LOCUS NC_014122:8 18271 bp DNA linear BCT 09-OCT-2011 DEFINITION Methanocaldococcus infernus ME chromosome, complete genome. ACCESSION NC_014122 SOURCE Methanocaldococcus infernus ME chromosome, complete genome. COMMENT locus start: 665684; locus end: 683954 FEATURES Location/Qualifiers source 1..18271 /organism="Methanocaldococcus infernus ME chromosome, complete genome." gene -725..9 /gene="" /locus_tag="" /db_xref="664959..665693" CDS -725..9 /gene="" /product="geranylgeranylglyceryl phosphate synthase" /translation="MKVEERINKIIEEDGSAYFILLDPEENIIDIAEQVYSYVDAFLV GGSIGISNLDEKVKELRKFKKPIILFPGNVDGLTRYADAVLYMSLMNSLNPYWIVTAP TLGALKILEYKLEPIPTAYLCIEPAKKTSVGFVGDIKEIPRDKPKIAALYCLSAKFFG MRWAYLEAGSGAEKPVSDEMIKLCKKLSGINLIVGGGIKKPEIAYNKVLAGADVIVTG NILEKDTNLAEKFYDSIKKAGREKWK" gene 0..719 /gene="" /locus_tag="" /db_xref="665684..666403" CDS 0..719 /gene="" /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /translation="MEIIPAVDIKEGRCVQLVQGDPNKKLLEIEDPVEVAKRWVNKGA NYLHLIDLDAALGEGDNLEVIKRIVEEVNVPVEVGGGIRDIERALELIELGVDRIIVG TKAITDSKFLDELNGYIEKDRIVLAVESKEGKVVIKGWKEKLNLKPIDVIEKFKDKVG YILYTNVDVEGLMKGIKIEEIKNLIKNSPLPVIYSGGVTKIDDIITLKELGAYGVVIG SALYKGKISLREALKVLENEG" gene 709..1035 /gene="" /locus_tag="" /db_xref="666393..666719" CDS 709..1035 /gene="" /product="protein of unknown function DUF192" /translation="MKVKIKDLEFEVELADNFIKRAFGLMLRDIKDKAMLFKYGKRKV RVHTYFMLYPIDILFIYNNKVVDAVRLKPWKGYKSKVYSNMMLEFKSLEDRDVKEFIG EEVIFK" gene complement(1028..2374) /gene="" /locus_tag="" /db_xref="666712..668058" CDS complement(1028..2374) /gene="" /product="RNA-metabolising metallo-beta-lactamase" /translation="MKLEIVAIGGYEEVGRNMTAINVDGEIIIMDMGVRLDRVLIHED TDISKLHSLELIEKGIIPNDTVMKNIEGEVKAIVLSHGHLDHIGAVPKLAHRYNAPII GTPYTIELVKREILSEKKFDVRNPLVVLNAGESIDLTPNITLEFIRITHSIPDSVLPV LHTPYGAIVYGNDFKFDNFPVVGERPDYRAIKRVGKNGVLCFISETTRINHEGKTPPE IIASGLLKNDLLATDNEKNGVIVTTFSSHIARIKSIVEIAEKMNRTPVLLGRSMMRYC GIAQDIGLVKFPDDLRIYGDPSSIEMALKMIMKEGKENYLIVATGHQGEEGAVLSRMA TNKTSYKFDRYDCVVFSADPIPNPMNAAQRYMLESRLKLLGVRIFKGAHVSGHASKED HRDMLRWLNPEHIIPSHGDFNLTAEYTKLAEEEGYRLGEDVHLLRNGQCLSFERVI" gene complement(2371..3435) /gene="" /locus_tag="" /db_xref="668055..669119" CDS complement(2371..3435) /gene="" /product="isopentenyl-diphosphate delta-isomerase, type 2" /translation="MEISIRKLEHIFLCSHCNVEYDRSTLLECIELIHKGTSNINFDD INTEVKLFGKRLSAPIIVSGMTGGFRGAEEINKNIAKAVEELNLGMGLGSQRAAIVNK ELEDTYRVVRDYTESLVIGNLGAVNFIKDGWDLEVIDRAIEMIDADALAIHFNPLQEI IQPEGDVNFKNISEKLKDIISEYKKHRDVPFIAKQVGEGFSKEDAKELEYFDAIDVQG SGGTSWAKVEYYRVKDKEKREILKNFLNWGIPTAQSILEVKSSYNKIIIGSGGLRSGI DIAKCLALGCSCTAVALPVLRAALKGYEKVVELLSKYIEELKITMFLVGAENIEELRR IPYILKEPLKSILVERGCKV" gene complement(3420..4415) /gene="" /locus_tag="" /db_xref="669104..670099" CDS complement(3420..4415) /gene="" /product="eIF-2B alpha/beta/delta-related uncharacterized protein" /translation="MLEPIVWEEDRLSLIDQRKLPNKLEYFICKDYRDVAYAIKEMVV RGAPAIGIAAAYGMALAEINNENIEEAYKTLKNTRPTAVNLFWALNRCLKAYKEGKSI VEEAKRIQREEEEVCKRIGEIGEKIVDDGDTILTHCNAGALATSKYGTALSVIRFAHY SGKRIRVIADETRPRLQGAKLTAFELNYEGIPVKVIVDSSAGFLMQRGEINKVIVGAD RILRDGTTYNKIGTYSLAILAKYHNIPFYVAAPLSTFDLESSEEDVKIEERDEREVAY IENIRIVPEGVSCINYAFDKTPAELITGIITEKGIIKPKEEEIIKLFKGIKWKSQ" gene complement(4416..4991) /gene="" /locus_tag="" /db_xref="670100..670675" CDS complement(4416..4991) /gene="" /product="methylase" /translation="MKLIYDKDVYEPAEDSYLLLKNIVDVKGKRVLDVGTGTGILAIA SALKGGIVEGIDINPKAIELAKKNAKLNGVKVKFYLSNLFENVKGKYDVILFNPPYLP TEEDDKIEGYLNYAFDGGKEGREILDRFIDQVPNYLKEGGVVQLVQSSLTDIEKTLKA FKLKGFSVEVVDKLKVPFEYLVVINAYKRGD" gene complement(4988..5788) /gene="" /locus_tag="" /db_xref="670672..671472" CDS complement(4988..5788) /gene="" /product="undecaprenyl diphosphate synthase" /translation="LLKKLILKGYKFTNNFIGFKIYEKLLEMEIDKNKIPKHIGIIMD GNRRLGQILGNKIEGHKLGAKKVKEVLRWCLELGVKVVTLYSFSIENFNRPKDEVEAL MNLFKEKFYEAAENRDIHKYKVRIKAIGRLDLLPEDVREAIRYAEEKTKHYSNYYINV AIAYGGQQEIVDAVRKIAEKVKRGEIEPEEINKELIDKHLYTAHLPYPYPDLIIRTSG EERISNFLIWQSSYSELYFCDVYWPLFRRIDLLRAIREYQRRERRFGR" gene complement(5794..6660) /gene="" /locus_tag="" /db_xref="671478..672344" CDS