LOCUS NC_013364:23 18108 bp DNA linear BCT 10-SEP-2013 DEFINITION Escherichia coli O111:H- str. 11128, complete genome. ACCESSION NC_013364 SOURCE Escherichia coli O111:H- str. 11128, complete genome. COMMENT locus start: 4306000; locus end: 4324107 COMMENT n1_4mer:GRV/n1_4mer:RV = 2.297491; n0_4mer:D = 31.918774; n0_4mer:PS = 15.543915 FEATURES Location/Qualifiers source 1..18108 /organism="Escherichia coli O111:H- str. 11128, complete genome." gene 419..772 /gene="arsR" /locus_tag="arsR" /db_xref="4306418..4306771" CDS 419..772 /gene="arsR" /product="DNA-binding transcriptional repressor ArsR" /translation="MSFLLPIQLFKILADETRLGIVLLLSELGELCVCDLCTALDQSQ PKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWAAKIIDEAWRCEQEKVQAIVRN LARQNCSGDSKNICS" gene 826..2115 /gene="arsB" /locus_tag="arsB" /db_xref="4306825..4308114" CDS 826..2115 /gene="arsB" /product="arsenite/antimonite transporter ArsB" /translation="MLLAGAIFVLTIVLVIWQPKGLGIGWSATLGAVLALVTGVVHPG DIPVVWNIVWNATAAFIAVIIISLLLDESGFFEWAALHVSRWGNGRGRLLFTWIVLLG AAVAALFANDGAALILTPIVIAMLLALGFSKGTTLAFVMAAGFIADTASLPLIVSNLV NIVSADFFGLGFREYASVMVPVDIAAIVATLVMLHLYFRKDIPQNYDMALLKSPAEAI KDPATFKTGWVVLLLLLVGFFVLEPLGIPVSAIAAVGALILFVVAKRGHAINTGKVLR GAPWQIVIFSLGMYLVVYGLRNAGLTEYLSGVLNVLADNGLWAATLGTGFLTAFLSSI MNNMPTVLVGALSIDGSTASGVIKEAMVYANVIGCDLGPKITPIGSLATLLWLHVLSQ KNMTISWGYYFRTGIIMTLPVLFVTLAALALRLSFTL" gene 2128..2553 /gene="arsC" /locus_tag="arsC" /db_xref="4308127..4308552" CDS 2128..2553 /gene="arsC" /product="arsenate reductase" /translation="MSNITIYHNPACGTSRNTLEMIRNSGTEPTIIHYLETPPTRDEL VKLIADMGISVRALLRKNVEPYEELGLAEDKFTDDRLIDFMLQHPILINRPIVVTPLG TRLCRPSEVVLEILPDAPKGAFSKEDGEKVVDEAGKRLK" gene complement(2687..2983) /gene="" /locus_tag="" /db_xref="4308686..4308982" CDS complement(2687..2983) /gene="" /product="hypothetical protein" /translation="MQLEEVAKALKELGHPTRLFIFKHLVKAGEQGLPVGELQKQLGI PGSTLSHHISALVSVGLVKQNRESRTLMCVSQYAMLEAIIEFLREECCVNSKIA" gene 3129..4091 /gene="" /locus_tag="" /db_xref="4309128..4310090" CDS 3129..4091 /gene="" /product="hypothetical protein" /translation="MFVFLAVELSLLFIVISAGVSLIRQKVPDHKIQQMMGARKGRGY LLAALLGAVTPFCSCSTIPMLRGLLSAKAGFGPTLTFLFVSPLLNPIIVGLMWMTFGW KVTLLYAIIAAGVSVLASIILDSLGFERHIIASKSSSANCCAPAKTSPGTTYTPIKVS CCSPAAKAIENPVVTCCSTKAVVSINPIKLATKDALQQFKDVLPYLLLGVLIGSFIYG FIPSAWIAAHAGADNPFAIPLSAVVGIPLYIRAEAVIPLASVLMTKGMGLGALMALII GSAGASLTEVILLKSMFRMPMIAAFLTVILGMAILMGYLTQLLF" gene 4297..4623 /gene="" /locus_tag="" /db_xref="4310296..4310622" CDS 4297..4623 /gene="" /product="putative IS629 transposase OrfA" /translation="MTKNTRFSPEVRQRAIRMVLESQDEYDSQWAAICSIAPKIGCTP ETLRVWVRQHERDTGGGDGGLTSAERQRLKELERENRELRRSNDILRQASAYFAKAEF DRLWKK" gene 4620..5510 /gene="" /locus_tag="" /db_xref="4310619..4311509" CDS 4620..5510 /gene="" /product="putative IS629 transposase OrfB" /translation="MMPLLDKLREQYGVGPVCSELHIAPSTYYHCQQQRHHPDKRSAR AQHDDWLKREIQRVYDENHQVYGVRKVWRQLLREGIRVARCTVARLMAVMGLAGVLRG KKVRTTISRKAVAAGDRVNRQFVAERPDQLWVADFTYVSTWQGFVYVAFIIDVFAGYI VGWRVSSSMETTFVLDALEQALWARRPSGTIHHSDKGSQYVSLAYTERLKEAGLLAST GSTGDSYDNAMAESINGLYKAEVIHRKSWKNRAEVELATLTWVDWYNNRRLLGRLGHT PPTEAEKAYYASIGNDDLAA" gene 5981..6295 /gene="" /locus_tag="" /db_xref="4311980..4312294" CDS 5981..6295 /gene="" /product="" /translation="MSIDFTPGIINTYHGDIYNCTTNTDNAKTPDTPKWPCDNWEEQQ PINSTFSGEGYISDQYDLAQHQLQQINACHTNTTYTNADYSKVVAQLVSLITNIETIS ST" gene 6467..6826 /gene="" /locus_tag="" /db_xref="4312466..4312825" CDS 6467..6826 /gene="" /product="" /translation="MFSDTNFIAEQRADLPTNIKDIQSLYQKMTKLYIEHSENKNRMK VFAGTNFIDFNMTGQNLSGFVLTLSRFYFEDLLNINFTDENLGDTIFYIKNTLPPNYI KMDNILTNKSKVYFQHY" gene 7021..7203 /gene="" /locus_tag="" /db_xref="4313020..4313202" CDS 7021..7203 /gene="" /product="" /translation="MSEYQFEVFQYETLNPKKMSHTPYLKRPLPNEKDINYGVEIEIP SGKRIRLSNHYQNIIP" gene 7451..8017 /gene="slp" /locus_tag="slp" /db_xref="4313450..4314016" CDS 7451..8017 /gene="slp" /product="outer membrane lipoprotein Slp" /translation="MNMTKGALILSLSFLLAACSSIPQNIKGNNQPDIQKSFVAVHNQ PGLYVGQQARFGGKVINVINGKTDTLLEIAVLPLDSYAKPDIEANYQGRLLARQSGFL DPVNYRNHFVTILGTIQGEQPGFINKVPYNFLEVNMQGIQVWHLREVVNTTYNLWDYG YGAFWPEPGWGAPYYTNAVSQVTPELVK" gene 8173..8703 /gene="yhiF" /locus_tag="yhiF" /db_xref="4314172..4314702" CDS 8173..8703 /gene="yhiF" /product="putative DNA-binding transcriptional regulator" /translation="MFLIITRDTMFFTAMKNILSKGNVVHIQNEEEIDVMLHQNAFVI IDTLMNNVFHSNFLTQIERLKPVHVIVFSPFNIKRCLGKVPVTFVPRTITIIDFVALI NGSYCSVPEANVSLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNL KRINELVRHQHIDYLV" gene complement(8745..9392) /gene="yhiD" /locus_tag="yhiD" /db_xref="4314744..4315391" CDS complement(8745..9392) /gene="yhiD" /product="putative Mg(2+) transport ATPase inner membrane protein" /translation="MTAEFIIRLILAAIACGAIGMERQMRGKGAGLRTHVLIGMGSAL FMIVSKYGFADVLSLDHVGLDPSRIAAQVVTGVGFIGAGNILVRNQNIVGLTTAADIW VTAAIGMVIGSGMYELGIYGSVMTLLVLEVFHQLTFRLMNKNYHLQLTLVNGNTVSML DWFKQQKIKTDLVSLQENEDHEVVAIDIQLHATTSIEDLLRLLKGMAGVKGVSIS" gene complement(9456..9794) /gene="hdeB" /locus_tag="hdeB" /db_xref="4315455..4315793" CDS complement(9456..9794) /gene="hdeB" /product="acid-resistance protein HdeB" /translation="MGYKMNISSLRKAFIFMGAVAALSLVNAQSALAANESAKDMTCQ EFIDLNPKAMTPVAWWMLHEETVYKGGDTVTLNETDLTQIPKVIEYCKKNPQKNLYTF KNQASNDLPN" gene complement(9898..10230) /gene="hdeA" /locus_tag="hdeA" /db_xref="4315897..4316229" CDS complement(9898..10230) /gene="hdeA" /product="stress response protein acid-resistance protein HdeD" /translation="MKKVLGVILGGLLLLPVVSNAADAQKAADNKKPVNSWTCEDFLA VDESFQPTAVGFAEALNNKDKPEDAVLDVQGIATVTPAIVQACTQDKQANFKDKVKGE WDKIKKDM" gene 10485..11057 /gene="hdeD" /locus_tag="hdeD" /db_xref="4316484..4317056" CDS 10485..11057 /gene="hdeD" /product="acid-resistance membrane protein HdeD" /translation="MLYIDKATILKFDLEMLKKHRRAIQFIAVLLFIVGLLCISFPFV SGDILSTVVGALLICSGIALIVGLFSNRSHNFWPVLSGFLVAVAYLLIGYFFIRAPEL GIFAIAAFIAGLFCVAGVIRLMSWYRQRSMKGSWLQLVIGVLDIVIAWIFLGATPMVS VTLVSTLVGIELIFSAASLFSFASLFVKQQ" gene 11856..12383 /gene="gadE" /locus_tag="gadE" /db_xref="4317855..4318382" CDS 11856..12383 /gene="gadE" /product="DNA-binding transcriptional activator GadE" /translation="MIFLMTKDSFLLQGFWQLKDNHEMIKINSLSEIKKVGNKPFKVI IDTYHNHILDEEAIKFLEKLDAERIIVLAPYHISKLKAKAPIYFVSRKESIKNLLEIT YGKHLPHKNSQLCFSHNQFKIMQLILKNKNESNITSTLNISQQTLKIQKFNIMYKLKL RRMSDIVTLGITSYF" gene 12722..13879 /gene="mdtE" /locus_tag="mdtE" /db_xref="4318721..4319878" CDS 12722..13879 /gene="mdtE" /product="multidrug resistance efflux transporter MdtE" /translation="MNRRRKLLIPLLFCGAMLTACDDKSAENAAAMTPEVGVVTLSPG SVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELN SAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAV EQATINLQYANVTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQD FLRMKEEVASGQIKQVQGSTPVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTLRAIF PNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLREIE ASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARAISSSQENASTESKQ" gene 13904..17017 /gene="mdtF" /locus_tag="mdtF" /db_xref="4319903..4323016" CDS 13904..17017 /gene="mdtF" /product="multidrug transporter MdtF, RpoS-dependent" /translation="MANYFIDRPVFAWVLAIIMMLAGGLAIMNLPVAQYPQIAPPTIT VSATYPGADAQTVEDSVTQVIEQNMNGLDGLMYMSSTSDAAGNASITLTFETGTSPDI AQVQVQNKLQLAMPSLPEAVQQQGISVDKSSSNILMVAAFISDNGSLNQYDIADYVAS NIKDPLSRTAGVGSVQLFGSEYAMRIWLDPQKLNKYNLVPSDVISQIKVQNNQISGGQ LGGMPQAADQQLNASIIVQTRLQTPEEFGKILLKVQQDGSQVLLRDVARVELGAEDYS TVARYNGKPAAGIAIKLATGANALDTSRAVKEELNRLSAYFPASLKTVYPYDTTPFIE ISIQEVFKTLVEAIILVFLVMYLFLQNFRATIIPTIAVPVVILGTFAILSAVGFTINT LTMFGMVLAIGLLVDDAIVVVENVERVIAEDKLPPKEATHKSMGQIQRALVGIAVVLS AVFMPMAFMSGATGEIYRQFSITLISSMLLSVFVAMSLTPALCATILKAAPEGGHKPN