagg ctgaagcagg ctcgtctgcc gtgggtcaaa acgctggagc 4681 agttcgactt taccttccag ccgggcatcg accgtaaggt tgtccgggaa ctggctggtc 4741 tggcgttcgt ggagcgcagc gaaaacgtga tcctgctggg ccctcctggt gtcggaaaaa 4801 ctcatctggc catagctctt ggcgtgaaag cggtggatgc gggacatcgg gtactgttta 4861 tgccactgga cagactgatc gcgacactga tgaaagcgaa acaggaaaac cggctggagc 4921 gtcagctaca gcaactgagt tatgcccggg tgttgatcct ggatgaaata ggctatctgc 4981 cgatgaacag agaggaagcc agtctgttct tccggctact gaaccgtcga tatgaaaaag 5041 cgagcatcat actgacgtca aacaaagggt tcgcagactg gggagaaatg ttcggagatc 5101 acgtactggc aacagcgatc ctggatcggc tgctacatca ctcaaccacg ctgaatatca 5161 aaggagagag ttaccggtta aaagagaaac gtaaagctgg agtgctgacc aaaaacacaa 5221 cgccaatcag tgatgatgaa atggtggaaa gcggacagca tcagtaacga aagtatttag 5281 cgggcatgaa aatggcaaat aacggtcaaa catcgtggcg ttgacagttt ggtccgactc 5341 tcactttttt atttgtttca ccattactta atcccattat cgtcggacta atgtggatga 5401 cctttggttg gaaagtcacc ttgttgtacg cgattatcgc agccggcgtc tccgttcttg 5461 ccagtattat cctggattct ctggggtttg aacgtcatat cattgccagt aaaagctcat 5521 cagcaaattg ttgtgctcca gcaaaaactt cgccgggaac gacatatacg cccataaaag 5581 tgagttgttg tagtccagcg gctaaagcca ttgagaaccc cgtagttacc tgttgcagta 5641 ccaaagctgt agtaagtatt aatcccataa aactagccac caaagatgcg ttgcaacagt 5701 ttaaagatgt actgccatat cttttgttag gagtattaat aggatctttt atttatggct 5761 ttattccctc agcgtggatt gccgctcatg caggagcaga taatcccttc gccatcccat 5821 taagcgccgt tgtcggtatt ccgctgtata tccgggctga ggcggttatc cctctggcat 5881 ctgttctgat gacaaaagga atgggtctgg gagcattaat ggcattaatc atcggcagtg 5941 ccggcgcaag cctgacggaa gtgatattac ttaaatcaat gttcagaatg ccgatgatag 6001 ctgcattcct gacggttata ttaggtatgg ctatcttgat gggctatttg actcaattgc 6061 tattttaaat agatgccagc agtaaactat aagatgcata gttagtgcca tatccttcta 6121 agtagaaaat catagacagg ataatcctta aaaatcacaa atgatttaac taatgcattg 6181 agaatgatga cggctcggtc aacaagtcat caacagacaa taaccacgta atcatgcttc 6241 tctgacattt tatcggagaa gcaatgtgag gtagcctgag tttaacggac actccttcct 6301 gaaatagaat ggcatcagaa ggagctaata atgagcagaa aaacccaacg ttactctaaa 6361 gagttcaaag ccgaagctgt cagaacggtt cctgaaaatc aactttcgat cagtgaaggc 6421 gcttcccgat tatctcttcc tgaaggcact ttaggacaat gggttaccgc cgccagaaaa 6481 gggctcggta ctcctggttc ccgcacggtg gctgaactgg aatctgaaat tctgcaactg 6541 cgtaaggcgt taaatgaagc tcgccttgag cgagatatat taaaaaaagc aacagcgtat 6601 tttgcacagg agtcgctgaa aaatacgcgt taatcgaaca atggcgacaa caatttccca 6661 ttgaagcgat gtgtcaggta tttggtgtat ccaggagcgg ttattacaac tgggtacagc 6721 atgaaccctc agacagaaaa caaagtgatg agcggctaaa actggagatt aaggtggcac 6781 atatccgcac tcgcgaaaca tatggaaccc ggcggctcca gacggagctg gcagagaatg 6841 gcatcatcgt tggtcgtgac cgactggcac