complement(5794..6660) /gene="" /product="protein of unknown function DUF89" /translation="MKIKPECAICIVRQIVDISKEVADEEEQFNLIKKCFKVIEENYG KDVVPAVMGTNVHRYFKEISGCEDPYKRLKEKANEIALKYYDYVKNLIKGDERERLRK SVLATIAGNTIDYGAYSTNLNIEEVLLKTLNEELKIDDSEELLKYLKDKNIKKVLYIC DNAGEIVFDKLLMELIKSYGKEVIAVVKGKPILNDATIEDAKVAKIDEVAKIVTTGSD IIGIILEECSEEFLKELDSSDIIIAKGMGNYESLTEYNIEKPIFFILKAKCNPVAQNI GVKRGDNVILKR" gene complement(6657..7445) /gene="" /locus_tag="" /db_xref="672341..673129" CDS complement(6657..7445) /gene="" /product="protein of unknown function DUF62" /translation="MYLRVENEVAKRERNDKMITLTTDFGLSEGYVGAMKGRIYSLLK KYNKGCEVVDISHEIEPFNIWHGAYVLKTSVPYFPKAIHIAVVDPTVGSERRSIVVET ENFFLVGPDNGLFTYLIEDFKVKNIYKIDESQYCPSKTFHGRDVYAVVGAEIFINDFK FEGERIKEIVKLDYKNRVIHIDRFGNIILGIRDFNLRPGDEVEIVFNGEKKIVAKFVE SYYQGKEGFICLRNSEGFLEVAKFMDSANKYLNVKHGDRVEVSL" gene complement(7391..8839) /gene="" /locus_tag="" /db_xref="673075..674523" CDS complement(7391..8839) /gene="" /product="methanogenesis marker protein 14" /translation="MGFLDSILNIFKKKRNIAYAKSQSVDLIELKKNPYYIVASVELG NTTTKSIVTATNMDTGKTYIISKAVRMTREVRKPKKGEKVFGKTLWGVELSREAVAEM VRDVLLESLKKANLTIDDLHFVVRSTGVTAGFASPEEVSEVIIALAQGCMLAGVPPAK MTPAMSKEQLPKPFDKYSFLDKIIFDGAVTGVLPPTGKEVVANEMEGELVTAGIKVGS KWTHVDFRNPCMSIDFGTTLAGRITDEKLPYSNVIGNLCGLAGAIADSIVRGSGKVDP KTGAVLDIKEDGKVNEEKAKEYSEEIHKYIIIKEVPKNVNRFGTVPVDPKSAEKAGTT LLGCDVGENGSDLEKLKEIGKEIYENYGMGTLLRTLDYTMAKVVKRLVELAHNKNLID EKTAIGVTGRAGITGKKPEIILEYLDELKIWDKVEDNVVFVEDGLALGASVMARCMNC LGTPKVPIGGVRGGPCILGLRMKWQRERGMIR" gene complement(8850..10355) /gene="" /locus_tag="" /db_xref="674534..676039" CDS complement(8850..10355) /gene="" /product="AMP phosphorylase" /translation="LLFLKVRLLDIDLLDLVLINPEDIKASQYFPGDRVVLIYKNKEE IGTIYSSTLVNRGEIGITKELAKSLKVKEGELITIKHADKPRSLAYIKKKMDKNKLSK EEIFLIVDEMVNNKLTNIEISAFVTSLYINGMDMDEIEALTIRMAETGEMVEWESLVF DVHSIGGVPGNKYALLTVPIVASAGLKIPKTSSRAITSAAGTADVMEVLTRVDLSIEE IKNVVKETNGCLVWGGALNLAPADDITINVERPLGIDPKPLLLSSVMAKKLAMGVSKL LIDIPIGREVKVKDEKEGNKLAREFIELGERLNITTECALTYGNQPIGRAIGPALEAK EALETLEDPYKGANSLVDKATHLAGILLEMGGIAPAGEGKEVAEELLFRKAHDKFMDI IVAQGGKEVRSEEIEVGKYFIDIVSPKDGYVIELSNNKITKIAKEAGAPNDKKAGVYL NVKVGDKVEKGDLLFTIYSSSEDRLKNAIKLARTLYPIKVEGILIKRIVRF" gene 10384..11502 /gene="" /locus_tag="" /db_xref="676068..677186" CDS 10384..11502 /gene="" /product="Radical SAM domain protein" /translation="MDVKKIEEYINKNFDKLPEGCKQCVRGEKLVLFITGTCKNNCYY CPLSEKRKDKDVIYANERLISSVEEAIEEAKLCSSRGVGITGGNPLLRVDRTKKYLEA LKKEFKDFHAHLYTTPETITTENLEKIKELDELRIHPTKIFNIGYKEEFVDELIKKIR LAKKYIPKVGVEIPSIPGMDEEILNLAYEIDGVADFLNINELEFSDENYENLEKRGFY PKDDVSNAIAGSEETALNVIKNFKGSLFIHYCPSILKDAIQMKNRLIRRAKNIAKPYE VVTDEGLLLRGIMIFDREEDLNEIVEILEDNEVEFEIDGNKIYLNPFILEDLLDLMKR ERFPIKFSAYISEYYPTVDKLEVERIPLHIKKRKLRFK" gene 11453..12442 /gene="" /locus_tag="" /db_xref="677137..678126" CDS 11453..12442 /gene="" /product="Radical SAM domain protein" /translation="LREFHFILKRENLDLSEIMIWIEDEITNNLERVKALTIILKTKG CSYRECVMCSYYLDSHKEVKDKEIIEQFEYAINKFKDFDMVKIFTSGSFLDDKEISKD VRDYILKRLSELNLKEIHIESRVEFITEDRLEELKDYNVVIGLGIESFNERVREVLNK GVSNEEIVRAISLIKKYKLTPKAYLLIKPPFLTESDAIKDAIYSGNKALELGCIVSFC PLTVHKDTLVEYFYKKGEYSPPFLWTVLEVLKNVRDGLVRCDTSGFGSLRGASNRCKC DREIIEKIKKFNLTQNREVLEHSCECKKLWEVFLETEKRNIVPLNRELTLTYQ" gene complement(12423..13541) /gene="" /locus_tag="" /db_xref="678107..679225" CDS complement(12423..13541) /gene="" /product="protein of unknown function DUF111" /translation="MFVIDPFSGVSGDMFISAFLDFVDKDELIETVKKVIDVDIEIKK VNKKGILANKIDISLRKNFSLSTYQEFKELIKNSNLNNKIKEDSLKILHLLAEAEAKV HGVEIEKVHFHEIADYDTIVDVVGASYIINKLNLKNNCFYRPINVGGGFVKTSHGLYP IPAPATAELLKGFRIFYSNYGELTTPTGGAILKYINPRLIESFEYSSISYGAGEKELE IPNVLRVFKLLNEEENIYIVETNVDDISPEVLGYLHEVLREKVRDLHFIPIYMKKNRP AYLIRAIVKDNPKEVTKIIMRETGTLGVRILKYKRVVAEREVKRVKVYGEEVRVKIGK IDNEVIMKKPEYEDLKRLALKLKKPLKDLYLEVIGKLE" gene complement(13543..14484) /gene="" /locus_tag="" /db_xref="679227..680168" CDS complement(13543..14484) /gene="" /product="Sua5/YciO/YrdC/YwlC family protein" /translation="MILKATEENIKKAAEVIRKGGLVAFPTETVYGLGADALNKEAVA