ALFARFNTLFEKSTQHYTDSTRSLLRCTGRYMVVYLLICAGMAVLFLRTPTSFLPEED QGVFMTTAQLPSGATMVNTTKVLQQVTDYYLTKEKDNVQSVFTVGGFGFSGQGQNNGL AFISLKPWSERVGEENSVTAIIQRAMIALSSINKAVVFPFNLPAVAELGTASGFDMEL LDNGNLGHEKLTQARNELLSLAAQSPDQVTGVRPNGLEDTPMFKVNVNAAKAEAMGVA LSDINQTISTAFGSSYVNDFLNQGRVKKVYVQAGTPFRMLPDNINQWYVRNASGTMAP LSAYSSTEWTYGSPRLERYNGIPSMEILGEAAAGKSTGDAMKFMADLVAKLPAGVGYS WTGLSYQEALSSNQAPALYAISLVVVFLALAALYESWSIPFSVMLVVPLGVVGALLAT DLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAVEMMQKEGKTPIEAIIEAARMRLRP ILMTSLAFILGVLPLVISHGAGSGAQNAVGTGVMGGMFAATVLAIYFVPVFFVVVEHL FARFKKA" gene complement(17380..18108) /gene="gadW" /locus_tag="gadW" /db_xref="4323379..4324107" CDS complement(17380..18108) /gene="gadW" /product="DNA-binding transcriptional activator GadW" /translation="MTHVCSVILIRRSFDIYHEQHKISLHNESIVLLEKNLADDFAFC SPDTRRLDIDELTVCHYLQNIRQLPRNLGLHSKDRLLINQSPPMPLVTAIFDSFNESG VNSPILSNMLYLSCLSMFSHKKELIPLLFNSISTVSGKVERLISFDIAKRWYLRDIAE RMYTSESLIKKKLQDENTCFSKILLASRMSMARRLLELRQIPLHTIAEKCGYSSTSYF INTFRQYYGVTPHQFAQHSPGTFS" ORIGIN 1 ctcactccgg ccagagcatc agttaacggc accacccgta cttctgacca ggactttgaa 61 agcgtttatg cgcattacca gagtgaaaat gcctcagagc taactggata atcatacagt 121 acattcaggt tataaaacca gcatgtcctt gcaatagttt cagtatggta ttagcattga 181 tgcgttagat aatggcattc tcactccagc cagtgccacc aactcagggc tggaaagtaa 241 aaaaccgacg caaagtcggt ttttttacgt cctgattcag acctcctttc aaatgaatag 301 ccaactcaaa attcacacct attaccttcc tctgcactta cacattcgtt aagtcatata 361 tgtttttgac ttatccgctt cgaagagaga cactacctgc aacaatcagg agcgcaatat 421 gtcatttctg ttacccatcc aattgttcaa aattcttgct gatgaaaccc gtctgggcat 481 cgttttactg ctcagcgaac tgggagagtt atgcgtctgc gatctctgca ctgctctcga 541 ccagtcgcag cccaagatct cccgccacct ggcattgctg cgtgaaagcg ggctattgct 601 ggaccgcaag caaggtaagt gggttcatta ccgcttatca ccgcatattc cagcatgggc 661 ggcgaaaatt attgatgagg cctggcgatg tgaacaggaa aaggttcagg cgattgtccg 721 caacctggct cgacaaaact gttccgggga cagtaagaac atttgcagtt aaaaatttag 781 ctaaacacat atgaattttc agatgtgttt tatccgggag gcattatgtt actggcaggc 841 gctatctttg tcctgaccat cgtattggtt atctggcagc cgaaaggttt aggcatcggc 901 tggagtgcaa cgctcggcgc agtactggcg ttagttacgg gcgtggtcca tccgggtgat 961 attccggtgg tgtggaatat cgtctggaac gcgacggctg cgtttatcgc cgtcattatc 1021 atcagcctgc tgctggatga gtccggcttt tttgaatggg cggcgctgca cgtctcacgc 1081 tggggtaatg gtcgtggtcg cttgctgttt acctggattg tcctgctcgg tgctgccgtt 1141 gccgccctgt ttgccaatga tggcgcggcg cttattttga caccgattgt catcgccatg 1201 ctgctggctt tagggttcag taaaggcact acgctggcgt tcgtgatggc ggccggattc 1261 attgccgata ccgccagcct gccgcttatt gtctccaact tggtgaatat cgtttccgct 1321 gatttctttg gcctcggctt tcgcgaatac gcctcggtga tggtgccggt ggatatcgcc 1381 gcgattgttg ccacgctggt gatgttacat ctctattttc gcaaagatat tccgcagaac 1441 tacgatatgg cgctgctgaa atctcccgca gaagcgatca aagatcctgc tacgttcaaa 1501 actggctggg ttgttttact gcttctgctg gtgggatttt tcgtcctgga accgctcggc 1561 attccggtga gcgccattgc agctgtgggc gcgctgatat tatttgtcgt cgctaaacgc 1621 ggtcatgcga ttaatacggg taaagtcctg cgcggtgccc cctggcagat tgtcatcttc 1681 tcgctcggca tgtatctggt ggtttatggc ctgcgcaatg ccggattaac ggaatatctt 1741 tctggcgtac tcaacgtgct ggcggataac ggcctgtggg ccgcgacgct cggcaccgga 1801 ttcctcaccg ccttcctctc ttctattatg aacaatatgc cgacggtact ggttggcgcg 1861 ttgtccattg atggcagcac ggcatctggc gttatcaaag aagcgatggt ttatgccaat 1921 gtgattggct gcgatttggg accgaaaatt accccaattg gtagcctggc tacgctactc 1981 tggctgcacg tactttcgca gaagaatatg actatcagct ggggatatta cttccgtaca 2041 gggattatca tgaccctgcc tgtgctgttt gtgacgctgg ctgcgctggc gctacgtctc 2101 tctttcactt tgtaatgaga tactgatatg agcaacatta ccatttatca caacccggcc 2161 tgcggcacgt cgcgtaatac gctggagatg atccgcaaca gcggcacaga accgaccatt 2221 atccattatc tggaaactcc gccaacgcgc gatgaactgg tcaaactcat tgccgatatg 2281 gggatttccg tacgcgcgct gctgcgtaaa aacgtcgaac cgtatgagga