gtcttcgtaa ggagctaagg ctacgctgta 6901 agcagaaacg caagttcaga gcgactacga actcgaacca caatctgcca gttgcgccaa 6961 atctgctgaa ccagacgttc gctcctacag caccaaatca ggtctgggtg gcggacctga 7021 cgtatgttgc cacacaggag ggatggttgt acctcgctgg catcaaagat gtttatacgt 7081 gcgaaattgt cggctacgcc atgggagagc gcatgacaaa agagctgaca ggtaaagccc 7141 tgtttatggc gctcaggagc cagcgcccac ctgccgggct aatccaccac tctgatcgag 7201 gttcacagta ctgcgcatac gattaccggg tcatacagga gcagtctggt ctgaaaacat 7261 caatgtcgcg taaaggtaac tgttacgaca acgctccgat ggaaagcttc tggggaacgc 7321 tgaaaaatga gagcctgagc cactatcgtt ttaataaccg ggatgaagcc atctcagtaa 7381 tacgggaata cattgagatt ttctacaatc gtcagcgtcg tcactctcgt ctggggaata 7441 tctccccggc agccttcagg gaaaaatatc atcagatggc tgcttaaaaa aagaacaaat 7501 ggtagtgtcc gctattgcca gtacacctca atgactcttt gtctcagtac cctcctcctt 7561 tttaaaaggc agatttcagt cgctaataca acacattttt aaatacactt taacctagtt 7621 cattattaca ctagactggc cccctgaatc tccagacaac cagtatcact taaataagtg 7681 atagtcttaa tactagtttt tagactagtc attggagtac agatgattga tgtcttaggg 7741 ccggagaaac gcagacggcg taccacacag gaaaagatcg caattgttca gcagagcttt 7801 gaaccgggga tgacggtctc cctcgttgcc cggcaacatg gtgtagcagc cagccagtta 7861 tttctctggc gtaagcaata ccaggaagga agtcttactg ctgtcgccgc cggagaacag 7921 gttgttcctg cctctgaact tgctgccgcc atgaagcaga ttaaagaact ccagcgcctg 7981 ctcggcaaga aaacgatgga aaatgaactc ctcaaagaag ccgttgaata tggacgggca 8041 aaaaagtgga tagcgcacgc gcccttattg cccggggatg gggagtaagc ttagtcagcc 8101 gttgtctccg ggtgtcgcgt gcgcagttgc acgtcattct cagacgaacc gatgactgga 8161 tggatggccg ccgcagtcgt cacactgatg atacggatgt gcttctccgt atacaccatg 8221 ttatcggaga gctgcccacg tatggttatc gtcgggtatg ggcgctgctt cgcagacagg 8281 cagaacttga tggtatgcct gcgatcaatg ccaaacgtgt ttaccggatc atgcgccaga 8341 atgcgctgtt gcttgagcga aaacctgctg taccgccatc gaaacgggca catacaggca 8401 gagtggccgt gaaagaaagc aatcagcgat ggtgctctga cgggttcgag ttctgctgtg 8461 ataacggaga gagactgcgt gtcacgttcg cgctggactg ctgtgatcgt gaggcactgc 8521 actgggcggt gactaccggc ggcttcaaca gtgaaacagt acaggacgtc atgctgggag 8581 cggtggaacg ccgcttcggc aacgatcttc cgtcgtctcc agtggagtgg ctgacggata 8641 atggttcatg ctaccgggct aatgaaacac gccagttcgc ccggatgttg ggacttgaac 8701 cgaagaacac ggcggtgcgg agtccggaga gtaacggaat agcagagagc ttcgtgaaaa 8761 cgataaagcg tgactacatc agtatcatgc ccaaaccaga cgggttaacg gcagcaaaga 8821 accttgcaga ggcgttcgag cattataacg aatggcatcc gcatagtgcg ctgggttatc 8881 gctcgccacg ggaatatctg cggcagcggg cttgtaatgg gttaagtgat aacagatgtc 8941 tggaaatata ggggcaaatc catacacatc taaaacatca caaaaaaaat cacttcacac 9001 actatcagag aacataataa ctttttaaaa tgagcgcatt ttgatagttg ttaacgattt 9061 cctttacgat actatcacta cccttttttt atacacaaat attaccgggt