KIFEVKQRPLIDPVIVHISKFEDLEKLAYPTELAYKLAKAFWPGPLTMVLPKKEVVPS IVTAGLDFVAIRMPAHPVALKLIEESKTFIAAPSANLFSKLSPTRAEHVYEQLGDKVD IILDGGKCDVGVESTIIDLTTEPPTILRLGGLDVEAIEKVIGEVKITKENKKIKAPGM LKKHYSPTTPLKIMKEPKPIPNLRCGLLAFKEPREGFEVVEILSRKGDLREAAANLYD SLHRLDKQNLDIIIAEAVPEVGLGRAIMDRLRKAQGL" gene 14564..14941 /gene="" /locus_tag="" /db_xref="680248..680625" CDS 14564..14941 /gene="" /product="hypothetical protein" /translation="MNINKDKIITPVLIGGVVGGILGVFCCLMYIVAGALATYLYSKE EFIELESSAVVGAIAGVIAGVIEFIINFILNMVFLIHMSNTPPMFSGFYSIALAIGFI FSIIFGAILGAIGGVLYHYIANR" gene 15045..15590 /gene="" /locus_tag="" /db_xref="680729..681274" CDS 15045..15590 /gene="" /product="non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family" /translation="LEIYFITGNINKVREAETILKDIKIKNIKIEYPELQGTLEEVAE FGAKYCYERLKKPLIVEDSGFFVEALKGFPGTYSRFVYETIGNEGILKLLKGVSDRRA YFKSVIGYCDENGVQLFSGVVKGYVSSEIRGDKGFGYDPIFIPEGYDKTFGELGIEEK SKVSHRRKAFEKLREFLLKKI" gene complement(15587..17197) /gene="" /locus_tag="" /db_xref="681271..682881" CDS complement(15587..17197) /gene="" /product="Protein of unknown function DUF128" /translation="MDLDRKLIEILDILSKYNEPVGAKIIAKELSKRGYKIGERAVRY HLKLLDSMGLTKKVGYLGRIITEKGLEELEKANISYRLGNIYSNILEKVILSDYQAGL VVVNRSIVYTDYEKALSLIKKVYENGLAIGDRVGIVDREKYIELYTLCSLNLDGLLVK NGIPVYHICGGIVKYENYEPVEFKEIIKYKATSIDPLLAFIERKKTDVLGIIENGEGY LPANFRVIGANYRERFERIIKKLDGIISYGSENVLGLDVGEEHIGIVMIGGLSPIAPF VEKDIPTEIIPMSSIVRLSSLHKLEKKSLKISTKKANVRIKTALSKMINLMAHVNYDI YEKDGDVIVNIGYIDKKYLDEALDILKEAYSKGLGISDRFGYEVLKDKVKIKTICAVT LDGIINNLGVPIIPKYGGILEVKEEEMRFIDIIKYSGTSLDPHEIFFNKVDCETTFLA GFREIHRICREELERIIELLEWNGIKCIGEPNNELAGVKVNKDMCGVITIGGANPLSF LNENEISVEIKAMHEITKFSELISYKDI" gene complement(17188..18270) /gene="" /locus_tag="" /db_xref="682872..683954" CDS complement(17188..18270) /gene="" /product="amino acid permease-associated region" /translation="VLTLKDAIFLTITSIVGGGIFILAPLTYLMFGSSSIYGWILLIP TALVMALPFSYATLKISESGGVYKFINDTLGKRIGIASGIIMWLSCVFALSGVVSFFN IVFNIYFSFPIKYFLVILITLLILSGLRIVGLAVRILGLTTILTILYICFKNGFNLEL YKFNLKEAIFSVYYSLWSTTGWEGVTMPLSAFKDQRAISLGLIIGTLIIGILYLLFAL TVVSLNLKSNSIEEILKALIGENIFLYICILTIIGSCAFSVLFTLSYMPYGFSKDKIF PKFFETLYRGVPIYGVLLNALLTIVLITLNVKVLVDISMFLTLVAYFILYLSVFKVGT KKIKFLTFLSLIVTGSLILLRMVVWI" ORIGIN 1 atggaaataa ttccagcagt agatataaag gagggaaggt gtgttcaact tgttcaagga 61 gatccaaata aaaagctgtt agagatagaa gatcctgttg aagttgctaa gagatgggtt 121 aataagggag ctaattactt acatcttata gacttagatg cagctcttgg ggagggagat 181 aacttagaag ttattaaaag gattgttgaa gaggttaatg ttcctgtaga ggttggagga 241 ggaattagag atatagagag agctttagag ttaattgagt taggagtgga tagaataatt 301 gtaggaacta aggcaataac tgatagcaaa tttttggatg agttaaatgg ttacatagag 361 aaagatagaa ttgtcttagc tgttgagagt aaagagggaa aggttgttat aaagggctgg 421 aaagagaagc taaatttaaa gcctattgat gtgatagaga aatttaagga taaagttggc 481 tacatactct acacaaatgt agatgttgaa ggcttaatga agggaataaa gatagaggaa 541 attaaaaatc ttataaaaaa ctctccccta ccagttatat actcaggagg agttactaag 601 attgatgaca taataacatt aaaagagctt ggagcttatg gagttgtgat aggctcagct 661 ctctataagg gaaagattag ccttagagaa gctttaaagg ttttagagaa tgaaggttaa 721 aattaaagat ttagagtttg aagtagagtt agctgacaac tttataaaaa gagcctttgg 781 cttaatgctg agggatatta aagataaggc tatgctcttc aaatatggga agagaaaggt 841 tagggttcat acttacttta tgctctatcc catagatatc ttattcattt ataataataa 901 agtggtagat gctgttagac taaaaccttg gaagggttat aagagtaagg tttattccaa 961 catgatgttg gagtttaaga gtttagagga tagggatgtt aaagagttca taggagaaga 1021 agttatcttt aaataaccct ctcaaagctt aggcattgtc cattcctcaa tagatggaca 1081 tcctctccta atctgtaacc ctcttcttca gccaactttg tatattctgc tgttaggtta 1141 aagtctccat gagatggaat aatatgctca gggttcagcc atcttagcat atccctatga 1201 tcttccttag aggcatgacc agaaacatga gctcctttaa agattctaac ccctaagagt 1261 tttaatcttg actctaacat atatctctga gctgcattca ttgggttagg gatagggtca 1321 gctgagaata caacacagtc atatctatca aacttatatg atgtcttatt tgtagccatc 1381 cttgatagaa cagctccttc ttctccttga tgccctgtag ccactattaa gtaattctct 1441 tttccttcct tcataatcat ctttaaagcc atctctatag agcttggatc cccataaatt 1501 cttaagtcat ctggaaactt aactaagcca atatcttgag ctattccaca