LOCUS NC_014498:5 18499 bp DNA linear BCT 06-SEP-2013 DEFINITION Streptococcus pneumoniae 670-6B chromosome, complete genome. ACCESSION NC_014498 SOURCE Streptococcus pneumoniae 670-6B chromosome, complete genome. COMMENT locus start: 2127000; locus end: 2145498 COMMENT n1_4mer:GRV/n1_4mer:RV = 1.931520; n0_4mer:D = 29.080826; n0_4mer:PS = 40.001978 FEATURES Location/Qualifiers source 1..18499 /organism="Streptococcus pneumoniae 670-6B chromosome, complete genome." gene 16..456 /gene="" /locus_tag="" /db_xref="2127015..2127455" CDS 16..456 /gene="" /product="mobile genetic element" /translation="MDLKFEGVDLEYKKAKNNLPESFWETYSAFANTNGGKIILGIDE KNIDTYQRVNRLPAKQNYEASKQLTDARFKRLVGVQRTTFEEMLAVLKTAYQLKHAKG GRKPKLSLEDLLMATLQYVREYRTYEEIAADFGIHESNLLRRSQ" gene 453..581 /gene="" /locus_tag="" /db_xref="2127452..2127580" CDS 453..581 /gene="" /product="tranposase" /translation="MSEVTLVQSGFTISRTPLSSEDTVIVDATEVKINRPKKRISE" gene 607..996 /gene="" /locus_tag="" /db_xref="2127606..2127995" CDS 607..996 /gene="" /product="transposase" /translation="MKAQAIVTSQGRIVSLDIAVNYCHDMKLFKMSRRNIGQAGKILS DSGYQGPMKIYPQAQTPRKSSKLKPLIAEDKAYNHALSKERSKVENIFAKVKTFKMFS TTYRNHRKRFELRMNLIAGIINHELGF" gene complement(1066..1392) /gene="" /locus_tag="" /db_xref="2128065..2128391" CDS complement(1066..1392) /gene="" /product="hypothetical protein" /translation="VILWSFDFANDHAHAFFMDNVEWSHADSYFFSFVSDDVEERYTE NVYLDSLSVKQKFKFIFDFGDEWRFECQVLREIETEDEEVYLVRSVGTSPEQYPDYDG FDYEEW" gene complement(1429..1638) /gene="" /locus_tag="" /db_xref="2128428..2128637" CDS complement(1429..1638) /gene="" /product="hypothetical protein" /translation="VKQKNYLVSNATVRQTYDKIAESECFLRAIGGIMLHLKLVKQEI EAEKPASVEAWVISVKFKKGCYRHI" gene complement(1790..3670) /gene="" /locus_tag="" /db_xref="2128789..2130669" CDS complement(1790..3670) /gene="" /product="N-acetyl-beta-D-glucosaminidase" /translation="MVRFIGLSPKQTQAIEVLKGHISLPDVEVAVTQSDQASISIEGE EGHYQLTYRKPHQLYRALSLLVTVLAEADKVEIEEQAAYEDLAYMVDCSRNAVLNVAS AKQMIEILALMGYSTFELYMEDTYQIEGQPYFGYFRGAYSAEELQEIEAYAQQFDMTF VPCIQTLAHLSAFVKWGVKEVQELRDVEDILLIGEEKVYDLIDGMFATLSKLKTRKVN IGMDEAHLVGLGRYLILNGVVDRSLLMCQHLERVLDIADKYGFHCQMWSDMFFKLMSA DGQYDRDVEIPEETRVYLDRLKDRVTLVYWDYYQDSEEKYNRNFRNHHKISHDLAFAG GAWKWIGFTPHNHFSRLVAIEANKACRANQIKEVIVTGWGDNGGETAQFSILPSLQIW AELSYRNDLDGLSAHFKTNTGLTVEDFMQIDLANLLPDLPGNLSGINPNRYVFYQDIL CPILDQHMTPEQDKPHFAQAAETLANIKEKAGNYAYLFETQAQLNAILSSKVDVGRRI RQAYQADDKESLQQIARQELPELRSQIEDFHALFSHQWLKENKVFGLDTVDIRMGGLL QRIKRAESRIEFYLAGQLDRIDELEVEILPFTDFYADKDFAATTANQWHTIATASTIY TT" gene complement(3664..4533) /gene="" /locus_tag="" /db_xref="2130663..2131532" CDS complement(3664..4533) /gene="" /product="ROK family protein" /translation="MTIATIDIGGTGIKFASLTPDGKILDKTSISTPENLEDLLAWLD QRLSEQGYSGIAMSVPGAVNQETGVIDGFSAVPYIHGFSWYEALSSYQLPVHLENDAN CVGLSELLAHPELENAACVVIGTGIGGAMIINGRLHRGRHGLGGEFGYMTTLAPAEKL NNWSQLASTGNMVRYVIEKSGHTDWDGRKIYQEAATGNALCQEAIERMNRNLAQGLLN IQYLIDPDVISLGGSISQNPDFIQGVKKAVDNFVDAYEEYTVAPVIQACTYHADANLY GALVNWLQEEKQW" gene complement(4617..7262) /gene="" /locus_tag="" /db_xref="2131616..2134261" CDS complement(4617..7262) /gene="" /product="glycosyl hydrolase, family 38" /translation="MENVVVHIISHSHWDREWYLPFESHRMQLVELFDNLFDLFENDP EFKSFHLDGQTIVLDDYLQIRPENRDKVQRYIDEGKLKIGPFYILQDDYLISSEANVR NTLIGQQEAAKWGKSTQIGYFPDTFGNMGQAPQILQKSGIHVAAFGRGVKPIGFDNQV LEDEQFTSQFSEMYWQGVDGSRVLGILFANWYSNGNEIPVDKDEALTFWKQKLSDVRA YASTNQWLMMNGCDHQPVQKNLSEAIRVANELFPDVIFVHSSFDEYVQAVEGALPEHL STVTGELTSQETDGWYTLANTSSSRIYLKQAFQENSNLLEQVVEPLTIITGGHNHKDQ LTYAWKTLLQNAPHDSICGCSVDEVHREMETRFAKVNQVGNFVKSNLLNEWKGKIATD KAQSDYLFTVINTGLHDKVDTVSTVIDVATCDFKELHPTEGYKKMAALILPSYRVEDL DGRPVEATIEDLGANFEYDLPKDKFRQARIARQVRVTIPVHLAPLSWTTFQLLEGKQE HREGIYQNGVIDTPFVTVSVDDNITVYDKTTHEAYEDFIRFEDRGDIGNEYIYFQPKG TEPIFAELKGHEVLENTDRYAKILLKHELTVPVSADEKLEEEQQGIIEFMKREAGRSE ELTNIPLETELTVFVDNPQIRFKTRFTNTAKDHRIRLLVKTHNTRPSNDSESIYEVVT