ggagataaaa 9121 gggaaatcaa aggtaattat atcaggaaga tataacgcat tacatttatt gtgtgtagaa 9181 gaaaatccat tcctgttcta attatccaat ttaaacatct tagcataaaa caaatgatga 9241 ataaggaatt ttatgtcaat tgactttacc ccaggtataa taaatacata tcacggcgat 9301 atttataact gcacaacaaa taccgataat gctaaaacgc cagacacacc gaagtggcct 9361 tgcgataatt gggaagaaca acaacccatt aattccacat tctctggaga aggatatatc 9421 tctgatcaat atgatttagt gcaacaccaa cttcaacaaa ttaatgcgtg ccacacgaac 9481 actacatata caaatgcaga ctactcaaaa gttgtggctc aacttgtaag tcttattact 9541 aacattgaaa cgataagttc gacacaactt acgcaacaga cacaatcaat acttaatcag 9601 attaataaca ttagatatga aaaaaacaaa agtgctgaat gtcgaatcat tgttgtcgct 9661 aatcctaaac ccgacaaggc aatcataact aaaattagcg tagaagaggg aatacccata 9721 acattcagtg tccaaaccat gttttcagat actaatttta ttgctgaaca acgagctgac 9781 ttaccaacta atataaaaga tattcaaagc ctgtatcaaa aaatgacgaa gttatatatt 9841 gagcacagtg aaaataaaaa caggatgaaa gtctttgccg gagccaactt tattgatttc 9901 aatatgacag gacagaacct gtccgggttc gttctaacct tgtcaaggtt ttatttcgaa 9961 gatctactta atataaattt cactgacgca aatttaggtg acactatttt ttacataaag 10021 aacaccctac ccccaaatta tataaagatg gacaatatct tgacaaacaa atcgaaggtt 10081 tattttcaac attattaacc attaatgaca actttttacg agcaaaagcg gaaattgctt 10141 cgacaataat taaattttta gaggccagga taaccaatct ttcatacaat gacatattaa 10201 aatatcagca agaattccaa aaacaatgtt ataagcaagt taaagccttt acgacactct 10261 ctcgatacaa taaaattcaa acatgggcag aaatgtctga atatcagttc gaagtatttc 10321 aatacgagac gcttaacccc aaaaaaatgt cacacacgcc ttatttaaag aggccacttc 10381 ctaatgaaaa agatataaat tatggggtgg aaatagaaat accatctggc aaaagaattc 10441 gcttatcaaa tcattatcag aatataatac cataatattg attattagca ctttataatt 10501 attgaatgaa aatagatttt atgtaatttt aaaacaaagg aggtaatgac tccaacttat 10561 tgatagtgtt ttatgttcag ataatgcccg atgactttgt catgcagctc caccgatttt 10621 gagaacgaca gcgacttccg tcccagccgt gccaggtgct gcctcaaatt caggttatgc 10681 cgctcaattc gctgcgtata tcgcttgctg attacgtgca gctttccctt caggcgggat 10741 tcatacagcg gccagccatc cgtcatccat atcaccacgt caaagggtga cagcaggctc 10801 ataagacgcc ccagcgtcgc catagtgcgt tcaccgaata cgtgcgcaac aaccgtcttc 10861 cggagactgt catacgcgta aaacagccag cgctggcgcg atttagcccc gacatagccc 10921 cactgttcgt ccatttccgc gcagacgatg acgtcactgc ccggctgtat gcgcgaggtt 10981 accgactgcg gcctgagttt tttaagtgac gtaaaatcgt gttgaggcca acgcccataa 11041 tgcgtgcagt tgcccggcat ccaacgccat tcatggccat atcaatgatt ttctggtgcg 11101 taccgggttg agaagcggtg taagtgaact gcagttgcca tgttttacgg cagtgagagc 11161 agagatagcg ctgatgtccg gcagtgcttt tgccgttacg caccaccccg tcagtagctg 11221 aacaggaggg acagctgata gaaacagaag ccactggagc acctcaaaaa caccatcata 11281 cactaaatca gtaagttggc agcatcacca acaaaggatt