gctgggcctt 2341 gcggaagata aatttactga cgatcggtta atcgacttta tgcttcagca cccgattctg 2401 attaatcgcc cgattgtggt gacgccgctg ggaactcgcc tgtgccgccc ttcagaagtg 2461 gtgctggaaa ttctgccaga tgcgccaaaa ggcgcattct ccaaggaaga tggcgagaaa 2521 gtggttgatg aagcgggtaa gcgcctgaaa taaagcggcg atatccactg ccgatagttg 2581 gtaaagtgcg ctttgtttat gtcggatgcg acgctaacgc gtcttatccg acctacaaaa 2641 ccgtgcaaat tcaatatatg gcatgaaata tgtagagcgt agcgcatcag gcaattttgc 2701 tatttacgca gcactcctcg cgtaagaatt caattatcgc ttccagcatt gcgtattgcg 2761 aaacacacat cagcgtccga ctctcacggt tttgtttgac cagtcctacc gataccagtg 2821 ctgatatatg gtggctgagt gtggagccag gtatcccaag ctgcttttgc aactcaccga 2881 ccggcaaccc ttgttccccg gctttgacaa gatgtttaaa tatgaacaaa cgggtcgggt 2941 gacctagctc tttcagcgct ttagcgactt cttccaactg catatgacac ccctctgtct 3001 ggttgatatt tcgataatac cagaaatatc ttgatctgaa tttcatttcg attattctgg 3061 aaatatagat ttatccaatg aggttacgta tgagtagttg gcttgcgatg ctgcaagatg 3121 ccgcagagat gtttgtgttt ctcgccgtcg agctttcgtt gctgtttata gtgattagtg 3181 ccggtgtcag cctgataaga caaaaggtgc cagaccataa aatccagcag atgatggggg 3241 ccagaaaagg gagaggctat ctcctggctg ctctgttggg agccgttacc ccgttctgta 3301 gttgctcgac aatacccatg ttacgtggat tgttgtcagc gaaagccggg tttggtccga 3361 ctctcacttt tttatttgtt tcaccattac ttaatcccat tatcgtcgga ctaatgtgga 3421 tgacctttgg ttggaaagtc accttgttgt acgcgattat cgcagccggc gtctccgttc 3481 ttgccagtat tatcctggat tctctggggt ttgaacgtca tatcattgcc agtaaaagct 3541 catcagcaaa ttgttgtgct ccagcaaaaa cttcgccggg aacgacatat acgcccataa 3601 aagtgagttg ttgtagtcca gcggctaaag ccattgagaa ccccgtagtt acctgttgca 3661 gtaccaaagc tgtagtaagt attaatccca taaaactagc caccaaagat gcgttgcaac 3721 agtttaaaga tgtactgcca tatcttttgt taggagtatt aataggatct tttatttatg 3781 gctttattcc ctcagcgtgg attgccgctc atgcaggagc agataatccc ttcgccatcc 3841 cattaagcgc cgttgtcggt attccgctgt atatccgggc tgaggcagtt atccctctgg 3901 catctgttct gatgacaaaa ggaatgggtc tgggagcatt aatggcatta atcatcggca 3961 gtgccggcgc aagcctgacg gaagtgatat tacttaaatc aatgttcaga atgccgatga 4021 tagctgcatt cctgacggtt atattaggta tggctatctt gatgggctat ttgactcaat 4081 tgctatttta aatagatgcc agcagtaaac tataagatgc atagttagtg ccatatcctt 4141 ctaagtagaa aatcatagac aggataatcc ttaaaaatca caaatgattt aactaatgca 4201 ttgagaatga tgacggctcg gtcaacaagt catcaacaga caataaccgc cccggaaatc 4261 ctggagacta aactccctga gaaagaggta aacaggatga ctaaaaatac tcgtttttcc 4321 cccgaagtcc gtcagcgggc gattcgtatg gttctggaaa gtcaggatga atatgactca 4381 cagtgggcgg caatttgttc cattgcccca aagattggct gtacgccgga gactctgcgt 4441 gtctgggttc gccagcatga gcgggatacc gggggcggtg atggtgggct caccagcgct 4501 gaacgtcagc gtctgaaaga gctggaacgt gaaaatcgtg aactgcgccg cagtaacgat 4561 atccttcgcc aggcttccgc ttattttgcg aaggcggagt tcgaccgcct ctggaaaaaa 4621 tgatgccact gctggataag ctgcgtgagc agtacggggt cggaccggta tgcagcgaac 4681 tgcatattgc cccgtcaacg tattaccatt gtcagcaaca gcgacatcat ccggataaac 4741 gcagtgcccg tgcgcagcac gacgactggc tgaagagaga gatacagcgc gtatacgatg 4801 aaaatcatca ggtgtacggt gtgcgtaaag tctggcgtca gttgttacgg gaaggaatca 4861 gggtggccag atgtacagtg gcacgtctca tggcggttat gggacttgcc ggtgttctcc 4921 ggggtaaaaa ggtccgtacg accatcagcc ggaaagccgt tgccgcaggc gaccgcgtaa 4981 accgtcagtt cgtggcagaa cgacctgacc agctgtgggt ggctgatttt acttacgtca 5041 gcacatggca gggcttcgtc tatgtggcgt ttatcattga tgtgtttgcc ggatacatcg 5101 tggggtggcg ggtctcatcg tctatggaaa cgacattcgt gctggatgcg ctggagcagg 5161 cgttgtgggc ccgtcgtccg tctggcacca tccatcacag cgataaaggc tctcagtatg 5221 tgtcactggc ctatacggag cgactaaaag aagccggatt actggcatca acagggagta 5281 caggcgactc gtatgacaac gcgatggctg agagcatcaa tggtctttac aaagcggagg 5341 taatacaccg taagagctgg aaaaaccgtg cagaagtgga actggccaca ctaacgtggg 5401 tggactggta taacaatcga cgattgctgg gaaggctggg ccatactcct ccgacagaag 5461 cagaaaaagc ttattatgct tccatcggaa acgatgatct ggcagcctga