gtatctcatc 1561 atactcctcc ctaagagtac tggagttcta ttcatctttt cagcaatctc aactattgac 1621 ttaattcttg ctatgtggga ggagaaggtt gtaactataa ctccattctt ctcattgtca 1681 gttgctaaga gatcattctt cagcaagcca gaggctataa tctctggtgg agtctttccc 1741 tcatggttta tccttgttgt ctctgagata aagcagagaa ctccattctt tccaactctt 1801 tttattgctc tatagtctgg cctctcccca acaactggga agttgtcaaa cttaaaatca 1861 tttccataaa ctatagctcc atagggagtg tgtagaacag gtaaaacaga gtctggaata 1921 ctgtgggtta ttctaataaa ctctaaggtt atgtttgggg ttaaatctat agattctcca 1981 gcatttaaaa caaccagtgg atttctaaca tcaaattttt tctcacttaa tatttccctt 2041 ttaacaagct ctatagtata tggagttcct ataattggag cattgtatct atgggctaac 2101 ttaggaacag cccctatgtg atcaagatgc ccatgggaga ggactatagc tttaacctct 2161 ccctcaatgt ttttcataac tgtatcattt ggaataattc ctttctctat taactctaag 2221 ctgtgtaact tagatatgtc agtatcttca tgaattaaaa ctctatctaa cctaaccccc 2281 atgtccataa tgatgatttc tccatctaca ttaatagctg tcatgtttct accaacttcc 2341 tcataaccac caatagcaac aatctccaat ttcatacttt acaccctctt tcaactaaga 2401 tactttttag tggctctttt aagatatagg gaattctcct taattcctca atgttttcag 2461 caccaactaa gaacatggta atctttagct cctctatata cttacttaaa agctctacaa 2521 ccttctcata gccttttaaa gctgctctca atacaggaag agctacagct gtacaagaac 2581 agccaagagc taagcattta gctatgtcaa ttccagacct taagcctcca gagccaataa 2641 tgattttatt ataagagctc ttaacctcta aaatagactg agctgtagga attccccaat 2701 ttaggaaatt ttttaagatt tctctttttt ctttatcttt aactctataa tattcaacct 2761 tagcccagga agttccacca cttccttgga catcaatagc atcaaaatat tcaagttctt 2821 tagcatcctc tttgctaaag ccctcaccaa cctgcttagc aatgaaagga acatctctat 2881 gctttttata ctcagagata atatctttta gcttctcact aatgttttta aaatttacat 2941 ccccctctgg ctgaataatc tcttgaagag ggttgaaatg gatagctaag gcatcagcat 3001 ctatcatttc tatagctctg tcaataactt ccaaatccca gccatcttta ataaaattta 3061 cagctcctaa gtttcctata accaagcttt cagtgtagtc tctgacaact ctgtaagtgt 3121 cttccagctc tttatttact atagcagctc tctgagagcc taagcccatt cctaagttta 3181 gctcttcaac agccttagct atatttttat taatttcctc agctcctcta aaccctccag 3241 tcattccaga gacaataata ggagctgaca acctcttccc aaaaagttta acctcagtgt 3301 ttatatcatc aaaattaata ttagatgtcc ctttatggat aagctcaata cactctaata 3361 gagtagatct atcatactca acattacagt ggctacatag gaagatatgc tctaacttcc 3421 ttattgagat ttccatttta tccctttaaa taattttatt atctcctctt ccttaggctt 3481 gataatccct ttctctgtta taattcctgt tattaactca gctggagttt tatcaaaggc 3541 atagtttata catgaaactc cttctggaac aatccttata ttttcaatgt aagccacttc 3601 cctctcatcc ctctcctcaa tcttaacatc ttcttcagaa ctctctaagt caaaggttga 3661 tagtggagca gctacataga atggaatatt atgatacttt gccaagatag ctaaagaata 3721 ggttccaatt ttgttatagg tagttccatc ccttaagatt ctgtcagctc caactataac 3781 cttgttaatc tcccccctct gcattaaaaa gccagctgag ctatcaacaa taaccttaac 3841 aggaattccc tcatagttga gttcaaaggc tgttaactta gccccttgta atcttggcct 3901 tgtttcatca gctataactc taatcctttt cccactgtag tgggcaaacc ttataacact 3961 tagagctgtt ccatacttag atgtagccaa ggctccagca ttacagtgag ttaagatagt 4021 atctccatca tcaactatct tctcccctat ctcccctatc ctcttacaaa cctcttcctc 4081 ctctctttgt atcctcttag cctcttccac tatactcttt ccttctttgt aagcttttaa 4141 acatctattt aatgcccaaa atagatttac tgctgtgggc cttgtatttt ttaaggtttt 4201 gtaagcctct tcaatattct cattattaat ctcagctaaa gccattccat aagctgcagc 4261 tatccctatg gctggagctc ctctaacaac catctccttt atggcatagg caacatccct 4321 ataatcttta caaataaaat attctaactt atttggcagt tttctttgat caattaggct 4381 taacctatct tcctcccaaa ctattggctc taacatttaa tctccccttt tataagcatt 4441 tattacaact aagtattcaa atggaacctt taatttatca acaacctcta cagagaatcc 4501 tttaagcttg aaagccttca gtgttttttc aatgtctgtt aaagagcttt gaaccagttg 4561 aactactcca ccctctttta aatagttagg aacttgatca ataaatctat ctaagatctc 4621 tcttccctcc tttcctccat caaaggcata gtttaagtaa ccctctattt tatcatcttc 4681 ctctgttgga agatatggag ggttaaaaag aatgacatca tactttcctt taacattttc 4741 aaatagatta ctaagataga actttacttt aaccccattt aacttagcat tcttcttggc 4801 caactctata gcctttggat ttatatctat tccttcaact attcctccct ttagagcaga 4861 ggctatagct aaaatccctg tacctgttcc aacatctaaa actctctttc ccttaacatc 