LOCUS NC_014494:1 18293 bp DNA linear BCT 09-SEP-2013 DEFINITION Streptococcus pneumoniae AP200 chromosome, complete genome. ACCESSION NC_014494 SOURCE Streptococcus pneumoniae AP200 chromosome, complete genome. COMMENT locus start: 47049; locus end: 65341 COMMENT n1_4mer:GRV/n1_4mer:RV = 3.320863; n0_4mer:D = 32.737516; n0_4mer:PS = 54.426036 FEATURES Location/Qualifiers source 1..18293 /organism="Streptococcus pneumoniae AP200 chromosome, complete genome." gene 1..9108 /gene="" /locus_tag="" /db_xref="47049..56156" CDS 1..9108 /gene="" /product="PblB, putative" /translation="LLYLLNKDVRTVRWNGEPLHEATSAIVKETMNGDFTLTVKYPIS DSGIYQLIQEDMLIKAPTPVLGAQLFRIKKPVENNDHLEITAYHISDDVMQRSITPVS VTSQSCGMALSRMVQNTKTALGDFSFNSDIQDRRTFNTTEIETLYSVLLDGKHSIVGT WEGELVRDNFAMTVKKSRGENRGVVITTHKNLKDYQRTKNSQNVVTRIHARSTFKPEG AEKETTIRVTVDSPLINSYPYINEKEYENNNAKSVEELQKWAQAKFSNEGIDKISDAI KIEAYELDGQVVHMGDTVNLKSWKHNVDVFKKAIAYEFDALKEEYISLILDDKAGAGG SRTSGGLSSAAYAILGVTESAQEVALENALQNADLDFDHKAGLLRQEISDGIELAKAK AEEVKQELSDTINQRFNSFDNGPLKEAKRKAEEALRNAGASSSLAQESKRIGLDSVAR LEAFKSQTTSAQTALSGDLDVLKRTIANDIRPKQAQAEAEIAKQVEALSRTKNELSGA STLLAQEAKRIELDSVARLEAFKSQTTSAQTALSGDLDVLKRTIANDIRPKQAQAEAE IAKQVEALSRTKNELSGASTLLAQEAKRIELDSVARLEAFKSQTTSAQTALSGDLDVL KRTIANDIRPKQAQAEAEIAKQVKALSRTKNELSGVKSAQATYEETTTRRLSELTNLA NGKASKSELTQTAEELASRIASVQAGSSRNYFRNSRSRTFTTGGQAVYDYRTFIVPDF WKNSDRFKRDYVRISFDVTFPVALVNDMPAMVHFSAHPWYAYRNLIFKGGTVERQHFE FTIDLSSSSEDYQTNNVFIRFGTNYGFPAGLQVVIENAMLSVGNYFPAYQPAYEDQED RVSVVESNFKQRADSLDAGVSRLTEGFRTKADISSLNVTAENIRQSVKSLETDTQNKL NQKLSQAEFEVRAGSIRQEILNATKDKASKSELTQTAEELSSKIASVQASGRNLFLNS LFKQDISKTGIWTTSTYTATIDSESKYLGHKALKIIGLNPSGRDGGNPKVTYPALGQF GKVIPGSTTNQDVTISFYAKANKNGIMLRSRLGNIGYKTGNVTLSTEIKRYVVHIPKG WTNESKQTTNEWLFNFNQEGTIWIWMPKFEISDVDTSYSEAPEDIEGQISTVESTFKQ RANSLEAGVRSLTEGLRTKVDISSLNVTAENIRQSVKSLETDTQNKLNQKLSQAEFEV RAGSIRQEILNATKDKASKSELTQTAEELASRIASVHLGRRNLLKGTKELARYKPVSE YNGFKVIRTVAGATRYQDSYVERTVIPTAGTEYIAIFYARASENDYPVRCHFYNPNTV VSSENSSGYKSRSSDGLSIIRLSTDWQLCWVKWTQTATDQAKTVIIGRHGPQVGGKEG VWVEICAPAIFEGNLAGDWSPAYEDQDERVSAVESNFKQRADSLEAGVNRLTEGLRTK ADISSLNVTAENIRQSVKSLETDTQNKLNQKLSQAEFEVRAGSIRQEILNATKDKASK SELTQTAEELSSKIASVQASGRNLFLNSLFKQDISKTGIWTTSTYTATIDSESKYLGH KALKIIGLNPSGRDGGNPKVTYPALGQFGKVIPGSTTNQDVTISFYAKANKNGIMLRS RLGNIGYKTGNVTLSTEIKRYVVHIPKGWTNESKQTTNEWLFNFNQEGTIWIWMPKFE ISDVDTSYSEAPEDIEGQISTVESTFKQRANSLEAGVRSLTEGLRTKVDISSLNVTAE NIRQSVKSLETDTQNKLNQKLSQAEFEVRAGSIRQEILNATKDKASKSELTQTAEELS SKIASVQVGGINLLRNTASLLIGDRSKGCWMSASGGNGRAISVEVLDPPKKMIKNMIR VIENTNGGNKDLTQLVRLRIGEKYTISCYARIASDSPNANVNLLFRSWANNTDLNRKF QKSISHKNWQKYSFTFTADAIENSIQFGQSGAGIIEICAPKIESGTLATDYSEAPEDI EGQISTVESTFKQRANSLDAGVSRLTEGLRTKVDISALNVTAENIRQSVKSLETDTQN KLNQKLSQAEFEVRAGSIRQEILNATKDKADKTLVVSEAGKLREEFSKMKVGGRNLWI KSKTVGAVIEKLPENHVTGQKECYRLENNSTLTFNLEPDFSSRLYQKVTFSAWIKYEN VVQGRNFWNVFNCFKHYLFRKNSETGVQSGPDYATLGMYKGSADWKYITFTYDYSEKT NFDQLKTSLRFNLEGATSGTAWVTGIKVEIGSVATDWSPAPEDADGLITEAKATFERT AQGLRTDLSAIQEYVNKNGQRQEALQRYTREESTRQATAVRELVNRDFVGKATYQEDV KGINQRIEAVKTSANKDIASQIASYRQSVDGKFTDISSQITTYKQDVGGQISGLSNRL TSSEQGTTTQISNISNRINSNKQGADNQISNLKTQVATNKDNAERQMGRISDQVSANK ANADSQFANVTNQLARKVETTDFQRVKETSKLYERILGNTENGIADKVARMALTNQLF QVEVGKYSVSGPNLIKNSDFKNATNEWGSTQNLGRLVKHSFYHNGQKDLMRLSNATKN ENFLYSHRFNLERNTDYVLNFRGFNNSALASYDVYILGRRAGESDGFTIVKKVVSSKK LSTSRCEDVSVTFNSGEMDNAYIRFDNNGSSSGTADLYITEVDLYKGYKPRTWQPHPE DAVADANKKLEATQTKMTQLAGSWVVENINSAGDIISGINLGANGHNRLSGKLTHITG ETLIDRAVIKSAMVDKLKTGNFEAGSVTTTILEAEAVTAEKLKVDNALIKKLTANDAF IDQLISKRIFSIKVESVISSSTFLEAYQGRIGGFTLGQFDQGGGRWISGVNQFSVGMG NGAGHGVRTAFWANWGNNWNYAGPKAWNVNTDGKMYCRNEVGFYDQVDFSNSSRANFY GNTTFSRSPVFSNGIELGSKDVLGDGWNPKGGRNAVVWWNQVGSGSVKYWMEQKSDRR LKENITDTAVKALDKINRLRMVAFDFIENKKHEEIGLIAQEAETIVPKIVSRDPENPD GYLHIDYTALVPYLIKAIQELNQKIEKMEKTIA" gene 9202..9405 /gene="" /locus_tag="" /db_xref="56250..56453" CDS 9202..9405 /gene="" /product="hypothetical