gttcacagat 5521 aaaacactct ccaggaaacc cggggcggtt caataaccac gtaatcatgc ttctctgaca 5581 ttttatcgga gaagcaatga ctctttgtct cagtaccctc ctccttttta aaaggcagat 5641 ttcagtcgct aatacaacac atttttaaat acactttaac ctggttcatt attacacatc 5701 taaaacatca caaaaatatt acttcacaca ctatcggaga acaaaataac tttttaaaat 5761 gagcgctttt tgatagttgt taacgtttcc ctttacgata ctatcactgc ctttttttat 5821 acacaaatat taccgggtgg aaatgaaagg gaatttaaag gtaattatat caggaagata 5881 taacgcatta tatttattgt gtgtagaaga aaatccattc ctgttctaat tatccaattt 5941 aaacatctta gcataaaaca aatgatgaat aaggaatttt atgtcaattg actttacccc 6001 aggtataata aatacatatc acggcgatat ttataactgc acaacaaata ccgataatgc 6061 taaaacgcca gacacaccga agtggccttg cgataattgg gaagaacaac aacccattaa 6121 ttccacattc tctggagaag gatatatctc tgatcaatat gatttagcgc aacaccaact 6181 tcaacaaatt aatgcgtgcc acacgaacac tacatataca aatgcagact actcaaaagt 6241 tgtggctcaa cttgtaagtc ttattactaa cattgaaacg ataagttcga cataacttac 6301 gcaacagaca caatcaatac ttaatcagat taataacatt agatatgaaa aaaacaaaag 6361 tgctgaatgt cgaatcattg ttgtcgctaa tcctaaaccc gacaaggcaa tcataactaa 6421 aattagcgta gaagagggaa tacccataac attcagtgtc caaaccatgt tttcagatac 6481 taattttatt gctgaacaac gagctgactt accaactaat ataaaagata ttcaaagcct 6541 gtatcaaaaa atgacgaagt tatatattga gcacagtgaa aataaaaaca ggatgaaagt 6601 ctttgccgga accaacttta ttgatttcaa tatgacagga cagaacctgt ccgggttcgt 6661 tctaaccttg tcaaggtttt atttcgaaga tctacttaat ataaatttca ctgacgaaaa 6721 tttaggtgac actatttttt acataaagaa caccctaccc ccaaattata taaagatgga 6781 caatatcttg acaaacaaat cgaaggttta ttttcaacat tattaaccat taatgacaac 6841 tttttacgag caaaagcgga aattgcttcg acaataatta aatttttaga ggccaggata 6901 accaatcttt catacaatga catattaaca tatcagcaag aattccaaaa acaatgttat 6961 aagcaagtta aagcctttac gacactctct cgatacaata aaattcaaac atgggcagaa 7021 atgtctgaat atcagttcga agtatttcaa tacgagacgc ttaaccccaa aaaaatgtca 7081 cacacgcctt atttaaagag gccacttcct aatgaaaaag atataaatta tggggtggaa 7141 atagaaatac catctggcaa aagaattcgc ttatcaaatc attatcagaa tataatacca 7201 taatattgat tattagcact ttataattat tgaataaaaa tagattttat gtaattttaa 7261 aacaaaggat tatattatgg ggcgatggat actcatgcca cgccccaaaa tcaatggaat 7321 tgaactaaac aaaagggata taaacatcag acaggtttac gttactatca ggcatatcac 7381 ctcagaatca gatgaaaact ataaagaaat atctattatg gctttaatat ttgttgataa 7441 ggatagtaac atgaacatga caaaaggtgc actcatcctc agcctttcat ttttgcttgc 7501 cgcatgtagt tcaattccgc aaaatatcaa aggcaataac caacctgata ttcaaaaaag 7561 ttttgttgct gttcataacc agccggggtt atatgttggt caacaagcgc gctttggtgg 7621 gaaggttatc aacgttatca atggcaaaac ggatacgttg ttagaaatcg ctgtattacc 7681 gttggatagc tatgcgaagc ctgatattga agccaactat cagggccgac tgctcgccag 7741 acaaagcggc ttccttgatc cagtgaacta tcgtaatcac tttgttacca tcctcggtac 7801 cattcagggt gaacaaccag gctttatcaa taaagtcccg tataacttcc tggaagtgaa 7861 tatgcagggc atccaggtgt ggcatttgag agaagtggtt aataccacct ataacctgtg 7921 ggattacggc tatggtgcat tctggccgga accgggctgg ggtgcgcctt actacaccaa 7981 tgcggtgagt caggtaacac ctgagctggt caaataacac caccgaaaga tgcagatgct 8041 ttctcagcat ctgcatcatg tattacataa aattaatata cagtaagcta actattatta 8101 ttataagccc tgtcctgtta attacctttg gcaaactgat tataaagtta atgtccgcac 8161 caggagtcgg ttatgtttct tataattacc agggatacga tgttcttcac cgcgatgaaa 8221 aacattctga gtaaaggtaa tgtcgttcat atacagaacg aagaagagat cgacgtaatg 8281 ttgcatcaga atgccttcgt cattattgat acattaatga ataatgtatt tcattctaat 8341 tttctcactc aaattgaacg attaaaacct gtccatgtca ttgttttctc cccctttaat 8401 attaaacgct gtctggggaa agtaccggtg acctttgttc cgcggactat cactatcatt 8461 gattttgtcg cactcatcaa tggcagttac tgctctgtgc ctgaagcgaa tgtgtcactt 8521 tcgcgcaagc aacatcaggt tctgagctgc attgcgaatc aaatgacaac tgaagatatt 8581 ctggagaaac tgaaaatatc gctaaaaacg ttctactgcc ataaacacaa tatcatgatg 8641 atcctcaatc ttaagcggat caatgagctg gtacgccatc agcatattga