atattatggg gcgatggata 11341 ctcatgccac gccccaaaat caatggaatt gaactaaaca aaagggatat aaacatcaga 11401 caggtttacg ttactatcag gcatatcgcc tcagaatcag atgaaaacta taaagaaata 11461 tctattatgg ttttaatatt tgttgataag gatagtaaca tgaacatgac aaaaggtgca 11521 ctcatcctca gcctttcatt tttgcttgcc gcatgtagtt caattccgca aaatatcaaa 11581 ggcaataacc aacctgatat tcaaaaaagt tttgttgctg ttcataacca gccggggtta 11641 tatgttggtc aacaagcgcg ctttggtggg aaggttatca acgttatcaa tggcaaaacg 11701 gatacgttgt tagaaatcgc tgtattaccg ttggatagct atgcgaaacc tgatattgaa 11761 gccaactatc agggccgact gctcgccaga caaagcggct tccttgaccc agtgaactat 11821 cgtaatcact ttgttaccat cctcggtacc attcagggtg aacaacctgg ctttatcaat 11881 aaagtcccgt ataacttcct ggaagtgaat atgcagggca tccaggtgtg gcatttgaga 11941 gaagtggtta ataccaccta taacctgtgg gattacggct atggtgcatt ctggccggaa 12001 ccgggctggg gtgcgcctta ctacaccaat gcggtgagtc aggtaacacc tgagctggtc 12061 aaataacacc accgaaagat gcagatgctt tctcagcatc tgcatcatgt attacataaa 12121 attaatatac agtaagctaa ctattattat tataagccct gtcctgttaa ttacctttgg 12181 caaattgatt ataaagttaa tgtccgcacc aggagtcggt tatgtttctt ataattacca 12241 gggatacgat gttcttcacc gcgatgaaaa acattctgag taaaggtaat gtcgttcata 12301 tacagaacga agaagagatc gacgtaatgt tgcatcagaa tgccttcgtc attattgata 12361 cattaatgaa taatgtattt cattctaatt ttctcactca aattgaacga ttaaaacctg 12421 tccatgtcat tgttttctcc ccctttaata ttaaacgctg tctggggaaa gtaccggtga 12481 cctttgttcc gcggactatc actatcattg attttgtcgc actcatcaat ggcagttact 12541 gctctgtgcc tgaagcgaat gtgtcacttt cgcgcaagca acatcaggtt ctgagctgca 12601 ttgcgaatca aatgacaact gaagatattc tggagaaact gaaaatatcg ctaaaaacgt 12661 tctactgcca taaacacaat atcatgatga tcctcaatct taagcggatc aatgagctgg 12721 tacgccatca gcatattgat tatctggtgt gaatttcagg cttacggtga gtctggctac 12781 gctgccacac agattagcta attgaaacgc ctttcacccc tgccatacct tttaataatc 12841 gcaacaggtc ttctatcgac gttgtggcat gaagctggat atcaatggcg accacttcat 12901 gatcttcatt ttcctgcaac gaaactaaat cagtttttat tttttgctgc ttaaaccagt 12961 cgagcattga taccatatta ccgttcacta atgtcagctg taaatggtaa tttttgttca 13021 tcaggcggaa ggttaattga tggaagactt ccagcaccaa caaggtcatc actgaaccat 13081 aaatacccag ttcgtacata ccgctgccaa taaccatacc tatggcggcg gtcacccaga 13141 tatccgctgc cgtcgtcaga cctacaatat tttggttacg aacgagaatg ttacctgcac 13201 cgataaaccc gacgcccgtc accacctgag cagcaatacg gctggggtcg agtccgacgt 13261 gatctaaaga cagcacgtca gcaaaaccat atttcgaaac aatcataaac agggcgcttc 13321 ccatgccaat taatacatgt gtgcgtaacc ctgctccttt gccgcgcatt tgcctttcca 13381 tgccaatagc gccacaggca attgccgcga gtataagacg tataataaat tctgctgtca 13441 tataaaaatg caaaaaggag cagcaagatg gctcaacttg ctactccttt ttacttgtac 13501 ctcattaatt cggcaagtca