RPNKPAASWENPENPQHQQAFVSLYDDEKGVTVSNKGLNEYEILGDNTIAVTILRASG ELGDWGYFPTPEAQCLREFEVEFALECHQAQERFSAFRRAKALQTPFTSLQLARQEGS VVATGSLLSHSVLSIPQVCPTAFKVAENEEGYVFRYYNMSQENVHISEHQQTILDLLE RPYPVHSGPLDPQEIRTEFIKKEEI" gene complement(7353..8633) /gene="" /locus_tag="" /db_xref="2134352..2135632" CDS complement(7353..8633) /gene="" /product="hypothetical protein" /translation="MIYSKEIVREWLDEVAERAKDHPEWVDVFERCYTDTLDNTVEIL EDGSTFVLTGDIPAMWLRDSTAQLRPYLHVAKRDALLRQTIAGLVKRQMTLVLKDPYA NSFNIEKNWKGHHETDHTDLNGWIWERKYEVDSLCYPLQLSYLLWKETGETSQFDETF VAATKEILHLWTVEQDHKNSPYRFVRDTDRKEDTLVNDGFGPDFAVTGMTWSAFRPSD DCCQYSYLIPSNMFAVVVLGYVQEIFAALNLADSQSVIADAKRLQDEIQEGIENYAYT TNSKGEKIYAFEVDGLGNASIMDDPNVPSLLAAPYLGYCSVDDEVYQATRRTILSSEN PYFYQGEYASGLGSSHTFYRYIWPIALSIQGLTTRDKAEKKFLLDQLVACDGGTGVMH ESFHVDDPTLYSREWFSWANMMFCELVLDYLDIR" gene 8804..10888 /gene="" /locus_tag="" /db_xref="2135803..2137887" CDS 8804..10888 /gene="" /product="antigen, cell wall surface anchor family" /translation="MKPLLETIDTRFGTTNKHAFSRGNTLPYTGVPFGMNYFVPQTSD QDGSWFFDPHLPIFQGIRLTHQPSPWIGDYSWLLLTPVTSQLGGDSLFHRQSSYDIDK ACFQPHYLKLFSLRYQIETQLTPTCYGASIRLKQKQGKALSLYLHAADELTVEQVDKR TLALRQEGKTETNKNPLMLFTALQMNTDILAISQEAGDWRIDLASSQTEMQLATSFIS PSQALINLPQEDFDSCKTSAQADWENLLHRFDIIETGEADRTFFDHCLYRLFLFPQTF YEVDESGQAIHMDLATGTVKPGVLFSNNGFWDTFRTTFPLFALIIPEHYQRFLEGFLN SYRDTGFLPKWLAPDERGMMPGTLLDGIIADSACKDVAPDLEGELFQAMLETASKADP LGINGRHGLAQYQELGYLSTDHHESVSHTLDYAYSDFCIASCAKKLENIEIAETYKAA SQNYRQLFDAETGYMRARDNQGDFHPDFSPYSWGRDYAEFSAIQATLGVLHDIPGLIQ LMGGKETFSNYLLKACQDAPLFETTGYGYEIHEMSEMATAPFGQIAISNQPSFHIPYL FRYSDYPDYTALLIKTLRQKAFHPSWEAYPGDEDNGSLSAWYIWSALGFYPTCPGKPS YDLGIPLFDHLRVYLAKEDKWLDIHTKQNHNHFNFVKECRLDKTLVSTIQHQDLLKAE QLTFTLSWLPSH" gene complement(10928..12607) /gene="" /locus_tag="" /db_xref="2137927..2139606" CDS complement(10928..12607) /gene="" /product="putative alpha-L-fucosidase 1" /translation="MKKIKPHGPLPSQTQLAYLGDELAAFIHFGPNTFYDQEWGTGQE DPERFNPSQLDAREWVRVLKETGFKKLILVVKHHDGFVLYPTAHTDYSVKVSPWRRGK GDLLLEVSQAATEFDMDMGVYLSPWDAHSPLYHVDREADYNAYYLVQLKEILSNPNYG NAGKFAEVWMDGARGEGAQKVNYEFEKWFETIRDLQGDCLIFSTEGTSIRWIGNERGY AGDPLWQKVNPDKLGTEAELNYLQHGDPSGTIFSIGEADVSIRPGWFYHEDQDPKSLE ELVEIYFHSVGRGTPLLLNIPPNQAGLFDAKDIERLYEFATYRNELYKEDLALGAEVS GPALSADFACRHLTDGLETSSWANDAALPIQLELDLGSPKTFDVIELREDLKLGQRIA AFHVQVEVDGVWQEFGSGHTVGYKRLLRGAVVEAQKIRVVITESQVLPLLTKISLYKT PRLSQTVAVQGLAFAEKSLAVAKGETLHFRIERSESSSSLEAKISIQPGTGVHGVAYQ DEIQVLQFQAGESKKDLHLPTLYFAGDKTLDFYLNLTVDGQLVDQLQVQVS" gene complement(12651..12764) /gene="" /locus_tag="" /db_xref="2139650..2139763" CDS complement(12651..12764) /gene="" /product="hypothetical protein" /translation="MTELFEEGTLRRKILSLPVGVGKSWRLDHFLLSTTCG" gene 13362..14591 /gene="arcA" /locus_tag="arcA" /db_xref="2140361..2141590" CDS 13362..14591 /gene="arcA" /product="arginine deiminase" /translation="MSSHPIQVFSEIGKLKKVMLHRPGKELENLLPDYLERLLFDDIP FLEDAQKEHDAFAQALRDEGIEVLYLEQLAAESLTSPEIRDQFIEEYLDEANIRDRQT KVAIRELLHGIKDNQELVEKTMAGIQKVELPEIPDEAKDLTDLVESDYPFAIDPMPNL YFTRDPFATIGNAVSLNHMFADTRNRETLYGKYIFKYHPIYGGKVDLVYNREEDTRIE GGDELVLSKDVLAVGISQRTDAASIEKLLVNIFKKNVGFKKVLAFEFANNRKFMHLDT VFTMVDYDKFTIHPEIEGDLHVYSVTYENEKLKIVEEKGDLAELLAQNLGVEKVHLIR CGGGNIVAAAREQWNDGSNTLTIAPGVVVVYDRNTVTNKILEEYGLRLIKIRGSELVR GRGGPRCMSMPFEREEV" gene 14649..15665 /gene="argF" /locus_tag="argF" /db_xref="2141648..2142664" CDS 14649..15665 /gene="argF" /product="ornithine carbamoyltransferase" /translation="MTNSVFQGRSFLAEKDFTRAELEYLIGLSAHLKDLKKRNIQHHY LAGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRM FDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVQENFGRLEGLTLV YCGDGRNNVANSLLVTGAILGVNVHIFSPKELFPEKEIVELAEGFAKESGAHVLITED ADEAVKDADVLYTDVWVSMGEEDKFAERVALLKPYQVNMDLVKKAGNENLIFLHCLPA FHDTHTVYGKDVAEKFGVEEMEVTDEVFRSKYARHFDQAENRMHTIKAVMAATLGNLY IPKV" gene 15830..16777 /gene="arcC" /locus_tag="arcC" /db_xref="2142829..2143776" CDS 15830..16777 /gene="arcC" /product="carbamate