ttatctggtg 8701 tgaatttcag gcttacggtg agtctggcta cgctgccaca cagattagct aattgaaacg 8761 cctttcaccc ctgccatacc ttttaataat cgcaacaggt cttctatcga cgttgtggca 8821 tgaagctgga tatcaatggc gaccacttca tgatcttcat tttcctgcaa cgaaactaaa 8881 tccgttttta ttttttgctg cttaaaccag tcgagcattg ataccgtatt accgttcact 8941 aatgtcagct gtaaatggta atttttgttc atcaggcgga aggttaattg atggaagact 9001 tccagcacca acaaggtcat cactgaacca taaataccca gttcgtacat accgctgcca 9061 ataaccatac ctatggcggc ggtcacccag atatccgctg ccgtcgtcag acctacaata 9121 ttttggttac gaacgagaat gttacctgca ccgataaacc cgacgcccgt caccacctga 9181 gcagcaatac ggctggggtc gagtccgacg tgatctaaag acagcacgtc agcaaaacca 9241 tatttcgaaa caatcataaa cagggcgctt cccatgccaa ttaatacatg tgtgcgtaac 9301 cctgctcctt tgccgcgcat ttgcctttcc atgccaatag cgccacaggc aattgccgcg 9361 agtataagac gtataataaa ttctgctgtc atataaaaat gcaaaaagga gcagcaagat 9421 ggctcaactt gctactcctt tttacttgta cctcattaat tcggcaagtc attagatgct 9481 tgatttttga aggtatacaa atttttctgc gggtttttct tacagtattc gatcacttta 9541 ggaatttgag tgagatcggt ttcatttaaa gtaacggtat cgccaccttt atatactgtt 9601 tcttcatgca gcatccacca tgcaaccggg gtcattgctt ttggattcag atcaataaat 9661 tcctggcagg tcatatcttt agcggattca ttggctgcca gcgcagattg tgcgttcacc 9721 agtgacaaag ccgctacagc gcccataaaa ataaacgctt tacggagaga tgaaatattc 9781 attttgtaac ccattcaata tagagattat atatgaacag gaggaatagc tgcttttaaa 9841 gaagatattc cggcctgttc aatatgcaag gaagtacgat gtaacgcatt cccggaatta 9901 catatctttc ttaattttgt cccattcgcc tttaacttta tctttaaagt tggcttgttt 9961 atcctgagta caagcctgaa cgatagctgg ggttacggtt gcaataccct gaacatctaa 10021 aaccgcatct tctggtttat ctttgttgtt cagcgcttca gcaaaaccaa ctgcagttgg 10081 ctggaaggat tcgtccacag ccaggaaatc ttcacaggtc caggagttga ccggtttttt 10141 gttatcagct gctttttgcg catccgctgc attgctcaca actggcagaa gaagcagacc 10201 accaagaata acgcctaata cttttttcat cgtaatatcc tcaactataa agtgaaagag 10261 ccgtcacgaa tcaatttcga cactgaggtt ataacctggt tttctgtata tgtcatgttg 10321 atggaaaata tcaaaatcag atatttttat ttcaatacaa tgagttacag atgcatcaga 10381 tactgcaatt aggaaatttt tattaaatcg actgcattct tagacgcgtt tttggcatag 10441 attgatagca ggggattttc ttcttaattt tatagggtgg ttctatgtta tatatagata 10501 aggcaacaat tttgaagttt gatctggaga tgctgaaaaa gcatcgcaga gcaatccagt 10561 ttattgccgt gctgctgttt atcgtcgggt tgctgtgtat cagtttcccg ttcgtctctg 10621 gcgatatttt aagcacagta gtgggtgcat tattaatctg ctcgggtatt gcgcttattg 10681 tcgggttatt cagcaaccgc agtcataatt tctggccggt attatccggt ttcctcgtcg 10741 cagtcgccta tttattgatc ggctatttct tcatccgcgc accggagctg ggcatttttg 10801 ccattgcggc atttattgcc ggtttgttct gtgttgcagg ggttattcgc ctgatgagtt 10861 ggtatcgtca gcgttcaatg aaaggcagct ggctacagct cgttattggt gtgctggata 10921 tcgtcattgc ctggatattc cttggtgcaa cgccgatggt gtctgtaacg ctggtttcca 10981 cactggtggg aattgaactg atatttagcg ccgccagcct gttcagcttc gccagtttgt 11041 tcgttaagca gcaataatta tcccggttgt caccaggatc atagtcactt gatgtgacta 11101 tgatccgatt aatactctct ccgctacgca gtgttgtaga tcaattgcgc actatcattg 11161 aaataattac ctgctagtga tcatttcaac ctactgaatt tcatctaatt tttttcactc 11221 catggcaaat tagccatttc aaacattatc atggctgata ttttccgtag tcaggtttaa 11281 tgttttaaaa gtgctgtggg aaagtgaaca aagagttccg taagcgttga tgctatgggc 11341 ggttaaataa gtaatccggg ttcatttttt tgcaactggc gttgattaca ttgcataaat 11401 atccgtgtct ccagacgcta tataaaaacc tgaagacatg aatgcgttat ttactcaggt 11461 aatttcaatg cgttaaaaga aagctggcaa tccaattgcc agcttaagtc gaaacaagga 11521 gactcgatat ttaaatcgga ttacatttta actttagtaa tattcttcag agatcacaaa 11581 ctggttattg ataacttatt cttggccagt aatccgcaaa cgttaacttt ttgtttgata 11641 tttacaaatt gataacaacc aggaatctta cttaggatca atatatggag tgcgtgatgg 11701 ataaatctga agtattgatt agtgttaata gacgtattag ttcacgaagg gcaaagttct 11761 tataggcgtt tactatattg aacaacgatt cggacaagga tgtaaataat gaaaaggatg 11821 acatgttcga aacgataacg