ttagatgctt gatttttgaa ggtatacaaa tttttctgcg 13561 ggtttttctt acagtattcg atcactttag gaatttgagt gagatcggtt tcatttaaag 13621 taacggtatc gccaccttta tatactgttt cttcatgcag catccaccat gcaaccgggg 13681 tcattgcttt tggattcaga tcaataaatt cctggcaggt catatcttta gcggattcat 13741 tggctgccag cgcagattgt gcgttcacca gtgacaaagc cgctacagcg cccataaaaa 13801 taaacgcttt acggagagat gaaatattca ttttgtaacc cattcaatat agagattata 13861 tatgaacagg aggaatagct gcttttaaag aagatattcc ggcctgttca atatgcaagg 13921 aagtacgatg taacgcattc ccggaattac atatctttct taattttgtc ccattcgcct 13981 ttaactttat ctttaaagtt ggcttgttta tcctgagtac aagcctgaac gatagctggg 14041 gttacggttg caataccctg aacatctaaa accgcatctt ctggtttatc tttgttgttc 14101 agcgcttcag caaaaccaac tgcagttggc tggaaggatt cgtccacagc caggaaatct 14161 tcacaggtcc aggagttgac cggttttttg ttatcagctg ctttttgcgc atccgctgca 14221 ttgctcacaa ctggcagaag aagcagacca ccaagaataa cgcctaatac ttttttcatc 14281 gtaatatcct caactataaa gtgaaagagc cgtcacgaat caatttcgac actgaggtta 14341 taacctggtt ttctgtatat gtcatgttga tataaaatat caaaatcaga tatttttatt 14401 tcaatacaat gagttacaga tgcatcagat actgtaatta ggaaattttt attaaatcga 14461 ctacattctt agacgcgttt ttggcataga ttgatagcag gggattttct tcttaatttt 14521 atagggtggt tctatgttat atatagataa ggcaacaatt ttgaagtttg atctggagat 14581 gcttaaaaaa catcgcagag caatccagtt tattgccgtg ctactgttta tcgtcgggtt 14641 gctgtgtatc agtttcccgt tcgtctctgg cgatatttta agcacagtag tgggtgcatt 14701 attaatctgc tcgggcattg cgcttattgt cgggttattc agcaaccgca gtcataattt 14761 ctggccggta ttatccggtt tcctcgtcgc agtcgcctat ttattgatcg gctatttctt 14821 catccgcgca ccggagctgg gcatttttgc cattgcggca tttattgccg gtttgttctg 14881 tgttgcaggg gttattcgcc tgatgagttg gtatcgtcag cgttcaatga aaggcagctg 14941 gctacagctc gttattggtg tgctggatat cgtcattgcc tggatattcc ttggtgcaac 15001 gccgatggtg tctgtaacgc tggtttccac actggtggga attgaactga tatttagcgc 15061 cgccagcctg ttcagcttcg ccagtttgtt cgttaagcag caataattat cccggttgtc 15121 acccggatca tagtcacttg atatgactat gatccgatta atactctctc cgctacggag 15181 tgttgtagat caattgcgca ctatcattga aataattacc tgctagtgat tatttcaacc 15241 tactgaattt catctaattt ttttcactcc atggcaaatt agccatttca aacattatca 15301 tggctgatat tttccgtagt caggtttaat gttttaaaag tgctgtggga aagtgaacaa 15361 agagttccgt aagcgttgat gctatgggcg gttaaataag taatccgggt tcattttttt 15421 gcaactggcg ttgattacat tgcataaata tccgtgtctc cagacgctat ataaaaacct 15481 gaagacatga atgcgttatt tactcaggta atttcaatgc gttaaaagaa agctggcaat 15541 ccaattgcca gcttaagtcg aaacaaggag actcgatatt taaatcggat tacattttaa 15601 ctttagtaat attcttcaga gatcacaaac tggttattga taacttattc ttgggcagta 15661 atccgcaaac gttaactttt tgtttactat ttacaagctg ataacaacca ggaatcttac 15721 