protein" /translation="MNTEQLNQALQMTISEMSTTSTDSMIASNFLSIQLNEQREENQR LQARVDELEALLDEQTKPADKGE" gene 9408..9758 /gene="" /locus_tag="" /db_xref="56456..56806" CDS 9408..9758 /gene="" /product="hypothetical protein" /translation="MAETIQNTNNLLDLTKITEPFDLASALRYMKENGEFIRCKNVSD DFYMYRDVQKRPVIVNGRRQLKDVETVWAFNQWGGTIATINVAVLLNHEFYIMKFDAE GNPDWTDPTVKPKE" gene 9768..10184 /gene="" /locus_tag="" /db_xref="56816..57232" CDS 9768..10184 /gene="" /product="hypothetical protein" /translation="MQIEFFNFLRSVVQTEDGLVLYALALIVSMEIIDFVTGTIAAII NPDIEYKSKIGINGLLRKISGVLLLMILIPASVLLPEKTGFVFLHSIYLGYIAFTFQS LIENYRKLKGNVTLFQPIVKVFQRLLEKDDDTKKGE" gene 10188..10520 /gene="" /locus_tag="" /db_xref="57236..57568" CDS 10188..10520 /gene="" /product="hypothetical protein" /translation="MQQITEIITNGAISILVILAGVVVRVVKEYLVKKGGEKTIKIVE ILAKNAVNAVEQVAAETGYKGDEKLAQARAKIRAELTKYNISMTDKDLDTFVESAVKQ MNDAWKGR" gene 10524..11480 /gene="" /locus_tag="" /db_xref="57572..58528" CDS 10524..11480 /gene="" /product="autolysin" /translation="MDIDRNRLRTGLPQVGVQPYRQVHAHSTGNRNSTAQNEADYHYR KDPELGFFSHVVGNGRVMQVGPVNNGSWDVGGGWNAESYAAVELIESHSTKEEFMTDY RLYIELLRNLADEAGLPKTLDTDDLAGIKTHEYCTNNQPNNHSDHVDPYPYLASWGIS REQFKQDIENGLSAATGWQKNGTGYWYVHSDGSYPKDKFEKINGTWYYFDGSGYMLSD RWKKHTDGNWYWFDNSGEMATGWKKIADKWYYFDVEGAMKTGWVKYKDTWYYLDAKEG AMVSNAFIQSADGTGWYYLKPDGTMADKPEFTVEPDGLITVK" gene complement(11618..11797) /gene="" /locus_tag="" /db_xref="58666..58845" CDS complement(11618..11797) /gene="" /product="hypothetical protein" /translation="MREVIQELLDSSMSTSAISQGAGVPWTTVSDLRKGKTSMDKMAL LTAEKLYEFATTDKQ" gene complement(11939..12094) /gene="" /locus_tag="" /db_xref="58987..59142" CDS complement(11939..12094) /gene="" /product="hypothetical protein" /translation="MKLNKEDWLRLLEKAIDNIPETVTAIASLVTAITVARQNKKRKP KSRQRKR" gene 12368..12835 /gene="" /locus_tag="" /db_xref="59416..59883" CDS 12368..12835 /gene="" /product="cytosine/adenosine deaminase" /translation="MYYTLEEKEVFMREALREAEIALEHDEIPIGCVIVKDGEIIGRG HNAREELQRAVMHAEIMAIEDANLSEESWRLLDCTLFVTIEPCVMCSGAIGLARIPNV VYGAKNQKFGAAGSLYNILTDERLNHRVEVEIGILEDECAAIMQDFFRNRRKK" gene 13021..13464 /gene="" /locus_tag="" /db_xref="60069..60512" CDS 13021..13464 /gene="" /product="dUTPase" /translation="MKIRGFELVSSFTDENLLPKRETAHAAGYDLKVAVRTVVAPGEI VLVPTGVKAYMQPTEVLYLYDRSSNPRKKGLVLINSVGVIDGDYYGNPGNEGHIFAQM KNITDQEVVLEVGERIVQAVFATFLIADGDAAGGVRTGGFGSTGH" gene 13466..13981 /gene="" /locus_tag="" /db_xref="60514..61029" CDS 13466..13981 /gene="" /product="fructose-2,6-bisphosphatase" /translation="MKIIFVRHGEPDYRELEERSYIGFGIDLAPLSEMGRQQVQKLSK NPLLSSAEIIVSSAVTRALETASYVVCATGLPLRVEPLLHEWQVYKTGIENFETARRL FLENKGELLPNSPIQYETATEMKSRFLECMSKYREHQTVVVVAHRMLMRQFVPNEKID FCQVIECELEI" gene 14094..15356 /gene="" /locus_tag="" /db_xref="61142..62404" CDS 14094..15356 /gene="" /product="putative ATP-dependent serine protease" /translation="VEEVEVAEVKNARVSLTGEKTKPMKLAEVTSINVNRTKTEMEEF NRVLGGGVVPGSLVLIGGDPGIGKSTLLQQVSTQLSQVGTVLYVSGEESAQQIKLRAE RLGDIDSEFYLYAETNMQSVRAEVERIQPDFLIIDSIQTIMSPEISGVQGSVSQVREV TAELMQLAKTNNIAIFIVGHVTKEGTLAGPRMLEHMVDTVLYFEGERHHTFRILRAVK NRFGSTNEIGIFEMQSGGLVEVLNPSQVFLEERLDGATGSSIVVTMEGTRPILAEVQA LVTPTMFGNAKRTTTGLDFNRASLIMAVLEKRAGLLLQNQDAYLKSAGGVKLDEPAID LAVAVAIASSYKDKPTNPQECFVGELGLTGEIRRVNRIEQRINEAAKLGFTKIYVPKN SLTGITLPKEIQVIGVTTIQEVLKKVFA" gene 15360..15926 /gene="" /locus_tag="" /db_xref="62408..62974" CDS 15360..15926 /gene="" /product="carbonic anhydrase" /translation="VTNSLKNDKIGEIFDYQIFKEGIVSYFEQFMQANQAYVALHGQL NLPLKPKTRVAIVTCMDSRLHVAQALGLALGDAHILRNAGGRVTEDMIRSLVISQQQM GTREIVVLHHTDCGAQTFENEPFQEYLKEELGVDVSDQDFLPFQDIEESVREDMQLLI ESPLIPDDVIISGAIYNVDTGSMTVVEL" gene 15951..16160 /gene="" /locus_tag="" /db_xref="62999..63208" CDS 15951..16160 /gene="" /product="hypothetical protein" /translation="MKKSSILFIFILLLCIGLQYETIYYTDGSRSGAEYGLMGISIFL ALFYMIPALYFLFRIGKNGNCQRRF" gene 16181..16765 /gene="" /locus_tag="" /db_xref="63229..63813" CDS 