4921 aacaatattt tttaagagta agtaagagtc ttcagctggt tcataaacat ctttatcata 4981 aattagcttc atcttccaaa tcttctctcc ctcctctgat attcccttat ggccctaagt 5041 aagtctatcc ttctaaatag tggccaatag acatcacaga agtatagctc tgaataagag 5101 ctttgccaga ttaaaaagtt acttattctt tcttctccag aggttcttat aatgagatca 5161 gggtaaggat agggaagatg agcagtatag agatgcttat caatcaactc cttgtttatt 5221 tcctctggct ctatctctcc cctcttaacc ttctcagcta tctttcttac agcatcaaca 5281 atctcctgct gtcctccata ggctatggct acattaatat agtagttaga ataatgctta 5341 gtcttctcct cagcatacct tatagcttcc ctaacatcct ctggtaataa atctaaccta 5401 ccaatagctt taatcctaac tttatactta tgtatatccc tattctcagc agcctcataa 5461 aatttctctt taaataggtt cattaaagct tcaacttcat ccttaggcct attaaaattt 5521 tctatggaga aggagtagag agtgacaact ttaactccta actctaaaca ccatcttaaa 5581 acttctttaa ccttcttagc ccctaactta tgcccctcta tcttgtttcc taaaatttgt 5641 cccagccttc tatttccatc cattattatg cctatatgtt ttggaatctt gttcttatca 5701 atctccatct ctaagagttt ttcgtaaatt ttaaagccaa tgaaattatt tgtaaattta 5761 tatcctttta aaattaactt ttttagcaag tgtttcacct ttttagtata acattatccc 5821 ctctcttaac tccaatattt tgagcaacag ggttacattt agcctttaaa ataaagaata 5881 ttggcttctc tatgttatat tcagttaaac tctcataatt tcccattcct ttagcaataa 5941 tgatatcaga gctatcaagc tcttttaaaa actcttctga gcattcctct aaaatgattc 6001 caataatgtc tgagccagtt gttactatct tagctacttc atcaatctta gccaccttag 6061 catcctcaat tgtagcatca tttagaatag gctttccctt aacaacagct ataacctctt 6121 tcccatagct ctttataagt tccattaata gtttgtcaaa aactatctct ccagcattgt 6181 cacagatata taaaactttt ttaatatttt tatcttttaa gtattttaat agctcttcag 6241 agtcgtctat cttcaactct tcatttaagg tttttaataa aacctcctct atatttaaat 6301 ttgtgctata tgctccatag tcaatggtgt ttccagcaat tgtagctaag acactcttcc 6361 ttaacctttc cctttcatcc cctttaatta aatttttaac atagtcatag tattttaaag 6421 ctatctcatt ggctttctct ttcaacctct tgtatgggtc ttcacagcca cttatctctt 6481 taaaatatct atgtacatta gttcccataa cagctggtac tacatccttt ccatagttct 6541 cttcaatgac tttaaagcat ttctttatta aattaaattg ctcttcttca tcagccacct 6601 ctttagagat gtcaacaatt tgcctaacta tacagatggc acactctggc tttatcttca 6661 tagactcacc tctaccctat ccccatgctt aacatttaaa tatttatttg cactatccat 6721 aaacttagcc acttctaaaa acccttcaga gtttctaaga cagataaatc cttctttccc 6781 ttgatagtag ctttctacaa atttagccac tatctttttc tctccattga acactatctc 6841 aacttcatcc cctggcctga ggttgaagtc tctaatgcct aaaatgatgt ttccaaacct 6901 atctatgtgt attactctat ttttatagtc taatttaaca atctccttaa tcctctctcc 6961 ttcaaatttg aagtcattta tgaaaatttc agctccaact acagcataga catctctccc 7021 atggaatgtt tttgaaggac aatattgaga ttcatcaatt ttatagatat ttttaacctt 7081 aaaatcttca attaaatagg tgaagaggcc attatcaggc ccaactaaga agaagttttc 7141 agtttcaact actattgatc tcctctcact tccaacagtt gggtcaacaa cagctatgtg 7201 aatagcttta ggaaagtaag ggacagaggt ttttagaaca taagctccat gccaaatatt 7261 gaatggctca atctcatggc ttatatctac aacttcacag cctttattgt acttctttaa 7321 taagctgtaa attcttccct tcatagcccc tacatagccc tcagataagc caaaatctgt 7381 agttagggtt atcatcttat cattcctctc tctctttgcc acttcattct caaccctaag 7441 atacatgggc ctcctctaac tcctccaata ggaaccttag gagttcctaa gcagttcata 7501 catctcgcca tgacactggc tcctaaggct aagccatcct caacaaaaac aacattatcc 7561 tcaactttat cccaaatttt tagctcatct aagtactcta aaattatctc tggcttcttt 7621 ccagtaattc cagctcttcc tgtaactcct atggctgttt tctcatcaat taagtttttg 7681 ttatgggcta actcaaccaa tcttttaaca acctttgcca tagtataatc taaggttctt 7741 aaaagtgttc ccattccata attctcataa atctcctttc caatctcctt aagcttctct 7801 aaatctgaac cattttctcc aacatcacag cctaaaagag tggttccagc cttctcagca 7861 gattttggat caactgggac agttccaaat ctattaacat tctttggaac ttcctttata 7921 atgatatact tatgaatctc ctcactatac tccttagcct tctcttcatt aaccttacca 7981 tcctctttaa tatctaacac agctccagtt tttgggtcaa cctttcctga acctctgaca 8041 atggaatcag ctatagctcc agctaagcca cagaggttac ctataacatt agaatatgga 8101 agtttttcat cagttatcct tcctgctaat gttgtcccaa agtctatact catacatggg 8161 tttctaaaat caacatgtgt ccatttactt cctactttaa ttccagctgt aactaattcc 8221 ccttccatct cattagccac tacttccttc cctgtaggtg gtagcactcc agtaacagct 8281 