LOCUS NC_016645:7 18308 bp DNA linear BCT 05-SEP-2013 DEFINITION Pyrobaculum sp. 1860 chromosome, complete genome. ACCESSION NC_016645 SOURCE Pyrobaculum sp. 1860 chromosome, complete genome. COMMENT locus start: 743792; locus end: 762099 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.783270; n0_4mer:D = 30.362354; n0_4mer:PS = 54.519430 FEATURES Location/Qualifiers source 1..18308 /organism="Pyrobaculum sp. 1860 chromosome, complete genome." gene complement(1..780) /gene="" /locus_tag="" /db_xref="743792..744571" CDS complement(1..780) /gene="" /product="hypothetical protein" /translation="VVRIKAQGTYKNFSTEVVGNKILLFGPNGGGKSTFIHLVLRALY EGLELGSTRNWDFLKSPGELGSEWEVVVELDGGGVVTCMYSVGRIKCEGPRRRLGVGY VGPCDAVSTRLGDPLDLCKGTVEIKDPSLAEYLEENWNVTTVDKVYGDKAKQGDIWIE MRDLAYGYKRALGIVATSYDVDLLAIEAFEAGLHYDLATTLIKFLSKIRAWVLMETHL AITVKTALVEGWSVYYVYDGGFSRVSSLDDLRRVAEVELSV" gene complement(790..1458) /gene="" /locus_tag="" /db_xref="744581..745249" CDS complement(790..1458) /gene="" /product="Cmr6 family CRISPR-associated RAMP protein" /translation="VLGFLKASGGGSVAIAEFSRDTVLYIYENPPSWPSPKDVEKYVE ELYESAKAVFKNVAILRFTLRTPLTIHTKWPYLPLEIGLAIHPLLNVPYIPGSSLKGL LSHHIDKACGLDAVELFGDAEHKGMLVVFDAYPVKWEKVMEPDIITPHYREVEGEISE VEASPTPLVYPTVPPGVEFAFIIAADADVGCIAELQQRIADALARGVGARTSLGYGRF KFKF" gene complement(1518..2651) /gene="" /locus_tag="" /db_xref="745309..746442" CDS complement(1518..2651) /gene="" /product="Cmr1 family CRISPR-associated RAMP protein" /translation="MSAVFRLTIATPMSLGWYKPEVLDRWFYIRPPSVKGLWRWWARA FVAGVMYEMGCLAGRSGKDVLLVPTSREAEAVSRVVGTVMGLGYAGEKAAMASKFALD IRVLREPSIDRTKGKVRVREYWADVHRFAYLTRKKPPIEYAVGGDFELEVSGGGPPQA LEVLLVALTLEGLGKGGRKGLGSIDVTAVYRFRLARDLKQLVEDVRGWLRRWISPCSG KRPPFPPMPAVAEGVAEIYRVEGLNFSHLHDFFLRSHRARVLKGNYAIPDELRERLLA WVLGLPRKEEKTETGYGIKGDVKRRASTFIVSFHNNHVTGRGGYLTVIRSADWPTALE WTGGGDQQINIDFEKVSEAYDTALSEFREYVEKLGGSMSRLWP" gene complement(2651..3073) /gene="" /locus_tag="" /db_xref="746442..746864" CDS complement(2651..3073) /gene="" /product="Cmr5 family CRISPR-associated protein" /translation="MDQIDFAVECTKAVAEVKSRDIQSRYASRARSLISDLYVLGPAY VVAVAAARSSKDAVELGLRAESCREVVEGVMNAREGPEWKAYALYGAVLLYTMKKVGV VSSTSFEDVLMELKRPSSALKSREVARWIKLLAEAYFK" gene complement(3061..3933) /gene="" /locus_tag="" /db_xref="746852..747724" CDS complement(3061..3933) /gene="" /product="Cmr4 family CRISPR-associated RAMP protein" /translation="MQALALFVYALSPLHVGVGRAEGAHVDLPVQRDEFELPVIWASS LKGALKSHAYKRGAGNDVRLVFGREPGERPDSISGVTLLDARLLLMPARSLRGVWIYV TTPHLLRLFTTYAEVYKGGEREGFKDAVENAQKLINNSIKNKALVSSKDYVDNGKIFL NEVEVEASVDPVVEAFANALRNLGIQLPKFDIAVVGDDLSREVIDRSLLVQYRVRLNR ETKTVAEGGLWSEEYVPQFTLFHSAVVCRDVGDRTADKVCALFNNLLGGNPAVLWVGG KETIGKGLVRIWIK" gene 3981..7049 /gene="" /locus_tag="" /db_xref="747772..750840" CDS 3981..7049 /gene="" /product="Crm2 family CRISPR-associated protein" /translation="MKSLTEFFLAKLWTLLHDPPHKVWILKDGKRCLDADTNIESWAE QHKLRGHERDALKIFDSFLNGRAHEYLKEPLLQLAKEADHYSSSFDRWISNIIFILDS KNIIKNIVFEYYNLHNIFSPSNYVIYVKNPDEKVLCDRIKKWVARISGLTNGVDNIEL VYHLVYASAELAWIKEDLPPPLAETRVPTHTIFDHLYAAAMTVNWLWEDRQNTEDTAS RDRQNTEDTASRPFSLMPKGYYVVIDTPGVSKILEASRKAGDFWAGSWLVSALMWLTA WSYIKSYGPDILLTPTARFNPFYYEFLRLWLEKENKKQIADKLIQLYEDVIAMAVGAK NGVKLSYLLRHAIIPPTITLALPKKENVEKLEEEILQNFNQAYRCIIHGLVLGEERNI ECTDEIVKKFIETWKSQIDENILKPVKSILYEIQPHLFEQLLIPRIVIIDIEKLYTEF QNIITGQSKETIDNINKETYQKFLKFLKNFKEQKSDSKKIDEDMISKYLLFHVVTKEA LRQLINTTMLPVGRTWFTLDGQPLMDYQKFTDAPGWIFCTTCLREPAVVKFGKAWKVK DGVPVVSYDDETIKRLNIDGNVDELQKIFKPGEALGPLCLLKRLLYLSTTLRPKFDTT EDVAIGWYTRRIYREISPLLKNTQTRECNVAVKYIEQKRGRDILAYGPIEEIRRLFRK CAESVEKYVDKDTATKISRFYGATQLYALLELRDTYAVIKADADDIRKVYTGNIPTTS YKQLLIQLADHSDSRDVKEFFTDLLKLLNALEELTNGKILVSPTYYAALSLSLMITAL KDIYKVEKIYEGMTVYAGGDDVLALASVDASLHVAETMRRNYWGDGGFHRIGQYAIPA VVVTGRSISVRYVNVLDHMGGEISKTLELLKEAKKTTWLLGGREVRKDTLVISDSRTN TSAYLPLIDSRNRVGTYIKYLRKMWGMMIGGELSGNAPSDYIATFGDVTEKLLDEEAL VKIYEYTLSRNLKKAAAWKYADVAAEAKKEGRTPLGDEIMKALAILRRYP" gene 7046..8041 /gene="" /locus_tag="" /db_xref="750837..751832" CDS 7046..8041 /gene="" /product="Cas_Cmr3-like protein" /translation="MTSNQKTLVLVIKPLEPLHFGKTQIPGIDLAGRDAAFTAPPPST ILGLLASIKGINYYNKPKPCNRPLEDLKTTYRELTGEELTPTIEGVDRPLIWGPVVYI EKIPHIPIEGGYFVPRGEMEKYIDNAAGENSKIKIKKATVNIKPGIALDPTSKTPRYG YLYGATYVGYPLASEIRYVVNMAIPTDQNYKGVYRLGGEGRLAQIELREKPVDIRGEK PEGESKKSEDAIVLTPLLFQPEDGYARTAGHPKGPTPGLECVEEIRGIYTGDTFKIVA EPMGLGYSEVCNRRRPLYYALPPGTVVKIKCKYKAVGLFSQLGYGAIIRTKDRLP" gene 8164..8589 /gene="" /locus_tag="" /db_xref="751955..752380" CDS 8164..8589 /gene="" /product="hypothetical protein" /translation="LRGGGGNIKHISSRVQKYVAAPRLELEDFLVLALAGMGAHPPLI AYLTEMPRERVELILEWLVEKGYLKREGNRYRWTKAAKPVLKQWRSNPEAAAALRRAF DKFARDVAAPVARAAWEAAFWWTMWLAAMKWLHYHPPED" gene complement(8995..9132) /gene="" /locus_tag="" /db_xref="752786..752923" CDS complement(8995..9132) /gene="" /product="hypothetical protein" /translation="MGVEVRYFGGVPCAPVLPRIVVGLERSELGTARLEVGSDVTDVY M" gene complement(9117..9518) /gene="" /locus_tag="" /db_xref="752908..753309" CDS complement(9117..9518) /gene="" /product="hypothetical protein" /translation="LGVKGWSYYAEAPSVRVVDAVLIVRRSEGAPSAVVMGQAEVIVG LDEVGRIINLEIDFTAFTRSTGRRLCGYCARLDGKVAKGRGEGGEAGRCGVHSTAVWL VLSFTPLILQFTRLEGATWLIYWRSNTWELR" gene 10030..10653 /gene="" /locus_tag="" /db_xref="753821..754444" CDS 10030..10653 /gene="" /product="hypothetical protein" /translation="MSVSVDLKTLEEVVERAVKKALAEARSYEMKAVAEALKALADYT KAGFTQVTTELGELKTQVADLKTRVSALETRTASLENRVSSLEKRVSNVEDSVDSLTE ATLSRYVWEDLREEVRARGEVVLSRRRNARVDGLDIDLLVETDRSVYVVEVKTRARRR DVDAVARKAEAARGAYGKPAVAILAGVRIGDDVEKYAKGKGVLVYRY" gene 10690..10803 /gene="" /locus_tag="" /db_xref="754481..754594" CDS 10690..10803 /gene="" /product="hypothetical protein" /translation="VGGRRLRDRGRLSEGGVYAVCEAGRLLCRHISKILNN" gene 10817..12148 /gene="" /locus_tag="" /db_xref="754608..755939" CDS 10817..12148 /gene="" /product="hypothetical protein" /translation="MNSKRGITWYLDRLFPILLVAGAVIYVSGYTTLGQLLMEVPIVA YYVPGLVLAAARLYLSIKKTENKILSALFGGVFLTSVLLIGATWLLGELYIGGLLDVG DLGDFLYVAISVLVYLSLMKVVDIVYSRRLAGVGRVDGGYLHVERGVAYGGFTFGLGT KSFVLIGGEDPAVLEMIRLHEEYHAKNRHPMKLQLYLLAALLLTGIMIRHGIWNTPVY PTAVLALAVGFLVFIRALETAADAYTWRALGPAAYERLKAFLKLRYGVEEPRRAPLWS RLTHTSRRDITLTTGDPIGAHWRLEFPLAGALASLSIITCKYYLLPQDIIYITLPAVF ASLLAFSISLAYVAKPLIRRLAGPAFTDRGVFNLGALSSSVYTTAAVAAVALGPWSHA LASAFLAYAMRHYLNSWRRGVALTATVYPVYLALNTAIMSLLHEISPPQPV" gene 12162..12284 /gene="" /locus_tag="" /db_xref="755953..756075" CDS 12162..12284 /gene="" /product="hypothetical protein" /translation="LAGEGDTWHTAPRRPTPTPRAAGLRAVPAHNHNLQLPGGY" gene 12525..13205 /gene="" /locus_tag="" /db_xref="756316..756996" CDS 12525..13205 /gene="" /product="hypothetical protein" /translation="VSLAEEVKRVLMENPDILAEVLVSRPEIIYKALAQLAPWQNLAT RQDIDELRKAARQDIDELKRALDELRKSVDQISLRLDALEKTVSQISLRVDALGARWG VLSEDAFREGVRELLRAAGYAVEKRLYYDADGYVYGYPSEVELDVVIKDGAVIAVEIA SSLRRGDLLAVKRKTELYTKTTGRPVNAVLVITPYISDRNPSYIKAMAERINIKLIAP EEAAARPV" gene complement(13231..13398) /gene="" /locus_tag="" /db_xref="757022..757189" CDS complement(13231..13398) /gene="" /product="hypothetical protein" /translation="MKKAPGMRGGAAGGAGIRTRRRAVSDRNSDLSRALSRGRGGAAV PRAFAVGRPSV" gene complement(13682..13843) /gene="" /locus_tag="" /db_xref="757473..757634" CDS complement(13682..13843) /gene="" /product="hypothetical protein" /translation="MAVEMGVMQQGAWRPRELRPLEISAAVRAPPRVLGVWEEEEKPR VRELDESLA" gene complement(14978..15388) /gene="" /locus_tag="" /db_xref="758769..759179" CDS complement(14978..15388) /gene="" /product="hypothetical protein" /translation="MAFWTFADIVLRMDELRHALERLILEEAQRLGQPVLVRESVDAT WSFFVPTAVFASFFIQLAVYAAWSLAFKIGGCRRGFATALVVVAVLTAALWLLVLPAV FFMGLPIEQPLMYLALNAGLAFIKYSECPKTRLG" gene complement(15412..15753) /gene="" /locus_tag="" /db_xref="759203..759544" CDS complement(15412..15753) /gene="" /product="hypothetical protein" /translation="MVKAFEYVEALASFYGAEDSAEETLELAGVSGRLPLGKMSQGMK