16181..16765 /gene="" /product="hypothetical protein" /translation="MFLSGWLSSFANTYIHDLLGVLFPDSTFLNAFESAIVAPLVEEP LKLLPLVFVLALIPVRKLKSLFLLGIASGLGFQMIEDIGYIRTDLPEGFDFTISRILE RIISGIASHWTFSGLAVVGVYLLYRAYKGQKVGKKQGLIFLGLALGTHFLFNSPFVEL ETELPLAIPVVTAIALYGFYHAYCFVEKHNELMT" gene 16910..17878 /gene="" /locus_tag="" /db_xref="63958..64926" CDS 16910..17878 /gene="" /product="phosphoribosylpyrophosphate synthetase" /translation="MSFSDLKLFALSSNKELAERVAQEIGIELGKSSVRQFSDGEIQV NIEESIRGKHVFILQSTSSPVNDNLLEILIMVDALKRASAESVNVVMPYYGYARQDRK ARAREPITSKLVANMLEVAGVDRLLTIDLHAAQIQGFFDIPVDHLMGAPLIADYFERR GMVGSDYVVVSPDHGGVTRARKLAEFLKTSIAIIDKRRSVDKMNTSEVMNIIGKVEGK TCILIDDMIDTAGTICHAADALAEAGAVEVYASCTHPVLSGPATDNIQKSAIKKLVVL DTIYLPEERLIDKIEQISIAHLLGDAIVRIHEKRPLSPLFDIEKKI" gene complement(17814..18293) /gene="" /locus_tag="" /db_xref="64862..65341" CDS complement(17814..18293) /gene="" /product="transposase-like protein" /translation="MEQLHFITKLLDIKDPNVQILNIINKDTHKEIIAKLDYDAPSCP ECGNQLKKYDFQKPSKIPYLETTGIPTRILLRKRRFKCYHCSKMMVAETSDDVQSYFF SFYYITVLNLALLDSPLLSIYSEKRRKNLRIISGLVIKFFSQYRKVEKVVVFHEYVR" ORIGIN 1 ttgctttatc tacttaataa agatgtaaga accgttcgat ggaacgggga gccacttcat 61 gaagcgactt cggcgattgt gaaagaaact atgaatggcg attttacctt gactgtgaaa 121 tatcctattt ctgattctgg tatttaccag ctcatccaag aagatatgct gataaaggct 181 ccgactcctg tcttaggagc gcagctattt cgtatcaaga aacctgttga gaacaatgac 241 catctggaaa ttacagccta tcacatttca gatgatgtga tgcaacgttc tataacacca 301 gtaagtgtga ctagtcagag ctgtggcatg gctctttctc gcatggttca aaacaccaaa 361 accgctttgg gagatttttc tttcaatagc gatatccagg accgtaggac cttcaatacg 421 actgaaatag aaactctgta ctctgtattg ctggacggta agcacagcat tgttggtaca 481 tgggaaggcg agctggttcg tgataacttt gcgatgactg taaagaagag tcgtggtgag 541 aatcgtggtg ttgttattac aacacataag aatctgaagg actaccaacg aaccaaaaac 601 agtcaaaatg ttgttacaag gattcatgct cgatccacat ttaagcctga aggtgctgaa 661 aaggaaacaa ctatcagagt gactgttgat agtcctctta ttaattctta tccttacata 721 aacgaaaaag agtatgagaa caacaacgca aaatccgttg aagagttgca gaagtgggca 781 caggctaagt tctcaaatga gggcattgac aagatctctg acgctatcaa gattgaagct 841 tatgaacttg atgggcaagt tgttcacatg ggtgatacgg tcaatctcaa gagctggaaa 901 cataatgttg atgtatttaa gaaagctatt gcttatgagt tcgatgcctt aaaagaagaa 961 tatatctctc tgattctcga tgataaggca ggagctggtg gttctagaac atctggtggc 1021 ttatctagcg cagcgtatgc cattcttgga gtaacagaat ctgcacaaga agttgccctt 1081 gaaaatgctc ttcaaaatgc tgacttagac tttgatcata aggctggatt gcttagacag 1141 gaaatttctg acggcatcga acttgccaag gccaaggcgg aagaagtcaa gcaagaactg 1201 tctgacacta tcaatcagcg ctttaatagc tttgacaacg ggccattgaa agaagctaag 1261 cgcaaggctg aggaagcttt gcgaaatgct ggcgcaagta gttctcttgc tcaggaatcc 1321 aagcggattg ggctggattc tgttgctaga cttgaagcgt ttaagtcgca gactacgagc 1381 gctcagacgg ctttgtcagg tgacttggat gttctaaaac gaactatcgc aaacgatatt 1441 cgaccgaagc aagcacaggc tgaagctgag attgccaagc aagttgaagc acttagccgg 1501 actaagaatg aactgtctgg cgcaagtacc ctacttgcac aggaagctaa gcggattgag 1561 ctggattctg ttgctagact tgaagcgttt aagtcgcaga ctacgagcgc tcagacggct 1621 ttgtcaggtg acttggatgt tctaaaacga actatcgcaa acgatattcg accgaagcaa 1681 gcacaggctg aagctgagat tgccaagcaa gttgaagcac ttagccggac taagaatgaa 1741 ctgtctggcg caagtaccct acttgcacag gaagctaagc ggattgagct ggattctgtt 1801 gctagacttg aagcgtttaa gtcgcagact acgagcgctc agacggcttt gtcaggtgac 1861 ttggatgttc taaaacgaac tatcgcaaac gatattcgac cgaagcaagc acaggctgaa 1921 gctgagattg ccaagcaagt taaagcactt agccggacta agaatgaact gtctggcgtg 1981 aagtcagcgc aagcgacgta tgaggagacg acgactcgta gactgtcaga actgaccaac 2041 ttggccaatg gtaaagccag caagtcagaa cttacgcaaa cagctgagga gctggctagt 2101 cggattgcga gtgtgcaggc aggtagttca cggaattact tcaggaattc acgttcaaga 2161 acgttcacaa caggaggtca agcggtatac gactatcgaa cattcatagt tcctgatttc 2221 tggaagaaca gtgacaggtt caagcgtgat tatgttcgca tatcttttga tgtgactttc 2281 cctgtcgccc tagtaaatga catgcctgct