ccatcaaaga taatcttgtc caagaatgag tatttatcaa aaggctttgg caactgttcc 8341 ttactcatag ctggagtcat ctttgcagga ggaacaccag ccaacataca gccctgggct 8401 aaggctatga ttacttcaga aacctcctct ggagaggcaa aaccagctgt aacccctgta 8461 cttctaacaa caaagtgtaa gtcatcaatt gttaagttag ccttcttcaa actttccaat 8521 aaaacatctc taaccatctc agccacagct tcccttgaaa gctcaacccc ccagagtgtt 8581 ttaccaaaaa ccttttcccc cttcttaggc ttcctaacct ctcttgtcat cctgacagct 8641 ttacttatta tataggtttt cccagtatcc atgttggtag ctgttactat agactttgtt 8701 gttgtattcc caagttctac tgaagcaaca atatagtaag ggtttttctt taactctatc 8761 agatcaacac tctgactttt tgcataggct atatttctct tctttttgaa aatatttaat 8821 atgctatcta agaatcccat tatctccctc ttaaaatctt acaattcttt ttattaagat 8881 accttcaacc tttataggat ataaagttct tgccagcttt atagcattct ttaacctatc 8941 ttcggagctt gagtaaatgg taaataaaag gtctcctttc tctactttat ctccaacctt 9001 cacatttaaa taaacaccag cctttttatc atttggagct ccagcctctt tagctatctt 9061 tgttatctta ttatttgata attcaattac ataaccatcc tttggagaga caatatctat 9121 aaaatacttc cctacttcaa tctcttcact tcttacctcc tttccaccct gagccactat 9181 tatgtccata aacttgtcat gagcctttct aaataatagc tcttcagcca cttctttccc 9241 ttctccagct ggagctatcc ctcccatctc taataggatg ccagctaagt gggtagcttt 9301 atcaactaag ctatttgcac ctttataagg atcttctaag gtttctaaag cctcttttgc 9361 ctctaaagct ggccctatgg ctctgccaat tggttggttt ccataggtta aggcacattc 9421 agtagtaata tttaacctct ccccaagctc tataaactct cttgctaact tgttcccctc 9481 tttctcatcc ttaaccttaa cctctcttcc aatagggatg tctatcaata atttactaac 9541 tcccatagcc aattttttag ccatgacact tgataataat agaggcttag ggtctatccc 9601 aagaggtctt tcaacattta tggttatgtc atcagctgga gccaagttta aagctccacc 9661 ccaaactaaa catccattag tttctttcac aacattttta atttcttcta tacttaaatc 9721 aacccttgtt agaacttcca taacatcagc tgttcctgct gctgaagtaa tagctcttga 9781 agaagtttta ggaatcttca gcccagctga agctacaata gggactgtta gaagagcata 9841 cttattccca ggaactcctc ctatggagtg gacatcaaaa accaagcttt cccattcaac 9901 catctctcca gtctcagcca tccttatggt taaagcttca atctcatcca tatccatgcc 9961 atttatgtag agagaggtga caaaggcaga gatctcaata tttgttagct tattattaac 10021 catttcatca acaattaaga atatctcttc cttacttaac ttattcttat ccatcttttt 10081 ctttatgtag gctaagcttc ttggcttgtc agcatgtttt atagttatta actccccttc 10141 cttaaccttt aaactcttag ccaactcttt agttatccct atctctcccc tattaactaa 10201 tgtagaggaa taaatagttc ctatctcttc cttatttttg tatattaaga caaccctatc 10261 tcctggaaaa tattgagaag ctttaatatc ctcaggattt attaatacta agtctaataa 10321 atctatatct aataacctaa cctttaggaa taacaaggaa taccaccata gaaagttgat 10381 agttatggat gtgaaaaaaa tagaggagta cataaataaa aattttgata aattacctga 10441 aggttgtaag cagtgtgtta gaggagagaa gttagttctc ttcatcacag ggacctgtaa 10501 aaataattgt tattattgtc ctctctcaga gaagaggaag gataaagatg tcatttatgc 10561 aaatgagaga cttattagta gtgtagaaga agctatagag gaggctaagc tctgtagtag 10621 cagaggagtt ggaattactg ggggtaaccc tttattaaga gtggatagaa caaaaaagta 10681 tttagaggct ttaaagaaag agtttaaaga ctttcatgct cacctctata caactcctga 10741 aaccataacc actgaaaatt tggagaagat aaaggagttg gatgagctaa ggatccatcc 10801 aacaaagatt tttaatattg gttataagga agagtttgtt gatgagctaa ttaaaaagat 10861 taggttagct aagaaatata ttccaaaggt tggggtggaa attccttcaa ttcctgggat 10921 ggatgaagaa attttaaact tagcctatga aatagatgga gtagcagact ttttaaatat 10981 aaatgagctt gagttttctg atgagaacta tgaaaacttg gagaagagag gattctatcc 11041 taaggatgat gttagcaatg ctatagctgg aagtgaagag actgctttaa atgtgataaa 11101 gaactttaaa ggctctctct ttattcacta ttgcccttcc atattaaaag atgccataca 11161 gatgaaaaat aggttaataa gaagagctaa gaatatagct aagccttatg aagtggttac 11221 tgatgaaggc ctcttattga gagggataat gatctttgat agagaggaag acttaaatga 11281 aatagttgaa atcttggaag ataatgaggt tgaatttgag atagatggaa ataagattta 11341 cttaaatccc tttatcttag aagacctctt agacctaatg aagagggaga ggtttcctat 11401 aaagttctct gcttacatct ctgagtatta tccaacagtt gataagttag aggttgagag 11461 aattccactt catattaaaa agagaaaact tagatttaag tgaaattatg atctggatag 11521 aagatgagat aaccaacaac ttggagagag ttaaggcact aaccataatt ctaaaaacta 11581 agggttgtag ttatagagag tgtgttatgt gctcttacta cttagactct