RLVQLAAALAVAPKVKLLVLDDPYVSVSPERSAELHDELLRRSRDGVLVLTARVPLKA TLQVDFLSLKP" gene complement(15746..15997) /gene="" /locus_tag="" /db_xref="759537..759788" CDS complement(15746..15997) /gene="" /product="putative ABC transporter" /translation="MLEARGLVVGYDKPLTKPLDFKLAKGESIVFYGPNGVGKTTLAK TIASLLKPLGGSVLLDGVPVPRARDYIFFLPEVVDLPDG" gene complement(15984..16412) /gene="" /locus_tag="" /db_xref="759775..760203" CDS complement(15984..16412) /gene="" /product="hypothetical protein" /translation="MYLAPANNVVGFLSALSRLMLKNAVFRAYLALGATAIALCFLLA SCRTYCLISIEVFLAPFAYIYVHETAQYIALGVDVELRLEKGYVVLEPRGNPKRPRGA VVAGALAPTVVGLASLPYAPLFSLIVLLSVALTLARYVGG" gene complement(16390..17406) /gene="" /locus_tag="" /db_xref="760181..761197" CDS complement(16390..17406) /gene="" /product="hypothetical protein" /translation="MLSFFLYHLKYIFMDIYFIILLILMMFVMITTEVFFGFIQMESS AYFLLIYILCVYAERRISGPLPAIFSARGLSATAAVTYSASLPVLLTAAWRSPTLLVA PLLAALRRRPALLVASLIAVAPLLPVGVAAVAVFEALARARLITTMGRGALRMSTLHP VAKALLAAAFMAVYLTVGGAANISIRGLSQFAATSPPPMTPVQLAALALFLLASYGLI FGASLDTYLDSRLRIYHLLKGRPSAKPIVTFFWLLAVSLPVCLFKECDVFTHTAFIAL WTASIWSLKPDIFRNEDAVALLLALFVAGYLSHYPQLLAAAALLPILPKLSEEIRHVL SSGQ" gene complement(17407..17811) /gene="" /locus_tag="" /db_xref="761198..761602" CDS complement(17407..17811) /gene="" /product="hypothetical protein" /translation="MRIARNNYISVIYGVVVGLLLIEISLVLATPFAAQSWYPFFTVV ASAGYKTIYPGPALIAAMLALGVASAFVVPRRYYGVFVVVLIIAAVVAIAILGSLASC ATCKWWFCSKVLSCGLEVGWLYVKNICLCYSP" ORIGIN 1 ctacaccgac agctccacct cagccacacg cctcaaatcg tctagagaag acacgcggct 61 gaaaccgccg tcatagacgt aatacacaga ccagccctct acaagcgcag tcttcacagt 121 tattgccaaa tgagtttcca tcaataccca tgctcttatc ttcgagagga atttgataag 181 cgttgtagcc aagtcgtagt gtaacccggc ttcaaaagcc tctatagcta acaaatcaac 241 gtcataagac gtagcaacta ttccaagcgc cctcttgtac ccatacgcga ggtccctcat 301 ctcaatccat atatccccct gcttcgcctt gtcgccatat accttgtcca ccgtggtgac 361 gttccaattc tcctccaggt actcagctag cgacggatct ttaatctcaa cagtcccctt 421 acacaaatcc agcggatctc ccaaccgcgt cgaaacagca tcacaaggac ccacgtatcc 481 gactccgagc cgccgacgcg gcccctcgca cttaatccgc cccacgctat acatgcacgt 541 tactacgcca cctccgtcca gctcaaccac cacctcccac tcactaccta actcccccgg 601 cgactttaag aaatcccaat ttctcgtaga tccaagttcc aaaccttcat aaagcgcacg 661 gagcaccagg tggataaagg tagatttacc cccgccattt ggtccgaaaa gtaatatctt 721 attacctaca acctccgttg agaaattttt atacgttccc tgagccttaa ttctcaccac 781 gttatatatt tagaatttaa atttaaatct tccgtatcct aacgaagtcc tagcccccac 841 gcctcttgct aacgcgtcag ctattctctg ctgaagctcc gcgatacacc ctacatcggc 901 atccgcggca atgatgaaag caaactccac acctggcggc accgtggggt aaaccagcgg 961 agtagggctc gcctccacct cagagatttc cccctccact tctcggtaat ggggcgtaat 1021 gatatccggc tccataacct tttcccactt cacgggatat gcgtcgaata cgacaagcat 1081 gcccttatgc tccgcatcgc cgaacagctc caccgcatct aatccacacg ccttatcaat 1141 atggtggctc agcagaccct taagcgagct acccgggata taaggcacat tcaacagggg 1201 atggatagct agcccaatct ctaagggcag gtacggccac tttgtgtgaa tcgttagcgg 1261 agtccttaac gtaaatcgca aaatagcaac gtttttgaat accgccttag cagactcgta 1321 gagctcctcc acatatttct ccacgtcttt tggagaaggc cagctggggg gattctcgta 1381 gatatacaac acagtatccc tcgaaaattc tgcaatagcc acactcccgc cgccactcgc 1441 cttgagaaaa cccaacacga cacaagatgt aatattatac gcgccagaac agttaaagta 1501 tctcccacta acgttgctca cggccatagc ctactcatac tcccaccaag cttctccaca 1561 tactcccgga actcggacaa agctgtatca tacgcctcag aaactttctc aaagtctata 1621 ttaatctgct gatcaccgcc acctgtccac tccagcgccg taggccagtc ggctgatcta 1681 atcacagtaa gatagccgcc tctacccgtc acatggttgt tgtggaagga gacaataaaa 1741 gtcgacgcac gtctcttgac atcgccctta atcccatagc ccgtctctgt cttctcctct 1801 ttccgcggaa ggccaagaac ccacgccaag agcctctccc taagctcatc cggaatggcg 1861 taattgccct tcagcacgcg ggccctatgc gaccgcaaaa agaagtcgtg taaatgagag 1921 aaatttaacc cctctacgcg gtagatctcc gccacaccct ctgcgacagc tggcataggc 1981 ggaaacggag gacgtttgcc agaacacgga gatatccacc tcctaagcca ccccctcacg 2041 tcctccacta gttgttttaa atcacgggca aggcggaagc