atggtgcatt ttagtgctca tccatggtat 2341 gcctacagaa acttaatttt taaaggtgga actgtcgaac gccaacattt tgagtttacg 2401 attgacttgt ctagttcttc tgaggactat cagactaata atgtgttcat tcgttttggt 2461 actaattatg gatttcctgc tggtctgcag gtcgtcattg agaacgctat gttatcggtt 2521 ggtaattatt ttccagccta tcaaccagcg tatgaagacc aagaagaccg tgtctcagta 2581 gtcgaatcca actttaagca gcgtgctgat tcactcgacg ctggtgtaag ccgtctgact 2641 gaagggttta gaactaaagc cgatatcagc tcactcaatg tgactgctga aaatatccgg 2701 caatctgtga agagccttga gacagatacg cagaacaagc taaatcagaa gttgagtcag 2761 gctgaatttg aggtgcgagc cggctctatc cgtcaggaaa tcctgaacgc aaccaaggat 2821 aaagccagca agtcagaact cacgcagaca gctgaggagc tctctagtaa gatagcgagt 2881 gtgcaggcat ccggtcgaaa tctattcttg aactcactat tcaagcagga tatttcaaaa 2941 acaggaattt ggacaacgag tacatatacg gctactatcg atagcgaaag taagtatctt 3001 ggacacaagg ctcttaaaat tataggtctg aatccatctg gccgtgatgg agggaatccc 3061 aaggttactt atccagctct gggtcaattc gggaaagtaa ttcccggaag tacgactaat 3121 caagatgtaa ccattagttt ttatgctaag gcaaataaaa atggaataat gctaagatct 3181 cgattaggga atatcggata taaaactgga aatgtgacat tgtcgacaga aattaagcga 3241 tatgttgtcc atattccaaa aggttggaca aacgaatcca agcagaccac aaatgaatgg 3301 ttgttcaatt tcaaccaaga aggaaccatt tggatttgga tgccgaagtt tgaaataagc 3361 gatgtagata cttcttattc agaagctcct gaagatatag aaggtcagat ttcaacagta 3421 gaatcgacct ttaaacaacg agccaactcg ctcgaagctg gtgtgagaag cttgactgaa 3481 gggcttagaa ccaaagtgga tatcagctca ctcaatgtga ctgctgagaa tatccggcaa 3541 tctgtgaaga gccttgagac agacacgcag aacaaactaa atcagaagtt gagtcaggct 3601 gaatttgagg tgcgagctgg ctctatccgt caggaaatcc tgaacgcaac caaagataaa 3661 gccagcaagt cagaacttac gcagacagct gaggagctag ctagtcggat tgcgagtgtg 3721 cacttagggc gcagaaatct gctgaaaggc acaaaagagc ttgcgagata caagccggtt 3781 agtgaatata atggttttaa agttatcaga acagtcgcag gagcaactag atatcaggat 3841 agctatgtgg aaagaaccgt tataccaacg gctgggacag agtatatagc tatcttttat 3901 gcacgagcca gtgaaaatga ctatcctgtg cgctgtcatt tttacaatcc taacacggtt 3961 gtatcatcag aaaacagcag cggatataag tcaaggtcgt cagatggctt gtctattatc 4021 cgtctctcga cagactggca gttgtgctgg gttaaatgga cccaaaccgc aacagatcaa 4081 gccaagacgg tcatcattgg ccgccatggc cctcaagtag gcggtaaaga gggggtatgg 4141 gttgaaatct gcgcccctgc catttttgag ggaaatcttg caggtgactg gtcaccagca 4201 tacgaagacc aagacgaacg tgtctcagcg gtcgaatcca actttaaaca gcgtgctgat 4261 tcactcgaag ctggtgtgaa tcgtctgact gaaggcctta gaactaaagc cgatatcagc 4321 tcactcaatg tgactgctga aaatatccgg caatctgtga agagccttga gacagatacg 4381 cagaacaagc taaatcagaa gttgagtcag gctgaatttg aggtgcgagc cggctctatc 4441 cgtcaggaaa tcctgaacgc aaccaaggat aaagccagca agtcagaact cacgcagaca 4501 gctgaggagc tctctagtaa gatagcgagt gtgcaggcat ccggtcgaaa tctattcttg 4561 aactcactat tcaagcagga tatttcaaaa acaggaattt ggacaacgag tacatatacg 4621 gctactatcg atagcgaaag taagtatctt ggacacaagg ctcttaaaat tataggtctg 4681 aatccatctg gccgtgatgg agggaatccc aaggttactt atccagctct gggtcaattc 4741 gggaaagtaa ttcccggaag tacgactaat caagatgtaa ccattagttt ttatgctaag 4801 gcaaataaaa atggaataat gctaagatct cgattaggga atatcggata taaaactgga 4861 aatgtgacat tgtcgacaga aattaagcga tatgttgtcc atattccaaa aggttggaca 4921 aacgaatcca agcagaccac aaatgaatgg ttgttcaatt tcaaccaaga aggaaccatt 4981 tggatttgga tgccgaagtt tgaaataagc gatgtagata cttcttattc agaagctcct 5041 gaagatatag aaggtcagat ttcaacagta gaatcgacct ttaaacaacg agccaactcg 5101 ctcgaagctg gtgtgagaag cttgactgaa gggcttagaa ccaaagtgga tatcagctca 5161 ctcaatgtga ctgctgagaa tatccggcaa tctgtgaaga gccttgagac agacacgcag 5221 aacaagctaa atcagaagtt gagtcaggct gaatttgagg tgcgagctgg ctctatccgt 5281 caggaaatcc tgaatgcaac caaggataaa gccagcaagt cagaacttac gcagacagct 5341 gaggagctct ctagtaagat agcgagtgtg caggtcggag gaatcaacct cttgcgtaat 5401 actgcgagtt tgttgattgg cgatcgttca aaaggatgtt ggatgagtgc aagcggagga 5461 aatgggcgag cgattagcgt agaagttttg gatcctccca aaaaaatgat aaaaaacatg 5521 attcgtgtta