cataaagaag 11641 tgaaagataa agaaattata gagcagtttg aatatgctat aaataaattt aaagattttg 11701 atatggttaa aattttcacc tcaggaagct tcttagatga taaagagatt tctaaggatg 11761 ttagagacta tatattaaaa agattgtctg agctaaactt aaaggagatt catatagagt 11821 caagggtaga gtttataact gaagataggt tagaggagct taaggattat aatgtggtga 11881 ttggcttagg aatagagagc tttaatgaaa gagttagaga agtcttaaat aaaggagtta 11941 gtaatgagga aattgtaaga gctataagct taataaaaaa atataagtta actcctaagg 12001 cttacctctt aataaagcct ccatttctaa ctgagagtga tgctataaaa gatgccattt 12061 actcaggaaa caaagcttta gagttaggct gtatagtttc cttttgtcct ttaacagttc 12121 ataaagatac tttggtagaa tacttttata aaaaaggaga gtactctcca ccatttttat 12181 ggactgtctt agaggtttta aaaaatgtta gagatggctt agttagatgt gacacctcag 12241 gctttggctc cctgagagga gcaagtaata ggtgtaaatg tgatagagag atcattgaaa 12301 aaattaaaaa atttaactta acacagaata gagaagtgtt agagcatagc tgtgagtgta 12361 aaaaactctg ggaagtattc ttagaaactg aaaaaagaaa tattgttcct ctaaataggg 12421 agcttactct aacttaccaa taacctctaa gtaaaggtct ttcaagggct tttttaattt 12481 taaagccagt ctttttaaat cttcatattc aggctttttc ataataactt cattatctat 12541 cttccctatc ttcaccctaa cctcttctcc ataaacttta actctcttca cttccctctc 12601 agcaacaacc ctcttatatt ttaaaatcct cacccctaag gttccagtct ctctcataat 12661 tattttagtc acttccttag ggttatcttt aactatagcc cttattaaat aagctggcct 12721 attcttcttc atgtaaattg gaatgaagtg aagatctcta accttctctc ttaaaacttc 12781 atgtaagtaa cctaaaacct ctggagagat gtcatcaaca ttagtctcaa ctatgtaaat 12841 attttcctcc tcattcaaca gtttaaaaac ccttaaaaca tttgggattt ccaactcttt 12901 ctctccagct ccataggaga tggaagagta ttcaaaactt tctataagcc ttggattaat 12961 gtactttaaa atagctccac ctgttggagt tgttagctct ccatagtttg agtaaaagat 13021 tctaaagcct tttaaaagtt cagcagttgc tggagctggg atagggtaga ggccatgaga 13081 agttttaaca aaacctccac caacatttat aggcctgtag aaacagttgt tttttaaatt 13141 tagcttattt attatgtaag aggctccaac aacatctact atagtgtcat aatcagctat 13201 ctcatggaaa tgaaccttct ctatctcaac tccatgaacc ttagcttcag cctcagcaag 13261 taggtgaagg atttttaaac tatcttcttt aattttatta ttaaggttag agtttttaat 13321 gagctcttta aactcttgat atgttgagag agaaaaattt ttccttaagc tgatatcaat 13381 tttgttagct aagattcctt ttttatttac tttttttatt tcaatatcaa catcaataac 13441 tttttttaca gtttctatta gctcatcttt atcaacaaag tctaagaatg ctgagataaa 13501 catgtctcca ctaactccgg agaagggatc tataacaaac atctcacaaa ccttgagcct 13561 ttcttaatct gtccataatg gcccttccca agccaacctc tggcacagct tcagctataa 13621 taatatctaa attttgctta tctaacctat gtaaggaatc atataaattt gctgcagcct 13681 ctcttaagtc tcctttcctt gaaagtattt caacaacttc aaaaccctct cttggctctt 13741 taaatgctaa taagccacac cttaagttag ggataggctt aggttctttc ataattttca 13801 gtggagttgt tggagagtag tgttttttca acatcccagg agcctttatc ttcttattct 13861 ccttggttat cttaacctct cctataactt tttcaatggc ttcaacatct aagcctccaa 13921 gccttaagat ggttgggggt tctgtagtaa gatcaataat agttgattca actccaacat 13981 cacacttacc accatctaaa ataatatcta ccttatctcc aagctgctca tagacatgct 14041 cagcccttgt tggtgagagc ttgctaaata agtttgcact tggagcagct ataaaagttt 14101 tagattcttc aattaatttt aaagccactg gatgggctgg cattcttatg gctacaaagt 14161 ctaagccagc tgtaacaata cttggcacaa cctccttttt aggtagaacc atagttaatg 14221 gccctggcca gaaggcttta gctaacttat aagctaactc tgttggataa gccaatttct 14281 ccaaatcctc aaattttgag atatgaacta tgacaggatc aattaaaggc ctctgcttaa 14341 cctcaaagat cttagctaca gcctctttat ttaaagcatc agcccctaag ccataaactg 14401 tttctgtagg aaaagctact aagccacctt ttctaatcac ttcagcagcc ttttttatat 14461 tttcttcagt tgcctttaga atcattttta tgacacctaa agccttatat aggagaaact 14521 ttaaaaattc attattatat ttaataattg tgaggtttta gcttatgaac ataaacaaag 14581 ataaaattat aactcctgtt ctcattggtg gagttgttgg agggatttta ggagtttttt 14641 gctgtttaat gtatattgtt gctggagcct tggcaacata tttatatagt aaagaggagt 14701 ttatagagtt ggaaagttca gctgtggttg gagccattgc tggtgtaata gctggtgtta 14761 ttgaatttat aataaacttc atcttaaata tggtttttct aattcatatg tctaacactc 14821 ctccaatgtt ctcaggattt tatagtattg ctttagccat tgggttcatc ttttccatta 14881 tctttggagc catcttaggg gctataggag gagttttata tcactacata gctaatagat 14941 aatccccagg