ggtacaccgc tgtgacgtca 2101 atagagccaa gccccttccg ccctcccttc cccagaccct caagcgtcaa cgcaaccaac 2161 agaacctcaa gagcttgcgg cgggccgcct ccacttacct ccagctcaaa atcgcccccc 2221 acagcgtact ctattggcgg ctttttgcgg gttaaataag cgaacctatg cacatccgcc 2281 caatactccc tcacccgcac cttacccttg gtacggtcta tagagggctc ccttaacacc 2341 ctgatatcca acgcgaattt ggatgccatt gccgcctttt cgccagcata tcctagaccc 2401 atcacagtgc ccaccaccct agataccgcc tcagcctctc tcgatgtggg aactaacagc 2461 acatccttac cgctcctgcc cgctagacac cccatttcgt acatgacccc ggcgacgaag 2521 gcccgagccc accacctcca aagacccttt acagacggcg gcctgatata gaaccacctg 2581 tcaagcacct caggtttgta ccacccaaga gacatcggcg ttgcaatagt aagcctaaat 2641 accgcagaca tcacttgaaa tacgcctcag ccagcaactt aatccaccta gccacctccc 2701 tagacttcag cgcggagctt ggtcgcttca actccattaa aacatcctca aaagacgtgg 2761 agctaactac tcccaccttc ttcatcgtgt agagaagcac agcgccatac agcgcatacg 2821 ccttccactc aggcccctcc ctagcgttca tcacaccttc cacaacctct ctacagctct 2881 cggcacgcaa ccctagctct acagcatctt tagaagatct ggcggcggcc acggcaacga 2941 catatgcagg acccagcaca tagagatctg agatcaaaga gcgagcccta ctcgcgtagc 3001 gcgactggat atctctcgac ttaacctcag cgacagcctt agtacactca acggcaaagt 3061 ctatttgatc catattctca ccagaccctt accaatagtc tccttccccc ccacccaaag 3121 cacagcaggg ttaccgccta gaaggttgtt aaacaatgca cataccttat cagctgttct 3181 atccccaaca tctctacaaa ccaccgccga atggaaaaga gtaaactgcg gcacatactc 3241 ctcgctccac aaacccccct cagccaccgt cttagtctcc ctattcagcc tcaccctgta 3301 ctgaaccaag agcgatctat caatcacctc gcggcttaag tcgtcgccaa caacagcaat 3361 atcaaacttc ggcaactgga tccccaggtt cctcaacgca ttagcaaagg cctccaccac 3421 ggggtcaaca gaagcctcaa cctctacctc gttaagaaaa atcttcccat tgtcaacgta 3481 atccttagag gatactaacg ccttgttttt aatgctatta ttgataagct tttgcgcgtt 3541 ctccacagca tctttaaagc cttccctctc accaccctta tacacctcgg catatgttgt 3601 aaaaagtctt aacaaatgag gtgtggtaac gtatatccag acacccctca gcgatcttgc 3661 gggcatgagg aggagcctgg cgtcaagtag cgtaacgccg gagatggagt ctggccgctc 3721 ccccggctcc ctaccaaaca ctaagcgaac gtcattcccc gcccccctct tgtatgcatg 3781 cgacttcaaa gcacccttga gcgaagacgc ccaaatcacg ggtaattcaa actcatctct 3841 ctgaacaggc agatccacat gagctccctc agctcggccc actcccacat gcagaggcga 3901 tagggcgtat acaaacagcg ctaaagcttg cataatctaa tgaaaccgta catttaaata 3961 ttttaataga caagacagcc atgaaatcac taaccgagtt tttcctagca aagctgtgga 4021 ccctcctcca cgatccccca cacaaggtct ggattctaaa agacggaaaa agatgcctag 4081 atgccgatac caacatagaa agctgggctg agcaacataa gttacgggga catgaaagag 4141 atgctctgaa aattttcgac agctttctaa atggcagagc acatgagtat ctcaaagagc 4201 ccctactaca acttgccaaa gaagctgacc actactcatc ttcatttgat cgctggatta 4261 gcaatataat atttatactt gactcaaaaa atatcattaa aaatatagta tttgaatact 4321 acaatctaca caatatattc tctccatcta attacgtaat ttatgtaaaa aatcctgatg 4381 aaaaagtact atgtgataga attaaaaaat gggtggcccg catcagcgga ttaacaaatg 4441 gcgttgacaa catagagctt gtgtaccact tagtctatgc atcggctgag ctggcgtgga 4501 taaaggagga cctacctcca cccttagcag agacccgcgt gcctacacac acaatctttg 4561 accacctcta cgccgccgcc atgacagtta actggctgtg ggaagatcgg cagaacaccg 4621 aagatacggc ctcacgggac cggcagaaca ccgaagatac ggcctcacgg cctttctcgc 4681 tcatgcccaa gggctattac gtcgtgatag acacacccgg cgtctcaaaa attttagagg 4741 cgtcgagaaa ggcaggagac ttctgggcag gtagctggct agtctctgcc ttgatgtggc 4801 ttacggcgtg gagctatatc aagtcctacg gacccgacat cttgcttacc cccacggcca 4861 gattcaaccc gttctactac gaattcctta gactctggct tgaaaaagaa aacaagaagc 4921 agatagcgga caagctaatc caactatacg aagacgttat agcgatggct gtgggggcaa 4981 aaaacggagt aaaactaagt tatctactga gacacgcaat tattccacct acaatcactc 5041 tcgcactacc aaaaaaagaa aatgttgaga aactagaaga agaaatacta caaaacttta 5101 accaagcata tcggtgcata atacatggac tagtgctagg agaagaaaga aacatagaat 5161 gtactgatga aatagttaaa aaattcatag aaacatggaa aagtcaaata gatgagaata 5221 ttctaaaacc cgtaaaatcc atactatacg aaatccaacc acatctcttt gaacaattat 5281 taattccacg aatagtaatt atagatatag aaaagctata taccgagttc caaaatatta 5341 taacaggtca