gctaaggagc aagttatgat ttttctcatg acgaaagatt 11881 cttttctttt acagggcttt tggcagttga aagataatca cgaaatgata aaaatcaatt 11941 ccctgtcaga gatcaaaaaa gtaggcaata aacccttcaa ggttatcatt gatacctatc 12001 acaatcatat ccttgatgaa gaagcgatta aatttctgga gaaattagat gccgagagaa 12061 ttattgtttt ggcaccttat cacatcagta aactaaaagc taaagcgcct atttattttg 12121 ttagccgcaa agaaagtatc aaaaatcttc ttgagattac ttatggtaaa cacttgcccc 12181 ataagaattc acaattatgt ttttcacata atcagttcaa aattatgcaa ctgattctga 12241 aaaataaaaa tgaaagcaat atcacgtcga cgctcaatat ttcgcaacaa acattaaaga 12301 ttcagaaatt caacattatg tacaagctga aactaagacg tatgagcgac atcgtcaccc 12361 tgggtatcac atcttatttt tagtcaggac ataagcaact gaaattgatg gctggcatga 12421 cgagggatgc agatgctgat ttcattaccc ccggtgatta ctaaaggaga ggctaaaacg 12481 actttattcc cctggtatgt gtatccacca gtagaaccct tcgttgcccg aatgctggca 12541 ggaactgttg gcagaacggc aacatttttt ttgtcgttga cctcaccatg tcgatcactg 12601 tgcctgtatc ccaccttact ggctgacaac cccactatgc cgctggtctg taaatccctc 12661 atatctctcc tcgcgcgcaa tttaaagaac cgttatttct caagaatttt cagggactaa 12721 aatgaacaga agaagaaagc tgttaatacc gttgttattc tgcggcgcga tgctcaccgc 12781 ctgcgatgac aaatcggcgg aaaacgccgc cgccatgacg cctgaggtcg gtgtcgtcac 12841 actctccccc ggttcggtca atgtgttgag cgaattgccc ggtagaaccg ttccttatga 12901 agttgccgag atacgtcccc aggtgggcgg tattatcatt aaacgcaact ttatcgaagg 12961 cgataaagtg aaccagggcg attcgctgta tcagattgat cctgcacctt tacaggccga 13021 gctaaactcc gccaaaggct cgctggcgaa agcgctctct accgccagca atgcccgcat 13081 cacctttaac cgccaggcat cgttgctgaa gaccaactac gttagccgtc aggattacga 13141 taccgcgcgc acccagttga atgaagcaga agccaatgtc accgtcgcca aagcggctgt 13201 tgaacaggcg acgatcaatc tgcaatacgc gaatgtcacc tcgccgatta cgggcgtcag 13261 cgggaaatcg tcggtgaccg tcggcgcact cgttaccgct aatcaggcag attcgctggt 13321 taccgtacaa cgtctggacc cgatttatgt cgatctcacg cagtcggtgc aagatttctt 13381 acgcatgaaa gaagaggtcg ccagtgggca aatcaaacag gttcagggca gtacgccagt 13441 acagctcaat ctggaaaatg gtaaacgcta cagccagacc ggcacgctga aattctccga 13501 cccgacggtg gatgaaacca cgggctccgt gacgttacgg gcgattttcc ccaacccaaa 13561 tggtgacttg ctgcctggca tgtacgtcac ggcattagtg gatgaaggta gccgccagaa 13621 tgtattactg gtgccgcagg aaggcgtcac ccacaacgcc cagggtaaag caacggcgct 13681 cattctggat aaagacgatg ttgtgcagct acgcgaaatt gaagccagca aagccatcgg 13741 cgaccagtgg gttgtcacct ctggcttgca ggctggcgat cgggtgatcg tttccggttt 13801 gcaacgcatt cgtccgggta tcaaagcacg agcaatttcc tccagccagg aaaacgccag 13861 caccgaatcg aaacaataac gttgcaggct taaggggact ttcatggcta actattttat 13921 tgatcgcccg gtttttgcct gggtacttgc cattattatg atgcttgcag gtggtctggc 13981 gatcatgaac ttaccggttg cgcagtatcc gcagattgcg ccaccgacca ttaccgtcag 14041 cgctacctat ccaggtgccg atgcgcaaac ggtagaagac tcggtcactc aggtgattga 14101 gcaaaatatg aatgggcttg atggcctgat gtacatgtct tcaaccagtg atgcggcggg 14161 taatgcctct atcactctga ccttcgagac tgggacatct cctgatatcg cacaggttca 14221 ggtgcaaaat aaactgcaac tcgctatgcc ttcattacct gaagcggtgc agcagcaggg 14281 gattagcgtt gataagtcga gcagtaatat tctgatggta gcggcgttta tttctgataa 14341 cggcagcctc aaccagtacg atatcgcgga ctatgtagcg tctaatatca aagacccgct 14401 aagccgtacc gcgggcgttg gtagcgtaca gctctttggt tccgagtacg ccatgcgtat 14461 ctggctggac ccgcaaaaac tcaataaata caatctggta ccttccgatg ttatttccca 14521 gattaaggtg caaaacaacc agatttccgg tggtcaactg ggtggcatgc cacaggcggc 14581 agaccagcaa ctaaacgcct cgatcattgt gcagacgcgt ctgcaaacgc cggaagaatt 14641 tggcaaaatc ctgttgaaag ttcagcaaga tggttcgcaa gtgctgctgc gtgatgtcgc 14701 ccgcgtcgaa cttggagcgg aagattattc caccgtggcg cgctataacg gcaaacctgc 14761 tgccgggatc gccatcaaac tggctaccgg agcaaacgcc ctggatacct cgcgggcagt 14821 caaagaggag ctgaaccgct tatcagccta tttccccgca agtctgaaga cggtttatcc 14881 ttacgacacc acgccgttta tcgaaatttc tattcaggaa gtttttaaaa cactggttga 14941 ggctatcatc ctcgtcttcc tggtcatgta