gtgggttagc ctccctgact tggctctgct taggatgatg ggagtgtgtt 15001 aatccctggg gacatcatct cttttaaagt tttaagggtg ggaaattgga gatctatttt 15061 attacaggga acataaataa ggttagggaa gctgaaacta ttttaaaaga tattaagatt 15121 aagaatataa aaatagagta tcctgaactt cagggaaccc ttgaagaagt tgctgagttt 15181 ggagctaagt actgttatga aagattaaaa aagcctttaa tagttgaaga tagcggcttt 15241 tttgttgaag ccttaaaagg atttcctggg acatactcaa ggtttgttta tgaaactata 15301 ggaaatgaag ggatattaaa attactaaaa ggagtaagtg ataggagagc ttactttaaa 15361 tctgttattg gctactgtga tgaaaatgga gttcaactat tttcaggagt agttaaaggt 15421 tatgtatcca gtgaaataag gggagataaa ggatttggct atgatcctat ctttattcca 15481 gagggttatg ataaaacatt tggagagctt gggattgagg agaagagtaa agtgtcccac 15541 agaaggaagg cttttgagaa gttaagagag ttcttactaa agaaaattta aatatcttta 15601 taactaataa gctctgaaaa tttggtaatt tcatgcatag ccttaatttc aacagagatc 15661 tcattttcat ttaagaagga tagagggtta gctccaccaa tggttataac tccacacata 15721 tctttattaa ccttaactcc agcaagctca ttatttggct ctcctatgca tttaattcca 15781 ttccactcta ataattcaat aattctctct aactcctctc tacaaattct atgtatctct 15841 ctaaagcctg ctaagaatgt agtttcacaa tcaaccttat taaagaagat ctcatgaggg 15901 tctaaagagg ttccactata cttaatgatg tctataaatc tcatctcctc ttctttaact 15961 tctaagattc ctccatactt aggaataatt ggaactccta agttatttat tatcccatct 16021 aaagttactg cacagattgt ttttatctta accttatcct ttaaaacctc ataaccaaac 16081 ctatctgaga ttcctaagcc cttactgtaa gcctctttta agatgtcaag ggcttcatct 16141 aaatatttct tatctatata accaatgtta actataacat ctccatcctt ctcatagata 16201 tcataattta catgagccat taggttgatc atcttagata gagctgtttt tatccttaca 16261 tttgcctttt tagtagaaat ttttaagctc tttttttcca acttatggag agagcttaac 16321 ctaacaattg atgacatagg gataatttca gttggaatat ctttctcaac aaatggagct 16381 attggagata ggccaccaat cataactatt cctatatgct cttcaccaac atccaagcct 16441 aagacattct cagagccata agaaataatt ccatccaact ttttaatgat tctctcaaac 16501 ctctccctat agttggctcc aataacccta aagtttgctg gtaggtagcc ttcaccattc 16561 tcaataatcc ctaagacatc agtttttttc ctttctataa atgccagtag aggatcaatt 16621 gaggtagcct tatactttat gatctcttta aactcaactg gctcatagtt ttcatattta 16681 acaattcctc cacagatgtg ataaactgga attccatttt taactaagag accatcaagg 16741 tttagtgagc ataaagtata gagctctata tacttctccc tatctactat cccaactcta 16801 tctccaatag ctaacccatt ttcataaacc ttctttatta aggaaagagc cttttcataa 16861 tctgtataaa ctattgatct attcacaacc actaaaccag cttgatagtc tgagaggata 16921 accttctcta agatatttga gtaaatattt cctaatctat atgagatatt agccttctct 16981 aactcctcta accctttttc agttataatt cttcctaaat agcctacttt tttagttaag 17041 cccatgctgt ctaagagctt taaatgatat cttacagccc tctctcctat cttatatcct 17101 ctcttgctaa gctctttagc tattatcttt gctcccactg gttcattata cttagacaat 17161 atatccaaga tttcaattaa cttcctatct aaatccatac taccatcctt aaaagaatta 17221 atgagcctgt cacaattaag gaaagaaagg ttaagaactt aattttttta gttcctactt 17281 taaatactga taagtagaga ataaagtatg ccactaaggt taagaacata cttatatcca 17341 ctaatacttt aacattaagg gttattaaaa ctattgtcag aagggcattt aaaagaactc 17401 cataaatagg aactcctcta tagagggttt caaagaactt aggaaaaatc ttatcctttg 17461 aaaagccata gggcatatat gagagtgtga agaggacact gaaggcacag cttcctataa 17521 tagtaaggat acaaatatac aaaaagatat tttctccaat taaagccttt aaaatttcct 17581 ctatactgtt actctttaaa tttagtgaaa ccactgttag agcaaagaga agataaagaa 17641 ttccaattat tagagttcct ataattaagc ctaaagatat agccctttga tccttaaaag 17701 ctgagagggg catggtaacc ccttcccagc ctgtagttga ccacagggaa taataaactg 17761 aaaagatagc ctcttttaaa ttaaatttat agagctctaa gttaaatcca tttttgaagc 17821 atatatataa gatggttaaa atagttgtta aacctaagat ccttacagct aagccaacaa 17881 ttcttaagcc tgaaagaatt aggagagtta tcaaaattac caaaaaatac ttaattggaa 17941 agctaaaata gatgttaaaa actatattaa agaatgaaac tactccagag agtgcaaaaa 18001 cacaagaaag ccacataata atgcctgaag ctatcccaat ccttttacca agagtgtcat 18061 taataaattt atatactcca ccactctcag aaatttttag tgttgcatag gagaagggta 18121 gagccataac taaggcagtt gggattaaga ggatccagcc atatatggaa gaggagccaa 18181 acattaagta tgttagaggg gctaagataa atatccctcc tccaacaatt gaagttatag 18241 ttaaaaagat agcatctttt aatgttagca c //