aagtaaagaa acaatagata atattaataa agaaacatat caaaaattcc 5401 ttaaattcct taaaaacttt aaagaacaaa aatcagattc taaaaaaata gacgaggaca 5461 tgatatctaa atatctactc ttccatgtag taactaaaga agcccttaga caactcataa 5521 atacaacaat gctacctgtc ggcagaactt ggtttacact agacggccaa ccactgatgg 5581 actaccagaa attcacagat gcgccaggct ggatattctg caccacttgc ctacgagagc 5641 cggcagtcgt aaaattcggc aaggcgtgga aagtaaaaga cggtgttccc gtagtctctt 5701 acgacgacga gacaataaag aggcttaata tagacggcaa cgttgacgag ctacaaaaaa 5761 tcttcaagcc tggcgaggct ctaggccccc tatgtctcct caaaagatta ctttatcttt 5821 caacaaccct acgtccgaaa tttgacacaa ccgaggacgt agccattgga tggtatacca 5881 ggaggatata tagagagata tctcccctcc tcaaaaatac gcaaactaga gaatgcaacg 5941 tcgcagtcaa atacatcgaa cagaaaagag gccgggatat cctggcctac ggcccaatag 6001 aagagatacg gcgcctgttt agaaaatgcg cagagtctgt agaaaagtat gtggataaag 6061 atacggcaac caaaattagt agattttatg gcgctacaca attatatgca ctactagagt 6121 taagagatac ctacgctgtg ataaaagccg acgcagacga catacgcaaa gtctacactg 6181 gaaacatccc aaccacgtca tataaacagt tgttgataca actcgcagat cacagcgata 6241 gcagagatgt aaaagaattc ttcacagacc tgctgaaatt gctaaacgcc ctcgaggaat 6301 tgaccaatgg aaaaatacta gtttcaccaa catactatgc cgccctctcg ctttcgctta 6361 tgataactgc acttaaagat atatacaaag tggaaaaaat ctacgagggt atgaccgtgt 6421 acgcgggtgg agacgacgta ctagccctag cgtctgtgga cgcctcgcta cacgtagccg 6481 aaacgatgag gcgtaattac tggggtgacg gaggcttcca cagaataggc caatacgcca 6541 tacctgcggt agtggtgact ggcagaagca tatcagtcag atacgtcaac gtgctcgacc 6601 atatgggcgg cgagatatcg aaaacattag aactgttaaa agaagcgaaa aaaaccacct 6661 ggttgctggg cggcagagaa gttagaaaag atacgctggt gataagcgac tcgagaacca 6721 acacctctgc atacctccca ctaatagatt caagaaatag agtaggcaca tacataaaat 6781 atctaagaaa aatgtggggg atgatgatcg gcggagaact cagcggcaac gccccgtctg 6841 actacatagc tacattcggc gacgtgacgg agaaattact cgacgaagaa gccctcgtca 6901 aaatttacga atacacgctc agtagaaacc tcaaaaaagc cgccgcatgg aaatacgcag 6961 atgtagcggc agaggcaaag aaagagggca gaaccccact gggagacgaa ataatgaaag 7021 cactggccat actcagaaga tacccatgac aagcaatcaa aagacgctgg tgcttgtaat 7081 caagccgctg gagccgctcc acttcggcaa gacgcagatc cccggcatag acctcgccgg 7141 cagagacgct gccttcacgg cgcccccgcc ctcgacaata ttaggcctcc tcgcctctat 7201 aaaaggcatc aactactaca acaagccaaa accctgcaac cgtccactag aagatctcaa 7261 aaccacatat agagaattga cgggagaaga actaacaccc acaatagagg gggtagacag 7321 acccctcatt tgggggccag tagtatacat agaaaaaatc ccacatatac ctatcgaggg 7381 aggatatttt gtacctagag gagaaatgga gaaatacatc gataatgccg caggagaaaa 7441 ctcaaaaatc aaaatcaaga aagcaacagt caacataaag ccaggcatag ccctagaccc 7501 gacgtccaaa acccccagat acggctacct ctacggagcc acatatgtag gctaccccct 7561 tgcatcagag atacgctacg tcgtaaacat ggcaatcccc acagatcaaa actacaaagg 7621 ggtctacaga ctcggaggag aaggcagact agcccagata gagttaagag aaaaaccagt 7681 agacataaga ggagaaaaac cggaaggtga atccaaaaag agcgaagatg ccatagtgct 7741 gactcccctc cttttccagc cagaagacgg ctatgcaaga acggcaggcc acccaaaggg 7801 tccaacaccc ggccttgaat gcgtcgaaga gatacgcggc atctacactg gcgacacatt 7861 caaaattgtc gccgagccaa tggggctcgg ctacagtgag gtatgcaaca gaaggagacc 7921 actctactac gccctcccac ctggaaccgt agtaaaaata aaatgtaaat ataaagcagt 7981 tggcctcttc tcacaactag gatatggagc gataataaga actaaagata gacttccctg 8041 aagagctcat acaagatcca taccaatatc aactagtgtc ggcaactaga tgtagagcct 8101 gctccaccag cggcgcagtt cgagatccgt tggaatctgt agtgctcgac gccacaaacc 8161 acgttgcggg gcggcggggg caacataaaa catataagta gccgtgtaca gaaatacgtg 8221 gcggcgccgc ggctggagct ggaggacttc ctcgtcctcg cgctggcggg catgggggcg 8281 cacccgcccc tcatcgccta cctaacggag atgccgaggg aaagggtgga gctcatcctc 8341 gaatggcttg tggagaaggg ctacttgaag agggagggga accgctacag gtggacaaaa 8401 gccgccaagc ccgtccttaa gcagtggcgc tcaaacccgg aggcggccgc cgcgcttagg 8461 cgcgccttcg acaaattcgc ccgcgacgtg gcggcgcccg tggcgagggc ggcgtgggag 8521 gcggcgtttt ggtggaccat gtggctggcg gcgatgaagt ggctccacta ccacccccca 8581 gaggactagc ctcagtacag ctgaaaggtg tattttggct