kinase" /translation="MANRKIVVALGGNAILSSDPSAKAQQEALVETAKHLVKLIKNGD DLIITHGNGPQVGNLLLQHLASDSEKNPAFPLDSLVAMTEGSIGFWLKNALQNALLDE GIEKNVASVVTQVVVDKNDPAFVNLSKPIGPFYSEEEAKAEAEKSGATFKEDAGRGWR KVVASPKPVDIKEIETIRTLLNNGQVVVAAGGGGIPVVKENNGHLTGVEAVIDKDFAS QRLAELVDADLFIILTGVDYVFVNYNKPNQEKLEHVNVAQLEEYIKQDQFAPGSMLPK VEAAIAFVNGRPEGKAVITSLENLGALIESESGTIIEKG" gene 16988..18499 /gene="" /locus_tag="" /db_xref="2143987..2145498" CDS 16988..18499 /gene="" /product="arginine-ornithine antiporter" /translation="MSEKAKKGFKMPSSYTVLLIIIAIMAVLTWFIPAGAFIEGIYET QPQNPQGIWDVLMAPIRAMLGTHPEEGSLIKETSAAIDVAFFILMVGGFLGIVNKTGA LDVGIASIVKKYKGREKMLILVLMPLFALGGTTYGMGEETMAFYPLLVPVMMAVGFDS LTGVAIILLGSQIGCLASTLNPFATGIASATAGVGTGDGIVLRLIFWVTLTALSTWFV YRYADKIQKDPTKSLVYSTRKEDLKHFNVEESSSVESTLSSKQKSVLFLFVLTFILMV LSFIPWTDLGVTIFDDFNAWLTGLPVIGNIVGSSTSALGTWYFPEGAMLFAFMGILIG VIYGLKEDKIISSFMNGAADLLSVALIVAIARGIQVIMNDGMITDTILNWGKEGLSGL SSQVFIVVTYIFYLPMSFLIPSSSGLASATMGIMAPLGEFVNVRPSLIITAYQSASGV LNLIAPTSGIVMGALALGRINIGTWWKFMGKLVVAIIVVTIALLLLGTFLPFL" ORIGIN 1 atgtaaagga aaaatatgga cttaaaattt gaaggggttg atttagaata caaaaaagct 61 aaaaacaatc ttccagagtc tttctgggaa acctactcag catttgcaaa tacaaatggc 121 gggaaaataa ttctcgggat agatgaaaaa aacattgaca cctaccaaag agtcaataga 181 ctccctgcga aacaaaatta tgaagcaagt aaacaactaa ccgatgcacg atttaagcgt 241 cttgttggtg ttcagcgtac cacttttgaa gagatgttag ctgtattaaa aacagcttat 301 caacttaaac acgcaaaagg tggacgaaaa cctaaattaa gcctagaaga ccttcttatg 361 gccactcttc aatatgtgcg agaatatcga acttatgaag aaattgcggc tgattttggt 421 atccacgaaa gcaacttact ccgtcggagc caatgagtga agtaactctt gttcaaagtg 481 gttttacgat ttcaagaact cctctcagtt ctgaggacac ggtgattgtg gatgcaacag 541 aggtaaaaat aaatcgtcct aaaaaaagaa ttagcgaatg attctggtaa aaagaaatgc 601 cacgctatga aggctcaagc gattgtcaca agtcaaggga gaattgtttc tttggatatc 661 gctgtgaact attgtcatga tatgaagttg ttcaaaatga gtcgcagaaa tatcggacaa 721 gctggtaaaa tcttgtctga cagtggttat caagggccca tgaagatata tcctcaagca 781 caaactccac gtaaatccag taaactcaag ccgctaatag ctgaagataa ggcttataac 841 catgcgctat ccaaggagag aagcaaggtt gagaacatct ttgccaaagt aaaaacgttt 901 aaaatgtttt caacaaccta tcgaaatcat cgtaaacgct tcgaattacg aatgaatttg 961 attgctggta ttatcaatca tgaactagga ttctagtttt gcaggaagtc tattgaaata 1021 ctaagcctac acagactgat tccaattgtt ttttagattt caattttacc attcttcata 1081 gtcaaaacca tcataatctg gatattgttc tggcgacgtt ccaaccgaac gtacgagata 1141 aacttcttcg tcctctgtct cgatttctct cagcacttgg cattcaaaac gccattcatc 1201 accgaagtcg aaaataaact taaatttttg tttgacactt aggctatcca gatagacatt 1261 ttctgtgtaa cgttcttcaa catcgtcact aacaaagcta aaaaagtaag aatctgcatg 1321 actccactca acattatcca tgaaaaatgc gtgagcatga tcatttgcaa aatcaaaact 1381 ccataaaatc acatctgcta gtttcgctaa cgtttttgtt tttggaatct atatatgtcg 1441 gtagcaacct tttttaaatt tgacggaaat gacccaagct tctacagatg ctggcttttc 1501 agcttctatt tcttgtttta ctaattttaa gtgtagcata atacctccaa ttgctcttag 1561 gaaacattca ctttctgcta ttttatcata agtttgtcta actgtagcat ttgaaaccag 1621 ataattcttc tgtttcacgc gaaacaccct gcgccaagca aggtgttctt gtttttatac 1681 tcaatgaaaa tcaaagagca aactaggaag ctagctgcag gctgctcaaa acactgtttt 1741 gaggttgtag atggaagctg acgtggtttg aagagatttt cgaagagtat taagtcgtat 1801 aaatcgtcga cgctgtcgca atggtatgcc actggttggc tgtagttgct gcgaaatcct 1861 tgtctgcgta gaagtcagta aatggtagga tttcaacttc cagctcgtcg atgcggtcaa 1921 gctgaccagc cagataaaac tcgatacggc tttctgctcg ttttatgcgt tgcaagagtc 1981 cgcccatacg gatgtcaact gtatccaaac caaagacctt gttttctttc agccattggt 2041 gactaaagag ggcatggaag tcttcaattt ggcttctaag ttctggtaat tcttgtctgg 2101 cgatttgttg taaactttct ttatcatccg cttggtaggc ctgacgaatg cgtcgtccca 2161 catctacttt gctacttaaa atagcattca actgggcctg agtttcaaag agataggcat 2221 agtttccagc tttttcttta atgttagcaa gcgtctcagc agcctgagcg aagtgcggtt 2281 tgtcctgttc aggtgtcatg tgttgatcaa gaatcggaca aagaatatcc tgataaaaaa 2341 catagcggtt gggattgata ccgctgagat tgcctggtag gtctggtaag aggttggcaa 2401 ggtcaatctg cataaaatcc