ttgaaaatac gaatggtgga aataaagatt taactcaact tgttagattg 5581 cgaattggtg aaaagtacac gatttcttgt tatgcaagga ttgctagcga tagcccaaat 5641 gcaaacgtga acttgctatt tcgttcgtgg gcaaataata ccgatttaaa tcgcaaattt 5701 cagaaatcca tctctcataa aaattggcaa aaatattcat ttacatttac tgctgatgca 5761 attgaaaatt caattcaatt tggacaatct ggcgcaggaa ttatcgaaat atgcgctccg 5821 aaaatcgaat caggaacgtt agcgactgat tacagcgaag ctcctgaaga tatagaaggt 5881 cagatttcaa cagttgaatc gaccttcaaa caacgagcca actcactcga cgctggtgta 5941 agccgtctga ctgaaggcct tagaactaaa gtggatatca gcgcactcaa cgtgactgct 6001 gagaatatcc ggcaatctgt gaagagtctt gagacagaca cgcagaacaa gctaaatcag 6061 aagttgagtc aggctgaatt tgaggtgcga gctggctcta tccgtcagga aatcctgaat 6121 gcaaccaagg acaaggcaga taagacttta gttgtatctg aagctgggaa attgcgtgaa 6181 gaattttcaa aaatgaaggt gggaggacgg aatctatgga taaaatccaa gacggttgga 6241 gctgtaattg aaaaattacc tgaaaaccac gtcacaggtc aaaaagaatg ctataggcta 6301 gagaacaact ctactttaac gttcaacctt gaaccagatt tcagctcaag gttgtatcaa 6361 aaagttactt ttagcgcttg gatcaagtac gaaaatgtag ttcaaggtcg aaatttttgg 6421 aatgtattta attgcttcaa acattatctt tttagaaaaa atagtgagac cggagtacag 6481 agtggtccag attatgctac gcttggtatg tataaaggtt cggcagattg gaaatatatt 6541 acattcactt atgactactc tgaaaaaaca aattttgatc aattgaagac atcattgcga 6601 ttcaatcttg aaggtgctac aagcggtaca gcttgggtaa caggaatcaa ggttgaaatc 6661 ggtagtgtgg cgacggactg gagtcctgcg cctgaggacg ctgatggtct catcactgag 6721 gctaaggcta cctttgagcg gacagctcag ggcttgcgaa ccgatttatc agctattcag 6781 gaatatgtaa ataaaaacgg tcagcgacag gaagccctac agcgctatac tcgtgaggag 6841 agcacgagac aagcgacagc agtccgtgag ctggtcaatc gtgatttcgt tggtaaggct 6901 acttatcaag aagatgttaa gggtatcaat caaaggattg aagctgttaa aactagtgcg 6961 aataaagaca tcgctagtca aatcgctagc tatcgtcaat ctgtagatgg taagttcacg 7021 gatatttcaa gtcagataac tacttataag caagatgtgg gcggtcaaat cagtggtcta 7081 tcaaatagac ttacaagcag tgagcaagga accactactc agatttcaaa tatttcaaat 7141 cggataaaca gtaataaaca aggcgcagat aatcagattt caaatttaaa gactcaggtc 7201 gctacaaaca aggataatgc tgaacgacaa atgggtagaa tatctgatca ggtttctgca 7261 aacaaagcga atgctgatag tcaatttgcg aatgtgacca atcaactagc gcgaaaagta 7321 gagactactg acttccagcg tgttaaggaa accagtaaac tttacgagcg gattttgggc 7381 aatactgaaa atggaattgc ggataaggtt gctcgcatgg ctctgaccaa tcaactgttt 7441 caggttgagg ttgggaaata tagtgtaagc ggccctaacc tcattaagaa tagtgatttt 7501 aaaaatgcta cgaatgaatg gggctcaact caaaatttag gaagattggt taagcatagc 7561 ttttatcaca acgggcagaa agaccttatg cgtttaagta atgcaactaa aaacgaaaac 7621 tttttgtata gtcaccgttt taatcttgaa cgaaatactg actatgtact gaattttaga 7681 ggatttaaca acagtgctct agcaagctat gatgtttata ttttgggacg aagagcaggc 7741 gagagcgatg gattcacaat cgttaagaaa gttgttagca gcaagaaact atctacctct 7801 agatgcgaag atgtctcagt aacttttaat tccggagaaa tggataatgc ttacattcgt 7861 tttgataaca atggctcatc atcaggaaca gctgatttgt atattacaga agttgacttg 7921 tacaaaggtt ataaacctag aacatggcaa ccacatccag aagatgcagt cgcagatgcg 7981 aataagaagc ttgaagcaac gcaaacaaaa atgactcaac tagctggctc atgggtagtt 8041 gaaaacatca actcggctgg agatatcatc tctggaatca atcttggcgc caatggtcat 8101 aatcggcttt ctgggaaatt aacccatata acaggcgaga ccctgattga cagagcagtc 8161 atcaagtctg ccatggttga taagctgaaa acgggcaatt ttgaagctgg ttcggtcacg 8221 actacgatat tagaagctga agcggtaact gctgagaagt tgaaagttga caatgcgctt 8281 attaaaaaat taactgcaaa tgatgctttt attgaccaac tgatatctaa acgtatcttc 8341 tctattaagg ttgagtccgt catttctagc tcaaccttcc tagaagccta tcaaggccga 8401 attggtggat tcacacttgg tcaatttgac cagggtggcg gtcgctggat ttcaggtgtc 8461 aatcagttct ctgttggtat ggggaatggt gccgggcatg gagtccggac agccttctgg 8521 gcgaactggg gaaataattg gaactatgcc ggacctaaag catggaacgt caatactgat 8581 gggaaaatgt actgtaggaa tgaagtcggt ttttatgatc aagtggattt ttcgaattca 8641 tcgagagcaa acttctatgg gaatactact ttttctcgtt ctcctgtgtt ttcaaatggt 8701 atcgaacttg gaagtaaaga tgttcttggt gatggttgga atcccaaagg