tgcagttggg gtttggatac 8641 gcggttctgg taagcgtaca tgtctctgtt tttccacaac caaataccct ggcgctgtgg 8701 tgtcgacacc aaatgtctag acacagagta tatctactgc cctgtcgcaa cgtgccgtag 8761 ttcagcgcga tgccggcgcc aaagggccct aaaacggatt cattgacttt atctacctct 8821 ctcggtgtta ggtacagcct ccactggagg tgctcagcca gatgccgaag gtgactccgc 8881 tgagagatgt tctacatcaa cttcgtggct acactctgat gccgtgaacc cactgcacgt 8941 ttacacaagg caacccctca atatcggagg cattcggagc tggcataact ttgactacat 9001 gtagacatct gtgacgtcgc tccccacctc aagccgcgct gtgcctagct cggagcgctc 9061 aagccccaca actatgcgag ggagcacagg cgcgcacggg accccgccga aatacctcac 9121 ctcaactccc atgtattgct tcgccaatat attaaccaag tagccccctc caacctggta 9181 aattgtaaaa tcaatggggt gaagcttaat accaaccaaa cggctgtact gtgaactccg 9241 caacggccgg cttcacctcc ctcacctctg cctttagcga ctttaccatc tagccgagcg 9301 cagtatccgc agagcctcct ccctgtcgat ctagtaaagg cggtgaagtc aatctcgagg 9361 ttgattatgc gccccacctc gtcgagcccc acaatcacct cggcctgccc cataaccacc 9421 gcagacggcg ccccctcaga cctcctcaca atgagcaccg cgtccaccac ccggacgcta 9481 ggcgcctcgg cgtagtaaga ccagcccttt acccccaaat tcccggtgta gttaaccgga 9541 ggctaccact cccacgaaga agtatgaaga aaagcccccc atatacgtcc tgctgtagat 9601 cacatccacg gctctacatg caattcgcta tttaaagaca acccccatcg gacacaagcc 9661 accccgtaga gctgacgaca aagacggcaa caagtagggc ccccgccgct ctacacagcc 9721 ctctacgtgc tctacccgcc cccagcgcca gacccgccgc tacgtcccga ggtagcgggc 9781 ccccagtcgg cggccagctc gcagagacct cccaccagct ggcgcatctc cacccggcaa 9841 cctccgccgc ggtggtcgct aattacgacc acgcagacga gaggacccgg cgccctcgca 9901 gaatgtcacg caacatgcaa agcgcaccca gaagcgcgcc cacccacgcc gcatccgcac 9961 atacgcagag acgcgcggag gcccatgtag atacggagcc gggctaattt taaaaagcgg 10021 ctccggtata tgtccgtgtc tgtggatttg aagacgcttg aggaggtggt ggagagagcc 10081 gtcaagaagg ccctggcaga agcccgtagc tacgagatga aggcagtcgc cgaggcgttg 10141 aaggcgctgg cagactacac caaagccgga tttacacaag tcaccacaga actcggagag 10201 ttgaaaactc aagtcgccga cttgaagacg agggtatctg cattagagac acgtacagct 10261 agtctagaaa atcgtgtatc tagtctagaa aaacgcgtat ctaacgtcga ggatagtgtg 10321 gactctctaa cagaggccac tctctcccgc tacgtctggg aggatcttag agaggaggtt 10381 agggctaggg gggaggtggt gctgtcgaga aggcggaacg cccgcgtgga cggcttggat 10441 atcgacctcc tcgtggagac ggatagatct gtctacgtgg tggaggtgaa gactagggcg 10501 aggaggaggg acgtcgacgc cgtggctagg aaggctgagg cggcccgagg cgcctacggc 10561 aagcccgcag tagccatcct cgccggcgta aggataggag acgacgtgga aaaatacgca 10621 aagggaaagg gggttctcgt atacagatac taatcagagc cgcggggtcc agcgagagct 10681 aggcctggcg tgggcgggag acggctccga gaccgcggac gcctctcaga gggcggcgtc 10741 tacgccgtct gcgaggcggg caggctactg tgtagacata tcagtaaaat tttaaacaac 10801 taaaaattct tatttaatga atagtaagag ggggattaca tggtatctcg ataggttatt 10861 ccctatttta ttagtagctg gtgctgtaat ttacgtaagc ggctacacta ctctaggaca 10921 gttgcttatg gaggtgccta ttgttgcgta ttacgtacct ggcctcgtct tagccgctgc 10981 aaggctttac ctatctataa aaaagacgga aaataaaatc ctctcggcgc tgttcggcgg 11041 agtattcctc acatcagtac ttttgatagg tgcgacatgg ctattaggtg agttgtatat 11101 aggtggttta ctagacgtcg gagatctcgg cgattttcta tacgttgcaa tttcagtatt 11161 agtgtatctg tcattgatga aggtcgtgga cattgtttac agtaggcggc tggccggcgt 11221 gggcagagta gacggcggct atctacatgt cgagagagga gtagcctacg gcggcttcac 11281 ctttgggctc gggacaaagt cgtttgtact aatcggcgga gaggaccccg ccgtgctaga 11341 gatgattagg ctacacgaag agtaccacgc gaagaacaga caccccatga agctccagct 11401 gtacctcctg gccgcgctcc tcctcacggg tatcatgata agacacggca tatggaacac 11461 gccggtctac cccacggctg ttttggcgct cgccgtcggc ttcctagtct tcataagggc 11521 gctggagaca gccgccgacg cctacacatg gcgcgccctg gggcccgcgg cgtacgagcg 11581 cctcaaagcc tttctcaagc tgaggtacgg cgtagaggag ccgcggaggg cccccctctg 11641 gtctaggctc acccacacct cgcgcagaga catcaccctc accacaggag accccatcgg 11701 cgcccactgg aggcttgaat tccccctagc gggcgccctg gcctctctat ccataataac 11761 ctgcaagtac tacctcttgc ctcaggacat tatctacatc acgctcccag ccgtcttcgc 11821 tagcctcctc gcgttctcca tctcactggc atacgtagcg