tcaaccgtta gaccagtatt ggtcttgaag tgcgcagaca 2461 aaccatctag gtcattgcga tagctgagtt ctgcccagat ttgcaagctt ggtaggatag 2521 agaactgggc agtttcacca ccattgtctc cccaacccgt tacgatgact tctttaatct 2581 gattggcacg gcaggcttta ttagcctcga tagccactag acggctaaaa tggttgtgag 2641 gtgtaaagcc aatccacttc caagctcccc ctgcaaatgc aaggtcatgg ctaatcttgt 2701 gatgattgcg gaaattacgg ttgtattttt cctcgctatc ctgataataa tcccagtaaa 2761 ccagagtcac acggtctttg agacggtcta ggtagacacg agtttcctct ggaatttcca 2821 catcacgatc gtactggcca tccgctgaca tgagtttgaa gaacatatca ctccacatct 2881 ggcagtggaa accatatttg tcagcaatat ccagcacgcg ctccaagtgt tggcacatga 2941 ggagactacg atccacaaca ccgttcaaaa tcaggtagcg tcccaaacca accaagtggg 3001 cttcgtccat cccgatattg accttgcgag tcttcagttt agacaacgtg gcaaacatgc 3061 catcaatcag gtcataaacc ttttcttcgc caatgagaag aatgtcctct acatcacgga 3121 gctcctgcac ttccttgaca ccccatttga caaaggccga caagtgggcc aaggtctgga 3181 tgcatggtac aaaggtcatg tcaaactgtt gagcataggc ttcgatttcc tgcaactcct 3241 cagctgaata agctccacgg aaatagccaa agtaaggctg cccttcaatc tggtaagtgt 3301 cttccatgta gagctcaaag gttgagtagc ccatgagagc caatatctca atcatctgct 3361 tggcagaagc gacattcagc accgcatttc gagaacagtc aaccatgtaa gccaaatctt 3421 cataagctgc ttgttcctca atctctactt tatcagcttc tgctagaact gttaccaaca 3481 aggacaaggc acgataaagt tggtgaggtt tgcggtaggt caattgatag tgaccttcct 3541 caccctcgat agagatagag gcttggtcag actgagtgac agccacttcc acatctggta 3601 gagaaatgtg accttttaaa acctcaatag cttgcgtttg tttgggacta agtcctataa 3661 atcttaccat tgcttttcct cctgtagcca gttgacaagg gcaccgtaga gattggcatc 3721 tgcgtgatag gtgcaggcct ggataactgg tgcgaccgtg tattcttcgt aggcatcgac 3781 aaagttatca acagccttct tgacaccttg gataaaatct ggattttgac tgatagagcc 3841 acccagactg atgacatctg gatcgatgag atactggata ttgagcaagc cttgcgccag 3901 attgcggttc atgcgctcaa tggcttcttg acaaagagca ttaccagttg cggcctcttg 3961 gtaaatcttg cgaccgtccc aatcagtatg accagatttt tcaatcacgt atcgtaccat 4021 attcccagtt gatgctagtt gcgaccagtt attaagtttt tcagcagggg caagggttgt 4081 catgtagcca aattctccac ccagaccgtg gcgacctcga tgaagtctac cattgataat 4141 catggctccg ccaatccctg tcccaatcac gacacaggct gcattttcaa gctctggatg 4201 agctagtagt tcactgagtc caacgcagtt ggcatcattt tctaaatgga caggtagctg 4261 ataagagcta agcgcctcat accaagaaaa gccatggatg tagggcaccg cactgaagcc 4321 atcaatcaca cctgtctctt gattgactgc acctggaacg ctcatagcaa tcccactgta 4381 accctgttct gacaagcgtt gatctagcca cgctagtaaa tcctccaagt tttcaggcgt 4441 tgaaatactt gtcttatcca gtattttccc atcaggagtc agactggcaa acttaatccc 4501 agtccctccg atatcaatcg ttgcaatggt cattgttttt accataaaaa ggggcgaatc 4561 agcagttagt ccttactttt tcgcccctcc tttcttttga tgtttacttt ttgaaattaa 4621 atttcttctt ttttgatgaa ttctgtacga atctcttgtg gatccaatgg tcctgaatga 4681 actggatatg gtcgctcaag taagtcaaga atggtttgtt gatgttctga tatgtgcaca 4741 ttttcttgac tcatattata gtaacggaag acatagcctt cttcattttc cgccacttta 4801 aaggctgttg gacaaacttg cggtatgctg agaacagaat ggctcaagag gctaccagtc 4861 gcaaccacgc ttccttcctg tctagcaagc tgaaggctgg taaacggtgt ctgcaaggct 4921 ttggcacgac ggaaagctga aaagcgttct tgggcttggt ggcattcaag tgcaaactcg 4981 acttcaaact cacgcaagca ttgtgcttct ggcgttggga agtagcccca gtcacctagc 5041 tcacctgatg cacgcaaaat ggtcacggca atggtgttat ccccaaggat ttcgtattca 5101 ttcaatccct tattggatac agtcacccct ttttcatcgt catacagact gacaaaagct 5161 tgttggtgtt gaggattttc aggattttcc catgaagcag ctggtttgtt tggtcgtgtc 5221 accacctcat agatactttc agaatcattg cttggacgcg tgttatgagt cttgaccaag 5281 agacggatac ggtgatcctt ggcagtgtta gtaaagcgag tcttgaagcg gatttgtgga 5341 ttgtcaacga agacagtcaa ctcagtttcc agaggaatgt ttgtcaattc ttctgaccgt 5401 ccagcctcac gcttcataaa ctcgatgata ccttgttgct cttcttctag cttttcatcc 5461 gcactgacag gcacggtcaa ttcatgtttg agcaagattt tagcatagcg atctgtgttt 5521 tccaagacct cgtggccctt aagctctgca aagattggct ctgttccttt tggttggaaa 5581 tagatatact cgtttccgat gtccccacgg tcttcgaagc ggataaagtc ttcataggct 5641 tcgtgagttg tcttgtcata