ttaggatcaa tatatggagt gcgtgatgga taaatctgaa gtattgatta gtgttaatag 15781 acgtattagt tcacgaaggg taaagttctt ataggcgttt actatattga acaacgattc 15841 ggacaaggat gtaaataatg aaaaggatga catgttcgaa acgataacgg ctaaggagca 15901 agttatgatt tttctcatga cgaaagattc ttttctttta cagggctttt ggcagttgaa 15961 agataatcac gaaatgataa aaatcaattc cctgtcagag atcaaaaaag taggcaataa 16021 acccttcaag gttatcattg atacctatca caatcatatc cttgatgaag aagcgattaa 16081 atttctggag aaattagatg ccgagagaat tattgttttg gcaccttatc acatcagtaa 16141 actaaaagct aaagcgccta tttattttgt tagccgcaaa gaaagtatca aaaatcttct 16201 tgagattact tatggtaaac acttgcccca taagaattca caattatgtt tttcacataa 16261 tcagttcaaa attatgcaac tgattctgaa aaataaaaat gaaagcaata tcacgtcgac 16321 gctcaatatt tcgcaacaaa cattaaagat tcagaaattc aacattatgt acaagctgaa 16381 actaagacgt atgagcgaca tcgtcaccct gggtatcaca tcttattttt agtcaggaca 16441 taagcaactg aaattgatgg ctggcatgac gagggatgca gatgctgatt tcattacccc 16501 cggtgattac taaaggagag gctaaaacga ctttattccc caggtatgtg tatccaccag 16561 tagaaccctt cgttgcccga atgctggcag gaactgttgg cagaacggca acattttttt 16621 tgtcgttgac ctcaccatgt cgatcactgt gcctgtatcc caccttactg gctgacaacc 16681 ccactatgcc gctggtctgt aaatccctca tatctctcct cgcgcgcaat ttaaagaacc 16741 gttatttctc aagaattttc agggactaaa atgaacagaa gaagaaagct gttaataccg 16801 ttgttattct gcggcgcgat gctcaccgcc tgcgatgaca aatcggcgga aaacgccgcc 16861 gccatgacgc ctgaggtcag tgtcgtcaca ctctcccccg gttcggtcaa tgtgttgagc 16921 gaattgcccg gtagaaccgt tccttatgaa gttgccgaga tacgtcccca ggtgggcggt 16981 attatcatta aacgcaactt tatcgaaggc gataaagtga accagggcga ttcgctgtat 17041 cagattgatc ctgcaccttt acaggccgag ctaaactccg ccaaaggctc gctggcgaaa 17101 gcgctctcta ccgccagcaa tgcccgcatc acctttaacc gccaggcatc gttgctgaag 17161 accaactacg ttagccgtca ggattacgac accgcgcgca cccagctgaa tgaagcagaa 17221 gccaatgtca ccgtcgccaa agcggctgtt gaacaggcga cgatcaatct gcaatacgcg 17281 aatgtcacct cgccgattac gggcgtcagc gggaaatcgt cggtgaccgt cggcgcactc 17341 gttaccgcta atcaggcaga ttcgctggtt accgtacaac gtctggaccc gatttatgtc 17401 gatctcacgc agtcggtgca ggatttcttg cgcatgaaag aagaggtcgc cagtgggcaa 17461 atcaaacagg ttcagggcag tacgccagta cagctcaatc tggaaaatgg taaacgctac 17521 agccagaccg gcacactgaa attctccgac ccgacggtgg atgaaaccac gggctccgtg 17581 acgttacggg cgattttccc caacccaaat ggtgacttgc tgcctggcat gtacgtcacg 17641 gcattagtgg atgaaggtag ccgccagaat gtattactgg tgccgcagga aggcgtcact 17701 cacaacgccc agggtaaagc aacggcgctc attctggata aagacgatgt tgtgcagcta 17761 cgcgaaattg aagccagcaa agccatcggc gaccagtggg ttgtcacctc tggcttgcag 17821 gctggcgatc gggtgatcgt ttccggtttg caacgcattc gtccgggtat caaagcacga 17881 gcaatttcct ccagccagga aaacgccagc accgaatcga aacaataa //