tctgtttttg cagaatttcc gtgccacaat 15001 catcccgacg attgccgtac cggtggttat tctcgggacg tttgcgatct tgtcggcggt 15061 cggtttcacc atcaacacgt taactatgtt cgggatggtg ctggcgatag ggttactggt 15121 ggatgacgcc atcgtggtgg tggagaacgt cgagcgtgtc attgcggaag ataagctacc 15181 accgaaggaa gcgacgcata aatcgatggg gcagatccaa cgtgcgctgg tcggtattgc 15241 tgttgttctt tccgcagtgt ttatgccgat ggcctttatg agcggcgcaa ccggggagat 15301 ctaccgccag ttctccatca cgctgatctc ctccatgctg ctttcagtat ttgtggcaat 15361 gagcctgacc cctgccctgt gcgccaccat tctgaaagcc gcgccggaag gcggtcacaa 15421 acctaacgcc ctgttcgcac gcttcaacac gctgtttgaa aaatcaactc agcactatac 15481 cgatagcacc cgctcgctgt tgcgttgtac cggtcgctac atggtggtct acctgctgat 15541 ttgcgccggg atggcggtgc tgttcctgcg tacaccgacc tctttcttac cagaagagga 15601 tcagggggta tttatgacca ccgcgcagtt accttccggt gccaccatgg ttaacaccac 15661 gaaagtgctg caacaggtga cggattatta tcttacaaaa gagaaagata atgttcagtc 15721 ggtgtttacc gttggcggct ttggcttcag cggccagggg caaaacaacg gcctggcgtt 15781 tatcagtctc aagccgtggt ctgaacgtgt cggtgaggaa aactcggtta ccgcgatcat 15841 tcagcgggca atgattgcgt taagcagtat caataaagcc gtcgtcttcc cgttcaactt 15901 acccgcggtg gctgaactgg gtaccgcgtc aggttttgat atggaactgc tggacaacgg 15961 taacctgggg cacgaaaaac taacccaggc acgaaacgag ctgttatcac tggcagcgca 16021 atcgcctgac caggtcaccg gggtacgccc gaacggcctg gaagatacgc cgatgttcaa 16081 agtgaacgtc aacgccgcga aagctgaggc aatgggtgtg gcgctgtctg atatcaacca 16141 gacaatttcc accgccttcg gcagcagcta cgtgaacgac ttcctcaacc aggggcgggt 16201 gaaaaaagtg tatgtccagg caggcacgcc gttccgtatg ttgccggata acatcaacca 16261 atggtatgta cgcaacgcct ctggcacgat ggcaccgctt tctgcctact cgtctaccga 16321 atggacctat ggttcaccgc gattggaacg ctacaacggc atcccgtcaa tggagatttt 16381 aggtgaagcg gcggccggga aaagtaccgg tgacgctatg aaatttatgg cagacctggt 16441 cgctaaactt ccggcaggcg tcggctactc atggaccgga ctgtcgtatc aggaagcgtt 16501 atcctcaaac caggctcctg cactgtatgc catttcactg gtcgtggtgt tcctcgccct 16561 cgccgcactc tatgagagct ggtcaattcc gttctcggtg atgttggttg ttccgttagg 16621 cgtcgttggc gcattactgg ccaccgatct gcgcggctta agtaatgacg tctacttcca 16681 ggttggtttg ctgaccacca tcgggctttc cgccaagaac gccatcctga ttgtcgaatt 16741 tgccgttgag atgatgcaga aagaagggaa aacgccgata gaggcaatca tcgaagcggc 16801 gcggatgcgt ttacgcccaa tcctgatgac ctctctggcc tttattctcg gcgtgctgcc 16861 gctggttatc agtcatggtg ccggttctgg cgcgcaaaac gcggtaggta ccggcgtgat 16921 gggcgggatg tttgccgcaa cagtgctggc aatttacttc gttccggtct ttttcgttgt 16981 agtggaacat ctctttgccc gctttaaaaa agcgtaacgt gtaaatgaga gtaaggttga 17041 acgtgaaggt tcagccttac tctttcctgc taaccattca ccactcaaca accagctaac 17101 cgtcaggaat accaggctta gtacacagca ctgaaagtag aaaccactcc agccattcgt 17161 catcaatttg aacagcacaa tactgaccca cattcccgta atcgtatgaa ttgtcagctt 17221 aataatccca aacatgccga gtcttttcct cctgaaaata cctataccgc ctggcaaact 17281 gcgaaagaga actagccggt agcccggcag aaatcatcag ggaagagttt cacatgaagc 17341 aggtgtgaga tcctgaccaa tattcaaatg caaaatatgt caggaaaagg tacctggcga 17401 atgttgcgca aactgatgtg gcgttacacc ataatattgt cgaaatgtgt ttataaagta 17461 cgacgtactg ctatagccac atttttctgc aatagtatgc agaggaattt gacgtaactc 17521 gagtaatcgt ctggccatcg acatcctgga agcgagtaat attttactga aacaggtatt 17581 ttcatcctgc aacttttttt tgatgagact ctcgctggta tacattcttt ccgcgatatc 17641 gcgcagatac caacgtttgg cgatatcaaa gctaataagg cgttcaactt ttcctgaaac 17701 agtgctgatg ctattgaaaa gtaaggggat cagttctttc ttatgagaaa acatcgataa 17761 acaggaaagg tagagcatat tgctcagtat cggtgaattt accccggatt cattgaagct 17821 atcaaaaatc gccgtcacca gcggcatggg gggtgactgg ttaattaata gacggtcttt 17881 gctatgtaac cctaaattgc gtggtagctg acgaatattt tgtaagtaat ggcaaactgt 17941 cagctcatcg atatccagtc gtcgcgtatc cggtgaacaa aacgcaaaat cgtctgccaa 18001 atttttctcc agcagcacga tactctcgtt atgcagcgat attttatgct gttcatgata 18061 aatatcgaat gaacgacgaa tgaggatcac cgagcagaca tgagtcat //