tactgtgata ttgtcatcca cactcaccgt tacgaatggt 5701 gtatcaatca ctccgttttg gtaaataccc tcacggtgtt cttgttttcc ttccagcaat 5761 tggaaggttg tccaagaaag cggcgctagg tgaactggaa tggtcacgcg cacttgtcga 5821 gcaatacgag cttggcggaa cttgtctttt ggtaaatcgt actcaaaatt agctccgagg 5881 tcttcgattg tagcctctac aggacgacca tccaagtcct ccacacggta acttggtaag 5941 ataagagcag ccatcttttt gtagccttct gttgggtgca attccttgaa atcacaagtc 6001 gccacatcaa tcactgtgct gacagtatcg accttatcat gcaagcctgt gttaatgaca 6061 gtaaagagat agtcactttg agccttatcc gtagcaattt tacccttcca ctcgttgagc 6121 aagttacttt taacaaagtt tcctacttgg ttgaccttgg caaaacgcgt ttccatctcg 6181 cggtgaactt cgtccacgct acagccacag atactatcat gtggcgcatt ctgcaaaagt 6241 gttttccaag cataggtcaa ctggtccttg tggttgtgtc caccagtgat aatagtcaag 6301 ggttctacca cttgctctag gaggttgcta ttttcttgga aggcttgttt taggtaaatg 6361 cgggatgaag aagtgttggc aagtgtgtac cagccatctg tttcctgact ggtcaactcg 6421 cctgtaacag ttgataagtg ttcaggaagc gcaccttcta cagcttgaac atattcatca 6481 aaagaactat gaacaaagat tacatccggg aagagttcat ttgccacacg aatggcttcg 6541 ctcagatttt tctgtacagg ctggtggtca cagccgttca tcatcaacca ttggttggtc 6601 gaagcgtagg cacgcacatc tgacaatttt tgtttccaga aggtcaaggc ctcatctttg 6661 tcaactggga tttcattccc attactgtac cagttggcaa agagaatacc taaaacacga 6721 ctaccatcca caccctgcca gtacatttct gaaaactggg atgtaaactg ctcatcttca 6781 aggacttggt tgtcaaatcc aatcggcttc acaccacgac caaaggccgc cacgtgaatg 6841 cctgattttt gaagaatttg aggcgcttgt cccatatttc caaaggtatc tggaaagtag 6901 ccaatctggg ttgatttacc ccatttggca gcttcttgtt gaccaatcaa ggtattgcgg 6961 acattggctt cactggagat caagtagtca tcctgcaaga tgtaaaaggg accaatttta 7021 agtttgccct cgtcaatgta gcgttggacc ttgtcacgat tttcagggcg aatttgtaag 7081 tagtcgtcaa ggacaatagt ttgtccatcc aagtggaaac tcttgaactc agggtcattt 7141 tcaaagagat caaagagatt gtcaaacaat tccaccaact gcatacgatg gctttcaaaa 7201 ggcaagtacc actcacggtc ccagtgacta tgtgagataa tatgtacaac aacattttcc 7261 atgaagtaaa acctcattct aaatttaaat tttaacgttt taaatgtaaa cttgtgattc 7321 tgataagaat cggttgagct aaagcgagcc ccttagcgaa tatccaagta atccaagacc 7381 aactcacaga acatcatgtt agcccaggag aaccattcac gagagtagag ggtcggatca 7441 tctacatgaa agctttcgtg catgacacct gtaccaccat cgcaggcaac cagctgatcc 7501 agcaagaatt ttttctctgc cttatctctt gttgtcaatc cttggataga aagggcgatt 7561 ggccagatat agcgatagaa ggtatgagaa cttccgagac cgctagcgta ttctccttgg 7621 tagaaatatg gattttcaga gctcaaaatg gtacgacgag tagcttgata cacttcatca 7681 tcgaccgaac agtagcccag atagggcgca gctagtagac ttggcacatt cggatcatcc 7741 atgatgctgg catttcctag gccatctact tcaaaagcgt aaatcttttc gcccttgctg 7801 ttggtggtgt aagcgtagtt ttcgattcct tcttggattt catcctgaag acgcttggca 7861 tcagcaataa cactctggct atcagctagg tttaatgctg cgaagatttc ttgcacataa 7921 cccaagacta ctacagcaaa catatttgac ggaatcaagt aactatactg acagcagtca 7981 tcgctcggac gaaaggctga ccaagtcatt cctgtcactg caaaatcagg tccaaagcca 8041 tcatttacca aggtgtcttc cttgcggtcc gtatctcgga caaaacgata aggagagttc 8101 ttatgatctt gttctaccgt ccacagatga agaatttcct tagtcgctgc gacaaaagtc 8161 tcatcaaact gactagtctc gccagtttct ttccagagga gataagacaa ctgcaaagga 8221 tagcaaagtg aatccacctc atacttgcgc tcccagatcc agccgttaag gtctgtgtgg 8281 tcagtctcgt ggtgcccttt ccagttcttc tcaatgttga aggagttagc atagggatcc 8341 ttgagtacca aggtcatctg acgtttgacc aaacctgcaa tggtctgacg caggagggca 8401 tctcttttag ctacatgaag gtagggtctg agttgggctg tcgaatctcg aagccacatg 8461 gcaggaatat ccccagtcaa gacaaaagtt gaaccatctt ctaagatttc aaccgtattg 8521 tccaaggtat cggtgtagca acgctcgaaa acatccaccc actctggatg gtccttagcc 8581 cgctctgcta cttcatctag ccattctcta acaatttctt tcgaataaat catcgtgcaa 8641 tttcctcttt caaacaagtt tcattttcag tatatagctt ttgagacaga aaatacatac 8701 acaaatgata gtcatttttc tacaaaatag ttatttttga aactcctttt ctaaagaccc 8761 tctttttctg atataatgta gaaaaacagc taaaggaaag actatgaaac cactacttga 8821 aaccatcgat acccgctttg gaactaccaa caagcatgcc ttttctcggg gaaataccct 8881 gccatacaca ggcgtgcctt