cggaaggaat 8761 gcggttgttt ggtggaatca ggtcggtagc ggtagcgtga agtattggat ggaacaaaaa 8821 tcagacagac gcttaaaaga gaacatcaca gatacagctg tgaaagcctt ggacaaaatc 8881 aacagattaa gaatggttgc atttgatttc atcgaaaata agaaacatga ggagattggt 8941 ctaatagctc aagaggctga aaccatcgtt ccaaaaattg tctcacgaga tcctgagaat 9001 ccagatggct atctgcatat cgactatacc gctttagttc cttacttaat caaggctatt 9061 caagaattaa atcaaaaaat agaaaaaatg gagaaaacaa tagcatgaat aacaacatgt 9121 tgaccaatat cgcacttaaa gcaattcagg agcttgctct tgaaaataga aaacgaacac 9181 acagattgga gaacttagaa aatgaacaca gaacagctta accaagcctt acaaatgaca 9241 attagtgaaa tgtcaacaac ttcaacagat tcgatgattg caagtaattt cttgagtatt 9301 cagttgaatg agcaaaggga agagaatcaa agacttcaag cacgagtgga tgagctggaa 9361 gctctgcttg atgaacaaac taaaccagca gacaaaggag aatagacatg gcagaaacaa 9421 ttcaaaacac aaataactta ctagacctta caaaaatcac agaaccattt gatcttgcga 9481 gcgctttgcg ctacatgaaa gaaaatggag aattcattcg ttgcaagaat gtaagcgatg 9541 acttctatat gtatcgtgat gttcaaaaac gtcctgtgat cgtaaatggc cgtcgccaac 9601 tcaaggatgt tgaaaccgtt tgggcgttca accagtgggg tggtacaatc gcaacaatca 9661 acgtcgccgt tctgttgaat catgaattct atatcatgaa atttgatgca gagggcaatc 9721 ctgactggac ggatccaacg gtaaaaccta aagaatagga ggtgtgtatg caaattgaat 9781 ttttcaattt tctaagaagt gtcgtacaga ctgaagatgg tttggtcttg tacgctctag 9841 cactgattgt ctcaatggaa atcattgatt ttgtgacagg gacgattgcg gcgattatca 9901 atcctgacat cgagtacaag agcaaaatcg gcattaacgg gctccttcgt aagatttcag 9961 gggttctctt actgatgatc ctcattccgg cgtccgtttt gttgcctgaa aagacaggtt 10021 ttgtattctt gcactcaatc tatctcgggt acatcgcatt tacttttcaa tctctcattg 10081 aaaattaccg caaattaaaa ggaaatgtta ctctttttca gccgattgta aaagtatttc 10141 agcgattact tgaaaaagat gatgatacga aaaaaggaga ataacaaatg caacaaatta 10201 ctgaaatcat tactaatgga gcaatcagca tcctagtcat tttggcaggg gtggtagtta 10261 gggtagtcaa ggaatacctc gtcaaaaaag gtggagaaaa gactatcaag attgttgaaa 10321 tcttggccaa gaacgcagtt aatgccgtgg agcaggtagc tgctgaaact ggctacaagg 10381 gagatgaaaa actggcacag gcccgcgcta aaattcgtgc tgagctgacc aaatataata 10441 tcagtatgac tgacaaagac ttagacacct tcgtagagtc agcagtgaag cagatgaatg 10501 acgcatggaa aggacgatag ggaatggata tcgatagaaa cagactacgt acaggcttgc 10561 cacaggttgg ggtgcagcct tatcgacaag tacatgctca ctcaacaggc aaccgtaact 10621 caaccgctca aaatgaagct gattaccact atagaaagga ccctgaacta gggttctttt 10681 cacatgttgt cggaaacggc cgtgtcatgc aagtaggtcc tgtgaacaac ggaagttggg 10741 atgttggggg cggttggaat gctgagagtt acgcagcggt tgaactgatt gaaagccatt 10801 caactaaaga agagttcatg acggactacc gcctctatat cgaattgcta cgcaatctag 10861 cggacgaagc aggcttgccg aagactcttg atacagacga cttggcaggt atcaagacgc 10921 atgaatactg taccaataac caaccaaaca accactcaga ccacgttgac ccttatccat 10981 atcttgcaag ttggggcatt agccgtgagc agtttaagca agacatcgaa aacggcttga 11041 gcgctgcaac aggctggcag aaaaatggca ctggctactg gtacgtacac tcagacggct 11101 cttatccaaa agataagttt gagaaaatca acggtacctg gtattatttc gatggctcag 11161 gctatatgct ttcagaccgc tggaagaagc acacagacgg caactggtac tggttcgaca 11221 actcaggcga aatggctaca ggctggaaga aaatcgctga caagtggtac tattttgatg 11281 tagaaggtgc catgaagaca ggctgggtca agtacaagga cacttggtac tacttagacg 11341 ctaaagaagg tgctatggta tcaaatgcct ttatccagtc agcagacgga acaggctggt 11401 actacctcaa accagacgga acgatggcag ataaaccaga gttcacagta gagccagatg 11461 gcttgattac agtaaaataa atagaaagga aactttctaa attgttcttt caccgcaggc 11521 tcaggcttgc ggttttttat ttgctctgat ttttcaaaaa agtgcttact tgaagaatag 11581 ggaggtgttt tgtcaaaaat aaaaacagtg accgaaatca ctgcttatca gttgtagcaa 11641 attcataaag tttttctgct gtgagaagtg ccattttgtc catgcttgtt tttccttttc 11701 tgaggtcaga aacagtagtc catggaactc cagcaccttg ggaaatagca gatgtagaca 11761 tcgaactgtc taacaattct tgaataactt ctctcatctt atttgtcctt tttatttttt 11821 agataaatat atacattgat tgcaattata aaaatagcta ttgcactaac cattgcattt 11881 cctctttcca tttgataaaa tagaggtgta aggggctttc gccccaacct cttagcgttt 11941 