aagcccttaa tccgcagatt 11881 ggcaggcccc gccttcacag accgcggcgt cttcaacctc ggcgccttgt cctcaagcgt 11941 ctacacaacc gccgccgttg ccgcagtagc cctaggcccg tggtcccatg cactggcctc 12001 cgcgtttcta gcctacgcca tgcgccacta cctaaacagc tggagacgcg gagtagccct 12061 cacagcaacc gtatatcctg tatacctggc gctaaacacc gccatcatgt cgctacttca 12121 tgagataagc ccaccacaac ccgtgtaacg gagaaggcgg attggcgggg gagggggaca 12181 cttggcacac cgcgccgagg cgccccacac ccacgccgcg ggccgcgggg ctgagggccg 12241 tcccggcaca caaccacaac ctccagctac ctggaggcta ttgacatctg gccgtagtgc 12301 ggacagccgc cgcagagagg cgcatcagct gtttcacttt taatttcaaa ccccgactca 12361 aagcgggctt gtgcatctca ctgacgtttc aactatcaca tcccaacgaa cgccgttatt 12421 gattttagag gcacatagac aacggcggca acccgctgtg tacagcggca ggtccgccgg 12481 ggcggggcct agaagcattt ttaaatctag gcgtaagcaa ctccgtgtct cttgccgagg 12541 aggtcaagag ggtattgatg gagaacccag atatactagc agaggtgctg gtctccagac 12601 ctgagataat ttacaaggcc ctggcccagc tggccccgtg gcagaacctg gctactagac 12661 aagatataga tgaattgaga aaagccgcta gacaagatat agatgagctg aagagagctt 12721 tagacgagtt gagaaaaagc gttgatcaga tatctctgag actagatgcg ctggaaaaaa 12781 ctgttagcca aatatctcta agagtagacg cgctcggcgc ccgctggggg gtcctcagcg 12841 aagacgcctt tagagagggg gtgagggagc ttctgcgcgc ggctggctac gcggtggaga 12901 agcggctgta ctacgacgca gacgggtacg tctacggata ccccagcgag gtggagctcg 12961 acgtagttat aaaagacggc gctgtaatcg ccgtggagat cgcctctagt ctgaggaggg 13021 gggatttgct tgccgtaaag cggaaaactg aactatatac aaaaaccacc ggaaggccag 13081 tcaacgcggt tttagtcata acgccgtata tcagcgacag aaacccaagc tacatcaaag 13141 ccatggctga gagaatcaac atcaaactca tagccccaga ggaggcggcg gcgaggcctg 13201 tttagaaacc ccggcccccg gcgacgcgcc tcacaccgaa gggcggccga cggcaaaggc 13261 tcgaggaaca gccgcgccgc cccggcccct gctgagagct cgacttagat cgctgtttct 13321 gtcagatacc gccctcctcc tcgtcctgat tccggcacct ccagcggcgc cacccctcat 13381 gccaggcgcc ttcttcatat gctcccccct cctcgcggcc tctctagcgc ccgcctttgt 13441 tgcgccgcgg cgttcgtcag tgatataagc actgtcaccc cccgtaggcc tcgcggcgct 13501 gaggcgcctc ggcttctact cggcgcgcac ctgcaagccc agatctttac gccactctgc 13561 ggtagccgtc gttaaccgcc gcgtcgtcgg tacttcgtag tgggcgcgtc cgcctccctc 13621 gcgccccgcg gctaacgccg agcgtatacc tcggcgagag ttcctccacg tcggcattca 13681 gctaggcaag gctctcgtcg agctccctaa ccctgggctt ttcctcctcc tcccacaccc 13741 ctaggaccct cggcggggcc ctcacagcgg ctgagatctc gagaggcctc agctccctcg 13801 gcctccacgc gccctgttgc atgaccccca tctcgacggc cataggtgca gaaggggggc 13861 ttgtagctaa tccttttgag gccgggctcg tagacacctg ccatccccct acagagcact 13921 cgtcgagagg ggccgctctg ggcttcggca cgccgagccg ctcggcgagg gcctccacta 13981 tcccctccgc ggtacccgtc ccccggcggc tagaggcaga gccctgaggg ccttgccgta 14041 tctcccaaca gtccccatag aggccgggcc ggctcttttc ggcaacgagg caagatgcgg 14101 acactgccgg aggcggcgga taggagacgc aggcggcccc ctatggaggg gctccgccgg 14161 gttgtgcgcc tccccacgtc cagcccaagt cggaaggcga ttgatctaga agcccgcgcc 14221 tctgccgcgt atgccgtcaa ttcctctcga caggctctcg gcctctcgga acgccgcggc 14281 gctctacagc tggctcttcc gaggtggcac gccaggcaaa aacagaactc agggagggcg 14341 tttcaaccac cttttgacta ccagtcagcg ggaccacggt ggggaggaga tcgtcgtcac 14401 taatacatcg ttaaggggga ctgtcatcac ccatctatcg cctcaactag atctataaac 14461 ctgcgtcccc gcgaacgaga acgtctcaac tatcctctgc cttcctgcag actcttcacc 14521 cctctgtgcc ggcccgagat atcatctgtt tcaactacat tctggtttct ggcatagagc 14581 atttaaattt tttccacagc tgtgaggagg aaagtctcaa ctatttctgc gaggcgcaac 14641 tactgacact cctcgttgtt aatgttctaa cttttgattt ctggccagtt ggctggaggc 14701 cggcaggcag tgcctctcca acaccgacat agcgacgagt cagatccgct acaatctgct 14761 ggagagagac gccgacaagg agctcccgcc ctaccttagg aggaacggga tagcgctcat 14821 agcctggtcc ccgctagcca agggtaccgc cgggatcggg cggccgcgcg ttttctagac 14881 ctccctcgtc gtctatctcc acgggccgtc ttcagccggc cctaggccga tctgtgcatc 14941 ctcaacgacg gcggccggga tcgtgatgac gcaataccta gccaagccgc gtcttggggc 15001 attcggagta ttttataaag gcgaggccgg cgtttagagc taggtacatc aacggctgtt 15061 ctatcggcaa tcccatgaag aagaccgcgg