ttgggatgaa ttattttgtg ccccagacca gtgaccagga 8941 tggatcttgg ttttttgatc cgcatctgcc tatctttcag gggattcgat taactcacca 9001 gcccagtcct tggattgggg actactcttg gctccttctg acacctgtca ccagtcaact 9061 gggtggagac agcctctttc accgccagtc ttcttatgat atagataaag cttgcttcca 9121 gcctcactat ttgaagctct tttccctgcg ctatcaaatt gaaacccagc tcacaccgac 9181 ttgctatggt gcttctattc gtttgaagca aaagcaaggc aaagccctct ccctctatct 9241 tcacgcagca gatgaactaa cagttgagca ggtagataag cggactctgg ctctcagaca 9301 agaagggaaa acagagacca ataaaaatcc actgatgctc ttcactgccc tgcaaatgaa 9361 cacggatatt cttgctatca gccaagaagc tggagactgg cgaattgact tagcaagtag 9421 tcaaaccgag atgcaactag ccacttcttt catctctcct tctcaagctc taatcaatct 9481 acctcaagaa gattttgata gctgtaaaac aagtgcccaa gcggattggg aaaatctcct 9541 ccatcgtttt gacattatag agacaggaga ggctgaccga accttctttg accactgcct 9601 ctacagactc ttcctcttcc cacagacttt ttatgaggtt gatgagtcag ggcaagccat 9661 ccacatggat ctggctactg gtactgtcaa gcctggtgtc ctctttagca acaatggttt 9721 ctgggatacc ttccgcacca ccttccccct ctttgccctt atcataccgg agcactatca 9781 acgcttttta gaaggtttcc tcaatagcta ccgcgatact ggtttccttc caaaatggct 9841 ggctccagat gaacggggta tgatgccagg tacactttta gacggtatta tcgcagatag 9901 cgcctgcaag gacgtggccc ctgacctaga aggagaactc ttccaagcca tgctcgaaac 9961 agccagcaaa gccgaccctc tcggaatcaa tggccgccac ggactagccc aataccaaga 10021 actaggttac ctctctaccg accaccacga aagtgttagc catactctag actatgccta 10081 tagtgacttt tgtatcgcta gctgtgccaa aaaactagag aacatagaaa tcgctgaaac 10141 ctacaaggct gcttcacaaa attaccgcca gctatttgac gctgagacag gttacatgcg 10201 agcacgagac aatcaaggag actttcaccc tgacttctct ccttatagtt gggggcgaga 10261 ctacgctgaa ttctctgcca ttcaagctac tttaggcgtt ctccacgaca tccctggctt 10321 aatccaactg atgggtggaa aagaaacctt tagcaactat cttttgaaag cttgtcaaga 10381 tgctcccctc tttgaaacaa caggctatgg ttacgaaatt cacgaaatga gcgagatggc 10441 tactgctcct tttggacaaa tagccatttc caaccagcct agtttccaca ttccttatct 10501 cttccgctac agcgattacc ctgactacac tgcccttctt atcaagacgc tccgtcagaa 10561 agcttttcac ccaagttggg aagcctatcc tggagatgaa gacaatggta gtctctctgc 10621 ttggtacatc tggtcagctc tcggatttta tccaacctgt ccaggaaaac caagctatga 10681 cctcggaatc cctctctttg accatctacg agtctacctc gctaaagaag ataaatggct 10741 ggatatccat actaaacaaa accacaacca ttttaacttt gtcaaagaat gccgactgga 10801 caaaacactc gtatcaacta ttcaacacca agacctctta aaagctgaac aactaacttt 10861 caccctcagc tggttaccaa gtcactaata accaaaagaa cctttgcatc gcgcaaaggt 10921 tcttctttta tgaaacttgg acttgaagtt gatccacaag ctgaccatcc accgttaggt 10981 tcagatagaa atccaaggtt ttatctcctg cgaaatacag ggttggtaga tgcaaatctt 11041 ttttgctttc ccctgcttgg aattgaagga cttgaatctc atcctgatag gcgacaccat 11101 ggacacctgt ccccggttga atcgaaatct tagcctctaa agaggagcta ctttcactac 11161 gttcaatcct aaaatgaaga gtctctccct ttgccacagc taggcttttt tctgcaaatg 11221 ctagcccctg aacagctact gtttgtgata acctcggagt tttatagagt gaaatcttgg 11281 tcaacaaagg caaaacctgt gattctgtaa tgactacacg tatcttctgt gcttcaacaa 11341 ctgctcctcg taagagacgt ttgtaaccaa cagtatgacc cgaaccaaac tcctgccaga 11401 caccatccac ctctacttgc acatgaaaag cagcgattcg ttgccctagc ttcaaatctt 11461 ctcttaactc aattacatca aaagttttag gagaacctaa gtcgagttct aactggatgg 11521 gcaaggctgc atcgtttgcc caagagctgg tctcaaggcc gtctgtcaaa tggcgacaag 11581 caaagtctgc ggaaagagct ggaccagata cctcagctcc cagagccaaa tcttctttat 11641 agagctcatt gcgataggtc gcaaattcat aaagtcgttc aatatccttt gcatcaaaga 11701 gcccagcttg attcggcgga atattaagca agagtggagt tcctcgccct actgagtgaa 11761 agtagatttc gaccaactcc tcgagagact taggatcctg atcctcatgg tagaaccagc 11821 ctggacggat ggaaacatct gcctctccga ttgaaaaaat cgtgcccgag ggatccccgt 11881 gctgaagata gttcagctct gcttctgttc ctagtttatc aggattcacc ttttgccaca 11941 gtggatcacc tgcataccct cgttcattgc caatccagcg gatactggtg ccttctgttg 12001 aaaaaatcaa gcaatcgccc tgcaggtcac gaatggtttc aaaccatttt tcaaattcat 12061 aattaacctt ttgcgcgccc tctcctctgg caccatccat ccaaacctca