acctttttct ttgacgggat ttcggtttac gctttttgtt ttgccttgcg accgttattg 12001 cggtcactag acttgcgata gcagttaccg tttcaggaat attgtctatt gccttttcaa 12061 gtaacctgag ccaatcttct ttgttcaact tcatcacccc ctttccttat cttgattata 12121 ttatatcacg gtacaccgag aaagtcaagc gttttgatga agttttttta attttttcaa 12181 aaaaaataga ccttgtccag aggtcgggga gttggagggg gcaccctcca aaagcattga 12241 tttaataagg ttttatttta cctttttcat aataatctcc ctatagagtc accgcattcg 12301 gtggcttttt ttgtgttggg attcatgata taataataaa atcgataagt aggaaaagag 12361 aaaagagatg tattatacgc ttgaagaaaa agaagtcttt atgagggagg ctttgagaga 12421 ggctgagatt gctcttgaac acgatgaaat tccaattggt tgtgtgattg tcaaagatgg 12481 ggaaatcatt ggtcgtgggc ataatgcgcg tgaggaatta cagcgagcgg ttatgcatgc 12541 ggaaattatg gctatagagg atgcgaactt gagtgaggag agctggcgct tgctggattg 12601 cacacttttt gtgaccattg aaccttgtgt catgtgtagt ggagcgattg ggcttgcccg 12661 cattccaaat gtggtctatg gggctaaaaa ccagaaattt ggcgctgctg ggagtttgta 12721 caatatcttg acagatgagc gtctcaatca tcgtgtggag gttgaaatag gaattttgga 12781 agatgaatgc gcagctatca tgcaggattt ttttagaaat agacggaaaa aataattttg 12841 cttttaaaat gaataggaat gtgatataat aaatagtgga gcaacagttc tgcgtgaagc 12901 gggtcagggg aggaatccag cagccctaag cgatttgaat tgtgtgctct tttttcgtgc 12961 tttttccgaa taaataagat agaataatct agaataaatg ataatagaaa agagaaaatt 13021 atgaaaattc gtggttttga attggtttca agttttacag atgaaaattt attgcccaag 13081 cgtgagacag cgcatgcggc tggttacgac ttaaaggttg ctgtgcgtac agttgttgcg 13141 ccaggagaga ttgtcttggt tccgacaggg gttaaggctt atatgcagcc gactgaggtt 13201 ctctacctct atgatcgttc ttcaaatcct cgtaagaagg gcttggtttt aattaactca 13261 gttggggtca ttgatgggga ttattatgga aatcctggaa atgaagggca tatttttgcg 13321 cagatgaaga atatcacaga ccaagaggtt gttcttgaag ttggggaacg tattgtccag 13381 gctgtttttg ctactttctt aattgcagat ggagatgcag ctggtggcgt tcgaactggt 13441 ggatttggat cgacagggca ctagaatgaa gattatcttt gtacgtcatg gggagccaga 13501 ttaccgtgag ttagaggagc gttcttatat aggatttggg atagatttgg cacccttgtc 13561 tgagatggga cggcagcaag tccagaaatt gagcaaaaat cctttactct cgtcagctga 13621 aataatcgta tcttctgcag tcacaagagc tttagaaacg gcttcgtatg tggtctgtgc 13681 tacgggtctt cctttaagag tagagccttt attacatgaa tggcaggtct ataaaacagg 13741 aatagaaaac tttgaaacag ctagaagact gtttttagaa aacaaggggg agttgcttcc 13801 taatagtcct attcaatatg agacagctac ggaaatgaag tctcggtttc tagaatgtat 13861 gtctaagtat cgagaacatc agactgtggt agttgttgct catcgaatgc tcatgcgcca 13921 gtttgtgcca aatgagaaga ttgatttttg ccaagtgatt gagtgtgagt tagagatata 13981 ggaagaggtt tgtcatcgca aagaaaaaag cgacatttgt atgtcaaaat tgtgggtata 14041 attcccctaa atatctggga cgttgcccca actgtggatc ttggtcttct tttgtggaag 14101 aggttgaggt tgccgaggtc aagaatgcgc gtgtgtcctt gacaggtgag aaaaccaagc 14161 ccatgaaact agctgaggtg acttccatca atgtcaatcg aaccaagacg gagatggagg 14221 aattcaaccg tgtgcttgga ggcggagtgg taccaggaag tctcgtcctc atcggtgggg 14281 atcctgggat tgggaaatca actcttctcc aacaagtctc aacccagttg tcccaagtgg 14341 ggacagttct ctatgtcagt ggggaggagt ctgcccagca gattaaacta cgtgcagagc 14401 gcttaggtga tattgatagt gagttttatc tctatgcaga gaccaatatg cagagtgttc 14461 gtgcagaagt ggagcgtatc cagccagact ttcttattat tgattccatc cagaccatca 14521 tgtctcctga gatttcaggg gtgcaggggt ctgtttctca ggtacgtgaa gtgaccgctg 14581 aactcatgca gttggccaag accaataaca ttgccatctt tatcgtaggt catgtgacca 14641 aagaaggaac cttggctggg cctcgtatgt tggagcatat ggtggatacg gtgctttact 14701 ttgaagggga gcgtcaccac acctttcgta ttttgagagc ggtcaaaaat cgttttggtt 14761 ccactaatga gattgggatt tttgagatgc agtcgggcgg cttggttgag gtactcaatc 14821 cgagtcaagt tttcctagaa gagcgtttgg atggggcgac tggttcctcc atcgttgtaa 14881 ccatggaagg gacgcgtccg attttggcgg aggttcaggc tttagtaaca ccgaccatgt 14941 ttggaaatgc caagcgtact acgacaggac ttgattttaa ccgtgctagc ttgattatgg 15001 ctgttttgga aaaacgggca gggcttctct tgcaaaatca ggatgcctat ctcaaatctg 15061 ctggtggtgt taaattggat gaacctgcca ttgacttggc tgttgcagtt gctattgctt 