gcagtacgag gagccacaac gcggccgtca 15121 acacggctac tacgaccaag gcggtcgcga agccccgcct acatccccct atcttgaagg 15181 ctagactcca agccgcgtac accgccagct gtatgaaaaa cgacgcgaac acggcagtgg 15241 gcacgaagaa gctccaagtc gcgtcgacgg actccctcac caagaccggt tgccccagcc 15301 gctgggcctc ctcgagtatg agcctctcaa gagcgtggcg caactcgtcc atcctcaaga 15361 ctatgtcggc aaatgtccag aaggccatga agaccgcgct tgcgaccgac ctcacggctt 15421 taaagacaag aagtcgacct gcagagtcgc cttcaggggg acgcgcgccg tcaggaccaa 15481 cacgccgtcc ctcgaccttc tcaacaactc gtcgtggagc tcggcggatc tctcagggga 15541 tacgctgacg tagggatcgt ccaagacgag caacttgacc ttgggcgcga ccgccaatgc 15601 ggcggccagc tggaccaacc tcttcatccc ctgcgacatc ttgcccaacg gcaagcgccc 15661 agacacgcct gccagttcga gggtctcctc ggccgagtcc tcagctccgt agaacgacgc 15721 aagcgcctcc acgtattcga aagccttaac catccggcag atccacgacc tccggcagga 15781 agaatatata gtccctagcc cttgggacag gcacgccgtc taggagcacg gagccgccga 15841 gcggtttcag cagagaggct attgttttgg ccaaagtcgt cttgccgacg ccgttaggcc 15901 cgtagaagac tatcgactcg cccttagcca gcttaaagtc caagggcttt gtcaagggct 15961 tgtcatagcc gacgactagg cctctagcct ccaacatatc tggccaacgt gagcgccacg 16021 gataataaaa ctatcagcga gaacaaaggc gcgtagggca gggacgcgag cccgacaaca 16081 gtcggcgcga gggcgcccgc gaccacagct ccgcgcggcc gcttagggtt tccgcggggc 16141 tccaagacca cgtagccttt ctccagcctc agctccacgt ctacgcccag ggcgatgtac 16201 tgcgccgtct cgtggacgta gatatacgca aacggcgcga ggaagacctc tatagatata 16261 aggcaatagg tccgacaaga ggcgaggagg aagcacagag ctatcgccgt cgctcccagc 16321 gccagataag ccctaaacac ggcgtttttt aacatgagcc tgctgagggc ggagaggaac 16381 ccaacgacgt tattggccgg agctaagtac atggcggatc tcctcggaaa gcttggggag 16441 gataggaaga agggccgcgg cggcgaggag ctgagggtaa tgcgacagat acccggcgac 16501 gaagagggcc agcaacaacg caacggcgtc ctcgttcctg aagatatccg gcttcaacga 16561 ccatatagac gccgtccaca acgcaataaa cgccgtgtgg gtaaacacgt cgcactcctt 16621 gaataggcac acggggagcg atacggctag gagccagaaa aacgtgacga tcggcttcgc 16681 cgaggggcgg cccttgagga gatgatatat acgcaggcgg ctgtccaaat aagtgtctaa 16741 agacgcgccg aagatcaagc cgtaggacgc caggaggaac aaagccaagg cggccagctg 16801 gacgggcgtc atgggaggag gcgacgttgc ggcgaactgg gatagacccc ttatggagat 16861 attggccgcg ccgccgactg ttaagtaaac cgccatgaac gccgccgcga gaagagcctt 16921 cgctacggga tgcaacgtcg acatgcgcaa ggctccccgg cccatcgtgg tgataagcct 16981 agccctcgcc agcgcctcga atacggccac ggcggcaacg cctacaggca ggaggggcgc 17041 aacggcgatc agagacgcca cgaggagcgc gggcctccta cgtaaggccg ctaggagagg 17101 ggcgacgaga agcgtcggcg atctccacgc cgccgtcaac aagacgggca acgacgccga 17161 atacgtcacc gccgcggtcg ccgagaggcc cctggcgctg aagatagccg gcagaggccc 17221 ggatatcctc ctctccgcgt agacgcacag tatgtatatt aataggaaat aggctgaact 17281 ctccatttga ataaaaccaa aaaagacttc tgtagtaatc ataacaaaca tcattaatat 17341 taataaaatt ataaaataaa tatccataaa tatgtattta agatggtaga ggaaaaagct 17401 gagcatttac gggctatagc agaggcatat attctttacg tagagccacc ccacctccaa 17461 gccgcaactc agcaccttgc tacagaacca ccacttacaa gtagcgcagg aggcgaggga 17521 gcctaggatc gctatggcta ctacagcggc tatgattaac accacgacga agacgccgta 17581 gtacctcctg ggcacgacga aggccgaggc caccccgagc gccaacatgg ccgcgatcag 17641 ggcaggacct ggatagatag tcttatagcc ggcggacgca accaccgtga agaacggata 17701 ccagctctgc gcggcaaacg gagttgccaa taccaacgat atctctatca acaacagccc 17761 tacaactacg ccgtatatca ccgatatata gttatttcta gctattcgca tggcttgcta 17821 acaacatcgg tattattttt tacttcgact aaaagctaaa ttttttgtat cgatagtcga 17881 tactacgtgc cgtgctgata caccacgcct atgatcacct cggcggtcga gcattttagc 17941 ggccggcctc atctcgccta tcatgtttca actatctttt gatttctggc cgtaggcggc 18001 gccgcacagc aggcgcaggt caaggtgacg tagtttcaac tatcttttga tttctggttg 18061 gcgagaggtt cggctgtctt gcgtatggct atatctttat cgcgtttcaa ctatcttttg 18121 atttctgggc cgggcaactc cggtgggccg gcatatctga ggcaatgatt gtttcaacta 18181 tcttttgatt tctggttgcc gagatggttg tgctgaatta ctacacgtta cttgtctggt 18241 ttcaactatc ttttgatttc tggtatgagt gccaccggta cccaacgtac tgcgcccaca 18301 atattctg //