gcgaacttac 12121 cagcattccc atagttagga tttgataaga tttccttcaa ctgaaccaga taataggcat 12181 tgtagtccgc ttctcggtcc acatgataga ggggactatg ggcatcccac ggtgacaggt 12241 agacccccat atccatatca aactctgtgg cagcttggga tacttcaagg agcaagtcgc 12301 cctttcctct cctccaagga ctgaccttaa ccgaataatc tgtgtgagct gtcggataaa 12361 ggacaaagcc atcgtggtgc ttgaccacca aaatcaactt tttgaagccc gtttccttga 12421 gcacacgaac ccactcacgc gcatccaact gactcgggtt aaagcgctca ggatcctcct 12481 gtccagtccc ccattcttgg tcataaaagg tattaggacc gaagtggata aaagctgcta 12541 gttcatctcc cagataagct agctgagtct gacttggtaa cggtccatgc ggtttgattt 12601 tcttcatcgt tatatatctc cttctttagc aacttctctt gttcacaagg ttatccacag 12661 gttgtggata ataaaaaatg atctaaccgc cagctctttc caactccaac tggtaggctc 12721 aggatttttc tcctcaatgt tccctcttca aacagctctg tcatatggtt ctgctaacac 12781 ctctcagaat gctactctcc ataattattc tcaggcttct ttcatgtcat tgtgtgaaaa 12841 ccattcactc tccagacttt tccacagatt gtgaataagt gattattcta aactatcatc 12901 tcgtcgacta taacaaaaaa taaaaagagg gtcaataaga taattatctc ttcctaaata 12961 ctcagaaaag attctataat ttgtacaatt gaacaagaaa tgcttctcca aaatctatct 13021 tcaaaagaat gttgcatctt tttatccttt cacacaaaca tttctcttta tacagatcca 13081 agtgataacc agatgataat tggacacttt ttggtcattt gtatattttt tgaaaaattt 13141 tttaaaaaaa ttttatatcc tttttataga agtttatgca tttgtatcta tgtattctat 13201 cctatgttat gtataataac ataaaattgt gctaaatatc ataatttata ttattttccg 13261 agaaattata gccattgaca ttacctagga attgcgttat aacataaatg taagcggtac 13321 ccaaaatggt gccaagtcaa aatttttaag gaggaaaata catgtcttca catccaattc 13381 aggtcttctc agaaattggg aaactgaaaa aagttatgtt gcaccgtcca ggcaaggagt 13441 tagaaaactt gttgccggac tatcttgaaa ggcttctttt tgatgatatt cctttcttgg 13501 aagatgctca aaaagaacat gatgcatttg cccaagctct tcgcgatgaa ggaattgagg 13561 ttctctacct agaacaactc gctgctgaat cattgacctc tccagaaatc cgcgatcaat 13621 ttatcgagga atacttagac gaagccaaca tccgtgatcg tcaaaccaag gttgctattc 13681 gtgaattgct tcacggcatc aaggacaacc aagaattggt tgaaaaaaca atggctggga 13741 ttcaaaaagt tgaattgcca gaaattcctg acgaagctaa agatctaact gacttagttg 13801 aatcagatta tccatttgca attgacccga tgccaaacct ctatttcact cgcgacccat 13861 ttgcaacaat tggaaacgcc gtatcgctta accacatgtt tgcagacact cgtaaccgtg 13921 aaacactcta cggtaagtat atcttcaaat accacccaat ctatggcgga aaagtggatt 13981 tggtctacaa ccgtgaagaa gatacgcgta tcgaaggtgg agacgagcta gttctttcta 14041 aagacgtcct tgcagtaggt atctctcaac gtacagacgc agcttctatc gaaaaacttt 14101 tggtcaacat cttcaagaaa aatgttggct tcaagaaagt tttggccttt gaatttgcta 14161 acaaccgtaa attcatgcac ttggatactg tcttcactat ggtagactat gacaagttca 14221 ctattcaccc agaaatcgaa ggcgaccttc acgtttactc agttacttac gaaaacgaaa 14281 aacttaaaat cgttgaagag aaaggtgact tagctgaact tcttgctcaa aaccttggtg 14341 tagaaaaagt tcatttgatt cgttgcggtg gtggcaatat cgtagcagct gcgcgtgaac 14401 aatggaacga cggttctaac actttgacca tcgcacctgg tgtggtagtt gtttatgacc 14461 gcaataccgt gaccaataag attttggaag aatacgggct tcgcttgatt aagattcgcg 14521 gaagtgaatt ggttcggggc cgtggtggac ctcgttgtat gtctatgcca tttgaacgtg 14581 aagaagtgta atcgctgttc ggcattcgtc aatagaaaat gtaaaaaata gaaagaggaa 14641 ataataaaat gacaaattca gtattccaag gacgcagctt cttagcagaa aaagacttta 14701 cccgtgcaga gttagaatac cttattggtc tttcagctca cttgaaagat ttgaaaaaac 14761 gcaatattca acaccactac cttgctggca agaatatcgc tctcctattt gaaaaaacat 14821 ctactcgtac tcgtgcagcc tttacaactg cggctatcga ccttggtgct cacccagaat 14881 acctcggagc aaatgatatt cagttgggta aaaaagaatc tactgaagat actgctaaag 14941 tattgggacg tatgtttgac gggattgaat tccgcggatt cagccaacgt atggttgaag 15001 aattggcaga attctcaggc gttccagtat ggaacggtct aactgacgaa tggcacccaa 15061 ctcaaatgct cgctgactac ttgactgttc aagaaaactt cggtcgcttg gaaggcttga 15121 cattggtata ctgtggtgat ggacgtaaca acgttgccaa cagcttgctc gtaacaggtg 15181 ctatccttgg tgtcaatgtt cacatcttct caccaaaaga actcttccca gaaaaagaaa 15241 tcgttgaatt ggcagaagga tttgctaaag aaagtggcgc acatgttctc atcactgaag 15301 