15121 cgagctacaa agacaaacca actaatcctc aggaatgttt tgtcggagaa ctgggcttga 15181 caggagagat tcggcgcgtg aatcgtattg agcaacgcat caacgaagct gctaaactgg 15241 gctttactaa gatttatgta cctaagaatt ccttgacagg aatcactctg cctaaggaaa 15301 ttcaggtcat tggcgtgaca acgattcagg aagttttgaa aaaggtcttt gcataatccg 15361 tgacaaattc tcttaaaaat gataagatag gagaaatatt tgactatcaa attttcaagg 15421 agggaatcgt gtcgtatttt gaacagttta tgcaagccaa tcaggcttat gttgccctac 15481 atgggcagtt aaatctgcca cttaaaccca aaacaagagt agctattgtg acctgtatgg 15541 actctcgtct gcacgttgcg caagctctgg gcttggcact tggggatgct catatcttgc 15601 ggaatgcagg tggtcgagtg actgaagaca tgattcgttc gctagttatt tcccagcaac 15661 aaatggggac aagagagatt gtggtattgc accatacaga ctgtggtgct cagacctttg 15721 aaaatgaacc ttttcaggag tatttaaaag aggaattagg tgtagatgtg tcagaccagg 15781 acttcttgcc cttccaagat atagaagaga gtgtacgcga ggatatgcaa ctgcttatcg 15841 agtctcccct aataccagac gatgtcatta tctctggtgc tatttacaat gttgatacag 15901 gaagtatgac agtcgtagaa ttataaatac ttcatttaga aagaaagtgt atgaagaaaa 15961 gcagtatttt atttattttt attttattgc tatgtattgg tttacagtat gaaaccatct 16021 actatacgga cggttcgagg tcaggtgcgg aatatggact aatgggaatt tctatctttc 16081 tagctctctt ttacatgatt ccggctcttt attttctctt ccgtattggg aaaaatggga 16141 attgccaaag aaggttttga ttctgtcttt attgggaggg atgttccttt caggatggtt 16201 gtctagtttt gctaatactt atatccatga tttactgggg gttcttttcc cagatagtac 16261 atttttaaat gcctttgaaa gtgctattgt ggctcctttg gtagaagaac ccttgaaatt 16321 attgccactt gtttttgttt tggctttgat tcctgtgcga aaattaaaat ctttgttttt 16381 acttggaatt gcttccggtt tgggattcca aatgattgag gatattggtt atattcgtac 16441 ggatttgcca gagggctttg actttactat ttcgcgaatt ttagagcgta tcatctcagg 16501 aattgcctct cactggactt tttcaggtct agctgtagta ggtgtttact tgctttacag 16561 agcctataaa ggacagaagg ttggcaagaa acagggactt atttttctag gtttagcctt 16621 gggaactcac ttcttgttta actctccttt tgtggagttg gaaacagagt tgcctttagc 16681 gattccagtg gttacggcta ttgctctcta tggtttttat catgcttatt gctttgttga 16741 gaaacacaat gagttgatga cctagaatat ttttcaaaag aatgatgcaa gggtacaaat 16801 atggtgccct tcttttattt ttgattgaaa aatagtgcaa aaagcgctac aatggtagat 16861 ggaaaatctt gtgaaaagca caagttatac atatataccg gaggaaatca tgtctttttc 16921 tgatttaaag ctgtttgccc tttcttctaa taaagaattg gcagaacgtg tggcgcagga 16981 gattgggata gagttgggga aatcaagtgt tcgccaattt tcagatggag agattcaggt 17041 caacattgaa gaatcaatcc gtgggaaaca cgtctttatc ttacaatcaa ctagttcgcc 17101 tgtaaatgac aatctgcttg aaattttgat tatggtagat gctttgaagc gtgcgagtgc 17161 agaatctgtt aatgttgtca tgccttacta tgggtatgca cgtcaggata gaaaggcgag 17221 agcgcgtgag ccaatcactt caaaacttgt cgcaaatatg cttgaagtag ctggagtgga 17281 tcgtttattg accatcgact tgcatgctgc gcaaattcaa ggattctttg atattcctgt 17341 ggatcatttg atgggtgctc ctctgattgc agattatttt gagcgtcgtg gtatggttgg 17401 ttctgactat gtggttgtca gcccggacca tggaggggtg actcgtgctc gtaagttggc 17461 agaatttttg aaaacatcta tcgctattat tgataaacgt cgtagcgttg ataagatgaa 17521 tactagtgaa gttatgaaca tcatcggtaa ggttgaaggc aagacttgta tcttgattga 17581 tgatatgatt gataccgctg gaacgatttg tcatgcggca gatgctcttg cggaagctgg 17641 tgctgttgaa gtctatgcaa gctgtacgca cccagttctt tctggtcctg ctacggacaa 17701 tatccaaaaa tcagctatta agaaattggt tgttttggat accatctatc tgccagaaga 17761 gcgtttgatt gataagattg agcagatttc aatcgctcat ctcctagggg atgctatcgt 17821 acgtattcat gaaaaacgac cactttctcc acttttcgat attgagaaaa aaatttaatg 17881 accaagcctg agatgattct caggtttttt cgtctttttt ccgaataaat agatagtagc 17941 ggtgaatcta gtaaagctag atttaaaact gtgatataat aaaaagagaa gaaatatgac 18001 tgtacgtcat cagaagtttc agcgaccatc atttttgaac agtgatagca cttgaatcga 18061 cgctttctaa ggagaattct agtaggtata ccagtcgttt caagataagg aattttagaa 18121 ggtttttgaa agtcatattt cttcaattgg tttccgcact cagggcaaga tggggcgtcg 18181 tagtccagtt tggcgatgat ttccttgtgt gtatccttat tgatgatgtt taaaatctgg 18241 acattagggt ctttaatgtc tagtaatttt gtgataaaat gtaattgttc cat //