atgctgatga agcagttaaa gatgcagacg ttctttacac agacgtttgg gtatcaatgg 15361 gtgaagaaga caaattcgca gaacgtgtag ctcttcttaa accttaccaa gtcaatatgg 15421 acttagttaa aaaagcaggc aatgaaaact tgatcttcct acactgcttg ccagcattcc 15481 acgatactca cactgtttat ggtaaagacg ttgctgaaaa atttggtgta gaagaaatgg 15541 aagtaacaga cgaagtcttc cgcagcaagt acgctcgcca cttcgatcaa gcagaaaacc 15601 gtatgcacac tatcaaagct gttatggctg ctacacttgg taacctttat attcctaaag 15661 tataatttta gataataaac cgtctaccaa cagctatgag ggctgcgact aatagcttta 15721 gtccggtcct cttttatgta atggtaatct attatttctt ataaaatatg tgaaaaatca 15781 ttaaattgaa atctaaacgc attctattga gtgtgataaa ggagaattta tggcaaatcg 15841 taaaattgta gtagctttgg gaggaaatgc gattctttct tctgacccat cagcaaaggc 15901 tcaacaagaa gctttagttg aaacagctaa gcatcttgta aaattgatta aaaatggaga 15961 tgatctgatt atcactcacg gtaatggacc tcaagttggg aatctcttgc tccaacattt 16021 ggcatcagac tctgaaaaga accctgcctt cccactcgac tcacttgtcg ctatgacaga 16081 aggtagcatc ggtttctggt tgaaaaatgc tttgcaaaat gctctcttgg atgaaggcat 16141 cgaaaaaaat gttgcctctg ttgtaacgca agttgtcgta gataaaaatg atccagcttt 16201 tgttaacttg agtaaaccaa tcggtccttt ctattcagaa gaagaagcaa aagcagaagc 16261 cgaaaaaagc ggagcgactt tcaaggaaga tgctggccgt ggctggcgta aggtcgttgc 16321 ctcaccaaaa cctgttgaca tcaaagaaat tgaaaccatc cgtactcttt taaataatgg 16381 tcaagtcgtc gtagctgcag gtggtggcgg tattcccgtc gtcaaagaaa acaatggaca 16441 tttgactggt gtcgaagcgg ttattgataa agacttcgct tcccaacgtt tggcagaatt 16501 ggttgatgca gacctcttca tcattttgac aggtgtagat tatgtatttg ttaactacaa 16561 caagccaaac caggaaaaat tggaacatgt gaatgttgcc cagctggaag aatatatcaa 16621 acaagatcag tttgcaccag gtagcatgct tccaaaagta gaagcagcta tcgcttttgt 16681 caatggtcgt ccagaaggaa aagcagttat tacttccctt gaaaatctag gcgccttgat 16741 tgaatctgaa agcggaacaa ttattgaaaa aggataagtt gttttactaa taagatgtat 16801 tctatttcta gtatctttat atcaaattag aaattattct tgaaaacatg tacaatattt 16861 caaaagatat tagtttttta gactttaata tggtaaaaca aatataaata gaaagcgttt 16921 tcttaaatgt ttatttaaga aagtagttgg ttttttacac tttgttagac atcaggagga 16981 aaaacaaatg agtgaaaaag ctaaaaaagg gtttaagatg ccttcatctt acaccgtatt 17041 attgataatc attgctatta tggcagtact aacttggttt atccctgcgg gggcctttat 17101 agaaggtatt tacgagactc agcctcaaaa tccacaaggg atttgggatg tcctcatggc 17161 accaattcgg gctatgctag gtactcatcc agaggaaggt tcgctcatta aagaaacgag 17221 cgcagcgatt gatgtagcct tcttcatcct tatggttggt ggtttccttg gcattgtcaa 17281 caaaactggt gctcttgacg tagggattgc ctctatcgtg aagaagtata agggccgcga 17341 aaaaatgtta attttggtac taatgccttt gtttgccctc ggtggtacaa cttatggtat 17401 gggtgaagaa acaatggcct tctatccact ccttgtgcca gttatgatgg ccgttggttt 17461 tgatagcctg actggtgttg caattatttt gctcggttct caaatcggct gtttggcatc 17521 tactctgaat ccatttgcga caggtattgc ttcagcgact gcgggagttg gtacagggga 17581 cggtatcgta cttcgtctga ttttctgggt taccttgact gctcttagta cttggtttgt 17641 ttaccgttat gcggataaga ttcaaaaaga tccgactaag tcactggttt atagtactcg 17701 caaagaagat ttgaaacact ttaacgtaga agaatcttca tctgtagaat ctacacttag 17761 cagcaaacaa aaatcagttc tctttttatt tgtgttgaca ttcatcttga tggtattgag 17821 cttcattcca tggacagacc ttggcgttac catttttgat gactttaatg cttggttgac 17881 tggtcttcca gttattggta atattgtcgg ttcatctact tctgcactag gtacttggta 17941 cttcccagaa ggcgcaatgc tctttgcctt tatgggtatc ctgattggtg ttatttatgg 18001 tcttaaagaa gataagatta tctcttcctt catgaatggt gctgctgact tgctcagtgt 18061 tgccttgatc gtagcgattg ctcgtggtat tcaagttatc atgaacgacg gtatgattac 18121 cgatacaatc ctcaactggg gtaaagaagg cttgagcggt ctatcttcac aagtctttat 18181 cgttgtaact tatatcttct atctacctat gtcattcttg atcccatctt catctggtct 18241 tgccagcgca actatgggta tcatggctcc acttggagaa tttgtaaatg tccgtcctag 18301 cttgattatc actgcttatc aatctgcttc aggtgtcttg aacttgattg caccaacatc 18361 tggtattgtg atgggagctc ttgcacttgg acgtatcaac attggtactt ggtggaaatt 18421 catgggcaaa ctcgtagtcg ctattattgt agtgaccatc gcccttcttc tccttggaac 18481 cttccttcca ttcctataa //